Motif ID: Tfap2b
Z-value: 0.950
Transcription factors associated with Tfap2b:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tfap2b | ENSMUSG00000025927.7 | Tfap2b |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfap2b | mm10_v2_chr1_+_19208914_19208967 | 0.04 | 7.1e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 14.3 | GO:1902460 | transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) |
| 3.1 | 3.1 | GO:0003134 | BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) |
| 2.3 | 7.0 | GO:0038095 | positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095) |
| 1.6 | 9.7 | GO:0003383 | apical constriction(GO:0003383) |
| 1.6 | 11.3 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 1.5 | 8.7 | GO:0097473 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 1.2 | 2.4 | GO:0010593 | negative regulation of lamellipodium assembly(GO:0010593) |
| 1.1 | 4.4 | GO:2000256 | endomitotic cell cycle(GO:0007113) thrombopoietin-mediated signaling pathway(GO:0038163) positive regulation of male germ cell proliferation(GO:2000256) |
| 1.0 | 5.9 | GO:0090005 | negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005) |
| 0.9 | 5.4 | GO:0070100 | negative regulation of chemokine-mediated signaling pathway(GO:0070100) |
| 0.8 | 4.2 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.8 | 2.3 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
| 0.7 | 7.6 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.6 | 6.5 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.6 | 2.3 | GO:0060857 | establishment of glial blood-brain barrier(GO:0060857) |
| 0.5 | 0.5 | GO:0010757 | negative regulation of plasminogen activation(GO:0010757) |
| 0.5 | 0.5 | GO:0061153 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 0.5 | 14.1 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.5 | 3.0 | GO:0070278 | extracellular matrix constituent secretion(GO:0070278) |
| 0.5 | 1.5 | GO:1902310 | positive regulation of peptidyl-serine dephosphorylation(GO:1902310) |
| 0.5 | 6.8 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.5 | 1.0 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.5 | 2.3 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.5 | 0.5 | GO:0044413 | evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) |
| 0.4 | 1.7 | GO:0071475 | cellular hyperosmotic salinity response(GO:0071475) |
| 0.4 | 5.0 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.4 | 3.9 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.4 | 3.9 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.4 | 1.1 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.4 | 1.1 | GO:0070172 | positive regulation of tooth mineralization(GO:0070172) |
| 0.4 | 2.2 | GO:0010694 | positive regulation of alkaline phosphatase activity(GO:0010694) |
| 0.4 | 4.3 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.3 | 3.8 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.3 | 4.1 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 0.3 | 0.6 | GO:0030997 | regulation of centriole-centriole cohesion(GO:0030997) |
| 0.3 | 0.6 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
| 0.3 | 1.7 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) |
| 0.3 | 2.9 | GO:0090286 | cytoskeletal anchoring at nuclear membrane(GO:0090286) |
| 0.3 | 7.2 | GO:1903077 | negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376) |
| 0.3 | 2.5 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.3 | 2.2 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
| 0.3 | 0.3 | GO:0042660 | positive regulation of cell fate specification(GO:0042660) |
| 0.2 | 1.0 | GO:1904684 | negative regulation of metalloendopeptidase activity(GO:1904684) |
| 0.2 | 2.4 | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431) |
| 0.2 | 2.9 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.2 | 1.1 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) |
| 0.2 | 1.1 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
| 0.2 | 3.3 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.2 | 0.7 | GO:0036166 | phenotypic switching(GO:0036166) |
| 0.2 | 3.0 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.2 | 0.8 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527) |
| 0.2 | 2.0 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.2 | 4.0 | GO:0060033 | anatomical structure regression(GO:0060033) |
| 0.2 | 1.1 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.2 | 3.7 | GO:0007263 | nitric oxide mediated signal transduction(GO:0007263) |
| 0.2 | 6.2 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.2 | 2.6 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.2 | 0.6 | GO:0019372 | lipoxygenase pathway(GO:0019372) |
| 0.1 | 0.6 | GO:0010755 | regulation of plasminogen activation(GO:0010755) |
| 0.1 | 2.2 | GO:0045820 | negative regulation of glycolytic process(GO:0045820) |
| 0.1 | 0.9 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 0.1 | 1.4 | GO:0021800 | cerebral cortex tangential migration(GO:0021800) |
| 0.1 | 0.5 | GO:0090298 | negative regulation of mitochondrial DNA replication(GO:0090298) |
| 0.1 | 0.5 | GO:0043973 | histone H3-K4 acetylation(GO:0043973) |
| 0.1 | 2.6 | GO:0006044 | N-acetylglucosamine metabolic process(GO:0006044) |
| 0.1 | 2.0 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.1 | 0.6 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.1 | 1.0 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.1 | 2.7 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 0.9 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.1 | 1.3 | GO:0001711 | endodermal cell fate commitment(GO:0001711) |
| 0.1 | 0.7 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.1 | 2.0 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.1 | 0.4 | GO:0001887 | selenium compound metabolic process(GO:0001887) selenocysteine metabolic process(GO:0016259) |
| 0.1 | 0.4 | GO:0003430 | growth plate cartilage chondrocyte growth(GO:0003430) |
| 0.1 | 0.1 | GO:0045575 | basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575) |
| 0.1 | 3.5 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.1 | 5.9 | GO:0001676 | long-chain fatty acid metabolic process(GO:0001676) |
| 0.1 | 0.6 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 0.1 | 0.8 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) positive regulation of lamellipodium morphogenesis(GO:2000394) |
| 0.1 | 0.3 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.1 | 0.5 | GO:0032811 | negative regulation of epinephrine secretion(GO:0032811) |
| 0.1 | 0.2 | GO:0071550 | death-inducing signaling complex assembly(GO:0071550) |
| 0.1 | 0.7 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.1 | 0.2 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) |
| 0.1 | 1.2 | GO:0032506 | cytokinetic process(GO:0032506) |
| 0.1 | 0.6 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
| 0.1 | 0.9 | GO:0030238 | male sex determination(GO:0030238) |
| 0.1 | 2.0 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.1 | 0.7 | GO:0046959 | habituation(GO:0046959) |
| 0.1 | 0.4 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.1 | 0.3 | GO:0010815 | bradykinin catabolic process(GO:0010815) |
| 0.1 | 1.3 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.1 | 0.5 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 0.1 | 0.2 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.1 | 2.1 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 1.2 | GO:0043486 | histone exchange(GO:0043486) |
| 0.0 | 0.8 | GO:0046498 | S-adenosylhomocysteine metabolic process(GO:0046498) |
| 0.0 | 0.1 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) regulation of vascular wound healing(GO:0061043) |
| 0.0 | 1.9 | GO:0006779 | porphyrin-containing compound biosynthetic process(GO:0006779) |
| 0.0 | 0.2 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.0 | 0.3 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.0 | 0.4 | GO:0060836 | foregut morphogenesis(GO:0007440) embryonic foregut morphogenesis(GO:0048617) lymphatic endothelial cell differentiation(GO:0060836) |
| 0.0 | 0.1 | GO:1902512 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) apoptotic process involved in embryonic digit morphogenesis(GO:1902263) positive regulation of apoptotic DNA fragmentation(GO:1902512) |
| 0.0 | 0.2 | GO:0040009 | regulation of growth rate(GO:0040009) |
| 0.0 | 1.5 | GO:0043392 | negative regulation of DNA binding(GO:0043392) |
| 0.0 | 2.4 | GO:0032526 | response to retinoic acid(GO:0032526) |
| 0.0 | 0.3 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.0 | 0.9 | GO:0030901 | midbrain development(GO:0030901) |
| 0.0 | 0.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.0 | 0.3 | GO:0014823 | response to activity(GO:0014823) |
| 0.0 | 0.7 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.0 | 0.2 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.0 | 1.4 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 1.8 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.0 | 1.9 | GO:0009952 | anterior/posterior pattern specification(GO:0009952) |
| 0.0 | 0.3 | GO:0046856 | phospholipid dephosphorylation(GO:0046839) phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 0.1 | GO:0021854 | hypothalamus development(GO:0021854) |
| 0.0 | 0.1 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.0 | 0.2 | GO:0032460 | negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463) |
| 0.0 | 0.2 | GO:0021522 | spinal cord motor neuron differentiation(GO:0021522) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.0 | GO:0002111 | BRCA2-BRAF35 complex(GO:0002111) |
| 0.5 | 8.7 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.4 | 6.6 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.4 | 2.2 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.4 | 1.7 | GO:0043564 | Ku70:Ku80 complex(GO:0043564) |
| 0.3 | 1.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.3 | 4.4 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.3 | 2.6 | GO:0090543 | Flemming body(GO:0090543) |
| 0.1 | 2.0 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 1.3 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 1.5 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 1.2 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.1 | 0.5 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.1 | 2.4 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.1 | 1.9 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 2.0 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 0.3 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.1 | 0.6 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.1 | 4.3 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 5.0 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 0.7 | GO:0032797 | SMN complex(GO:0032797) |
| 0.1 | 11.7 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.1 | 3.0 | GO:0032420 | stereocilium(GO:0032420) |
| 0.1 | 0.7 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 8.5 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 14.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.9 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 2.2 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 1.9 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.3 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.0 | 15.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.2 | GO:0032389 | MutLalpha complex(GO:0032389) |
| 0.0 | 0.6 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 4.5 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.3 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 1.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 1.1 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 0.7 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 0.3 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.2 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 0.2 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
| 0.0 | 0.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.5 | GO:0099738 | cell cortex region(GO:0099738) |
| 0.0 | 0.5 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 1.2 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 0.2 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 2.2 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 2.4 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.2 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 4.2 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 0.8 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 1.3 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.3 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 1.4 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 2.0 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 1.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.7 | GO:0005776 | autophagosome(GO:0005776) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.0 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 0.9 | 4.4 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 0.7 | 5.4 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.6 | 14.8 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.5 | 2.6 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.5 | 2.0 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.5 | 4.3 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.4 | 3.1 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 0.4 | 5.7 | GO:0005522 | profilin binding(GO:0005522) |
| 0.4 | 2.0 | GO:0098634 | protein binding involved in cell-matrix adhesion(GO:0098634) |
| 0.4 | 1.1 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.4 | 2.5 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.3 | 5.4 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.3 | 1.1 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) |
| 0.3 | 2.4 | GO:0051022 | Rho GDP-dissociation inhibitor binding(GO:0051022) |
| 0.3 | 2.9 | GO:0043495 | protein anchor(GO:0043495) |
| 0.2 | 2.7 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.2 | 0.7 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.2 | 0.5 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.2 | 7.0 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.2 | 5.6 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.2 | 0.9 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 0.2 | 2.0 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.2 | 1.2 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.2 | 2.3 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.2 | 1.7 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 0.2 | 3.0 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.2 | 4.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.2 | 1.2 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.2 | 0.8 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.1 | 0.4 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.1 | 0.7 | GO:0030621 | U4 snRNA binding(GO:0030621) |
| 0.1 | 0.7 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.1 | 11.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 11.5 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.1 | 4.2 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 3.2 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.1 | 1.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 3.9 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 1.5 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 0.3 | GO:0034597 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
| 0.1 | 0.5 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.1 | 0.3 | GO:0034211 | GTP-dependent protein kinase activity(GO:0034211) |
| 0.1 | 0.8 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 0.9 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.1 | 0.3 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.1 | 3.3 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 10.5 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 0.5 | GO:1990430 | G-protein coupled GABA receptor activity(GO:0004965) extracellular matrix protein binding(GO:1990430) |
| 0.1 | 0.2 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924) |
| 0.1 | 0.5 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 0.7 | GO:0050308 | carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308) |
| 0.1 | 1.7 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 3.9 | GO:0035591 | signaling adaptor activity(GO:0035591) |
| 0.1 | 1.9 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.1 | 2.5 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 1.1 | GO:0051920 | peroxiredoxin activity(GO:0051920) |
| 0.1 | 0.4 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.1 | 0.6 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.1 | 2.7 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 0.7 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
| 0.0 | 0.1 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.0 | 0.5 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 1.3 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.9 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.3 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.0 | 0.9 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.1 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) AP-3 adaptor complex binding(GO:0035651) |
| 0.0 | 3.2 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.9 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 0.3 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 2.3 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 0.1 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.0 | 0.9 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 1.0 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.4 | GO:0046965 | retinoic acid receptor activity(GO:0003708) retinoid X receptor binding(GO:0046965) |
| 0.0 | 3.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 1.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.5 | GO:0004180 | carboxypeptidase activity(GO:0004180) |
| 0.0 | 1.2 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.5 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 21.7 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 1.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 3.1 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.2 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.0 | 0.2 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 1.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.6 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.0 | 0.2 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.9 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 7.3 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.2 | 26.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.3 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.1 | 3.1 | PID_EPO_PATHWAY | EPO signaling pathway |
| 0.1 | 1.7 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 1.7 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 3.3 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 2.6 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.0 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.6 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.5 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.2 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.4 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.8 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 2.6 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 0.8 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.6 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.7 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.0 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.8 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.4 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.3 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.0 | 0.3 | ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY | PI3K Pathway |
| 0.0 | 0.4 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 0.3 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 1.0 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 0.8 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.1 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.1 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 8.7 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.2 | 3.7 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.2 | 3.9 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.2 | 6.8 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.2 | 1.9 | REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.2 | 2.5 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 3.5 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.1 | 7.4 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.3 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 2.6 | REACTOME_KERATAN_SULFATE_BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.1 | 2.0 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 2.3 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 1.4 | REACTOME_P38MAPK_EVENTS | Genes involved in p38MAPK events |
| 0.1 | 1.7 | REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS | Genes involved in Prolonged ERK activation events |
| 0.1 | 4.6 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 2.7 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 1.2 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.5 | REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway |
| 0.0 | 2.6 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.6 | REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 0.0 | 0.7 | REACTOME_INTEGRATION_OF_PROVIRUS | Genes involved in Integration of provirus |
| 0.0 | 6.8 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.5 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 0.5 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.7 | REACTOME_METABOLISM_OF_NON_CODING_RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 1.1 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 1.1 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.9 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 1.5 | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 2.2 | REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.0 | 0.7 | REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.0 | 0.6 | REACTOME_EXTENSION_OF_TELOMERES | Genes involved in Extension of Telomeres |
| 0.0 | 2.2 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.9 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.5 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 0.1 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
