Motif ID: Tbx19

Z-value: 0.862


Transcription factors associated with Tbx19:

Gene SymbolEntrez IDGene Name
Tbx19 ENSMUSG00000026572.5 Tbx19



Activity profile for motif Tbx19.

activity profile for motif Tbx19


Sorted Z-values histogram for motif Tbx19

Sorted Z-values for motif Tbx19



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx19

PNG image of the network

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Top targets:


Showing 1 to 20 of 104 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_101468164 12.423 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr18_-_82406777 9.516 ENSMUST00000065224.6
 Galr1
galanin receptor 1
chr7_-_132776855 7.121 ENSMUST00000106168.1
 Fam53b
family with sequence similarity 53, member B
chr9_+_15520830 6.398 ENSMUST00000178999.1
 Smco4
single-pass membrane protein with coiled-coil domains 4
chr2_-_113758638 6.372 ENSMUST00000099575.3
 Grem1
gremlin 1
chr9_-_21760275 6.073 ENSMUST00000098942.4
 Spc24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr3_+_94693556 5.911 ENSMUST00000090848.3
ENSMUST00000173981.1
ENSMUST00000173849.1
ENSMUST00000174223.1
 Selenbp2



selenium binding protein 2



chr7_-_132786914 5.577 ENSMUST00000065371.7
ENSMUST00000106166.1
 Fam53b

family with sequence similarity 53, member B

chr17_+_6978860 5.496 ENSMUST00000089119.5
ENSMUST00000179728.1
 Rnaset2b

ribonuclease T2B

chr6_-_54593139 4.731 ENSMUST00000046520.6
 Fkbp14
FK506 binding protein 14
chr11_-_101171302 4.178 ENSMUST00000164474.1
ENSMUST00000043397.7
 Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr17_-_35027909 3.944 ENSMUST00000040151.2
 Sapcd1
suppressor APC domain containing 1
chr7_+_130936172 3.925 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr10_+_20347788 3.369 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr2_+_179442427 3.144 ENSMUST00000000314.6
 Cdh4
cadherin 4
chrY_+_897782 3.050 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr16_-_45844303 2.976 ENSMUST00000036355.6
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr6_+_124808885 2.952 ENSMUST00000143040.1
ENSMUST00000052727.4
ENSMUST00000130160.1
 Spsb2


splA/ryanodine receptor domain and SOCS box containing 2


chr14_-_66124482 2.667 ENSMUST00000070515.1
 Ephx2
epoxide hydrolase 2, cytoplasmic
chr14_+_115042752 2.648 ENSMUST00000134140.2
 Mir17hg
Mir17 host gene 1 (non-protein coding)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.7 GO:0035411 catenin import into nucleus(GO:0035411)
0.8 12.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
3.6 10.8 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
2.1 6.4 GO:1901228 regulation of osteoclast proliferation(GO:0090289) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) negative regulation of bone development(GO:1903011)
0.7 3.9 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.1 3.4 GO:0000266 mitochondrial fission(GO:0000266)
0.1 3.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.6 3.0 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.4 3.0 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.9 2.7 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673)
0.3 2.6 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.5 2.3 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.1 2.2 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.3 2.1 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 2.1 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.3 2.0 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.3 2.0 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.2 2.0 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.1 2.0 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 1.6 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.2 GO:0005615 extracellular space(GO:0005615)
0.0 8.1 GO:0005769 early endosome(GO:0005769)
1.0 6.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 5.9 GO:0001650 fibrillar center(GO:0001650)
0.1 5.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 3.0 GO:0045180 basal cortex(GO:0045180)
0.0 2.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 2.0 GO:0045179 apical cortex(GO:0045179)
0.0 2.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 1.5 GO:0033093 multivesicular body membrane(GO:0032585) Weibel-Palade body(GO:0033093)
0.0 1.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 1.4 GO:0005785 signal recognition particle receptor complex(GO:0005785) dense body(GO:0097433)
0.0 1.4 GO:0070469 respiratory chain(GO:0070469)
0.0 1.4 GO:0031526 brush border membrane(GO:0031526)
0.1 0.7 GO:0005787 signal peptidase complex(GO:0005787)
0.2 0.6 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.5 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 10.8 GO:0004966 galanin receptor activity(GO:0004966)
0.0 10.4 GO:0003924 GTPase activity(GO:0003924)
0.7 6.4 GO:0036122 BMP binding(GO:0036122)
0.5 5.9 GO:0008430 selenium binding(GO:0008430)
0.1 5.5 GO:0004540 ribonuclease activity(GO:0004540)
0.2 3.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 3.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 3.0 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.5 2.7 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 2.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 2.3 GO:0070403 NAD+ binding(GO:0070403)
0.1 2.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.6 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 1.5 GO:0003951 NAD+ kinase activity(GO:0003951)
0.1 1.5 GO:0031489 myosin V binding(GO:0031489)
0.0 1.5 GO:0005109 frizzled binding(GO:0005109)
0.0 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 1.4 GO:0015091 signal recognition particle binding(GO:0005047) ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.2 1.4 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 1.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 PID_BMP_PATHWAY BMP receptor signaling
0.1 6.1 PID_PLK1_PATHWAY PLK1 signaling events
0.0 2.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.7 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.6 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 6.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 4.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 3.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 3.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.1 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 1.5 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.5 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.4 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 0.9 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.9 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.7 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 0.6 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.1 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules