Motif ID: Tbx1_Eomes

Z-value: 1.045

Transcription factors associated with Tbx1_Eomes:

Gene SymbolEntrez IDGene Name
Eomes ENSMUSG00000032446.8 Eomes
Tbx1 ENSMUSG00000009097.9 Tbx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Eomesmm10_v2_chr9_+_118478344_1184784510.421.7e-04Click!


Activity profile for motif Tbx1_Eomes.

activity profile for motif Tbx1_Eomes


Sorted Z-values histogram for motif Tbx1_Eomes

Sorted Z-values for motif Tbx1_Eomes



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx1_Eomes

PNG image of the network

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Top targets:


Showing 1 to 20 of 149 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 36.858 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_+_6730051 31.585 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr2_-_13011747 24.716 ENSMUST00000061545.5
 C1ql3
C1q-like 3
chr1_-_138847579 22.006 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr1_+_6730135 20.617 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr6_+_15196949 19.855 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr4_+_125490688 19.426 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr7_-_28302238 14.510 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr1_+_132316112 12.351 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2

chr1_+_153665274 12.237 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr2_-_57114970 10.378 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr17_+_29093763 10.287 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr1_+_153665666 10.035 ENSMUST00000111814.1
ENSMUST00000111810.1
 Rgs8

regulator of G-protein signaling 8

chr1_+_153665587 9.056 ENSMUST00000147700.1
 Rgs8
regulator of G-protein signaling 8
chr1_+_153665627 8.512 ENSMUST00000147482.1
 Rgs8
regulator of G-protein signaling 8
chr18_-_46212595 7.113 ENSMUST00000037011.4
 Trim36
tripartite motif-containing 36
chr11_-_84068357 7.020 ENSMUST00000100705.4
 Dusp14
dual specificity phosphatase 14
chr13_-_89742490 6.935 ENSMUST00000109546.2
 Vcan
versican
chr11_-_84068766 6.712 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr2_+_164562579 6.582 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.4 52.2 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
2.8 39.8 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.2 28.7 GO:0050807 regulation of synapse organization(GO:0050807)
4.4 22.0 GO:0035262 gonad morphogenesis(GO:0035262)
1.7 19.9 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
1.8 19.4 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
2.9 14.5 GO:0007386 compartment pattern specification(GO:0007386)
0.4 12.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.3 12.4 GO:0042149 cellular response to glucose starvation(GO:0042149)
2.6 10.4 GO:0051866 general adaptation syndrome(GO:0051866)
1.1 10.3 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 9.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.3 7.1 GO:0007340 acrosome reaction(GO:0007340)
1.9 5.6 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 5.4 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
2.3 4.5 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.6 4.5 GO:0044027 hypermethylation of CpG island(GO:0044027)
1.3 3.8 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.3 3.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.7 3.5 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 48.3 GO:0032993 protein-DNA complex(GO:0032993)
1.0 39.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 24.5 GO:0005581 collagen trimer(GO:0005581)
0.6 19.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 10.9 GO:0016607 nuclear speck(GO:0016607)
3.4 10.3 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 7.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 5.4 GO:0031965 nuclear membrane(GO:0031965)
0.2 4.5 GO:0001741 XY body(GO:0001741)
0.0 4.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.9 3.8 GO:0031983 vesicle lumen(GO:0031983)
0.4 3.8 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
1.1 3.3 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.1 3.1 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 2.4 GO:0005814 centriole(GO:0005814)
0.0 2.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.3 GO:0070469 respiratory chain(GO:0070469)
0.0 2.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 2.1 GO:0060077 inhibitory synapse(GO:0060077)
0.4 1.9 GO:1990357 terminal web(GO:1990357)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 41.9 GO:0001047 core promoter binding(GO:0001047)
0.9 39.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
3.9 19.4 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.4 14.5 GO:0005112 Notch binding(GO:0005112)
0.8 12.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 11.8 GO:0000287 magnesium ion binding(GO:0000287)
3.4 10.3 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 7.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.4 6.9 GO:0005540 hyaluronic acid binding(GO:0005540)
1.3 6.6 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 6.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 4.7 GO:0051015 actin filament binding(GO:0051015)
0.6 4.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.3 4.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.6 3.8 GO:0070728 leucine binding(GO:0070728)
0.3 3.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 3.2 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.6 3.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.5 3.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.2 3.1 GO:0070410 co-SMAD binding(GO:0070410)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 24.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 14.4 PID_NOTCH_PATHWAY Notch signaling pathway
1.1 10.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 6.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 5.6 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 5.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 3.1 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 3.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 3.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 2.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 2.5 PID_PLK1_PATHWAY PLK1 signaling events
0.1 2.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.1 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 1.8 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.4 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 0.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 37.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
1.1 19.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.4 10.3 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.5 6.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.4 5.6 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.1 4.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 4.5 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 4.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.8 3.1 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 3.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 3.0 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 2.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.2 2.5 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 2.4 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 2.2 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 2.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.8 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels