Motif ID: Tfap2a

Z-value: 1.267


Transcription factors associated with Tfap2a:

Gene SymbolEntrez IDGene Name
Tfap2a ENSMUSG00000021359.9 Tfap2a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2amm10_v2_chr13_-_40733768_407338360.056.6e-01Click!


Activity profile for motif Tfap2a.

activity profile for motif Tfap2a


Sorted Z-values histogram for motif Tfap2a

Sorted Z-values for motif Tfap2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_100015817 16.969 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr15_-_45114926 14.897 ENSMUST00000022967.5
 Kcnv1
potassium channel, subfamily V, member 1
chr12_-_67221221 13.398 ENSMUST00000178814.1
ENSMUST00000179345.2
 Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr9_+_21184103 12.049 ENSMUST00000115458.2
 Pde4a
phosphodiesterase 4A, cAMP specific
chr1_+_159737510 9.975 ENSMUST00000111669.3
 Tnr
tenascin R
chr17_+_69969073 9.544 ENSMUST00000133983.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr10_-_86498836 9.498 ENSMUST00000120638.1
 Syn3
synapsin III
chr17_+_69969387 9.156 ENSMUST00000146730.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr9_+_26733728 8.971 ENSMUST00000160899.1
ENSMUST00000161431.1
ENSMUST00000159799.1
 B3gat1


beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)


chr13_-_98206151 8.890 ENSMUST00000109426.1
 Arhgef28
Rho guanine nucleotide exchange factor (GEF) 28
chr5_-_146585239 8.736 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr17_+_69969217 8.585 ENSMUST00000060072.5
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr7_+_121392266 8.577 ENSMUST00000084628.3
 Hs3st2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chrX_-_162643575 7.971 ENSMUST00000101102.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chrX_-_162643629 7.954 ENSMUST00000112334.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr9_+_109931774 7.700 ENSMUST00000169851.2
 Map4
microtubule-associated protein 4
chr10_+_86021961 7.271 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chr12_-_76822510 7.259 ENSMUST00000021459.7
 Rab15
RAB15, member RAS oncogene family
chr14_+_33923582 7.147 ENSMUST00000168727.1
 Gdf10
growth differentiation factor 10
chr14_+_68083853 7.048 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 256 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 27.3 GO:0070842 aggresome assembly(GO:0070842)
1.1 22.7 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.5 17.2 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
4.2 17.0 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.1 12.1 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
1.6 10.9 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
2.5 10.0 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.2 9.3 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.1 9.3 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.7 8.9 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.2 7.9 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
1.5 7.7 GO:0051012 microtubule sliding(GO:0051012)
0.3 7.7 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.7 7.6 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 7.6 GO:0007623 circadian rhythm(GO:0007623)
1.9 7.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.9 7.3 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
2.3 7.0 GO:0045110 intermediate filament bundle assembly(GO:0045110)
1.4 7.0 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.2 7.0 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 37.1 GO:0014069 postsynaptic density(GO:0014069)
0.0 26.0 GO:0005794 Golgi apparatus(GO:0005794)
0.2 19.8 GO:0030175 filopodium(GO:0030175)
0.1 15.8 GO:0000139 Golgi membrane(GO:0000139)
0.2 14.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 13.3 GO:0031225 anchored component of membrane(GO:0031225)
0.8 12.4 GO:0043196 varicosity(GO:0043196)
0.5 12.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 11.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 11.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
3.3 10.0 GO:0072534 perineuronal net(GO:0072534)
0.2 8.3 GO:0016459 myosin complex(GO:0016459)
0.2 8.1 GO:0048786 presynaptic active zone(GO:0048786)
0.6 7.6 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 7.5 GO:0008021 synaptic vesicle(GO:0008021)
1.5 7.3 GO:1990037 Lewy body core(GO:1990037)
0.1 7.1 GO:0016605 PML body(GO:0016605)
2.3 7.0 GO:0033596 TSC1-TSC2 complex(GO:0033596)
1.7 6.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
2.2 6.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 22.7 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
2.8 17.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.4 14.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.8 13.5 GO:0046625 sphingolipid binding(GO:0046625)
0.0 13.5 GO:0005525 GTP binding(GO:0005525)
0.3 12.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 11.6 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 11.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 11.0 GO:0030165 PDZ domain binding(GO:0030165)
1.4 10.9 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.4 10.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.7 10.2 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 9.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.5 8.6 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.3 7.8 GO:0043274 phospholipase binding(GO:0043274)
0.1 7.6 GO:0043130 ubiquitin binding(GO:0043130)
0.1 7.5 GO:0005262 calcium channel activity(GO:0005262)
1.5 7.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 7.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.3 6.9 GO:0045295 gamma-catenin binding(GO:0045295)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 14.3 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 13.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 11.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 8.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 7.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 5.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 4.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 4.3 PID_ATM_PATHWAY ATM pathway
0.1 4.1 PID_BMP_PATHWAY BMP receptor signaling
0.2 4.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 4.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 3.7 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 3.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 3.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 3.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.2 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 3.1 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 2.6 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 2.6 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 2.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 22.7 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
1.1 17.0 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.5 15.2 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.5 13.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.5 12.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 11.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 8.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 8.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 7.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 6.7 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.3 5.7 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.4 5.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 4.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 4.2 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 4.2 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 3.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 3.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.2 3.3 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 3.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 3.2 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription