Motif ID: Tcf7l1
Z-value: 0.927
Transcription factors associated with Tcf7l1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tcf7l1 | ENSMUSG00000055799.7 | Tcf7l1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tcf7l1 | mm10_v2_chr6_-_72788952_72789061 | 0.28 | 1.3e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 14.6 | GO:0061181 | regulation of chondrocyte development(GO:0061181) |
| 2.3 | 6.8 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) |
| 1.7 | 5.2 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 1.3 | 3.9 | GO:0060242 | contact inhibition(GO:0060242) |
| 1.2 | 4.9 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 1.2 | 7.3 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.9 | 2.8 | GO:0060392 | negative regulation of SMAD protein import into nucleus(GO:0060392) |
| 0.9 | 3.5 | GO:0021698 | cerebellar cortex structural organization(GO:0021698) |
| 0.7 | 3.3 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.6 | 6.7 | GO:1901250 | regulation of lung goblet cell differentiation(GO:1901249) negative regulation of lung goblet cell differentiation(GO:1901250) |
| 0.6 | 6.6 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.6 | 3.5 | GO:0097473 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 0.6 | 7.4 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.6 | 2.3 | GO:0021812 | neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812) |
| 0.6 | 2.3 | GO:0090238 | positive regulation of arachidonic acid secretion(GO:0090238) |
| 0.5 | 2.2 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.5 | 1.5 | GO:1904956 | regulation of endodermal cell fate specification(GO:0042663) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) |
| 0.5 | 3.5 | GO:0048617 | embryonic foregut morphogenesis(GO:0048617) |
| 0.5 | 1.0 | GO:1900368 | regulation of RNA interference(GO:1900368) |
| 0.5 | 1.5 | GO:1903334 | positive regulation of protein folding(GO:1903334) |
| 0.4 | 3.4 | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA(GO:0035280) |
| 0.4 | 1.2 | GO:0001705 | ectoderm formation(GO:0001705) |
| 0.4 | 2.8 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.4 | 2.0 | GO:0042117 | monocyte activation(GO:0042117) |
| 0.4 | 1.2 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.4 | 1.9 | GO:0007403 | glial cell fate determination(GO:0007403) |
| 0.4 | 1.5 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) |
| 0.4 | 5.9 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.4 | 3.3 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.4 | 7.4 | GO:0048368 | lateral mesoderm development(GO:0048368) |
| 0.3 | 3.9 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.3 | 3.6 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.3 | 1.0 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 0.3 | 2.1 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
| 0.3 | 1.9 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.3 | 0.8 | GO:0010643 | cell communication by chemical coupling(GO:0010643) negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 0.3 | 2.1 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.3 | 1.0 | GO:0030576 | Cajal body organization(GO:0030576) |
| 0.3 | 1.3 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 0.2 | 1.0 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.2 | 2.7 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.2 | 1.4 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.2 | 0.9 | GO:0045578 | negative regulation of B cell differentiation(GO:0045578) |
| 0.2 | 3.0 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
| 0.2 | 2.1 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077) |
| 0.2 | 1.0 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.2 | 0.9 | GO:0038026 | reelin-mediated signaling pathway(GO:0038026) |
| 0.2 | 4.5 | GO:0014912 | negative regulation of smooth muscle cell migration(GO:0014912) |
| 0.2 | 2.2 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.2 | 1.3 | GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) |
| 0.2 | 4.1 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
| 0.2 | 3.3 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.2 | 0.3 | GO:0010936 | negative regulation of macrophage cytokine production(GO:0010936) |
| 0.2 | 1.2 | GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511) |
| 0.2 | 1.9 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.2 | 0.5 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 0.2 | 1.3 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.2 | 8.2 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.2 | 1.4 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.2 | 1.1 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 0.1 | 2.8 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.1 | 0.3 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
| 0.1 | 1.0 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) |
| 0.1 | 0.4 | GO:0035973 | aggrephagy(GO:0035973) |
| 0.1 | 5.6 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
| 0.1 | 4.1 | GO:0009409 | response to cold(GO:0009409) |
| 0.1 | 0.5 | GO:0060368 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368) |
| 0.1 | 2.8 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
| 0.1 | 0.7 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.1 | 1.3 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 1.2 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.1 | 4.0 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.1 | 3.3 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 0.6 | GO:1901339 | regulation of store-operated calcium channel activity(GO:1901339) |
| 0.1 | 3.1 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042) |
| 0.1 | 2.2 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 0.5 | GO:0000189 | MAPK import into nucleus(GO:0000189) positive regulation of cytokine secretion involved in immune response(GO:0002741) |
| 0.1 | 2.0 | GO:0016242 | negative regulation of macroautophagy(GO:0016242) |
| 0.1 | 0.4 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.1 | 1.0 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.1 | 0.4 | GO:0090666 | scaRNA localization to Cajal body(GO:0090666) |
| 0.1 | 0.7 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.1 | 0.7 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.1 | 0.1 | GO:0060481 | lobar bronchus epithelium development(GO:0060481) |
| 0.1 | 0.8 | GO:0045056 | transcytosis(GO:0045056) |
| 0.1 | 0.3 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.1 | 1.1 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.1 | 0.6 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.1 | 1.4 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
| 0.1 | 0.6 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.1 | 2.1 | GO:0006739 | NADP metabolic process(GO:0006739) |
| 0.1 | 1.0 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.1 | 0.7 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.1 | 0.6 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.0 | 0.5 | GO:2000465 | regulation of glycogen (starch) synthase activity(GO:2000465) |
| 0.0 | 1.3 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.0 | 0.3 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.0 | 0.1 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.0 | 0.6 | GO:0030813 | positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197) |
| 0.0 | 1.1 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.0 | 3.6 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 0.7 | GO:0046688 | response to copper ion(GO:0046688) |
| 0.0 | 0.6 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.0 | 0.1 | GO:0060217 | positive regulation of chromatin assembly or disassembly(GO:0045799) hemangioblast cell differentiation(GO:0060217) |
| 0.0 | 2.3 | GO:0032024 | positive regulation of insulin secretion(GO:0032024) |
| 0.0 | 0.7 | GO:0009749 | response to glucose(GO:0009749) |
| 0.0 | 0.6 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 1.2 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.0 | 2.4 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 0.2 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.0 | 0.1 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.0 | 0.1 | GO:0009212 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075) |
| 0.0 | 0.7 | GO:0042632 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
| 0.0 | 3.6 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.0 | 4.2 | GO:0030336 | negative regulation of cell migration(GO:0030336) |
| 0.0 | 0.2 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.0 | 0.4 | GO:0006336 | DNA replication-independent nucleosome assembly(GO:0006336) |
| 0.0 | 0.8 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
| 0.0 | 0.5 | GO:0097178 | ruffle assembly(GO:0097178) |
| 0.0 | 0.3 | GO:0034308 | primary alcohol metabolic process(GO:0034308) |
| 0.0 | 0.1 | GO:0043652 | engulfment of apoptotic cell(GO:0043652) |
| 0.0 | 0.6 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 2.2 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.0 | 0.1 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
| 0.0 | 0.2 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.0 | 0.9 | GO:0040008 | regulation of growth(GO:0040008) |
| 0.0 | 1.2 | GO:0001678 | cellular glucose homeostasis(GO:0001678) |
| 0.0 | 0.0 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) |
| 0.0 | 0.8 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.0 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 7.4 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.9 | 2.8 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
| 0.8 | 0.8 | GO:1902737 | dendritic filopodium(GO:1902737) |
| 0.7 | 7.8 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.6 | 1.9 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 0.6 | 2.3 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) |
| 0.5 | 2.2 | GO:0008623 | CHRAC(GO:0008623) |
| 0.5 | 4.8 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.4 | 3.4 | GO:0070578 | RISC-loading complex(GO:0070578) |
| 0.3 | 3.9 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.3 | 1.0 | GO:0031074 | nucleocytoplasmic shuttling complex(GO:0031074) |
| 0.3 | 4.0 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.3 | 5.6 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.3 | 0.8 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.3 | 1.0 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.3 | 4.0 | GO:0036038 | MKS complex(GO:0036038) |
| 0.2 | 3.5 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.2 | 3.9 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 2.2 | GO:0031105 | septin complex(GO:0031105) |
| 0.1 | 0.4 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 0.1 | 1.4 | GO:0016342 | catenin complex(GO:0016342) |
| 0.1 | 3.5 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.1 | 1.2 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.1 | 1.5 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.1 | 0.7 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.1 | 0.6 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.1 | 0.4 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.1 | 4.0 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 0.5 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 0.1 | GO:0043224 | nuclear SCF ubiquitin ligase complex(GO:0043224) |
| 0.0 | 0.7 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 17.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 2.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 1.2 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.5 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.0 | 0.5 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.7 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 0.1 | GO:0034272 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 0.0 | 1.2 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 0.4 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.0 | 1.2 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 3.1 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 0.7 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 1.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.8 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.6 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.8 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.2 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 2.0 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.6 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.6 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 1.2 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.8 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.3 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.9 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.5 | GO:0032587 | ruffle membrane(GO:0032587) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.2 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 1.1 | 6.8 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.8 | 3.3 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.8 | 2.4 | GO:0005118 | sevenless binding(GO:0005118) |
| 0.8 | 3.9 | GO:0005113 | patched binding(GO:0005113) |
| 0.8 | 14.6 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.7 | 3.0 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.7 | 5.2 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.5 | 1.6 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
| 0.5 | 2.0 | GO:0030292 | hyalurononglucosaminidase activity(GO:0004415) protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.5 | 1.5 | GO:0048019 | receptor antagonist activity(GO:0048019) |
| 0.5 | 1.9 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.4 | 3.9 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.4 | 2.5 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.4 | 3.1 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.4 | 3.5 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.4 | 2.2 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.3 | 1.0 | GO:0019966 | interleukin-1 binding(GO:0019966) |
| 0.3 | 0.9 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.3 | 5.2 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.3 | 5.8 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.3 | 2.3 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.3 | 0.8 | GO:0042954 | lipoprotein transporter activity(GO:0042954) |
| 0.3 | 3.7 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.2 | 1.0 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.2 | 1.5 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.2 | 0.9 | GO:0038025 | reelin receptor activity(GO:0038025) |
| 0.2 | 2.3 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.2 | 4.0 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.2 | 2.6 | GO:0005522 | profilin binding(GO:0005522) |
| 0.2 | 1.0 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 0.2 | 3.4 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.2 | 1.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 3.0 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.6 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.1 | 1.0 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.1 | 0.7 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 0.5 | GO:2001069 | glycogen binding(GO:2001069) |
| 0.1 | 1.9 | GO:0001163 | RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.1 | 1.5 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 0.1 | 2.8 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.1 | 0.6 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) |
| 0.1 | 4.0 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 3.5 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 0.3 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.1 | 0.8 | GO:0030375 | thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.1 | 2.6 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 0.6 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.1 | 16.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 7.4 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 3.8 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 1.3 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.1 | 1.2 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 0.5 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
| 0.1 | 0.6 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.1 | 1.0 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 1.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 4.4 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.1 | 1.1 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.7 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 2.1 | GO:0050661 | NADP binding(GO:0050661) |
| 0.0 | 1.4 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 1.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 1.2 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 2.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.6 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 1.2 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.0 | 0.5 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 2.0 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 0.5 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
| 0.0 | 1.6 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.2 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.0 | 0.2 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.0 | 2.8 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.3 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.0 | 0.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.1 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 0.2 | GO:0000182 | rDNA binding(GO:0000182) |
| 0.0 | 0.3 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.5 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 1.0 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 5.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 9.6 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 1.4 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 4.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.4 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 0.4 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.1 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 0.0 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) |
| 0.0 | 0.5 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.2 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.3 | 2.3 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 6.8 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 17.8 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 4.6 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 4.2 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.1 | 2.8 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.1 | 4.0 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.1 | 2.2 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 6.7 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 3.3 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.3 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 2.8 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.1 | 2.6 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.1 | 2.3 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 1.8 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 1.2 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.6 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 5.0 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.8 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.0 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.6 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 0.9 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.0 | 3.0 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.5 | PID_PTP1B_PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 0.1 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.1 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.7 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.0 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.6 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 2.0 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.8 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.4 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.1 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.3 | 3.5 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.2 | 2.0 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 3.1 | REACTOME_PLATELET_SENSITIZATION_BY_LDL | Genes involved in Platelet sensitization by LDL |
| 0.2 | 5.2 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.2 | 3.5 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 1.6 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 3.0 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 1.5 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PC | Genes involved in Acyl chain remodelling of PC |
| 0.1 | 0.5 | REACTOME_GAB1_SIGNALOSOME | Genes involved in GAB1 signalosome |
| 0.1 | 2.0 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.1 | 2.5 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 1.2 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 5.2 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 0.8 | REACTOME_STEROID_HORMONES | Genes involved in Steroid hormones |
| 0.1 | 2.0 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 0.6 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.1 | 1.0 | REACTOME_REGULATORY_RNA_PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.1 | 0.5 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 1.8 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.9 | REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 1.1 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 1.1 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 0.6 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 3.3 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 0.1 | REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 0.3 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 2.6 | REACTOME_SIGNALING_BY_FGFR | Genes involved in Signaling by FGFR |
| 0.0 | 1.1 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 1.0 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 0.8 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
