Motif ID: Tcf4_Mesp1

Z-value: 2.181

Transcription factors associated with Tcf4_Mesp1:

Gene SymbolEntrez IDGene Name
Mesp1 ENSMUSG00000030544.5 Mesp1
Tcf4 ENSMUSG00000053477.9 Tcf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf4mm10_v2_chr18_+_69344503_69344530-0.243.4e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf4_Mesp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_67922136 76.931 ENSMUST00000021288.3
ENSMUST00000108677.1
Usp43

ubiquitin specific peptidase 43

chr15_-_66831625 76.386 ENSMUST00000164163.1
Sla
src-like adaptor
chr13_+_83504032 57.163 ENSMUST00000163888.1
ENSMUST00000005722.7
Mef2c

myocyte enhancer factor 2C

chr15_+_54571358 45.683 ENSMUST00000025356.2
Mal2
mal, T cell differentiation protein 2
chr13_-_57907587 40.880 ENSMUST00000172326.1
Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr10_+_123264076 37.814 ENSMUST00000050756.7
Fam19a2
family with sequence similarity 19, member A2
chr17_-_26201328 33.923 ENSMUST00000025019.2
Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr9_-_29411736 32.118 ENSMUST00000115236.1
Ntm
neurotrimin
chr12_+_82616885 31.756 ENSMUST00000161801.1
Rgs6
regulator of G-protein signaling 6
chr2_-_163918683 27.534 ENSMUST00000044734.2
Rims4
regulating synaptic membrane exocytosis 4
chr11_-_7213897 26.995 ENSMUST00000020702.4
ENSMUST00000135887.2
Igfbp3

insulin-like growth factor binding protein 3

chr17_-_26201363 26.870 ENSMUST00000121959.1
Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr14_-_121797670 26.727 ENSMUST00000100299.3
Dock9
dedicator of cytokinesis 9
chr3_-_82145865 26.712 ENSMUST00000048976.6
Gucy1a3
guanylate cyclase 1, soluble, alpha 3
chr10_+_81257277 26.013 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
Matk


megakaryocyte-associated tyrosine kinase


chr5_+_37028329 25.763 ENSMUST00000173836.1
Jakmip1
janus kinase and microtubule interacting protein 1
chr19_-_57314896 25.613 ENSMUST00000111524.1
Ablim1
actin-binding LIM protein 1
chr7_+_123982799 25.058 ENSMUST00000106437.1
Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr9_+_107935876 24.547 ENSMUST00000035700.8
Camkv
CaM kinase-like vesicle-associated
chr14_-_39472825 23.287 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
Nrg3


neuregulin 3



Gene overrepresentation in biological_process category:

Showing 1 to 20 of 601 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 95.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
2.6 92.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.6 66.1 GO:0016579 protein deubiquitination(GO:0016579)
19.1 57.2 GO:2000111 cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.4 44.2 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
6.0 42.2 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
8.1 40.3 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.8 39.3 GO:0034605 cellular response to heat(GO:0034605)
9.6 38.3 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
6.9 34.5 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.3 34.0 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.6 33.2 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
7.6 30.4 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
2.0 29.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.3 28.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
7.0 28.1 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512)
1.1 27.6 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
5.3 26.7 GO:0075136 response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136)
4.4 26.3 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
2.9 26.2 GO:0071420 cellular response to histamine(GO:0071420)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 240 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 171.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 70.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 63.5 GO:0030016 myofibril(GO:0030016)
0.4 53.8 GO:0031225 anchored component of membrane(GO:0031225)
1.7 48.4 GO:0033268 node of Ranvier(GO:0033268)
0.3 46.1 GO:0005802 trans-Golgi network(GO:0005802)
2.2 42.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
1.4 37.4 GO:0000930 gamma-tubulin complex(GO:0000930)
2.1 35.8 GO:0032279 asymmetric synapse(GO:0032279)
0.5 34.2 GO:0005913 cell-cell adherens junction(GO:0005913)
2.6 33.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.7 29.3 GO:0048786 presynaptic active zone(GO:0048786)
0.6 28.2 GO:0031901 early endosome membrane(GO:0031901)
1.9 27.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.8 27.6 GO:0032809 neuronal cell body membrane(GO:0032809)
6.7 27.0 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
8.8 26.3 GO:0043512 inhibin A complex(GO:0043512)
0.4 24.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.8 23.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 23.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 382 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 102.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
2.4 91.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.8 71.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
8.7 60.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
3.6 57.7 GO:0003680 AT DNA binding(GO:0003680)
1.3 53.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
4.4 52.4 GO:0004016 adenylate cyclase activity(GO:0004016)
1.3 43.6 GO:0030552 cAMP binding(GO:0030552)
1.7 42.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
4.9 39.5 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 39.5 GO:0003924 GTPase activity(GO:0003924)
2.0 35.5 GO:0050811 GABA receptor binding(GO:0050811)
6.9 34.5 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.8 33.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
2.9 31.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.5 28.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
5.4 26.9 GO:0072542 protein phosphatase activator activity(GO:0072542)
1.2 25.9 GO:0030506 ankyrin binding(GO:0030506)
0.5 25.9 GO:0015459 potassium channel regulator activity(GO:0015459)
0.8 24.7 GO:0042805 actinin binding(GO:0042805)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 77.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.9 65.1 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
1.4 56.8 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
1.4 54.1 PID_ALK1_PATHWAY ALK1 signaling events
1.2 41.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.6 32.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.7 29.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.7 29.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.8 26.6 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
1.7 25.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.6 25.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.7 22.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.6 21.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.6 21.4 PID_INSULIN_PATHWAY Insulin Pathway
0.7 18.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 17.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.8 17.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 16.7 PID_P73PATHWAY p73 transcription factor network
0.5 15.1 PID_RAS_PATHWAY Regulation of Ras family activation
1.0 14.9 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 68.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
1.8 58.0 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
1.7 46.9 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
1.4 45.7 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
1.5 39.8 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
1.2 39.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.7 38.7 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
1.9 34.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.4 33.9 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
1.9 30.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.7 28.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
1.7 27.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
6.6 26.3 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
1.0 24.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
1.8 23.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.0 22.7 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
1.4 22.6 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
1.1 22.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
1.1 21.9 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
1.3 20.8 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway