Motif ID: Tcf7_Tcf7l2

Z-value: 1.817

Transcription factors associated with Tcf7_Tcf7l2:

Gene SymbolEntrez IDGene Name
Tcf7 ENSMUSG00000000782.9 Tcf7
Tcf7l2 ENSMUSG00000024985.12 Tcf7l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7mm10_v2_chr11_-_52282564_52282579-0.583.6e-08Click!
Tcf7l2mm10_v2_chr19_+_55742242_557424680.537.1e-07Click!


Activity profile for motif Tcf7_Tcf7l2.

activity profile for motif Tcf7_Tcf7l2


Sorted Z-values histogram for motif Tcf7_Tcf7l2

Sorted Z-values for motif Tcf7_Tcf7l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7_Tcf7l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_152081529 24.090 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr15_+_85859689 24.076 ENSMUST00000170629.1
 Gtse1
G two S phase expressed protein 1
chr15_+_102296256 22.208 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr2_+_102706356 21.928 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
 Slc1a2


solute carrier family 1 (glial high affinity glutamate transporter), member 2


chr10_-_92165159 19.616 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr4_-_43499608 18.894 ENSMUST00000136005.1
ENSMUST00000054538.6
 Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr14_-_52020698 16.388 ENSMUST00000067549.7
 Zfp219
zinc finger protein 219
chr7_+_67655414 16.319 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr7_+_27499315 16.271 ENSMUST00000098644.2
ENSMUST00000108355.1
 Prx

periaxin

chr7_+_45216671 16.212 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr2_+_153031852 16.148 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr18_-_62756275 15.980 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr17_-_47016956 15.673 ENSMUST00000165525.1
 Gm16494
predicted gene 16494
chr10_-_92164666 15.338 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr3_+_76074270 15.280 ENSMUST00000038364.8
 Fstl5
follistatin-like 5
chr10_+_127725392 14.720 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr6_-_40436104 14.037 ENSMUST00000039008.6
ENSMUST00000101492.3
 E330009J07Rik

RIKEN cDNA E330009J07 gene

chr5_-_44102032 13.501 ENSMUST00000171543.1
 Prom1
prominin 1
chr2_+_20737306 12.742 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr13_-_97747399 12.460 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 26.3 GO:2001222 regulation of neuron migration(GO:2001222)
1.5 22.2 GO:0000212 meiotic spindle organization(GO:0000212)
3.1 21.9 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.0 18.7 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
1.0 17.8 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.7 16.2 GO:0048368 lateral mesoderm development(GO:0048368)
0.1 16.2 GO:0006275 regulation of DNA replication(GO:0006275)
0.3 16.1 GO:0001947 heart looping(GO:0001947)
5.2 15.7 GO:0030421 defecation(GO:0030421)
0.1 15.5 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
3.7 14.7 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
4.6 13.9 GO:0061181 regulation of chondrocyte development(GO:0061181)
4.5 13.5 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
3.3 13.1 GO:0006982 response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449)
0.4 12.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.7 11.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 11.0 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
3.6 10.8 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
1.0 10.8 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.5 10.7 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 24.8 GO:0005667 transcription factor complex(GO:0005667)
0.6 21.9 GO:0030673 axolemma(GO:0030673)
0.3 21.3 GO:0072686 mitotic spindle(GO:0072686)
0.2 19.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 19.3 GO:0072562 blood microparticle(GO:0072562)
5.4 16.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.3 16.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.7 15.1 GO:0010369 chromocenter(GO:0010369)
0.2 14.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
4.5 13.5 GO:0071914 prominosome(GO:0071914)
0.3 13.5 GO:0005720 nuclear heterochromatin(GO:0005720)
0.2 13.1 GO:0000922 spindle pole(GO:0000922)
0.1 12.1 GO:0005815 microtubule organizing center(GO:0005815)
2.1 10.5 GO:0036449 microtubule minus-end(GO:0036449)
2.6 10.4 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 10.3 GO:0016605 PML body(GO:0016605)
1.1 10.1 GO:0030478 actin cap(GO:0030478)
0.6 9.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
2.3 9.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 9.2 GO:1990204 oxidoreductase complex(GO:1990204)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 32.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 24.8 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 24.7 GO:0045296 cadherin binding(GO:0045296)
3.7 21.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 21.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 21.6 GO:0003677 DNA binding(GO:0003677)
0.7 16.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 16.6 GO:0008201 heparin binding(GO:0008201)
0.0 16.3 GO:0003682 chromatin binding(GO:0003682)
0.8 15.0 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
2.4 14.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 14.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.7 13.9 GO:0070411 I-SMAD binding(GO:0070411)
0.2 13.4 GO:0070491 repressing transcription factor binding(GO:0070491)
0.8 12.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.0 11.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.5 11.4 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.6 10.8 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.2 10.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 10.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 22.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.2 18.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.3 16.4 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.4 14.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.4 14.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 13.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 12.8 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.3 12.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 11.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.4 9.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 8.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.6 8.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 7.9 PID_PLK1_PATHWAY PLK1 signaling events
0.2 7.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 5.4 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 4.7 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 4.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 4.3 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.5 PID_CXCR3_PATHWAY CXCR3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 18.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.6 18.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 18.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.5 13.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.4 11.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 11.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 11.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.6 11.0 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.4 10.7 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 10.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.6 10.2 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.3 10.1 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.7 10.0 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.4 9.9 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.3 9.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
1.5 9.2 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.4 9.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 8.1 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.3 7.1 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 6.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis