Motif ID: Tead3_Tead4
Z-value: 1.255
Transcription factors associated with Tead3_Tead4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tead3 | ENSMUSG00000002249.11 | Tead3 |
| Tead4 | ENSMUSG00000030353.9 | Tead4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tead3 | mm10_v2_chr17_-_28350747_28350820 | 0.48 | 9.4e-06 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 22.5 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
| 2.3 | 6.9 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
| 2.2 | 11.1 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 2.2 | 2.2 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 2.1 | 10.7 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 1.8 | 21.2 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 1.8 | 3.5 | GO:0072289 | metanephric nephron tubule formation(GO:0072289) |
| 1.6 | 4.8 | GO:1904580 | regulation of intracellular mRNA localization(GO:1904580) |
| 1.6 | 11.1 | GO:1901300 | positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) |
| 1.5 | 6.0 | GO:1902724 | positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728) |
| 1.5 | 4.4 | GO:0048866 | stem cell fate specification(GO:0048866) |
| 1.4 | 11.5 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 1.4 | 9.6 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 1.3 | 3.9 | GO:0038095 | positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095) |
| 1.2 | 6.2 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 1.2 | 9.9 | GO:0070314 | G1 to G0 transition(GO:0070314) |
| 1.2 | 3.6 | GO:0070543 | response to linoleic acid(GO:0070543) |
| 1.1 | 6.7 | GO:0032346 | positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298) |
| 1.1 | 3.3 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 1.1 | 5.3 | GO:0060591 | chondroblast differentiation(GO:0060591) |
| 1.1 | 4.2 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
| 1.0 | 3.1 | GO:1903011 | regulation of osteoclast proliferation(GO:0090289) negative regulation of bone development(GO:1903011) |
| 1.0 | 3.0 | GO:0033088 | negative regulation of immature T cell proliferation in thymus(GO:0033088) |
| 0.9 | 2.8 | GO:0071918 | urea transmembrane transport(GO:0071918) |
| 0.9 | 9.2 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.9 | 4.4 | GO:0042891 | antibiotic transport(GO:0042891) dipeptide transport(GO:0042938) |
| 0.8 | 4.9 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.8 | 5.6 | GO:0060372 | regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) |
| 0.8 | 4.0 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.8 | 3.8 | GO:0021943 | formation of radial glial scaffolds(GO:0021943) |
| 0.6 | 3.2 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.6 | 2.5 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 0.6 | 2.5 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
| 0.6 | 6.6 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.5 | 1.6 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104) |
| 0.5 | 2.6 | GO:0071376 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.5 | 0.5 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
| 0.5 | 2.4 | GO:1902732 | positive regulation of chondrocyte proliferation(GO:1902732) |
| 0.5 | 0.5 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
| 0.4 | 2.2 | GO:0032298 | positive regulation of DNA-dependent DNA replication initiation(GO:0032298) |
| 0.4 | 2.2 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.4 | 3.5 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.4 | 18.4 | GO:0035411 | catenin import into nucleus(GO:0035411) |
| 0.4 | 2.0 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
| 0.4 | 1.6 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.4 | 5.8 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.4 | 5.4 | GO:0055059 | asymmetric neuroblast division(GO:0055059) |
| 0.4 | 4.6 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.4 | 1.1 | GO:0048687 | positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) |
| 0.4 | 1.5 | GO:2001045 | closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.4 | 1.1 | GO:0010957 | negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) |
| 0.3 | 1.0 | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
| 0.3 | 3.4 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.3 | 2.0 | GO:0070094 | positive regulation of glucagon secretion(GO:0070094) |
| 0.3 | 2.3 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.3 | 1.0 | GO:1902396 | protein localization to bicellular tight junction(GO:1902396) |
| 0.3 | 3.7 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.3 | 2.1 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.3 | 1.8 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.3 | 1.7 | GO:0033139 | regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033139) |
| 0.3 | 4.4 | GO:0097113 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.3 | 0.8 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 0.3 | 2.6 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.3 | 1.3 | GO:1905169 | protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171) |
| 0.3 | 0.5 | GO:0072095 | regulation of branch elongation involved in ureteric bud branching(GO:0072095) |
| 0.2 | 1.3 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
| 0.2 | 1.1 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
| 0.2 | 1.3 | GO:0015879 | carnitine transport(GO:0015879) |
| 0.2 | 1.7 | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431) |
| 0.2 | 2.1 | GO:0002467 | germinal center formation(GO:0002467) |
| 0.2 | 0.6 | GO:0070309 | notochord formation(GO:0014028) axial mesoderm morphogenesis(GO:0048319) lens fiber cell morphogenesis(GO:0070309) |
| 0.2 | 0.7 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.2 | 0.7 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.2 | 1.1 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.2 | 1.2 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.2 | 2.7 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201) |
| 0.2 | 0.6 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
| 0.2 | 0.5 | GO:0008065 | establishment of blood-nerve barrier(GO:0008065) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.2 | 1.1 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.2 | 1.5 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.1 | 2.1 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.1 | 0.7 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 0.1 | 0.5 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
| 0.1 | 7.4 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.1 | 0.8 | GO:1903275 | positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) |
| 0.1 | 3.8 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 0.4 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
| 0.1 | 1.4 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 0.6 | GO:0090310 | negative regulation of methylation-dependent chromatin silencing(GO:0090310) |
| 0.1 | 0.7 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.1 | 0.6 | GO:0002667 | lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) negative regulation of protein kinase C signaling(GO:0090038) |
| 0.1 | 1.8 | GO:0003215 | cardiac right ventricle morphogenesis(GO:0003215) |
| 0.1 | 0.8 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.1 | 0.5 | GO:0019244 | lactate biosynthetic process from pyruvate(GO:0019244) |
| 0.1 | 0.3 | GO:2000319 | negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
| 0.1 | 2.1 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.1 | 1.4 | GO:0035313 | wound healing, spreading of epidermal cells(GO:0035313) regulation of cellular response to hypoxia(GO:1900037) |
| 0.1 | 3.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.4 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.1 | 1.5 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.1 | 0.5 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.1 | 0.8 | GO:0009950 | dorsal/ventral axis specification(GO:0009950) |
| 0.1 | 0.4 | GO:0035745 | T-helper 2 cell cytokine production(GO:0035745) |
| 0.1 | 4.5 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.1 | 0.7 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
| 0.1 | 0.4 | GO:0060178 | regulation of exocyst localization(GO:0060178) |
| 0.1 | 1.4 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.1 | 1.3 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.1 | 0.7 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.1 | 1.0 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
| 0.1 | 1.6 | GO:0006767 | water-soluble vitamin metabolic process(GO:0006767) |
| 0.1 | 0.4 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.1 | 0.9 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.1 | 1.5 | GO:0060438 | trachea development(GO:0060438) |
| 0.1 | 0.4 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.1 | 0.8 | GO:0045199 | maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.1 | 0.8 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.1 | 0.2 | GO:0016095 | polyprenol catabolic process(GO:0016095) |
| 0.1 | 1.2 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
| 0.1 | 0.5 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.1 | 0.3 | GO:0033580 | protein glycosylation at cell surface(GO:0033575) protein galactosylation at cell surface(GO:0033580) protein galactosylation(GO:0042125) |
| 0.1 | 3.2 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 0.1 | 3.4 | GO:0042058 | regulation of epidermal growth factor receptor signaling pathway(GO:0042058) |
| 0.1 | 5.6 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.1 | 0.2 | GO:0000415 | negative regulation of histone H3-K36 methylation(GO:0000415) |
| 0.1 | 3.7 | GO:0042307 | positive regulation of protein import into nucleus(GO:0042307) |
| 0.1 | 1.5 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.1 | 0.9 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 0.1 | 1.2 | GO:2001273 | regulation of glucose import in response to insulin stimulus(GO:2001273) |
| 0.0 | 2.6 | GO:0048747 | muscle fiber development(GO:0048747) |
| 0.0 | 4.5 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 0.0 | 0.6 | GO:0001946 | lymphangiogenesis(GO:0001946) |
| 0.0 | 1.8 | GO:0001658 | branching involved in ureteric bud morphogenesis(GO:0001658) |
| 0.0 | 4.4 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 2.7 | GO:0019319 | hexose biosynthetic process(GO:0019319) |
| 0.0 | 0.1 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.0 | 0.2 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
| 0.0 | 0.4 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 1.7 | GO:0006779 | porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014) |
| 0.0 | 1.0 | GO:0051893 | regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109) |
| 0.0 | 0.7 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 2.8 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 0.0 | 0.8 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
| 0.0 | 0.8 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 0.8 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 1.7 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.0 | 2.3 | GO:0000187 | activation of MAPK activity(GO:0000187) |
| 0.0 | 0.3 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.0 | 1.0 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.0 | 1.2 | GO:0060479 | lung cell differentiation(GO:0060479) lung epithelial cell differentiation(GO:0060487) |
| 0.0 | 0.1 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.0 | 3.8 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.3 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.0 | 0.3 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
| 0.0 | 0.6 | GO:0016572 | histone phosphorylation(GO:0016572) |
| 0.0 | 0.1 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.0 | 1.2 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 0.8 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 0.0 | 0.1 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 0.0 | 0.2 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.0 | 0.2 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.0 | 0.6 | GO:0007129 | synapsis(GO:0007129) |
| 0.0 | 0.3 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
| 0.0 | 1.0 | GO:0051453 | regulation of intracellular pH(GO:0051453) |
| 0.0 | 0.8 | GO:0050728 | negative regulation of inflammatory response(GO:0050728) |
| 0.0 | 2.1 | GO:0006275 | regulation of DNA replication(GO:0006275) |
| 0.0 | 0.0 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.0 | 1.8 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.0 | 0.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 1.8 | GO:0006813 | potassium ion transport(GO:0006813) |
| 0.0 | 1.0 | GO:0042098 | T cell proliferation(GO:0042098) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 11.1 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 3.4 | 10.2 | GO:0030934 | collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934) |
| 2.3 | 6.9 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 1.7 | 6.7 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.8 | 10.7 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.8 | 4.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.7 | 2.2 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.7 | 2.0 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.6 | 1.9 | GO:0034679 | integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679) |
| 0.6 | 1.9 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.5 | 2.1 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.5 | 1.6 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.5 | 6.2 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.5 | 4.5 | GO:0030478 | actin cap(GO:0030478) |
| 0.5 | 3.2 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.4 | 7.6 | GO:0031045 | dense core granule(GO:0031045) |
| 0.4 | 22.1 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.4 | 5.7 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.4 | 1.1 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.4 | 3.4 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.3 | 1.5 | GO:0031523 | Myb complex(GO:0031523) |
| 0.3 | 1.7 | GO:0008091 | spectrin(GO:0008091) |
| 0.3 | 1.1 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.2 | 3.0 | GO:0043219 | lateral loop(GO:0043219) |
| 0.2 | 1.5 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.2 | 2.2 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.2 | 1.1 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.2 | 2.0 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 3.0 | GO:0010369 | chromocenter(GO:0010369) |
| 0.2 | 3.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.2 | 2.3 | GO:0043196 | varicosity(GO:0043196) |
| 0.1 | 1.3 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.1 | 0.7 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 2.3 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 0.7 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.1 | 0.4 | GO:0031074 | nucleocytoplasmic shuttling complex(GO:0031074) |
| 0.1 | 1.8 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 0.5 | GO:0098858 | actin-based cell projection(GO:0098858) |
| 0.1 | 0.4 | GO:0008623 | CHRAC(GO:0008623) |
| 0.1 | 0.6 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 1.0 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.1 | 1.9 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.1 | 29.2 | GO:0043235 | receptor complex(GO:0043235) |
| 0.1 | 0.9 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 1.0 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 17.0 | GO:0001726 | ruffle(GO:0001726) |
| 0.1 | 7.8 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 39.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 5.3 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 1.5 | GO:0044447 | axoneme part(GO:0044447) |
| 0.1 | 1.7 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 2.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 1.0 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 2.8 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 2.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 3.1 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 3.3 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 1.2 | GO:0032420 | stereocilium(GO:0032420) |
| 0.1 | 1.3 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.4 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.0 | 4.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 3.2 | GO:0016528 | sarcoplasm(GO:0016528) |
| 0.0 | 0.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 1.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 0.5 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.2 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.0 | 1.3 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 0.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 4.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.2 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.0 | 0.8 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 1.2 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 1.0 | GO:0005874 | microtubule(GO:0005874) |
| 0.0 | 5.5 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 0.3 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 2.7 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.6 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 1.2 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.0 | 0.6 | GO:0031256 | leading edge membrane(GO:0031256) |
| 0.0 | 1.3 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 0.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 11.1 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834) |
| 2.4 | 21.2 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 2.3 | 6.9 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 2.1 | 10.7 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 1.5 | 4.4 | GO:0042936 | dipeptide transporter activity(GO:0042936) |
| 1.4 | 30.4 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 1.3 | 12.1 | GO:0030274 | LIM domain binding(GO:0030274) |
| 1.2 | 3.6 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 1.0 | 3.0 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.9 | 2.8 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 0.9 | 2.8 | GO:0050656 | 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
| 0.8 | 6.9 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.7 | 6.0 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.7 | 2.0 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 0.7 | 4.7 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.6 | 1.9 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 0.6 | 1.9 | GO:0071936 | coreceptor activity involved in Wnt signaling pathway(GO:0071936) |
| 0.6 | 1.7 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.5 | 4.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.5 | 1.6 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924) |
| 0.5 | 6.7 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.5 | 4.1 | GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008) |
| 0.5 | 3.4 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.5 | 2.8 | GO:0015204 | urea transmembrane transporter activity(GO:0015204) |
| 0.5 | 6.4 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.4 | 4.0 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.4 | 2.2 | GO:0005113 | patched binding(GO:0005113) |
| 0.4 | 6.2 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.4 | 8.4 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.4 | 1.5 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.4 | 2.3 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.4 | 1.5 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.3 | 3.1 | GO:0043184 | BMP binding(GO:0036122) vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.3 | 4.8 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.3 | 3.5 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.3 | 1.3 | GO:0015226 | amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226) |
| 0.3 | 1.6 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.3 | 2.7 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.3 | 0.9 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 0.3 | 1.1 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.2 | 14.5 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.2 | 5.3 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.2 | 2.0 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.2 | 4.4 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.2 | 3.4 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.2 | 0.9 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.2 | 4.4 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.2 | 0.7 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 0.2 | 2.5 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.2 | 0.7 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
| 0.2 | 1.1 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.2 | 1.1 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 0.2 | 2.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.2 | 1.5 | GO:0071253 | connexin binding(GO:0071253) |
| 0.2 | 3.2 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.2 | 0.6 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 0.2 | 2.2 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.1 | 1.4 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 1.8 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 0.4 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.1 | 0.9 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.1 | 0.5 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.1 | 3.0 | GO:0042805 | actinin binding(GO:0042805) |
| 0.1 | 1.0 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.1 | 0.6 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.1 | 2.6 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 3.5 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.1 | 1.0 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
| 0.1 | 2.3 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 1.9 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.1 | 0.3 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.1 | 2.3 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 0.3 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.1 | 4.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 0.8 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.1 | 0.2 | GO:0047751 | 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751) |
| 0.1 | 5.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 7.5 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 1.3 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.1 | 2.5 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 0.8 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.1 | 1.0 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 0.8 | GO:0048038 | quinone binding(GO:0048038) |
| 0.1 | 0.5 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 1.9 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 2.3 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.1 | 1.0 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 3.4 | GO:0017022 | myosin binding(GO:0017022) |
| 0.1 | 0.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 2.2 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 1.2 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 9.4 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.0 | 0.3 | GO:0047276 | N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276) |
| 0.0 | 5.0 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 4.1 | GO:0005539 | glycosaminoglycan binding(GO:0005539) |
| 0.0 | 0.2 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.0 | 8.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 3.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.6 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 0.2 | GO:0009378 | four-way junction helicase activity(GO:0009378) |
| 0.0 | 0.8 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 2.4 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 0.2 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.0 | 0.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.7 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.2 | GO:0070739 | protein-glutamic acid ligase activity(GO:0070739) |
| 0.0 | 0.6 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 0.5 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 0.2 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 4.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.3 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.0 | 1.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.6 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.4 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 1.0 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 1.0 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.5 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 35.6 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
| 0.7 | 5.3 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.4 | 12.6 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.4 | 12.4 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.4 | 6.0 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.4 | 16.4 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 4.8 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.2 | 6.9 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 3.0 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 6.7 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 1.6 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.1 | 3.5 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.1 | 3.0 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 2.8 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 5.2 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 2.1 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 3.0 | ST_GAQ_PATHWAY | G alpha q Pathway |
| 0.1 | 3.5 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 6.7 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.1 | 4.1 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.1 | 2.0 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.1 | 7.4 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 5.7 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.1 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 0.6 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 3.6 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 0.6 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.1 | 3.9 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.1 | 3.0 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.1 | 7.8 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.6 | PID_NFAT_3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.1 | 0.7 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 7.1 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.1 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.3 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.0 | 2.6 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 3.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.3 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 0.2 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.9 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 0.5 | PID_P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 37.9 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.9 | 12.1 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.9 | 11.2 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.6 | 7.6 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.6 | 13.2 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.5 | 14.8 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.5 | 11.1 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.4 | 6.9 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.3 | 6.6 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.3 | 17.1 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.3 | 1.5 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.2 | 4.8 | REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.2 | 6.1 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 1.3 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.2 | 3.3 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.2 | 5.6 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 2.6 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 0.8 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.2 | 7.6 | REACTOME_PI3K_AKT_ACTIVATION | Genes involved in PI3K/AKT activation |
| 0.1 | 3.0 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.1 | 2.8 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 2.6 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.1 | 2.8 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 1.2 | REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH | Genes involved in NCAM signaling for neurite out-growth |
| 0.1 | 2.8 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.1 | 1.3 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 3.0 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.1 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 8.8 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 7.9 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 2.3 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.5 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 2.1 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.1 | 1.0 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 0.5 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 3.0 | REACTOME_SIGNAL_TRANSDUCTION_BY_L1 | Genes involved in Signal transduction by L1 |
| 0.1 | 3.3 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.8 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 2.6 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 6.8 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.2 | REACTOME_ANDROGEN_BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.0 | 0.8 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.3 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 1.0 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 1.6 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 2.2 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.7 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.6 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.3 | REACTOME_CIRCADIAN_CLOCK | Genes involved in Circadian Clock |
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