Motif ID: Tbx15

Z-value: 0.768


Transcription factors associated with Tbx15:

Gene SymbolEntrez IDGene Name
Tbx15 ENSMUSG00000027868.5 Tbx15



Activity profile for motif Tbx15.

activity profile for motif Tbx15


Sorted Z-values histogram for motif Tbx15

Sorted Z-values for motif Tbx15



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx15

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_125490688 22.359 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr4_+_48045144 11.698 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr6_+_108213086 9.880 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr3_-_82074639 9.045 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr16_-_23988852 8.879 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr10_+_123264076 7.796 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr5_+_32136458 7.725 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr19_-_10304867 6.504 ENSMUST00000039327.4
 Dagla
diacylglycerol lipase, alpha
chr7_+_79810727 6.132 ENSMUST00000107394.1
 Mesp2
mesoderm posterior 2
chr17_-_81649607 6.115 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr8_+_23035116 5.936 ENSMUST00000117296.1
ENSMUST00000141784.2
 Ank1

ankyrin 1, erythroid

chr11_+_98348404 5.712 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr4_-_129121889 5.619 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chr18_-_74961252 5.272 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr6_-_28831747 4.980 ENSMUST00000062304.5
 Lrrc4
leucine rich repeat containing 4
chr17_-_29237759 4.882 ENSMUST00000137727.1
ENSMUST00000024805.7
 Cpne5

copine V

chr15_-_71727815 4.561 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr2_-_57114970 4.540 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr13_-_43304153 4.321 ENSMUST00000055341.5
 Gfod1
glucose-fructose oxidoreductase domain containing 1
chr9_+_47530173 4.201 ENSMUST00000114548.1
ENSMUST00000152459.1
ENSMUST00000143026.1
ENSMUST00000085909.2
ENSMUST00000114547.1
ENSMUST00000034581.3
 Cadm1





cell adhesion molecule 1






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 187 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 22.4 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
4.1 20.6 GO:0032763 regulation of mast cell cytokine production(GO:0032763)
1.6 9.9 GO:0042045 epithelial fluid transport(GO:0042045)
3.0 9.0 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.3 8.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.4 7.7 GO:0003334 keratinocyte development(GO:0003334)
2.5 7.4 GO:0001928 regulation of exocyst assembly(GO:0001928)
2.4 7.2 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
2.4 7.1 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
2.3 6.8 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.2 6.8 GO:0001919 regulation of receptor recycling(GO:0001919)
3.3 6.5 GO:0098917 retrograde trans-synaptic signaling(GO:0098917)
1.6 6.3 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.2 6.3 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
2.0 6.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
1.5 6.1 GO:0008078 mesodermal cell migration(GO:0008078)
1.9 5.7 GO:0007621 negative regulation of female receptivity(GO:0007621)
1.9 5.7 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.9 5.4 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
1.3 5.3 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 33.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 14.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.7 10.7 GO:0043196 varicosity(GO:0043196)
3.3 9.9 GO:0031088 platelet dense granule membrane(GO:0031088)
0.5 8.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 8.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 7.5 GO:0014704 intercalated disc(GO:0014704)
0.0 7.3 GO:0005925 focal adhesion(GO:0005925)
0.1 7.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.5 6.8 GO:0043083 synaptic cleft(GO:0043083)
0.3 5.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 5.7 GO:0001650 fibrillar center(GO:0001650)
0.0 5.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 5.1 GO:0005769 early endosome(GO:0005769)
0.1 5.0 GO:0005657 replication fork(GO:0005657)
0.0 4.8 GO:0030425 dendrite(GO:0030425)
0.6 4.5 GO:0071203 WASH complex(GO:0071203)
0.0 4.3 GO:0000139 Golgi membrane(GO:0000139)
0.1 4.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.8 3.8 GO:0030314 junctional membrane complex(GO:0030314)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 22.4 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.5 16.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.6 10.5 GO:0030275 LRR domain binding(GO:0030275)
3.3 9.9 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.4 9.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.8 9.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.8 9.0 GO:0004016 adenylate cyclase activity(GO:0004016)
0.3 8.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
2.4 7.1 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
1.4 6.8 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.7 5.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.9 5.7 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.6 5.7 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
1.4 5.5 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1 5.4 GO:0048487 beta-tubulin binding(GO:0048487)
1.3 5.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 5.1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 5.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.6 4.9 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 4.6 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 27.3 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.3 8.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 8.2 PID_FOXO_PATHWAY FoxO family signaling
0.1 7.4 PID_FGF_PATHWAY FGF signaling pathway
0.2 7.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 6.3 PID_SHP2_PATHWAY SHP2 signaling
0.4 5.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 5.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 4.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 4.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 4.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.9 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 3.7 PID_INSULIN_PATHWAY Insulin Pathway
0.1 3.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 3.2 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1 3.1 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 3.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.5 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 2.4 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 2.3 PID_REELIN_PATHWAY Reelin signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 23.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
1.2 22.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.6 13.8 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
1.0 9.6 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 7.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 7.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 6.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 6.5 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.5 6.1 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 5.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 5.0 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 4.6 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 4.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 3.9 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 3.7 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 3.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 3.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 3.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.3 2.8 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 2.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK