Motif ID: Tbx21

Z-value: 1.040


Transcription factors associated with Tbx21:

Gene SymbolEntrez IDGene Name
Tbx21 ENSMUSG00000001444.2 Tbx21



Activity profile for motif Tbx21.

activity profile for motif Tbx21


Sorted Z-values histogram for motif Tbx21

Sorted Z-values for motif Tbx21



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx21

PNG image of the network

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Top targets:


Showing 1 to 20 of 132 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56969864 18.700 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 18.549 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr9_-_112185726 18.133 ENSMUST00000160240.1
ENSMUST00000162065.1
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr9_-_112185939 15.047 ENSMUST00000070218.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr18_+_67088287 14.820 ENSMUST00000025402.7
 Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr19_+_12460749 9.308 ENSMUST00000081035.7
 Mpeg1
macrophage expressed gene 1
chr10_-_13868932 9.204 ENSMUST00000019942.5
ENSMUST00000162610.1
 Aig1

androgen-induced 1

chr10_-_13868779 8.604 ENSMUST00000105534.3
 Aig1
androgen-induced 1
chr7_+_45785331 8.448 ENSMUST00000120005.1
ENSMUST00000123585.1
 Lmtk3

lemur tyrosine kinase 3

chr18_+_37020097 8.154 ENSMUST00000047614.1
 Pcdha2
protocadherin alpha 2
chr11_-_74590186 7.263 ENSMUST00000102521.1
 Rap1gap2
RAP1 GTPase activating protein 2
chr11_-_74590065 7.181 ENSMUST00000145524.1
ENSMUST00000047488.7
 Rap1gap2

RAP1 GTPase activating protein 2

chrX_-_152769461 7.107 ENSMUST00000101141.2
ENSMUST00000062317.4
 Shroom2

shroom family member 2

chr7_-_4789541 7.106 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238
chr8_-_68735058 6.260 ENSMUST00000136060.1
ENSMUST00000130214.1
ENSMUST00000078350.6
 Csgalnact1


chondroitin sulfate N-acetylgalactosaminyltransferase 1


chr16_+_8470763 6.248 ENSMUST00000046470.9
ENSMUST00000150790.1
ENSMUST00000142899.1
 Mettl22


methyltransferase like 22


chr1_+_34801704 5.675 ENSMUST00000047664.9
 Arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr6_-_50261743 5.522 ENSMUST00000101405.3
ENSMUST00000165099.1
ENSMUST00000170142.1
 Dfna5


deafness, autosomal dominant 5 (human)


chr9_-_106656081 5.427 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr10_-_75560330 5.108 ENSMUST00000051129.9
 Fam211b
family with sequence similarity 211, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 37.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 34.0 GO:0034605 cellular response to heat(GO:0034605)
2.7 16.2 GO:0009405 pathogenesis(GO:0009405)
0.1 14.4 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.1 8.5 GO:0060113 inner ear receptor cell differentiation(GO:0060113)
0.1 8.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.6 7.7 GO:0045217 cell-cell junction maintenance(GO:0045217)
1.9 7.5 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
1.6 6.3 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 5.7 GO:0046847 filopodium assembly(GO:0046847)
0.1 5.4 GO:0014047 glutamate secretion(GO:0014047)
0.8 4.9 GO:0032796 uropod organization(GO:0032796)
0.4 4.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.5 4.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.4 4.3 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 4.3 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.8 4.2 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.5 4.1 GO:0051014 actin filament severing(GO:0051014)
0.1 4.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
1.0 3.9 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 37.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 14.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 7.7 GO:0045335 phagocytic vesicle(GO:0045335)
0.2 7.5 GO:0016592 mediator complex(GO:0016592)
0.1 7.1 GO:0031941 filamentous actin(GO:0031941)
0.0 7.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 6.9 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.4 6.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 5.4 GO:0042734 presynaptic membrane(GO:0042734)
0.4 4.9 GO:0032426 stereocilium tip(GO:0032426)
0.2 4.6 GO:0031430 M band(GO:0031430)
0.1 4.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 4.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 4.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.0 GO:0055037 recycling endosome(GO:0055037)
1.0 3.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.4 3.8 GO:0034709 methylosome(GO:0034709)
0.1 3.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 3.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 3.4 GO:0045211 postsynaptic membrane(GO:0045211)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 33.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 26.9 GO:0003682 chromatin binding(GO:0003682)
0.1 15.7 GO:0005096 GTPase activator activity(GO:0005096)
0.6 14.8 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 8.6 GO:0008013 beta-catenin binding(GO:0008013)
2.5 7.5 GO:0032052 bile acid binding(GO:0032052)
0.1 7.5 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.3 7.1 GO:0032794 GTPase activating protein binding(GO:0032794)
1.6 6.3 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.3 5.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 5.8 GO:0019003 GDP binding(GO:0019003)
0.2 5.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
1.1 5.4 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.4 4.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 4.8 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 4.6 GO:0030507 spectrin binding(GO:0030507)
1.4 4.3 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 4.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 4.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 4.1 GO:0008266 poly(U) RNA binding(GO:0008266)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 14.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 4.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 3.9 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 3.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.2 3.5 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 3.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 3.0 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 3.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 2.7 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 1.9 PID_MYC_PATHWAY C-MYC pathway
0.0 0.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.6 PID_RHOA_PATHWAY RhoA signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 14.8 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.4 14.4 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.4 7.5 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 7.5 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 7.2 REACTOME_AMYLOIDS Genes involved in Amyloids
0.3 6.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 5.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.4 5.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 4.2 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 3.8 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.5 3.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 3.5 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.3 3.4 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 3.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 3.0 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 2.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 2.1 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 2.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.8 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.0 1.5 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm