Motif ID: Tbr1

Z-value: 0.937


Transcription factors associated with Tbr1:

Gene SymbolEntrez IDGene Name
Tbr1 ENSMUSG00000035033.9 Tbr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbr1mm10_v2_chr2_+_61804453_61804538-0.431.1e-04Click!


Activity profile for motif Tbr1.

activity profile for motif Tbr1


Sorted Z-values histogram for motif Tbr1

Sorted Z-values for motif Tbr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbr1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_111733924 6.207 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chr12_+_85473883 5.879 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene
chr7_-_46672537 5.562 ENSMUST00000049298.7
 Tph1
tryptophan hydroxylase 1
chr1_-_186705980 4.860 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chr11_-_32222233 4.294 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr19_-_57008187 4.038 ENSMUST00000118800.1
ENSMUST00000111584.2
ENSMUST00000122359.1
ENSMUST00000148049.1
 Afap1l2



actin filament associated protein 1-like 2



chr7_-_19698206 3.921 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr10_+_57784859 3.909 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr4_-_109665249 3.805 ENSMUST00000063531.4
 Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr15_+_79891631 3.626 ENSMUST00000177350.1
ENSMUST00000177483.1
 Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chrY_+_897782 3.505 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr11_-_69900949 3.487 ENSMUST00000102580.3
 2810408A11Rik
RIKEN cDNA 2810408A11 gene
chr7_+_30413744 3.475 ENSMUST00000032800.9
 Tyrobp
TYRO protein tyrosine kinase binding protein
chr2_+_71528657 3.453 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr11_-_69900930 3.442 ENSMUST00000018714.6
ENSMUST00000128046.1
 2810408A11Rik

RIKEN cDNA 2810408A11 gene

chr3_+_95526777 3.271 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr8_+_45885479 3.120 ENSMUST00000034053.5
 Pdlim3
PDZ and LIM domain 3
chr3_+_94693556 3.007 ENSMUST00000090848.3
ENSMUST00000173981.1
ENSMUST00000173849.1
ENSMUST00000174223.1
 Selenbp2



selenium binding protein 2



chr18_+_5591860 2.982 ENSMUST00000025081.5
ENSMUST00000159390.1
 Zeb1

zinc finger E-box binding homeobox 1

chr5_+_64812336 2.971 ENSMUST00000166409.1
 Klf3
Kruppel-like factor 3 (basic)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 321 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 7.8 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
2.3 7.0 GO:0030421 defecation(GO:0030421)
1.2 7.0 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.2 6.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.4 5.9 GO:0035994 response to muscle stretch(GO:0035994)
0.4 5.7 GO:0060134 prepulse inhibition(GO:0060134)
0.7 5.6 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 5.4 GO:0035411 catenin import into nucleus(GO:0035411)
1.6 4.9 GO:1902256 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.9 4.7 GO:0002339 B cell selection(GO:0002339)
0.2 4.5 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 4.4 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 4.3 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.2 4.0 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
1.3 3.9 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.8 3.9 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.9 3.6 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.7 3.5 GO:0035262 gonad morphogenesis(GO:0035262)
0.7 3.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 3.3 GO:0010447 response to acidic pH(GO:0010447)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.9 GO:0005667 transcription factor complex(GO:0005667)
0.7 8.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 8.9 GO:0005604 basement membrane(GO:0005604)
0.0 6.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.0 5.9 GO:0035976 AP1 complex(GO:0035976)
0.0 5.3 GO:0016324 apical plasma membrane(GO:0016324)
1.3 3.9 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.9 3.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 3.7 GO:0005770 late endosome(GO:0005770)
0.1 3.6 GO:0045171 intercellular bridge(GO:0045171)
0.3 3.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 2.9 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.6 2.6 GO:0019815 B cell receptor complex(GO:0019815)
0.1 2.6 GO:0016235 aggresome(GO:0016235)
0.2 2.4 GO:0042571 immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571)
0.1 2.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.4 2.3 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.4 2.2 GO:0031262 Ndc80 complex(GO:0031262)
0.2 2.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 201 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
1.7 7.0 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 6.1 GO:0008083 growth factor activity(GO:0008083)
0.4 6.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.9 5.6 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.5 5.2 GO:0008430 selenium binding(GO:0008430)
1.2 4.9 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.4 4.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 4.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.3 4.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 4.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 4.3 GO:0030695 GTPase regulator activity(GO:0030695)
0.3 4.0 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 4.0 GO:0005504 fatty acid binding(GO:0005504)
1.3 3.9 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 3.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 3.8 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 3.8 GO:0017022 myosin binding(GO:0017022)
0.0 3.8 GO:0019905 syntaxin binding(GO:0019905)
0.9 3.7 GO:0031720 haptoglobin binding(GO:0031720)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 7.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.3 5.9 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.5 4.9 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 4.0 PID_PLK1_PATHWAY PLK1 signaling events
0.1 3.7 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.1 3.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 2.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 2.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 2.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 2.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 2.0 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.6 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.5 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 1.4 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 1.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 1.3 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 1.3 NABA_COLLAGENS Genes encoding collagen proteins
0.1 1.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.9 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.5 5.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 5.3 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 4.4 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.3 3.9 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 3.8 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
1.1 3.3 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 3.2 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 2.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.6 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.4 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.3 2.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 2.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.8 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.8 REACTOME_DNA_REPAIR Genes involved in DNA Repair
0.2 1.6 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.6 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.1 1.6 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.5 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.5 REACTOME_AMYLOIDS Genes involved in Amyloids