Motif ID: Tcf21_Msc
Z-value: 1.196
Transcription factors associated with Tcf21_Msc:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Msc | ENSMUSG00000025930.5 | Msc |
| Tcf21 | ENSMUSG00000045680.7 | Tcf21 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 11.6 | GO:0038095 | positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095) |
| 3.3 | 36.5 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 2.0 | 12.0 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 2.0 | 5.9 | GO:1904760 | myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760) |
| 1.6 | 7.9 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) |
| 1.1 | 3.4 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 1.0 | 5.1 | GO:0032224 | positive regulation of synaptic transmission, cholinergic(GO:0032224) |
| 0.9 | 2.8 | GO:0031660 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) |
| 0.9 | 4.3 | GO:0003105 | negative regulation of glomerular filtration(GO:0003105) positive regulation of NAD(P)H oxidase activity(GO:0033864) positive regulation of toll-like receptor 2 signaling pathway(GO:0034137) |
| 0.9 | 3.5 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.9 | 10.3 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.8 | 4.2 | GO:1902732 | positive regulation of chondrocyte proliferation(GO:1902732) |
| 0.8 | 13.2 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.8 | 9.0 | GO:0030432 | peristalsis(GO:0030432) |
| 0.8 | 5.7 | GO:0042574 | retinal metabolic process(GO:0042574) |
| 0.8 | 5.4 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.8 | 2.3 | GO:0002586 | positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) |
| 0.7 | 10.4 | GO:0048194 | Golgi vesicle budding(GO:0048194) |
| 0.7 | 12.9 | GO:0097113 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.7 | 2.6 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.6 | 3.2 | GO:0061511 | centriole elongation(GO:0061511) |
| 0.6 | 3.8 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
| 0.6 | 6.8 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.6 | 2.4 | GO:1904451 | regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453) |
| 0.6 | 4.8 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.6 | 1.8 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.6 | 4.1 | GO:0060372 | regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) |
| 0.6 | 1.8 | GO:1900039 | positive regulation of cellular response to hypoxia(GO:1900039) |
| 0.6 | 1.7 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.6 | 1.7 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.6 | 2.2 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.5 | 1.6 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 0.5 | 2.2 | GO:0010891 | negative regulation of sequestering of triglyceride(GO:0010891) positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.5 | 1.6 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.5 | 1.6 | GO:0035622 | intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034) |
| 0.5 | 6.7 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.5 | 2.0 | GO:0046210 | nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346) |
| 0.5 | 2.0 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
| 0.5 | 5.4 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.5 | 5.3 | GO:0048199 | vesicle targeting, to, from or within Golgi(GO:0048199) |
| 0.5 | 5.2 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.5 | 3.2 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 0.5 | 1.8 | GO:0042373 | vitamin K metabolic process(GO:0042373) |
| 0.5 | 4.1 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.4 | 1.3 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.4 | 1.7 | GO:1905076 | regulation of interleukin-17 secretion(GO:1905076) positive regulation of T-helper 17 type immune response(GO:2000318) |
| 0.4 | 2.5 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.4 | 1.2 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.4 | 6.1 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.4 | 3.6 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.4 | 1.1 | GO:1901052 | sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053) |
| 0.4 | 2.9 | GO:0043383 | negative T cell selection(GO:0043383) negative thymic T cell selection(GO:0045060) |
| 0.4 | 1.8 | GO:0050912 | detection of chemical stimulus involved in sensory perception(GO:0050907) detection of chemical stimulus involved in sensory perception of taste(GO:0050912) |
| 0.4 | 1.1 | GO:0016237 | lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521) negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis(GO:0090157) |
| 0.4 | 3.2 | GO:0002347 | response to tumor cell(GO:0002347) |
| 0.4 | 1.1 | GO:0003032 | detection of oxygen(GO:0003032) |
| 0.3 | 1.4 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
| 0.3 | 4.9 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.3 | 1.7 | GO:0046864 | retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143) |
| 0.3 | 2.0 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.3 | 1.0 | GO:0036292 | DNA rewinding(GO:0036292) |
| 0.3 | 3.1 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.3 | 0.9 | GO:0098968 | neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968) |
| 0.3 | 0.9 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.3 | 11.2 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.3 | 4.2 | GO:1902004 | positive regulation of beta-amyloid formation(GO:1902004) |
| 0.3 | 4.8 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.3 | 0.8 | GO:1904049 | negative regulation of spontaneous neurotransmitter secretion(GO:1904049) |
| 0.3 | 6.5 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.3 | 0.8 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
| 0.3 | 1.6 | GO:0009256 | 10-formyltetrahydrofolate metabolic process(GO:0009256) |
| 0.3 | 0.8 | GO:0016332 | establishment or maintenance of polarity of embryonic epithelium(GO:0016332) |
| 0.3 | 7.6 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.3 | 8.3 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 0.2 | 2.7 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.2 | 7.9 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.2 | 1.4 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.2 | 1.0 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 0.2 | 2.3 | GO:0042095 | interferon-gamma biosynthetic process(GO:0042095) |
| 0.2 | 0.7 | GO:1901675 | negative regulation of histone H3-K27 acetylation(GO:1901675) |
| 0.2 | 3.2 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
| 0.2 | 1.1 | GO:0046601 | positive regulation of centriole replication(GO:0046601) |
| 0.2 | 0.4 | GO:1903978 | regulation of microglial cell activation(GO:1903978) |
| 0.2 | 1.5 | GO:0015791 | polyol transport(GO:0015791) |
| 0.2 | 0.9 | GO:0036515 | serotonergic neuron axon guidance(GO:0036515) |
| 0.2 | 1.7 | GO:0048102 | autophagic cell death(GO:0048102) |
| 0.2 | 0.8 | GO:1900377 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
| 0.2 | 0.8 | GO:0002337 | B-1a B cell differentiation(GO:0002337) |
| 0.2 | 2.3 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 0.2 | 4.5 | GO:0048368 | lateral mesoderm development(GO:0048368) |
| 0.2 | 1.4 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.2 | 0.6 | GO:0046381 | CMP-N-acetylneuraminate metabolic process(GO:0046381) |
| 0.2 | 0.6 | GO:0021852 | pyramidal neuron migration(GO:0021852) |
| 0.2 | 3.7 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.2 | 1.3 | GO:0014043 | negative regulation of neuron maturation(GO:0014043) |
| 0.2 | 2.1 | GO:0060297 | regulation of sarcomere organization(GO:0060297) |
| 0.2 | 1.1 | GO:0051790 | short-chain fatty acid biosynthetic process(GO:0051790) |
| 0.2 | 2.2 | GO:0001523 | retinoid metabolic process(GO:0001523) |
| 0.2 | 1.5 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.2 | 0.6 | GO:0046416 | D-amino acid metabolic process(GO:0046416) |
| 0.2 | 1.1 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.2 | 1.1 | GO:0003383 | apical constriction(GO:0003383) |
| 0.2 | 0.4 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) |
| 0.2 | 4.1 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.2 | 1.3 | GO:0010888 | negative regulation of lipid storage(GO:0010888) |
| 0.2 | 0.5 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.2 | 2.5 | GO:0071378 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
| 0.2 | 1.2 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.2 | 1.2 | GO:2000252 | negative regulation of feeding behavior(GO:2000252) |
| 0.2 | 3.1 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.2 | 0.7 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
| 0.2 | 1.4 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
| 0.2 | 1.4 | GO:0007625 | grooming behavior(GO:0007625) |
| 0.2 | 0.9 | GO:0000454 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) |
| 0.2 | 1.2 | GO:0043619 | regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619) |
| 0.2 | 1.7 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.2 | 1.6 | GO:0046498 | S-adenosylhomocysteine metabolic process(GO:0046498) |
| 0.2 | 1.6 | GO:0046643 | regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643) |
| 0.2 | 0.8 | GO:0002326 | B cell lineage commitment(GO:0002326) |
| 0.2 | 0.2 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.2 | 0.6 | GO:0046618 | drug export(GO:0046618) |
| 0.2 | 17.8 | GO:0051592 | response to calcium ion(GO:0051592) |
| 0.2 | 0.3 | GO:0060467 | negative regulation of fertilization(GO:0060467) |
| 0.2 | 0.5 | GO:0072717 | cellular response to actinomycin D(GO:0072717) |
| 0.1 | 4.8 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.1 | 2.6 | GO:0051043 | regulation of membrane protein ectodomain proteolysis(GO:0051043) |
| 0.1 | 1.9 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.1 | 1.0 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.1 | 1.1 | GO:0014842 | regulation of skeletal muscle satellite cell proliferation(GO:0014842) regulation of skeletal muscle cell proliferation(GO:0014857) |
| 0.1 | 1.1 | GO:0015074 | DNA integration(GO:0015074) |
| 0.1 | 1.7 | GO:0097084 | vascular smooth muscle cell development(GO:0097084) |
| 0.1 | 1.9 | GO:0032695 | negative regulation of interleukin-12 production(GO:0032695) |
| 0.1 | 0.7 | GO:0048703 | embryonic viscerocranium morphogenesis(GO:0048703) |
| 0.1 | 0.8 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.1 | 0.4 | GO:0060017 | parathyroid gland development(GO:0060017) |
| 0.1 | 0.5 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.1 | 0.2 | GO:0042359 | vitamin D metabolic process(GO:0042359) |
| 0.1 | 0.6 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
| 0.1 | 0.6 | GO:0016264 | gap junction assembly(GO:0016264) |
| 0.1 | 0.6 | GO:1901386 | negative regulation of voltage-gated calcium channel activity(GO:1901386) |
| 0.1 | 1.4 | GO:0007602 | phototransduction(GO:0007602) |
| 0.1 | 0.6 | GO:0072429 | response to intra-S DNA damage checkpoint signaling(GO:0072429) |
| 0.1 | 0.3 | GO:0061365 | positive regulation of triglyceride lipase activity(GO:0061365) |
| 0.1 | 1.1 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.1 | 0.7 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.1 | 6.4 | GO:0007569 | cell aging(GO:0007569) |
| 0.1 | 0.5 | GO:0071476 | cellular hypotonic response(GO:0071476) |
| 0.1 | 4.2 | GO:1901264 | carbohydrate derivative transport(GO:1901264) |
| 0.1 | 0.2 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.1 | 0.9 | GO:0090003 | regulation of Golgi to plasma membrane protein transport(GO:0042996) regulation of establishment of protein localization to plasma membrane(GO:0090003) |
| 0.1 | 0.5 | GO:1904781 | positive regulation of protein localization to centrosome(GO:1904781) |
| 0.1 | 0.5 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
| 0.1 | 0.6 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.1 | 0.3 | GO:0050904 | diapedesis(GO:0050904) |
| 0.1 | 1.5 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.1 | 0.7 | GO:0033004 | negative regulation of mast cell activation(GO:0033004) |
| 0.1 | 4.5 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.1 | 1.7 | GO:0043010 | camera-type eye development(GO:0043010) |
| 0.1 | 0.5 | GO:0006721 | terpenoid metabolic process(GO:0006721) |
| 0.1 | 0.2 | GO:0035106 | operant conditioning(GO:0035106) |
| 0.1 | 1.3 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.1 | 0.8 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.1 | 1.5 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
| 0.1 | 0.4 | GO:0061009 | common bile duct development(GO:0061009) |
| 0.1 | 0.2 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
| 0.1 | 1.0 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.1 | 1.4 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
| 0.1 | 0.7 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 0.2 | GO:0035519 | protein K29-linked ubiquitination(GO:0035519) |
| 0.1 | 0.6 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.1 | 1.0 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 0.3 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.1 | 1.6 | GO:0060008 | Sertoli cell differentiation(GO:0060008) |
| 0.1 | 0.1 | GO:1902630 | regulation of membrane hyperpolarization(GO:1902630) |
| 0.1 | 0.6 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.1 | 0.8 | GO:0032933 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 0.1 | 0.5 | GO:0034115 | negative regulation of heterotypic cell-cell adhesion(GO:0034115) cell-cell adhesion involved in gastrulation(GO:0070586) regulation of cell-cell adhesion involved in gastrulation(GO:0070587) |
| 0.1 | 0.1 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) |
| 0.1 | 0.3 | GO:0055091 | phospholipid homeostasis(GO:0055091) |
| 0.1 | 1.3 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.1 | 1.2 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.0 | 0.1 | GO:0042117 | monocyte activation(GO:0042117) |
| 0.0 | 0.2 | GO:1901525 | positive regulation of autophagosome maturation(GO:1901098) negative regulation of macromitophagy(GO:1901525) |
| 0.0 | 0.2 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 0.0 | 1.8 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.0 | 0.7 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.0 | 2.3 | GO:0007605 | sensory perception of sound(GO:0007605) |
| 0.0 | 0.9 | GO:0003016 | respiratory system process(GO:0003016) |
| 0.0 | 0.2 | GO:0016557 | peroxisome membrane biogenesis(GO:0016557) |
| 0.0 | 0.6 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.0 | 0.2 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.0 | 0.3 | GO:1902895 | positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895) |
| 0.0 | 0.3 | GO:0060050 | positive regulation of protein glycosylation(GO:0060050) |
| 0.0 | 0.5 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.0 | 3.5 | GO:0002028 | regulation of sodium ion transport(GO:0002028) |
| 0.0 | 0.6 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.0 | 0.2 | GO:1905169 | protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171) |
| 0.0 | 2.8 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.0 | 0.3 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.0 | 0.6 | GO:0001937 | negative regulation of endothelial cell proliferation(GO:0001937) |
| 0.0 | 0.5 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.0 | 1.1 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.0 | 0.4 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.0 | 0.4 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
| 0.0 | 0.4 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.0 | 0.4 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 1.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.1 | GO:0032298 | positive regulation of DNA-dependent DNA replication initiation(GO:0032298) |
| 0.0 | 0.3 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.0 | 0.5 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
| 0.0 | 0.3 | GO:0001954 | positive regulation of cell-matrix adhesion(GO:0001954) |
| 0.0 | 0.1 | GO:2000409 | positive regulation of T cell extravasation(GO:2000409) |
| 0.0 | 1.7 | GO:0007093 | mitotic cell cycle checkpoint(GO:0007093) |
| 0.0 | 1.8 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.0 | 1.1 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 2.2 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 0.1 | GO:1901072 | glucosamine-containing compound catabolic process(GO:1901072) |
| 0.0 | 0.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.1 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.0 | 0.7 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.0 | 0.6 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.0 | 0.1 | GO:1904152 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) regulation of retrograde protein transport, ER to cytosol(GO:1904152) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.0 | 0.2 | GO:0000731 | DNA synthesis involved in DNA repair(GO:0000731) |
| 0.0 | 0.6 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.0 | 0.9 | GO:0015992 | proton transport(GO:0015992) |
| 0.0 | 0.2 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.0 | 0.3 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.0 | 0.9 | GO:0030879 | mammary gland development(GO:0030879) |
| 0.0 | 0.1 | GO:0046685 | response to arsenic-containing substance(GO:0046685) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.5 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 1.1 | 3.2 | GO:0034667 | integrin alpha3-beta1 complex(GO:0034667) |
| 0.9 | 4.3 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.7 | 2.8 | GO:0000942 | condensed nuclear chromosome outer kinetochore(GO:0000942) |
| 0.6 | 2.4 | GO:0097574 | lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795) |
| 0.6 | 4.9 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.6 | 3.0 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
| 0.6 | 1.7 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.6 | 2.3 | GO:0061702 | inflammasome complex(GO:0061702) |
| 0.5 | 1.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.4 | 1.7 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.4 | 17.1 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.4 | 3.2 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.3 | 0.7 | GO:0016011 | dystroglycan complex(GO:0016011) |
| 0.3 | 7.2 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.3 | 16.6 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.3 | 4.7 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.3 | 1.8 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.3 | 5.1 | GO:0005605 | basal lamina(GO:0005605) |
| 0.2 | 3.4 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.2 | 0.9 | GO:0045098 | type III intermediate filament(GO:0045098) |
| 0.2 | 0.9 | GO:0001651 | dense fibrillar component(GO:0001651) |
| 0.2 | 1.8 | GO:0030478 | actin cap(GO:0030478) |
| 0.2 | 3.1 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.2 | 1.1 | GO:0098536 | deuterosome(GO:0098536) |
| 0.2 | 4.3 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.2 | 1.0 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.2 | 1.5 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.2 | 0.8 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.2 | 1.5 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.2 | 0.9 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.2 | 1.1 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.2 | 10.4 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.1 | 9.9 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 6.2 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 1.7 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
| 0.1 | 0.6 | GO:0008623 | CHRAC(GO:0008623) |
| 0.1 | 1.1 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 0.8 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
| 0.1 | 1.5 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 11.6 | GO:0030175 | filopodium(GO:0030175) |
| 0.1 | 2.0 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 0.6 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
| 0.1 | 1.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 1.0 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.1 | 1.4 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 1.7 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.1 | 0.5 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.1 | 0.7 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 5.8 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 0.3 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 1.0 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.1 | 5.7 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 0.2 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.1 | 3.6 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 0.4 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.1 | 5.4 | GO:0005776 | autophagosome(GO:0005776) |
| 0.1 | 0.6 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.1 | 10.8 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 0.3 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 1.7 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.1 | 0.6 | GO:0097449 | astrocyte projection(GO:0097449) |
| 0.1 | 0.3 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.1 | 3.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 2.0 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.1 | 2.2 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 0.3 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 0.3 | GO:0002177 | manchette(GO:0002177) |
| 0.1 | 20.3 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.1 | GO:0000836 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.0 | 0.5 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 1.0 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.0 | 0.6 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.6 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 2.3 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 0.1 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.0 | 4.8 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 1.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 8.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 2.8 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.2 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.0 | 0.6 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 1.1 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 0.8 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 2.7 | GO:0044306 | neuron projection terminus(GO:0044306) |
| 0.0 | 0.1 | GO:0044297 | cell body(GO:0044297) |
| 0.0 | 0.6 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 2.3 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.7 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 3.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 2.6 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.7 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.5 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.6 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 6.7 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 1.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 15.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 2.0 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 1.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.1 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.0 | 0.8 | GO:0070161 | adherens junction(GO:0005912) anchoring junction(GO:0070161) |
| 0.0 | 0.4 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 0.3 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.4 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.8 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 0.2 | GO:0005798 | Golgi-associated vesicle(GO:0005798) |
| 0.0 | 0.4 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 1.0 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 2.0 | GO:0005794 | Golgi apparatus(GO:0005794) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 36.5 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 2.1 | 6.4 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 1.9 | 5.7 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 1.9 | 11.3 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 1.7 | 5.2 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 1.3 | 7.9 | GO:0035184 | histone threonine kinase activity(GO:0035184) |
| 1.1 | 4.3 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 1.0 | 3.1 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
| 1.0 | 3.0 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.7 | 2.8 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.6 | 1.8 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.6 | 7.0 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.5 | 3.8 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.5 | 4.1 | GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008) |
| 0.5 | 7.7 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.5 | 12.9 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.5 | 2.0 | GO:0004103 | choline kinase activity(GO:0004103) |
| 0.5 | 16.1 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.5 | 2.0 | GO:0016708 | nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726) |
| 0.5 | 2.5 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.5 | 2.3 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
| 0.4 | 4.9 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.4 | 1.3 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 0.4 | 3.5 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.4 | 1.1 | GO:0046997 | sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997) |
| 0.4 | 1.1 | GO:0019779 | Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779) |
| 0.3 | 1.0 | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) |
| 0.3 | 1.6 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.3 | 3.9 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.3 | 2.2 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.3 | 3.2 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
| 0.3 | 6.6 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.3 | 2.3 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.3 | 1.1 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.3 | 2.0 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.3 | 8.9 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.3 | 1.1 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.3 | 2.1 | GO:0031432 | titin binding(GO:0031432) |
| 0.3 | 1.0 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.2 | 0.9 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.2 | 1.1 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.2 | 4.7 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.2 | 2.2 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.2 | 1.3 | GO:0009374 | biotin binding(GO:0009374) |
| 0.2 | 2.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 2.9 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.2 | 2.2 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.2 | 0.6 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.2 | 1.7 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.2 | 5.3 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 0.6 | GO:0016155 | formyltetrahydrofolate dehydrogenase activity(GO:0016155) |
| 0.2 | 2.8 | GO:0004559 | alpha-mannosidase activity(GO:0004559) |
| 0.2 | 0.6 | GO:0042954 | lipoprotein transporter activity(GO:0042954) |
| 0.2 | 2.2 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.2 | 1.3 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.2 | 1.6 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.2 | 1.0 | GO:0019841 | retinal binding(GO:0016918) retinol binding(GO:0019841) |
| 0.2 | 0.7 | GO:0034481 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) chondroitin sulfotransferase activity(GO:0034481) |
| 0.2 | 1.5 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.2 | 4.0 | GO:0043236 | laminin binding(GO:0043236) |
| 0.2 | 0.5 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.2 | 0.5 | GO:0046969 | histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) |
| 0.2 | 0.3 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.2 | 1.2 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.2 | 2.6 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
| 0.1 | 0.7 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.1 | 0.6 | GO:0008802 | betaine-aldehyde dehydrogenase activity(GO:0008802) |
| 0.1 | 0.6 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) phosphatidylcholine-translocating ATPase activity(GO:0090554) |
| 0.1 | 1.2 | GO:0050308 | sugar-phosphatase activity(GO:0050308) |
| 0.1 | 1.7 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.1 | 0.9 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.1 | 1.2 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 2.8 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 20.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 0.3 | GO:0008732 | threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.1 | 1.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 6.2 | GO:0016209 | antioxidant activity(GO:0016209) |
| 0.1 | 4.2 | GO:1901505 | carbohydrate derivative transporter activity(GO:1901505) |
| 0.1 | 2.0 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 8.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 5.7 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.1 | 5.2 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 2.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 3.2 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 0.8 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.1 | 10.5 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 1.7 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 1.8 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 1.4 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.1 | 1.0 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.1 | 0.6 | GO:0048256 | flap endonuclease activity(GO:0048256) |
| 0.1 | 2.8 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.1 | 6.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 0.9 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.1 | 0.4 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.1 | 1.5 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 1.8 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.1 | 0.5 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 3.1 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 2.8 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 3.5 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.1 | 0.6 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.1 | 1.4 | GO:0016675 | oxidoreductase activity, acting on a heme group of donors(GO:0016675) |
| 0.1 | 1.6 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.1 | 1.0 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 0.2 | GO:0016979 | lipoate-protein ligase activity(GO:0016979) |
| 0.1 | 0.3 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.1 | 0.5 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 0.1 | 0.8 | GO:0048038 | quinone binding(GO:0048038) |
| 0.1 | 1.7 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.1 | 0.6 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.0 | 2.8 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 1.1 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 2.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 8.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.3 | GO:0004645 | phosphorylase activity(GO:0004645) |
| 0.0 | 0.3 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.6 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.0 | 1.4 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 1.3 | GO:0050661 | NADP binding(GO:0050661) |
| 0.0 | 0.2 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.0 | 0.9 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 0.2 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.0 | 0.6 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.6 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 1.2 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.0 | 0.1 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
| 0.0 | 1.2 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.3 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 1.7 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 1.3 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.3 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.0 | 0.2 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
| 0.0 | 1.9 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.7 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 0.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 4.0 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 0.4 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 1.1 | GO:0008528 | G-protein coupled peptide receptor activity(GO:0008528) |
| 0.0 | 0.2 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 8.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 1.0 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.0 | 2.8 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.1 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 0.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.6 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.6 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.0 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 0.0 | 2.0 | GO:0019902 | phosphatase binding(GO:0019902) |
| 0.0 | 0.5 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 0.5 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.1 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.6 | 8.4 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.6 | 36.2 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.4 | 12.7 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.2 | 3.8 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
| 0.2 | 2.0 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.1 | 2.4 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.1 | 0.7 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
| 0.1 | 1.3 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.1 | 2.0 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.1 | 0.7 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 3.6 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 3.5 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 3.0 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 3.6 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 3.6 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.1 | 4.0 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 2.6 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.1 | 1.3 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 1.5 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 6.1 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.1 | 7.1 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.8 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.1 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 2.3 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.2 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.7 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.4 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 3.6 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.8 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 3.6 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.1 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.5 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 5.2 | NABA_MATRISOME_ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.0 | 0.6 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.8 | PID_P73PATHWAY | p73 transcription factor network |
| 0.0 | 0.5 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.3 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 0.2 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 0.5 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 5.5 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.3 | 3.0 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.3 | 3.2 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.3 | 1.4 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.3 | 2.7 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.3 | 1.8 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.2 | 1.9 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 1.3 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 12.7 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 5.9 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 3.4 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.2 | 4.3 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.2 | 2.3 | REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in RORA Activates Circadian Expression |
| 0.2 | 15.1 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 1.8 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 4.3 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 7.8 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 1.8 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 6.0 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 1.2 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.1 | 4.4 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 2.5 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 2.4 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 11.1 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 1.7 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 0.7 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 0.7 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 1.4 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 1.2 | REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 0.6 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 1.3 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 3.5 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.6 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.2 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.9 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 1.8 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.7 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 1.7 | REACTOME_MUSCLE_CONTRACTION | Genes involved in Muscle contraction |
| 0.0 | 1.3 | REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 2.2 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.6 | REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 1.2 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.3 | REACTOME_ELONGATION_ARREST_AND_RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 0.6 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 1.2 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.5 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 1.9 | REACTOME_G_ALPHA1213_SIGNALLING_EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.0 | 0.8 | REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.0 | 1.4 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_SIGNALING_BY_CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 1.7 | REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.0 | 1.4 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.4 | REACTOME_DOUBLE_STRAND_BREAK_REPAIR | Genes involved in Double-Strand Break Repair |
| 0.0 | 0.2 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
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