Motif ID: Tcf7l1

Z-value: 0.927


Transcription factors associated with Tcf7l1:

Gene SymbolEntrez IDGene Name
Tcf7l1 ENSMUSG00000055799.7 Tcf7l1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l1mm10_v2_chr6_-_72788952_727890610.281.3e-02Click!


Activity profile for motif Tcf7l1.

activity profile for motif Tcf7l1


Sorted Z-values histogram for motif Tcf7l1

Sorted Z-values for motif Tcf7l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7l1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_152081529 7.447 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr7_+_45216671 7.390 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr11_+_108920800 7.251 ENSMUST00000140821.1
 Axin2
axin2
chr3_+_131110350 6.846 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr7_-_115824699 6.626 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr18_-_62756275 6.603 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr2_+_153031852 5.972 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr14_-_52020698 5.546 ENSMUST00000067549.7
 Zfp219
zinc finger protein 219
chr17_-_70851189 5.245 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr11_+_108921648 5.209 ENSMUST00000144511.1
 Axin2
axin2
chr14_-_98169542 5.202 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr15_+_34238026 4.684 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr10_+_80150448 4.343 ENSMUST00000153477.1
 Midn
midnolin
chr14_+_27039001 4.247 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr4_+_62583568 4.184 ENSMUST00000098031.3
 Rgs3
regulator of G-protein signaling 3
chr18_+_82914632 4.148 ENSMUST00000071233.6
 Zfp516
zinc finger protein 516
chr2_+_70474923 4.055 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr17_-_35697971 3.935 ENSMUST00000146472.1
 Ddr1
discoidin domain receptor family, member 1
chr6_+_29735667 3.933 ENSMUST00000001812.4
 Smo
smoothened homolog (Drosophila)
chr6_-_148944750 3.894 ENSMUST00000111562.1
ENSMUST00000081956.5
 Fam60a

family with sequence similarity 60, member A


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.9 14.6 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.2 8.2 GO:2001222 regulation of neuron migration(GO:2001222)
0.6 7.4 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.4 7.4 GO:0048368 lateral mesoderm development(GO:0048368)
1.2 7.3 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
2.3 6.8 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.6 6.7 GO:1901250 regulation of lung goblet cell differentiation(GO:1901249) negative regulation of lung goblet cell differentiation(GO:1901250)
0.6 6.6 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.4 5.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 5.6 GO:0071300 cellular response to retinoic acid(GO:0071300)
1.7 5.2 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
1.2 4.9 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.2 4.5 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 4.2 GO:0030336 negative regulation of cell migration(GO:0030336)
0.2 4.1 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 4.1 GO:0009409 response to cold(GO:0009409)
0.1 4.0 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.3 3.9 GO:0060242 contact inhibition(GO:0060242)
0.3 3.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.3 3.6 GO:0060539 diaphragm development(GO:0060539)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.9 GO:0005667 transcription factor complex(GO:0005667)
0.7 7.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
2.5 7.4 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.3 5.6 GO:0071564 npBAF complex(GO:0071564)
0.5 4.8 GO:0001739 sex chromatin(GO:0001739)
0.3 4.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.3 4.0 GO:0036038 MKS complex(GO:0036038)
0.1 4.0 GO:0031519 PcG protein complex(GO:0031519)
0.3 3.9 GO:0044294 dendritic growth cone(GO:0044294)
0.2 3.9 GO:0016580 Sin3 complex(GO:0016580)
0.2 3.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 3.5 GO:0051233 spindle midzone(GO:0051233)
0.4 3.4 GO:0070578 RISC-loading complex(GO:0070578)
0.0 3.1 GO:0000922 spindle pole(GO:0000922)
0.9 2.8 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.6 2.3 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.5 2.2 GO:0008623 CHRAC(GO:0008623)
0.1 2.2 GO:0031105 septin complex(GO:0031105)
0.0 2.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.0 GO:0043198 dendritic shaft(GO:0043198)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.8 14.6 GO:0070411 I-SMAD binding(GO:0070411)
0.0 9.6 GO:0003682 chromatin binding(GO:0003682)
0.1 7.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
1.1 6.8 GO:0030284 estrogen receptor activity(GO:0030284)
0.3 5.8 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 5.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.7 5.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.3 5.2 GO:0070410 co-SMAD binding(GO:0070410)
0.1 4.4 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 4.3 GO:0005096 GTPase activator activity(GO:0005096)
1.4 4.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 4.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 4.0 GO:0005112 Notch binding(GO:0005112)
0.8 3.9 GO:0005113 patched binding(GO:0005113)
0.4 3.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 3.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 3.7 GO:0015197 peptide transporter activity(GO:0015197)
0.4 3.5 GO:0034711 inhibin binding(GO:0034711)
0.1 3.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.4 10.2 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.2 6.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 6.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 5.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 4.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 4.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 4.0 PID_ALK1_PATHWAY ALK1 signaling events
0.1 3.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.8 PID_MYC_PATHWAY C-MYC pathway
0.1 2.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 2.6 PID_FGF_PATHWAY FGF signaling pathway
0.3 2.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.3 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.3 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 2.2 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 2.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.8 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.1 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 5.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 5.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 3.5 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 3.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 3.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.2 3.1 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 3.0 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 2.6 REACTOME_SIGNALING_BY_FGFR Genes involved in Signaling by FGFR
0.1 2.5 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 2.0 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.0 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 2.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.8 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.6 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 1.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.1 1.2 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.1 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 1.1 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 1.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins