Motif ID: Tcf21_Msc

Z-value: 1.196

Transcription factors associated with Tcf21_Msc:

Gene SymbolEntrez IDGene Name
Msc ENSMUSG00000025930.5 Msc
Tcf21 ENSMUSG00000045680.7 Tcf21



Activity profile for motif Tcf21_Msc.

activity profile for motif Tcf21_Msc


Sorted Z-values histogram for motif Tcf21_Msc

Sorted Z-values for motif Tcf21_Msc



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf21_Msc

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144893077 17.098 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_48045144 11.636 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr4_+_144892813 11.182 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr3_+_90537242 10.992 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr1_-_14310198 10.638 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr5_-_28210022 9.723 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr3_+_90537306 9.386 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chr11_+_99864476 9.075 ENSMUST00000092694.3
 Gm11559
predicted gene 11559
chr11_+_113619318 9.027 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr9_-_40346290 8.512 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr4_+_144893127 8.191 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_-_84305385 7.992 ENSMUST00000122849.1
ENSMUST00000132283.1
 Trim2

tripartite motif-containing 2

chr7_+_122289297 7.915 ENSMUST00000064989.5
ENSMUST00000064921.4
 Prkcb

protein kinase C, beta

chr16_+_43510267 7.871 ENSMUST00000114695.2
 Zbtb20
zinc finger and BTB domain containing 20
chr6_-_54566484 7.750 ENSMUST00000019268.4
 Scrn1
secernin 1
chr6_+_29398920 7.220 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr6_+_80018877 6.732 ENSMUST00000147663.1
ENSMUST00000128718.1
ENSMUST00000126005.1
ENSMUST00000133918.1
 Lrrtm4



leucine rich repeat transmembrane neuronal 4



chr18_+_60293372 6.522 ENSMUST00000171297.1
 F830016B08Rik
RIKEN cDNA F830016B08 gene
chr11_-_107915041 6.510 ENSMUST00000039071.2
 Cacng5
calcium channel, voltage-dependent, gamma subunit 5
chr1_-_97977233 6.427 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 36.5 GO:0042572 retinol metabolic process(GO:0042572)
0.2 17.8 GO:0051592 response to calcium ion(GO:0051592)
0.8 13.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.7 12.9 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
2.0 12.0 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
3.9 11.6 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.3 11.2 GO:0007520 myoblast fusion(GO:0007520)
0.7 10.4 GO:0048194 Golgi vesicle budding(GO:0048194)
0.9 10.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.8 9.0 GO:0030432 peristalsis(GO:0030432)
0.3 8.3 GO:0035458 cellular response to interferon-beta(GO:0035458)
1.6 7.9 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.2 7.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.3 7.6 GO:0006730 one-carbon metabolic process(GO:0006730)
0.6 6.8 GO:0009404 toxin metabolic process(GO:0009404)
0.5 6.7 GO:0001675 acrosome assembly(GO:0001675)
0.3 6.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 6.4 GO:0007569 cell aging(GO:0007569)
0.4 6.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
2.0 5.9 GO:1904760 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.3 GO:0005667 transcription factor complex(GO:0005667)
0.4 17.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 16.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 15.6 GO:0005615 extracellular space(GO:0005615)
0.1 11.6 GO:0030175 filopodium(GO:0030175)
0.1 10.8 GO:0032993 protein-DNA complex(GO:0032993)
0.2 10.4 GO:0031985 Golgi cisterna(GO:0031985)
0.1 9.9 GO:0031526 brush border membrane(GO:0031526)
0.0 8.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 7.2 GO:0002080 acrosomal membrane(GO:0002080)
0.0 6.7 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 6.2 GO:0030667 secretory granule membrane(GO:0030667)
0.1 5.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 5.7 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 5.4 GO:0005776 autophagosome(GO:0005776)
0.3 5.1 GO:0005605 basal lamina(GO:0005605)
0.6 4.9 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 4.8 GO:0036064 ciliary basal body(GO:0036064)
0.3 4.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
1.5 4.5 GO:0071149 TEAD-2-YAP complex(GO:0071149)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.2 36.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 20.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 16.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.5 12.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
1.9 11.3 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 10.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.3 8.9 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 8.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 8.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 8.1 GO:0005509 calcium ion binding(GO:0005509)
1.3 7.9 GO:0035184 histone threonine kinase activity(GO:0035184)
0.5 7.7 GO:0016805 dipeptidase activity(GO:0016805)
0.6 7.0 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 6.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 6.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
2.1 6.4 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 6.2 GO:0016209 antioxidant activity(GO:0016209)
1.9 5.7 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 5.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 5.3 GO:0070064 proline-rich region binding(GO:0070064)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 36.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.4 12.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.6 8.4 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 7.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 6.1 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 5.2 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.6 5.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 4.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.2 3.8 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 3.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 3.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 3.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.0 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 2.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 2.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 2.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.1 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 12.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 11.1 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 7.8 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 6.0 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 5.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.8 5.5 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 4.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 4.3 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 4.3 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 3.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 3.4 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.3 3.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 3.0 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.3 2.7 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.5 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.1 2.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 2.3 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 2.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 1.9 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation