Motif ID: Tfap2c

Z-value: 1.100


Transcription factors associated with Tfap2c:

Gene SymbolEntrez IDGene Name
Tfap2c ENSMUSG00000028640.5 Tfap2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2cmm10_v2_chr2_+_172550761_172550782-0.512.0e-06Click!


Activity profile for motif Tfap2c.

activity profile for motif Tfap2c


Sorted Z-values histogram for motif Tfap2c

Sorted Z-values for motif Tfap2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_70493156 15.682 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr6_+_4505493 13.839 ENSMUST00000031668.8
 Col1a2
collagen, type I, alpha 2
chr14_+_119138415 12.996 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr11_-_106715251 9.574 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
 Pecam1



platelet/endothelial cell adhesion molecule 1



chr6_+_4504814 8.744 ENSMUST00000141483.1
 Col1a2
collagen, type I, alpha 2
chr7_-_4789541 7.044 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238
chr16_+_91225550 7.015 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr12_-_76709997 6.267 ENSMUST00000166101.1
 Sptb
spectrin beta, erythrocytic
chr4_+_152338887 6.256 ENSMUST00000005175.4
 Chd5
chromodomain helicase DNA binding protein 5
chr15_+_76457438 6.126 ENSMUST00000043089.7
 Scx
scleraxis
chr9_-_29412204 5.640 ENSMUST00000115237.1
 Ntm
neurotrimin
chr4_+_152338619 5.621 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr9_-_29411736 5.271 ENSMUST00000115236.1
 Ntm
neurotrimin
chr7_-_31126945 5.071 ENSMUST00000098548.4
 Scn1b
sodium channel, voltage-gated, type I, beta
chr1_-_184883218 5.048 ENSMUST00000048308.5
 C130074G19Rik
RIKEN cDNA C130074G19 gene
chr4_+_124657646 4.614 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr5_-_35679416 4.608 ENSMUST00000114233.2
 Htra3
HtrA serine peptidase 3
chr6_+_38663061 4.522 ENSMUST00000114874.3
 Clec2l
C-type lectin domain family 2, member L
chr7_-_25237849 4.387 ENSMUST00000071739.5
ENSMUST00000108411.1
 Gsk3a

glycogen synthase kinase 3 alpha

chr2_+_152736244 4.367 ENSMUST00000038368.8
ENSMUST00000109824.1
 Id1

inhibitor of DNA binding 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 23.5 GO:0043589 skin morphogenesis(GO:0043589)
2.6 15.7 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
2.2 13.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
1.7 11.9 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 10.7 GO:0010977 negative regulation of neuron projection development(GO:0010977)
2.4 9.6 GO:0050904 diapedesis(GO:0050904)
1.6 7.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.5 7.4 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
2.4 7.3 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
2.3 7.0 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 6.3 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
2.0 6.1 GO:0061056 sclerotome development(GO:0061056)
0.2 5.4 GO:0048535 lymph node development(GO:0048535)
0.2 5.3 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
1.7 5.1 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.2 5.1 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.6 5.0 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 4.6 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
1.1 4.4 GO:0036015 response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.6 4.4 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074) negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.5 22.6 GO:0005584 collagen type I trimer(GO:0005584)
5.2 15.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 14.1 GO:0031225 anchored component of membrane(GO:0031225)
0.5 11.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
1.9 9.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
1.1 7.9 GO:0005638 lamin filament(GO:0005638)
1.0 6.3 GO:0008091 spectrin(GO:0008091)
0.3 5.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 5.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 4.5 GO:0005874 microtubule(GO:0005874)
0.0 4.4 GO:0043235 receptor complex(GO:0043235)
0.0 4.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 4.1 GO:0030027 lamellipodium(GO:0030027)
0.2 4.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 4.0 GO:0031519 PcG protein complex(GO:0031519)
0.3 3.8 GO:0032426 stereocilium tip(GO:0032426)
0.1 3.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 3.8 GO:0044295 axonal growth cone(GO:0044295)
0.0 3.6 GO:0043197 dendritic spine(GO:0043197)
0.0 3.6 GO:0030141 secretory granule(GO:0030141)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 22.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
2.2 15.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
3.2 13.0 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
3.0 11.9 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.0 11.1 GO:0003779 actin binding(GO:0003779)
0.1 10.3 GO:0030246 carbohydrate binding(GO:0030246)
0.3 9.1 GO:0071837 HMG box domain binding(GO:0071837)
0.3 7.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 7.4 GO:0070888 E-box binding(GO:0070888)
0.8 7.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 7.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.3 6.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 6.0 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.3 5.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.7 5.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 4.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 4.4 GO:0070628 proteasome binding(GO:0070628)
0.1 4.3 GO:0030507 spectrin binding(GO:0030507)
0.5 4.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 4.1 GO:0019903 protein phosphatase binding(GO:0019903)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 30.2 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 18.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 12.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 8.3 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.3 7.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.2 6.9 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 6.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 4.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 4.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 4.4 PID_ALK1_PATHWAY ALK1 signaling events
0.1 3.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.4 3.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 3.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 3.2 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 2.9 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 2.3 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 1.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 1.9 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.9 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 1.6 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 22.8 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.3 13.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 12.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3 11.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.7 9.6 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.7 7.3 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 5.0 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.2 4.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 3.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 3.4 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.3 3.3 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.3 3.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 3.3 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.4 3.2 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 3.0 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.9 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 2.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 2.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.3 2.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 2.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides