Motif ID: Tcf3

Z-value: 0.757


Transcription factors associated with Tcf3:

Gene SymbolEntrez IDGene Name
Tcf3 ENSMUSG00000020167.8 Tcf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf3mm10_v2_chr10_-_80433615_804336550.496.7e-06Click!


Activity profile for motif Tcf3.

activity profile for motif Tcf3


Sorted Z-values histogram for motif Tcf3

Sorted Z-values for motif Tcf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_28302238 11.762 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr15_-_78773452 7.108 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr12_-_34528844 6.462 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr1_+_74791516 5.923 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr19_-_45560508 5.640 ENSMUST00000026239.6
 Poll
polymerase (DNA directed), lambda
chr17_-_35703971 5.591 ENSMUST00000148065.1
 Ddr1
discoidin domain receptor family, member 1
chr8_-_122699066 5.451 ENSMUST00000127984.1
 Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr17_-_35704000 5.442 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1

chr15_+_34238026 5.440 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr6_-_72235559 4.488 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr4_-_43523388 4.468 ENSMUST00000107913.3
ENSMUST00000030184.5
 Tpm2

tropomyosin 2, beta

chr12_+_109459843 4.397 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr17_+_75178797 4.258 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr1_-_97977233 4.150 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase
chr17_+_75178911 3.988 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr6_+_56017489 3.934 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr7_+_45216671 3.929 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr5_+_144545883 3.824 ENSMUST00000071782.6
 Nptx2
neuronal pentraxin 2
chr8_+_94977101 3.768 ENSMUST00000179619.1
 Gpr56
G protein-coupled receptor 56
chr11_+_113619318 3.742 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 255 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 15.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
2.4 11.8 GO:0007386 compartment pattern specification(GO:0007386)
0.4 9.0 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.8 8.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.3 7.4 GO:0040034 regulation of development, heterochronic(GO:0040034)
1.7 6.7 GO:0060032 notochord regression(GO:0060032)
0.6 6.5 GO:0034983 peptidyl-lysine deacetylation(GO:0034983) regulation of skeletal muscle fiber development(GO:0048742)
0.5 6.5 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.7 6.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.9 5.6 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.8 5.5 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.3 4.8 GO:0048194 Golgi vesicle budding(GO:0048194)
1.6 4.7 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
1.1 4.5 GO:0010288 response to lead ion(GO:0010288)
0.4 4.5 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.2 4.4 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.3 4.2 GO:0009404 toxin metabolic process(GO:0009404)
0.1 4.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.2 3.9 GO:0048368 lateral mesoderm development(GO:0048368)
0.5 3.7 GO:0071600 otic vesicle morphogenesis(GO:0071600)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.9 11.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
2.7 8.2 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 7.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 7.8 GO:0005923 bicellular tight junction(GO:0005923)
0.2 7.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.5 6.7 GO:0097542 ciliary tip(GO:0097542)
0.0 6.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 5.6 GO:0000922 spindle pole(GO:0000922)
0.0 5.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.3 5.2 GO:0031528 microvillus membrane(GO:0031528)
1.1 4.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 4.3 GO:0031012 extracellular matrix(GO:0031012)
0.1 4.2 GO:0031985 Golgi cisterna(GO:0031985)
1.3 3.9 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 3.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 3.7 GO:0045177 apical part of cell(GO:0045177)
0.1 3.5 GO:0031941 filamentous actin(GO:0031941)
0.0 3.2 GO:0032993 protein-DNA complex(GO:0032993)
0.6 3.1 GO:0097149 centralspindlin complex(GO:0097149)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 15.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.4 13.9 GO:0005112 Notch binding(GO:0005112)
0.4 13.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 12.0 GO:0070888 E-box binding(GO:0070888)
0.2 8.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
2.0 8.0 GO:0050436 microfibril binding(GO:0050436)
0.0 7.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
2.4 7.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 6.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.6 5.6 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.3 5.5 GO:0051861 glycolipid binding(GO:0051861)
0.1 5.5 GO:0005109 frizzled binding(GO:0005109)
0.2 4.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.7 4.7 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.2 4.7 GO:0071837 HMG box domain binding(GO:0071837)
0.1 4.3 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
1.4 4.2 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 4.1 GO:0005096 GTPase activator activity(GO:0005096)
0.1 4.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.5 3.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 8.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 7.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 7.3 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.2 6.9 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 6.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 6.0 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.2 5.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 5.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 4.7 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.2 4.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 4.6 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 3.6 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.3 3.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.4 3.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.4 PID_BARD1_PATHWAY BARD1 signaling events
0.1 3.3 NABA_COLLAGENS Genes encoding collagen proteins
0.1 3.1 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 3.1 PID_PLK1_PATHWAY PLK1 signaling events
0.1 2.5 PID_IL6_7_PATHWAY IL6-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.4 7.8 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 6.5 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.1 5.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 4.7 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 4.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 4.4 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.1 4.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 4.2 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 3.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 3.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 3.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 3.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 2.9 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 2.9 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.2 2.8 REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.4 2.6 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 2.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism