Motif ID: Tcf4_Mesp1
Z-value: 2.181


Transcription factors associated with Tcf4_Mesp1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Mesp1 | ENSMUSG00000030544.5 | Mesp1 |
Tcf4 | ENSMUSG00000053477.9 | Tcf4 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Tcf4 | mm10_v2_chr18_+_69344503_69344530 | -0.24 | 3.4e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 601 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 95.3 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
2.6 | 92.2 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
0.6 | 66.1 | GO:0016579 | protein deubiquitination(GO:0016579) |
19.1 | 57.2 | GO:2000111 | cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) |
0.4 | 44.2 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
6.0 | 42.2 | GO:0061092 | regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
8.1 | 40.3 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
0.8 | 39.3 | GO:0034605 | cellular response to heat(GO:0034605) |
9.6 | 38.3 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
6.9 | 34.5 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
0.3 | 34.0 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
0.6 | 33.2 | GO:0010812 | negative regulation of cell-substrate adhesion(GO:0010812) |
7.6 | 30.4 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
2.0 | 29.9 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
1.3 | 28.7 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
7.0 | 28.1 | GO:1902512 | positive regulation of apoptotic DNA fragmentation(GO:1902512) |
1.1 | 27.6 | GO:0043496 | regulation of protein homodimerization activity(GO:0043496) |
5.3 | 26.7 | GO:0075136 | response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136) |
4.4 | 26.3 | GO:0046880 | regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884) |
2.9 | 26.2 | GO:0071420 | cellular response to histamine(GO:0071420) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 240 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 171.8 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
0.4 | 70.5 | GO:0045211 | postsynaptic membrane(GO:0045211) |
0.4 | 63.5 | GO:0030016 | myofibril(GO:0030016) |
0.4 | 53.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
1.7 | 48.4 | GO:0033268 | node of Ranvier(GO:0033268) |
0.3 | 46.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
2.2 | 42.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
1.4 | 37.4 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
2.1 | 35.8 | GO:0032279 | asymmetric synapse(GO:0032279) |
0.5 | 34.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
2.6 | 33.2 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
0.7 | 29.3 | GO:0048786 | presynaptic active zone(GO:0048786) |
0.6 | 28.2 | GO:0031901 | early endosome membrane(GO:0031901) |
1.9 | 27.9 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
0.8 | 27.6 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
6.7 | 27.0 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
8.8 | 26.3 | GO:0043512 | inhibin A complex(GO:0043512) |
0.4 | 24.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
1.8 | 23.9 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.1 | 23.2 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 382 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.6 | 102.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
2.4 | 91.5 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
0.8 | 71.3 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
8.7 | 60.8 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
3.6 | 57.7 | GO:0003680 | AT DNA binding(GO:0003680) |
1.3 | 53.7 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
4.4 | 52.4 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
1.3 | 43.6 | GO:0030552 | cAMP binding(GO:0030552) |
1.7 | 42.1 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
4.9 | 39.5 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
0.2 | 39.5 | GO:0003924 | GTPase activity(GO:0003924) |
2.0 | 35.5 | GO:0050811 | GABA receptor binding(GO:0050811) |
6.9 | 34.5 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
0.8 | 33.0 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
2.9 | 31.7 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
0.5 | 28.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
5.4 | 26.9 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
1.2 | 25.9 | GO:0030506 | ankyrin binding(GO:0030506) |
0.5 | 25.9 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
0.8 | 24.7 | GO:0042805 | actinin binding(GO:0042805) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 71 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 77.7 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
0.9 | 65.1 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
1.4 | 56.8 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
1.4 | 54.1 | PID_ALK1_PATHWAY | ALK1 signaling events |
1.2 | 41.3 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.6 | 32.5 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
0.7 | 29.6 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
0.7 | 29.5 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.8 | 26.6 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
1.7 | 25.6 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
0.6 | 25.6 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
0.7 | 22.3 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
0.6 | 21.5 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
0.6 | 21.4 | PID_INSULIN_PATHWAY | Insulin Pathway |
0.7 | 18.5 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
0.1 | 17.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.8 | 17.6 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
0.2 | 16.7 | PID_P73PATHWAY | p73 transcription factor network |
0.5 | 15.1 | PID_RAS_PATHWAY | Regulation of Ras family activation |
1.0 | 14.9 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 140 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.8 | 68.6 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
1.8 | 58.0 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
1.7 | 46.9 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
1.4 | 45.7 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
1.5 | 39.8 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
1.2 | 39.2 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
1.7 | 38.7 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
1.9 | 34.1 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
1.4 | 33.9 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
1.9 | 30.2 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.7 | 28.3 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
1.7 | 27.9 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
6.6 | 26.3 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
1.0 | 24.5 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
1.8 | 23.3 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
1.0 | 22.7 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
1.4 | 22.6 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
1.1 | 22.6 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
1.1 | 21.9 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
1.3 | 20.8 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |