Motif ID: Tead3_Tead4
Z-value: 1.255
Transcription factors associated with Tead3_Tead4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tead3 | ENSMUSG00000002249.11 | Tead3 |
| Tead4 | ENSMUSG00000030353.9 | Tead4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tead3 | mm10_v2_chr17_-_28350747_28350820 | 0.48 | 9.4e-06 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 171 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 22.5 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
| 1.8 | 21.2 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.4 | 18.4 | GO:0035411 | catenin import into nucleus(GO:0035411) |
| 1.4 | 11.5 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 2.2 | 11.1 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 1.6 | 11.1 | GO:1901300 | positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) |
| 2.1 | 10.7 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 1.2 | 9.9 | GO:0070314 | G1 to G0 transition(GO:0070314) |
| 1.4 | 9.6 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 0.9 | 9.2 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.1 | 7.4 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 2.3 | 6.9 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
| 1.1 | 6.7 | GO:0032346 | positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298) |
| 0.6 | 6.6 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 1.2 | 6.2 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 1.5 | 6.0 | GO:1902724 | positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728) |
| 0.4 | 5.8 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.8 | 5.6 | GO:0060372 | regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) |
| 0.1 | 5.6 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.4 | 5.4 | GO:0055059 | asymmetric neuroblast division(GO:0055059) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 81 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 39.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 29.2 | GO:0043235 | receptor complex(GO:0043235) |
| 0.4 | 22.1 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 17.0 | GO:0001726 | ruffle(GO:0001726) |
| 3.7 | 11.1 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.8 | 10.7 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 3.4 | 10.2 | GO:0030934 | collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934) |
| 0.1 | 7.8 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.4 | 7.6 | GO:0031045 | dense core granule(GO:0031045) |
| 2.3 | 6.9 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 1.7 | 6.7 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.5 | 6.2 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.4 | 5.7 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 5.5 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 5.3 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.8 | 4.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 4.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.5 | 4.5 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 4.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.4 | 3.4 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 118 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 30.4 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 2.4 | 21.2 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.2 | 14.5 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 1.3 | 12.1 | GO:0030274 | LIM domain binding(GO:0030274) |
| 2.8 | 11.1 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834) |
| 2.1 | 10.7 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 0.0 | 9.4 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.0 | 8.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.4 | 8.4 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.1 | 7.5 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 2.3 | 6.9 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.8 | 6.9 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.5 | 6.7 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.5 | 6.4 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.4 | 6.2 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.7 | 6.0 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.2 | 5.3 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 5.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 5.0 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.5 | 4.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 41 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 35.6 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
| 0.4 | 16.4 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.4 | 12.6 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.4 | 12.4 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 7.8 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 7.4 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 7.1 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 6.9 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 6.7 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 6.7 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.4 | 6.0 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.1 | 5.7 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.7 | 5.3 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 5.2 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 4.8 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.1 | 4.1 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.1 | 3.9 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.1 | 3.6 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 3.5 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.1 | 3.5 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 49 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 37.9 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.3 | 17.1 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.5 | 14.8 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.6 | 13.2 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.9 | 12.1 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.9 | 11.2 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.5 | 11.1 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 8.8 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 7.9 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.6 | 7.6 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.2 | 7.6 | REACTOME_PI3K_AKT_ACTIVATION | Genes involved in PI3K/AKT activation |
| 0.4 | 6.9 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 6.8 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 6.6 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 6.1 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 5.6 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 4.8 | REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.2 | 3.3 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 3.3 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.0 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
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