Motif ID: Tbx5
Z-value: 0.765
Transcription factors associated with Tbx5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tbx5 | ENSMUSG00000018263.8 | Tbx5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tbx5 | mm10_v2_chr5_+_119834663_119834663 | 0.06 | 6.2e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 152 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 15.3 | GO:0035022 | positive regulation of Rac protein signal transduction(GO:0035022) |
| 2.2 | 11.0 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 1.4 | 7.0 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.6 | 6.9 | GO:0060272 | embryonic skeletal joint morphogenesis(GO:0060272) |
| 1.7 | 6.8 | GO:1900224 | positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224) |
| 0.8 | 5.9 | GO:0031508 | pericentric heterochromatin assembly(GO:0031508) |
| 0.6 | 5.8 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 1.1 | 5.6 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.1 | 4.8 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 1.2 | 4.7 | GO:0007228 | positive regulation of hh target transcription factor activity(GO:0007228) |
| 0.2 | 4.1 | GO:0046596 | regulation of viral entry into host cell(GO:0046596) |
| 0.4 | 4.0 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.1 | 4.0 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.5 | 3.7 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 1.1 | 3.3 | GO:0003349 | epicardium-derived cardiac endothelial cell differentiation(GO:0003349) |
| 0.1 | 3.3 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 1.1 | 3.2 | GO:0034184 | positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) |
| 0.3 | 3.2 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.0 | 3.2 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.8 | 3.0 | GO:0030091 | protein repair(GO:0030091) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 67 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.2 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.2 | 10.3 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 7.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 6.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.2 | 5.3 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.4 | 5.2 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.5 | 4.8 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 4.8 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 4.5 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 3.8 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.1 | 3.3 | GO:0090544 | BAF-type complex(GO:0090544) |
| 1.1 | 3.2 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.2 | 3.0 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.6 | 2.9 | GO:1990357 | terminal web(GO:1990357) |
| 0.3 | 2.8 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.0 | 2.8 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.1 | 2.5 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 2.5 | GO:0019867 | mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968) |
| 0.0 | 2.4 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.2 | 2.3 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 106 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.4 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 1.9 | 15.3 | GO:0031432 | titin binding(GO:0031432) |
| 0.2 | 7.0 | GO:0005112 | Notch binding(GO:0005112) |
| 1.4 | 6.9 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.1 | 6.9 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.1 | 6.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 5.7 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.6 | 5.6 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.0 | 5.4 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 5.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 4.7 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 4.5 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 4.3 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.4 | 4.0 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
| 0.1 | 3.2 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 3.2 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 3.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 3.1 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 3.1 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.5 | 3.0 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 29 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 11.0 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 9.8 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 7.3 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.2 | 6.6 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 5.6 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 4.2 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.1 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 3.6 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 3.4 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.1 | 3.2 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.8 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.6 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.8 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.1 | 1.6 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.5 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 0.0 | 1.5 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 1.2 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.1 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.7 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.6 | PID_RHOA_PATHWAY | RhoA signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 46 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.2 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 12.0 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.4 | 11.0 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.1 | 5.9 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 4.9 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 3.8 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.7 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 2.8 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 2.8 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 2.6 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.2 | 2.5 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 2.4 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.2 | 2.1 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.1 | 2.1 | REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 2.0 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 1.9 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 1.9 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.8 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 1.7 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.6 | REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
