Motif ID: Tfap2b

Z-value: 0.950


Transcription factors associated with Tfap2b:

Gene SymbolEntrez IDGene Name
Tfap2b ENSMUSG00000025927.7 Tfap2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2bmm10_v2_chr1_+_19208914_192089670.047.1e-01Click!


Activity profile for motif Tfap2b.

activity profile for motif Tfap2b


Sorted Z-values histogram for motif Tfap2b

Sorted Z-values for motif Tfap2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_5740885 14.304 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr2_+_91945703 13.489 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr12_+_70825492 9.721 ENSMUST00000057859.7
 Frmd6
FERM domain containing 6
chr18_+_64340225 7.578 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr1_-_14310198 7.296 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr4_+_48045144 7.012 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr17_+_83215271 5.930 ENSMUST00000170794.1
 Pkdcc
protein kinase domain containing, cytoplasmic
chr13_+_49187485 5.684 ENSMUST00000049022.8
ENSMUST00000120733.1
 Ninj1

ninjurin 1

chr12_+_84009481 5.444 ENSMUST00000168120.1
 Acot1
acyl-CoA thioesterase 1
chr11_+_35121126 5.427 ENSMUST00000069837.3
 Slit3
slit homolog 3 (Drosophila)
chr1_-_98095596 4.980 ENSMUST00000058762.8
ENSMUST00000097625.3
 Pam

peptidylglycine alpha-amidating monooxygenase

chr2_+_153031852 4.798 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr4_-_133967235 4.573 ENSMUST00000123234.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr7_+_27607997 4.443 ENSMUST00000142365.1
 Akt2
thymoma viral proto-oncogene 2
chr17_-_35700520 4.346 ENSMUST00000119825.1
 Ddr1
discoidin domain receptor family, member 1
chr4_+_109978004 4.300 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr7_+_27607748 4.280 ENSMUST00000136962.1
 Akt2
thymoma viral proto-oncogene 2
chr4_-_22488296 4.143 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2
chr4_+_8690399 3.985 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr4_-_133967296 3.930 ENSMUST00000105893.1
 Hmgn2
high mobility group nucleosomal binding domain 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.8 14.3 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.5 14.1 GO:0040034 regulation of development, heterochronic(GO:0040034)
1.6 11.3 GO:0048752 semicircular canal morphogenesis(GO:0048752)
1.6 9.7 GO:0003383 apical constriction(GO:0003383)
1.5 8.7 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.7 7.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 7.2 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
2.3 7.0 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.5 6.8 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.6 6.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.2 6.2 GO:0007520 myoblast fusion(GO:0007520)
1.0 5.9 GO:0090005 negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1 5.9 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.9 5.4 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.4 5.0 GO:0009404 toxin metabolic process(GO:0009404)
1.1 4.4 GO:2000256 endomitotic cell cycle(GO:0007113) thrombopoietin-mediated signaling pathway(GO:0038163) positive regulation of male germ cell proliferation(GO:2000256)
0.4 4.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.8 4.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.3 4.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.2 4.0 GO:0060033 anatomical structure regression(GO:0060033)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 14.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 11.7 GO:0043296 apical junction complex(GO:0043296)
0.5 8.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 8.5 GO:0032993 protein-DNA complex(GO:0032993)
0.4 6.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 5.0 GO:0030667 secretory granule membrane(GO:0030667)
0.0 4.5 GO:0001650 fibrillar center(GO:0001650)
0.3 4.4 GO:0032433 filopodium tip(GO:0032433)
0.1 4.3 GO:0031901 early endosome membrane(GO:0031901)
0.0 4.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.7 3.0 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 3.0 GO:0032420 stereocilium(GO:0032420)
0.3 2.6 GO:0090543 Flemming body(GO:0090543)
0.1 2.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 2.4 GO:0000139 Golgi membrane(GO:0000139)
0.4 2.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 2.2 GO:0001726 ruffle(GO:0001726)
0.0 2.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 2.0 GO:0005662 DNA replication factor A complex(GO:0005662)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 21.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.6 14.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 11.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 11.5 GO:0005080 protein kinase C binding(GO:0005080)
0.1 10.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 7.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.4 5.7 GO:0005522 profilin binding(GO:0005522)
0.2 5.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.7 5.4 GO:0048495 Roundabout binding(GO:0048495)
0.3 5.4 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
1.7 5.0 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.9 4.4 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.5 4.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 4.2 GO:0070412 R-SMAD binding(GO:0070412)
0.2 4.1 GO:0071837 HMG box domain binding(GO:0071837)
0.1 3.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 3.9 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 3.5 GO:0017124 SH3 domain binding(GO:0017124)
0.1 3.3 GO:0005109 frizzled binding(GO:0005109)
0.1 3.2 GO:0000400 four-way junction DNA binding(GO:0000400)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 26.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.4 15.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.2 7.3 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 5.3 PID_BMP_PATHWAY BMP receptor signaling
0.1 3.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 3.1 PID_EPO_PATHWAY EPO signaling pathway
0.1 2.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.0 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 2.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.7 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.7 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 0.8 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.8 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.7 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 7.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 6.8 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 6.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 3.9 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 3.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 3.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 3.3 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.6 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 2.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 2.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 2.2 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 2.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 1.9 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 1.7 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 1.5 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)