Motif ID: Tbx5

Z-value: 0.765


Transcription factors associated with Tbx5:

Gene SymbolEntrez IDGene Name
Tbx5 ENSMUSG00000018263.8 Tbx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx5mm10_v2_chr5_+_119834663_1198346630.066.2e-01Click!


Activity profile for motif Tbx5.

activity profile for motif Tbx5


Sorted Z-values histogram for motif Tbx5

Sorted Z-values for motif Tbx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_26229707 13.664 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr1_-_138848576 10.975 ENSMUST00000112030.2
Lhx9
LIM homeobox protein 9
chr7_-_28302238 6.999 ENSMUST00000108315.3
Dll3
delta-like 3 (Drosophila)
chr14_+_122475397 6.816 ENSMUST00000075888.5
Zic2
zinc finger protein of the cerebellum 2
chr5_-_5514730 5.888 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
Cldn12



claudin 12



chr10_+_93641041 5.633 ENSMUST00000020204.4
Ntn4
netrin 4
chr3_+_126596993 5.471 ENSMUST00000163226.1
ENSMUST00000066466.6
ENSMUST00000169051.1
Camk2d


calcium/calmodulin-dependent protein kinase II, delta


chr5_-_5514873 5.133 ENSMUST00000060947.7
Cldn12
claudin 12
chr3_+_126596951 5.080 ENSMUST00000106402.1
Camk2d
calcium/calmodulin-dependent protein kinase II, delta
chr3_+_108383829 5.030 ENSMUST00000090561.3
ENSMUST00000102629.1
ENSMUST00000128089.1
Psrc1


proline/serine-rich coiled-coil 1


chr4_+_128883549 5.017 ENSMUST00000035667.8
Trim62
tripartite motif-containing 62
chr3_+_126597299 4.732 ENSMUST00000106400.2
ENSMUST00000106401.1
Camk2d

calcium/calmodulin-dependent protein kinase II, delta

chrX_+_100625737 4.544 ENSMUST00000048962.3
Kif4
kinesin family member 4
chr18_-_46212595 4.011 ENSMUST00000037011.4
Trim36
tripartite motif-containing 36
chr18_+_35829798 3.694 ENSMUST00000060722.6
Cxxc5
CXXC finger 5
chr9_-_43239816 3.653 ENSMUST00000034512.5
Oaf
OAF homolog (Drosophila)
chr15_-_98004634 3.523 ENSMUST00000131560.1
ENSMUST00000088355.5
Col2a1

collagen, type II, alpha 1

chr15_-_98004695 3.420 ENSMUST00000023123.8
Col2a1
collagen, type II, alpha 1
chr4_-_134018829 3.398 ENSMUST00000051674.2
Lin28a
lin-28 homolog A (C. elegans)
chr1_+_132316112 3.306 ENSMUST00000082125.5
ENSMUST00000072177.7
Nuak2

NUAK family, SNF1-like kinase, 2

chr4_-_19708922 3.246 ENSMUST00000108246.2
Wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr18_+_5591860 3.240 ENSMUST00000025081.5
ENSMUST00000159390.1
Zeb1

zinc finger E-box binding homeobox 1

chr4_-_41517326 3.201 ENSMUST00000030152.6
ENSMUST00000095126.4
1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr19_-_23273893 3.170 ENSMUST00000087556.5
Smc5
structural maintenance of chromosomes 5
chr6_-_49214954 3.121 ENSMUST00000031838.7
Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr19_+_38931008 3.098 ENSMUST00000145051.1
Hells
helicase, lymphoid specific
chr10_-_120899067 3.050 ENSMUST00000092143.5
Msrb3
methionine sulfoxide reductase B3
chr2_-_53191214 3.028 ENSMUST00000076313.6
ENSMUST00000125243.1
Prpf40a

PRP40 pre-mRNA processing factor 40 homolog A (yeast)

chr1_+_109982710 2.919 ENSMUST00000112701.1
Cdh7
cadherin 7, type 2
chr7_+_81858993 2.902 ENSMUST00000041890.1
Tm6sf1
transmembrane 6 superfamily member 1
chr9_-_95845215 2.900 ENSMUST00000093800.2
Pls1
plastin 1 (I-isoform)
chr19_+_38930909 2.851 ENSMUST00000025965.5
Hells
helicase, lymphoid specific
chr18_+_82914632 2.834 ENSMUST00000071233.6
Zfp516
zinc finger protein 516
chr8_-_80739497 2.813 ENSMUST00000043359.8
Smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr17_-_70851189 2.811 ENSMUST00000059775.8
Tgif1
TGFB-induced factor homeobox 1
chr7_-_115824699 2.714 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr1_+_63273261 2.631 ENSMUST00000114132.1
ENSMUST00000126932.1
Zdbf2

zinc finger, DBF-type containing 2

chr1_+_74601548 2.574 ENSMUST00000087186.4
Stk36
serine/threonine kinase 36
chr5_-_100719675 2.554 ENSMUST00000112908.1
ENSMUST00000045617.8
Hpse

heparanase

chr7_+_31059342 2.529 ENSMUST00000039775.7
Lgi4
leucine-rich repeat LGI family, member 4
chr15_+_79028212 2.505 ENSMUST00000180086.1
H1f0
H1 histone family, member 0
chr11_-_84068766 2.499 ENSMUST00000018792.5
Dusp14
dual specificity phosphatase 14
chr5_+_43233928 2.442 ENSMUST00000114066.1
ENSMUST00000114065.1
Cpeb2

cytoplasmic polyadenylation element binding protein 2

chr9_-_96437434 2.422 ENSMUST00000070500.2
BC043934
cDNA sequence BC043934
chr7_-_79594924 2.408 ENSMUST00000172788.1
Rhcg
Rhesus blood group-associated C glycoprotein
chr4_+_108460000 2.400 ENSMUST00000097925.2
Zcchc11
zinc finger, CCHC domain containing 11
chr7_-_141443989 2.365 ENSMUST00000026580.5
Lrdd
leucine-rich and death domain containing
chr12_+_53248677 2.330 ENSMUST00000101432.2
Npas3
neuronal PAS domain protein 3
chr14_+_31217850 2.297 ENSMUST00000090180.2
Sema3g
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr1_-_51915968 2.188 ENSMUST00000046390.7
Myo1b
myosin IB
chr9_+_74848437 2.182 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
Gm16551


Gm20649
predicted gene 16551


predicted gene 20649
chr9_+_107400043 2.171 ENSMUST00000166799.1
ENSMUST00000170737.1
Cacna2d2

calcium channel, voltage-dependent, alpha 2/delta subunit 2

chr1_+_74601441 2.137 ENSMUST00000087183.4
ENSMUST00000148456.1
ENSMUST00000113694.1
Stk36


serine/threonine kinase 36


chr19_+_54045182 2.119 ENSMUST00000036700.5
Adra2a
adrenergic receptor, alpha 2a
chr9_-_62537036 2.095 ENSMUST00000048043.5
Coro2b
coronin, actin binding protein, 2B
chrX_+_129749740 1.979 ENSMUST00000167619.2
ENSMUST00000037854.8
Diap2

diaphanous homolog 2 (Drosophila)

chrX_+_129749830 1.971 ENSMUST00000113320.2
Diap2
diaphanous homolog 2 (Drosophila)
chr15_-_89425856 1.954 ENSMUST00000109313.2
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr9_-_48911067 1.950 ENSMUST00000003826.7
Htr3a
5-hydroxytryptamine (serotonin) receptor 3A
chr6_+_54039558 1.929 ENSMUST00000046856.7
Chn2
chimerin (chimaerin) 2
chr10_+_79682169 1.905 ENSMUST00000020550.5
Cdc34
cell division cycle 34
chr2_-_54085542 1.900 ENSMUST00000100089.2
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr1_-_105356658 1.873 ENSMUST00000058688.5
ENSMUST00000172299.1
Rnf152

ring finger protein 152

chr3_+_90062781 1.868 ENSMUST00000029551.2
1700094D03Rik
RIKEN cDNA 1700094D03 gene
chrX_-_147554050 1.861 ENSMUST00000112819.2
ENSMUST00000136789.1
Lrch2

leucine-rich repeats and calponin homology (CH) domain containing 2

chrX_+_42151002 1.835 ENSMUST00000123245.1
Stag2
stromal antigen 2
chr5_+_111733924 1.824 ENSMUST00000180627.1
Gm26897
predicted gene, 26897
chr9_-_44320229 1.812 ENSMUST00000065080.8
C2cd2l
C2 calcium-dependent domain containing 2-like
chr3_+_75557530 1.787 ENSMUST00000161776.1
ENSMUST00000029423.8
Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr10_+_79682304 1.775 ENSMUST00000166603.1
Cdc34
cell division cycle 34
chr11_+_94741782 1.727 ENSMUST00000021240.6
Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr4_-_123750236 1.710 ENSMUST00000102636.3
Akirin1
akirin 1
chr6_+_125049952 1.702 ENSMUST00000088294.5
ENSMUST00000032481.7
Acrbp

proacrosin binding protein

chr3_+_121426495 1.657 ENSMUST00000029773.8
Cnn3
calponin 3, acidic
chr8_+_83389846 1.655 ENSMUST00000002259.6
Clgn
calmegin
chr10_-_29535857 1.634 ENSMUST00000092623.3
Rspo3
R-spondin 3 homolog (Xenopus laevis)
chr15_-_9748777 1.602 ENSMUST00000159368.1
ENSMUST00000159093.1
ENSMUST00000162780.1
ENSMUST00000160236.1
ENSMUST00000041840.7
Spef2




sperm flagellar 2




chr13_-_99900645 1.568 ENSMUST00000022150.6
Cartpt
CART prepropeptide
chr15_-_38300693 1.529 ENSMUST00000074043.5
Klf10
Kruppel-like factor 10
chr4_-_132398199 1.516 ENSMUST00000136711.1
ENSMUST00000084249.4
Phactr4

phosphatase and actin regulator 4

chr5_+_113490447 1.512 ENSMUST00000094452.3
Wscd2
WSC domain containing 2
chr4_+_129287614 1.511 ENSMUST00000102599.3
Sync
syncoilin
chr9_-_67760208 1.499 ENSMUST00000068526.5
M5C1000I18Rik
RIKEN cDNA M5C1000I18 gene
chr5_-_116591811 1.490 ENSMUST00000076124.5
Srrm4
serine/arginine repetitive matrix 4
chr1_-_172329261 1.469 ENSMUST00000062387.2
Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr11_+_70657687 1.461 ENSMUST00000134087.1
ENSMUST00000170716.1
Eno3

enolase 3, beta muscle

chr11_-_28583995 1.455 ENSMUST00000146385.2
Ccdc85a
coiled-coil domain containing 85A
chr11_-_46312220 1.453 ENSMUST00000129474.1
ENSMUST00000093166.4
ENSMUST00000165599.2
Cyfip2


cytoplasmic FMR1 interacting protein 2


chr6_+_54039935 1.438 ENSMUST00000114403.1
Chn2
chimerin (chimaerin) 2
chr14_+_31019125 1.418 ENSMUST00000112095.1
ENSMUST00000112098.3
ENSMUST00000112106.1
ENSMUST00000146325.1
Pbrm1



polybromo 1



chr10_-_86705485 1.403 ENSMUST00000020238.7
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr5_-_24329556 1.397 ENSMUST00000115098.2
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr14_-_59440779 1.336 ENSMUST00000111253.2
ENSMUST00000095775.3
ENSMUST00000161459.1
Setdb2


SET domain, bifurcated 2


chr3_-_119783262 1.292 ENSMUST00000029780.7
Ptbp2
polypyrimidine tract binding protein 2
chr7_-_102100227 1.289 ENSMUST00000106937.1
Art5
ADP-ribosyltransferase 5
chr11_+_116280939 1.284 ENSMUST00000055872.2
Galr2
galanin receptor 2
chr9_-_106199253 1.266 ENSMUST00000140761.1
Ppm1m
protein phosphatase 1M
chr4_+_33031371 1.257 ENSMUST00000124992.1
Ube2j1
ubiquitin-conjugating enzyme E2J 1
chr14_-_72709534 1.255 ENSMUST00000162478.1
Fndc3a
fibronectin type III domain containing 3A
chr14_+_31019183 1.238 ENSMUST00000052239.5
Pbrm1
polybromo 1
chr4_-_133602168 1.234 ENSMUST00000057311.3
Sfn
stratifin
chr10_+_86705811 1.230 ENSMUST00000061458.7
ENSMUST00000075632.6
BC030307

cDNA sequence BC030307

chr1_-_178337774 1.229 ENSMUST00000037748.7
Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr4_+_117096049 1.227 ENSMUST00000030443.5
Ptch2
patched homolog 2
chr12_+_51348019 1.220 ENSMUST00000054308.6
G2e3
G2/M-phase specific E3 ubiquitin ligase
chr13_-_56296551 1.210 ENSMUST00000021970.9
Cxcl14
chemokine (C-X-C motif) ligand 14
chr19_+_8764934 1.188 ENSMUST00000184663.1
Nxf1
nuclear RNA export factor 1
chr7_-_102099932 1.187 ENSMUST00000106934.1
Art5
ADP-ribosyltransferase 5
chrX_+_20425688 1.171 ENSMUST00000115384.2
Phf16
PHD finger protein 16
chrX_+_20364481 1.160 ENSMUST00000033372.6
ENSMUST00000115391.1
ENSMUST00000115387.1
Rp2h


retinitis pigmentosa 2 homolog (human)


chr12_-_27342696 1.158 ENSMUST00000079063.5
Sox11
SRY-box containing gene 11
chr1_+_66364623 1.155 ENSMUST00000077355.5
ENSMUST00000114012.1
Map2

microtubule-associated protein 2

chr2_+_103970221 1.135 ENSMUST00000111140.2
ENSMUST00000111139.2
Lmo2

LIM domain only 2

chr2_-_10048580 1.116 ENSMUST00000026888.4
Taf3
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr10_-_114801364 1.106 ENSMUST00000061632.7
Trhde
TRH-degrading enzyme
chr16_+_31664130 1.098 ENSMUST00000023454.5
Dlg1
discs, large homolog 1 (Drosophila)
chr4_-_108833608 1.097 ENSMUST00000102742.4
Btf3l4
basic transcription factor 3-like 4
chr2_+_103970115 1.080 ENSMUST00000111143.1
ENSMUST00000138815.1
Lmo2

LIM domain only 2

chr7_-_130573118 1.061 ENSMUST00000159694.1
Nsmce4a
non-SMC element 4 homolog A (S. cerevisiae)
chrX_-_49797700 1.038 ENSMUST00000033442.7
ENSMUST00000114891.1
Igsf1

immunoglobulin superfamily, member 1

chr10_-_91082653 1.032 ENSMUST00000159110.1
Apaf1
apoptotic peptidase activating factor 1
chr5_-_124425907 1.009 ENSMUST00000065263.5
Sbno1
sno, strawberry notch homolog 1 (Drosophila)
chr19_-_4439388 1.007 ENSMUST00000117462.1
ENSMUST00000048197.3
Rhod

ras homolog gene family, member D

chr10_-_77113928 0.996 ENSMUST00000149744.1
Col18a1
collagen, type XVIII, alpha 1
chr9_+_88581036 0.993 ENSMUST00000164661.2
Trim43a
tripartite motif-containing 43A
chr4_+_33031527 0.990 ENSMUST00000029944.6
Ube2j1
ubiquitin-conjugating enzyme E2J 1
chr1_+_91366412 0.985 ENSMUST00000086861.5
Fam132b
family with sequence similarity 132, member B
chr1_-_125912160 0.984 ENSMUST00000159417.1
Lypd1
Ly6/Plaur domain containing 1
chr2_-_38926217 0.983 ENSMUST00000076275.4
ENSMUST00000142130.1
Nr6a1

nuclear receptor subfamily 6, group A, member 1

chr8_+_47713266 0.978 ENSMUST00000180928.1
E030037K01Rik
RIKEN cDNA E030037K01 gene
chr12_+_51348370 0.978 ENSMUST00000121521.1
G2e3
G2/M-phase specific E3 ubiquitin ligase
chr2_-_37703845 0.978 ENSMUST00000155237.1
Strbp
spermatid perinuclear RNA binding protein
chr6_+_42286676 0.966 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr5_+_23434435 0.962 ENSMUST00000094962.2
ENSMUST00000115128.1
Kmt2e

lysine (K)-specific methyltransferase 2E

chr4_+_83525540 0.961 ENSMUST00000053414.6
ENSMUST00000126429.1
Ccdc171

coiled-coil domain containing 171

chr7_+_113513829 0.959 ENSMUST00000033018.8
Far1
fatty acyl CoA reductase 1
chr8_+_83389878 0.954 ENSMUST00000109831.2
Clgn
calmegin
chr4_+_84884418 0.951 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chr11_+_69965396 0.946 ENSMUST00000018713.6
Cldn7
claudin 7
chr11_-_69900949 0.944 ENSMUST00000102580.3
2810408A11Rik
RIKEN cDNA 2810408A11 gene
chr11_-_69900930 0.927 ENSMUST00000018714.6
ENSMUST00000128046.1
2810408A11Rik

RIKEN cDNA 2810408A11 gene

chr15_+_8169067 0.904 ENSMUST00000110617.1
2410089E03Rik
RIKEN cDNA 2410089E03 gene
chr11_-_120598346 0.894 ENSMUST00000026125.2
Alyref
Aly/REF export factor
chr8_+_3353415 0.894 ENSMUST00000098966.3
A430078G23Rik
RIKEN cDNA A430078G23 gene
chr10_+_81136223 0.876 ENSMUST00000048128.8
Zbtb7a
zinc finger and BTB domain containing 7a
chr7_+_30553263 0.872 ENSMUST00000044048.7
Hspb6
heat shock protein, alpha-crystallin-related, B6
chr16_+_31663841 0.871 ENSMUST00000115201.1
Dlg1
discs, large homolog 1 (Drosophila)
chr7_+_127485221 0.870 ENSMUST00000048896.6
Fbrs
fibrosin
chr16_+_18348181 0.869 ENSMUST00000115614.2
ENSMUST00000115613.1
ENSMUST00000090103.3
Arvcf


armadillo repeat gene deleted in velo-cardio-facial syndrome


chr4_-_141874879 0.863 ENSMUST00000036854.3
Efhd2
EF hand domain containing 2
chr2_-_39190687 0.855 ENSMUST00000142872.1
ENSMUST00000038874.5
Scai

suppressor of cancer cell invasion

chr14_-_70642268 0.854 ENSMUST00000022697.5
Fgf17
fibroblast growth factor 17
chr2_+_68861433 0.844 ENSMUST00000028426.2
Cers6
ceramide synthase 6
chr18_+_42275353 0.835 ENSMUST00000046972.7
ENSMUST00000091920.5
Rbm27

RNA binding motif protein 27

chrX_+_36795642 0.820 ENSMUST00000016463.3
Slc25a5
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
chr15_-_78803015 0.820 ENSMUST00000164826.1
Card10
caspase recruitment domain family, member 10
chr6_-_119330723 0.816 ENSMUST00000068351.7
Lrtm2
leucine-rich repeats and transmembrane domains 2
chr14_+_54259227 0.812 ENSMUST00000041197.7
Abhd4
abhydrolase domain containing 4
chr18_-_54990124 0.803 ENSMUST00000064763.5
Zfp608
zinc finger protein 608
chr8_+_33517306 0.802 ENSMUST00000124496.1
Tex15
testis expressed gene 15
chr11_+_72607221 0.798 ENSMUST00000021148.6
ENSMUST00000138247.1
Ube2g1

ubiquitin-conjugating enzyme E2G 1

chr3_-_75556759 0.788 ENSMUST00000162138.1
ENSMUST00000029424.5
ENSMUST00000161137.1
Pdcd10


programmed cell death 10


chr4_+_154869585 0.782 ENSMUST00000079269.7
ENSMUST00000163732.1
ENSMUST00000080559.6
Mmel1


membrane metallo-endopeptidase-like 1


chr12_+_3426857 0.765 ENSMUST00000111215.3
ENSMUST00000092003.5
ENSMUST00000144247.2
ENSMUST00000153102.2
Asxl2



additional sex combs like 2 (Drosophila)



chr1_-_75219245 0.754 ENSMUST00000079464.6
Tuba4a
tubulin, alpha 4A
chr6_+_42286709 0.750 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr7_-_74554474 0.744 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
Slco3a1


solute carrier organic anion transporter family, member 3a1


chr16_+_17276337 0.737 ENSMUST00000159065.1
ENSMUST00000159494.1
ENSMUST00000159811.1
Tmem191c


transmembrane protein 191C


chrX_-_100625901 0.729 ENSMUST00000059099.6
Pdzd11
PDZ domain containing 11
chr4_+_84884276 0.728 ENSMUST00000047023.6
Cntln
centlein, centrosomal protein
chr19_+_45015168 0.719 ENSMUST00000039016.6
Lzts2
leucine zipper, putative tumor suppressor 2
chr15_-_99457742 0.711 ENSMUST00000023747.7
Nckap5l
NCK-associated protein 5-like
chr15_+_16778101 0.707 ENSMUST00000026432.6
Cdh9
cadherin 9
chr4_+_148000722 0.694 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr4_+_118428078 0.691 ENSMUST00000006557.6
ENSMUST00000167636.1
ENSMUST00000102673.4
Elovl1


elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1


chr7_+_113513854 0.680 ENSMUST00000067929.8
ENSMUST00000129087.1
ENSMUST00000164745.1
ENSMUST00000136158.1
Far1



fatty acyl CoA reductase 1



chr7_+_25681158 0.667 ENSMUST00000108403.3
B9d2
B9 protein domain 2
chr10_-_127751707 0.656 ENSMUST00000079692.5
Gpr182
G protein-coupled receptor 182
chr12_-_88286055 0.639 ENSMUST00000179741.1
Gm7104
predicted gene 7104
chr15_-_63997969 0.622 ENSMUST00000164532.1
Fam49b
family with sequence similarity 49, member B
chr14_+_31019159 0.611 ENSMUST00000112094.1
ENSMUST00000144009.1
Pbrm1

polybromo 1

chr4_-_108833544 0.596 ENSMUST00000102740.1
ENSMUST00000102741.1
Btf3l4

basic transcription factor 3-like 4

chr13_+_49682100 0.580 ENSMUST00000165316.1
ENSMUST00000047363.7
Iars

isoleucine-tRNA synthetase

chr5_-_77115145 0.579 ENSMUST00000081964.5
Hopx
HOP homeobox
chr3_+_34020075 0.578 ENSMUST00000001620.8
ENSMUST00000167354.1
Fxr1

fragile X mental retardation gene 1, autosomal homolog

chr13_+_80886095 0.574 ENSMUST00000161441.1
Arrdc3
arrestin domain containing 3
chr2_+_118861954 0.572 ENSMUST00000028807.5
Ivd
isovaleryl coenzyme A dehydrogenase
chr3_-_95306794 0.569 ENSMUST00000107183.1
ENSMUST00000164406.1
ENSMUST00000123365.1
Anxa9


annexin A9


chrX_-_57392962 0.555 ENSMUST00000114730.1
Rbmx
RNA binding motif protein, X chromosome
chrX_+_135885851 0.545 ENSMUST00000180025.1
ENSMUST00000068755.7
ENSMUST00000148374.1
Bhlhb9


basic helix-loop-helix domain containing, class B9


chr7_-_105787567 0.534 ENSMUST00000144189.1
Dchs1
dachsous 1 (Drosophila)
chr9_+_88839164 0.526 ENSMUST00000163255.2
Trim43c
tripartite motif-containing 43C
chr6_+_35252692 0.524 ENSMUST00000130875.1
1810058I24Rik
RIKEN cDNA 1810058I24 gene
chr10_-_91082704 0.521 ENSMUST00000162618.1
ENSMUST00000020157.6
ENSMUST00000160788.1
Apaf1


apoptotic peptidase activating factor 1


chr3_-_89402650 0.516 ENSMUST00000168325.1
ENSMUST00000057431.5
Lenep

lens epithelial protein

chr11_+_54304180 0.516 ENSMUST00000108904.3
ENSMUST00000108905.3
Acsl6

acyl-CoA synthetase long-chain family member 6

chr7_+_44496588 0.515 ENSMUST00000107927.3
Fam71e1
family with sequence similarity 71, member E1
chr1_-_74601345 0.507 ENSMUST00000136078.1
ENSMUST00000132081.1
ENSMUST00000113721.1
ENSMUST00000027357.5
Rnf25



ring finger protein 25



chr2_-_52676571 0.500 ENSMUST00000178799.1
Cacnb4
calcium channel, voltage-dependent, beta 4 subunit
chr2_-_68472138 0.487 ENSMUST00000102715.3
Stk39
serine/threonine kinase 39

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 15.3 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
2.2 11.0 GO:0035262 gonad morphogenesis(GO:0035262)
1.7 6.8 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
1.4 7.0 GO:0007386 compartment pattern specification(GO:0007386)
1.2 4.7 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
1.1 5.6 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
1.1 3.3 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
1.1 3.2 GO:0034184 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
1.0 2.9 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.9 2.6 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.8 5.9 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.8 2.4 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.8 3.0 GO:0030091 protein repair(GO:0030091)
0.7 2.7 GO:0061386 closure of optic fissure(GO:0061386)
0.7 2.7 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.6 5.8 GO:0010587 miRNA catabolic process(GO:0010587)
0.6 6.9 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.5 2.1 GO:0035624 receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.5 1.6 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.5 1.4 GO:1902302 regulation of potassium ion export(GO:1902302)
0.5 3.7 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.4 1.2 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.4 4.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.4 2.8 GO:0016584 nucleosome positioning(GO:0016584)
0.4 2.2 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.3 1.6 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.3 1.3 GO:1902608 regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608)
0.3 1.2 GO:0009957 epidermal cell fate specification(GO:0009957)
0.3 3.2 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.3 0.8 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.2 0.7 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.2 2.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 0.5 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.2 2.2 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.2 2.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 1.6 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.2 1.6 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.2 0.6 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.2 1.8 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.2 2.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 2.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 0.7 GO:0046013 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.2 1.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 4.1 GO:0046596 regulation of viral entry into host cell(GO:0046596)
0.2 0.5 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.2 0.5 GO:1904152 regulation of retrograde protein transport, ER to cytosol(GO:1904152) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.2 1.2 GO:0031424 keratinization(GO:0031424)
0.2 0.6 GO:0003192 mitral valve formation(GO:0003192) cell migration involved in endocardial cushion formation(GO:0003273) condensed mesenchymal cell proliferation(GO:0072137)
0.2 0.5 GO:0006106 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.2 0.9 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 4.0 GO:0007340 acrosome reaction(GO:0007340)
0.1 0.7 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 0.9 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.1 2.1 GO:0048240 sperm capacitation(GO:0048240)
0.1 4.8 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.1 2.6 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.1 0.8 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.1 1.4 GO:0071318 cellular response to ATP(GO:0071318)
0.1 0.8 GO:0098532 histone H3-K27 trimethylation(GO:0098532) positive regulation of bone development(GO:1903012)
0.1 1.6 GO:0007288 sperm axoneme assembly(GO:0007288)
0.1 2.3 GO:0042711 maternal behavior(GO:0042711)
0.1 0.4 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 0.4 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.1 1.9 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.3 GO:0097278 complement-dependent cytotoxicity(GO:0097278)
0.1 1.6 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 0.3 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.1 3.3 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.6 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.1 0.3 GO:0007521 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003256) muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.1 2.5 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 0.4 GO:0001575 globoside metabolic process(GO:0001575)
0.1 0.6 GO:0006551 leucine metabolic process(GO:0006551)
0.1 0.6 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.9 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 0.2 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.1 2.8 GO:0009409 response to cold(GO:0009409)
0.1 0.2 GO:0021852 pyramidal neuron migration(GO:0021852)
0.1 2.5 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.1 2.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.5 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 1.5 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.1 0.9 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.1 0.5 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 0.8 GO:0006857 oligopeptide transport(GO:0006857)
0.1 0.3 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.5 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 1.0 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 0.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 1.2 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 0.5 GO:2000858 mineralocorticoid secretion(GO:0035931) aldosterone secretion(GO:0035932) regulation of mineralocorticoid secretion(GO:2000855) positive regulation of mineralocorticoid secretion(GO:2000857) regulation of aldosterone secretion(GO:2000858) positive regulation of aldosterone secretion(GO:2000860)
0.1 0.1 GO:0002339 B cell selection(GO:0002339)
0.1 0.8 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 0.7 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.5 GO:0006691 leukotriene metabolic process(GO:0006691)
0.1 3.0 GO:0032465 regulation of cytokinesis(GO:0032465)
0.1 2.3 GO:0030517 negative regulation of axon extension(GO:0030517)
0.1 1.3 GO:0060009 Sertoli cell development(GO:0060009)
0.1 2.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 1.0 GO:0042119 neutrophil activation(GO:0042119)
0.1 1.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.1 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.3 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 1.8 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0 0.8 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.1 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 1.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.6 GO:0001916 positive regulation of T cell mediated cytotoxicity(GO:0001916)
0.0 0.1 GO:0003211 cardiac ventricle formation(GO:0003211)
0.0 1.4 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.0 0.4 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 1.0 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) negative regulation of protein localization to plasma membrane(GO:1903077) signal transduction involved in cellular response to ammonium ion(GO:1903831) negative regulation of protein localization to cell periphery(GO:1904376) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 2.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.1 GO:0009446 putrescine biosynthetic process(GO:0009446)
0.0 0.1 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.0 2.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.6 GO:2000637 positive regulation of gene silencing by miRNA(GO:2000637)
0.0 1.0 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.2 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.5 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.9 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 1.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0097107 postsynaptic density organization(GO:0097106) postsynaptic density assembly(GO:0097107) NMDA glutamate receptor clustering(GO:0097114) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0 0.3 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.1 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 2.2 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway(GO:2001243)
0.0 0.9 GO:0045103 intermediate filament-based process(GO:0045103)
0.0 2.5 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.5 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 3.2 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.3 GO:0006833 water transport(GO:0006833)
0.0 0.8 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.1 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.0 2.6 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.3 GO:0032366 intracellular sterol transport(GO:0032366) intracellular cholesterol transport(GO:0032367)
0.0 2.1 GO:0051028 mRNA transport(GO:0051028)
0.0 0.4 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 1.2 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.0 1.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.1 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 1.5 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 0.5 GO:0010259 multicellular organism aging(GO:0010259)
0.0 0.5 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.0 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.0 0.2 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.5 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.3 GO:0051225 spindle assembly(GO:0051225)
0.0 0.1 GO:0042182 ketone catabolic process(GO:0042182)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0035061 interchromatin granule(GO:0035061)
0.6 1.8 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.6 2.9 GO:1990357 terminal web(GO:1990357)
0.5 4.8 GO:0002177 manchette(GO:0002177)
0.4 1.8 GO:0031983 vesicle lumen(GO:0031983)
0.4 5.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.4 13.2 GO:0043194 axon initial segment(GO:0043194)
0.4 1.6 GO:0043293 apoptosome(GO:0043293)
0.3 1.4 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.3 2.0 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.3 2.8 GO:0005677 chromatin silencing complex(GO:0005677)
0.2 1.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.2 1.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.2 2.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.0 GO:0044530 supraspliceosomal complex(GO:0044530)
0.2 5.3 GO:0005721 pericentric heterochromatin(GO:0005721)
0.2 1.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 10.3 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 3.0 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 0.8 GO:0071817 MMXD complex(GO:0071817)
0.1 1.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 1.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.7 GO:0042629 mast cell granule(GO:0042629)
0.1 3.3 GO:0090544 BAF-type complex(GO:0090544)
0.1 4.5 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 2.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 2.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.3 GO:0033093 multivesicular body membrane(GO:0032585) Weibel-Palade body(GO:0033093)
0.1 6.6 GO:0005604 basement membrane(GO:0005604)
0.1 3.8 GO:0005876 spindle microtubule(GO:0005876)
0.1 2.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 0.5 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.7 GO:0036038 MKS complex(GO:0036038)
0.0 1.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.9 GO:0035869 ciliary transition zone(GO:0035869)
0.0 1.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.0 0.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.4 GO:0031526 brush border membrane(GO:0031526)
0.0 1.1 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 2.5 GO:0019867 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.0 1.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 4.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.1 GO:0030027 lamellipodium(GO:0030027)
0.0 1.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 7.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0097542 ciliary tip(GO:0097542)
0.0 1.7 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.6 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.9 GO:0005814 centriole(GO:0005814)
0.0 2.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.2 GO:0000346 transcription export complex(GO:0000346)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 15.3 GO:0031432 titin binding(GO:0031432)
1.4 6.9 GO:0042289 MHC class II protein binding(GO:0042289)
0.8 2.5 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.7 2.1 GO:0004936 alpha-adrenergic receptor activity(GO:0004936) epinephrine binding(GO:0051379)
0.6 5.6 GO:0043237 laminin-1 binding(GO:0043237)
0.5 3.0 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.5 1.9 GO:0051378 serotonin binding(GO:0051378)
0.5 2.4 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.4 2.6 GO:0045545 syndecan binding(GO:0045545)
0.4 1.2 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.4 2.0 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.4 4.0 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.3 2.0 GO:0097016 L27 domain binding(GO:0097016)
0.3 1.6 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.3 1.3 GO:0004966 galanin receptor activity(GO:0004966)
0.3 1.2 GO:0034046 poly(G) binding(GO:0034046)
0.3 1.5 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.3 1.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 0.9 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.3 1.4 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.2 0.7 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.2 1.8 GO:0043559 insulin binding(GO:0043559)
0.2 7.0 GO:0005112 Notch binding(GO:0005112)
0.2 1.4 GO:0046790 virion binding(GO:0046790)
0.2 2.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 2.8 GO:0070410 co-SMAD binding(GO:0070410)
0.2 1.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 2.5 GO:0003680 AT DNA binding(GO:0003680)
0.2 0.5 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 1.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 6.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 4.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.4 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.4 GO:0051765 inositol tetrakisphosphate kinase activity(GO:0051765)
0.1 2.4 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.1 3.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 2.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.8 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.1 1.0 GO:0034711 inhibin binding(GO:0034711)
0.1 3.1 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.0 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 1.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.3 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1 0.6 GO:0023029 MHC class Ib protein binding(GO:0023029)
0.1 0.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 4.7 GO:0070888 E-box binding(GO:0070888)
0.1 0.8 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.8 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 2.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 2.8 GO:0031491 nucleosome binding(GO:0031491)
0.1 3.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 0.3 GO:0050436 microfibril binding(GO:0050436)
0.1 2.1 GO:0016504 peptidase activator activity(GO:0016504)
0.1 0.8 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.1 0.7 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 0.6 GO:0031690 adrenergic receptor binding(GO:0031690)
0.1 0.5 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.4 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.7 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 6.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 2.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 0.3 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 3.2 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.9 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 1.6 GO:0005109 frizzled binding(GO:0005109)
0.0 2.9 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.5 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.1 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 0.6 GO:0015464 acetylcholine receptor activity(GO:0015464)
0.0 0.1 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.0 5.4 GO:0004386 helicase activity(GO:0004386)
0.0 1.0 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 15.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.3 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.6 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 5.0 GO:0051015 actin filament binding(GO:0051015)
0.0 0.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.5 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 1.1 GO:0002039 p53 binding(GO:0002039)
0.0 3.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 5.7 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.4 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.2 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 4.3 GO:0003682 chromatin binding(GO:0003682)
0.0 0.0 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 11.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 9.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 6.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 7.3 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 1.6 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 1.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.2 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 5.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 3.6 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 4.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 3.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 0.5 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.7 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.3 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.5 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 2.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 4.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.5 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.4 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 2.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.5 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.3 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 1.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.6 PID_LKB1_PATHWAY LKB1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 11.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.4 12.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 2.1 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 2.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 1.4 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.1 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 2.6 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 0.9 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 3.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.4 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 4.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 5.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 0.8 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 0.5 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.1 2.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.5 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.9 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 14.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.5 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.8 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.8 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.5 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 1.6 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 1.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.2 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.7 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 0.7 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.4 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.7 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 3.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 1.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 2.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 0.2 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.1 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels