Motif ID: Tfap2d

Z-value: 0.873


Transcription factors associated with Tfap2d:

Gene SymbolEntrez IDGene Name
Tfap2d ENSMUSG00000042596.7 Tfap2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2dmm10_v2_chr1_+_19103022_191030430.361.4e-03Click!


Activity profile for motif Tfap2d.

activity profile for motif Tfap2d


Sorted Z-values histogram for motif Tfap2d

Sorted Z-values for motif Tfap2d



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2d

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_84009481 9.682 ENSMUST00000168120.1
 Acot1
acyl-CoA thioesterase 1
chr11_-_32222233 8.006 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr5_+_28165690 5.723 ENSMUST00000036177.7
 En2
engrailed 2
chr12_+_83987854 5.346 ENSMUST00000021649.7
 Acot2
acyl-CoA thioesterase 2
chr8_-_105637350 5.322 ENSMUST00000182863.1
 Gm5914
predicted gene 5914
chr2_+_26586607 5.291 ENSMUST00000174211.1
ENSMUST00000145575.2
ENSMUST00000173920.1
 Egfl7


EGF-like domain 7


chr7_+_130936172 5.255 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr11_+_74619594 4.749 ENSMUST00000100866.2
 E130309D14Rik
RIKEN cDNA E130309D14 gene
chr7_-_4789541 4.665 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238
chr9_-_79718631 4.454 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1
chr5_+_129584169 4.436 ENSMUST00000031390.8
 Mmp17
matrix metallopeptidase 17
chr6_+_72355425 4.197 ENSMUST00000069695.2
ENSMUST00000132243.1
 Tmem150a

transmembrane protein 150A

chr9_-_79718518 4.026 ENSMUST00000071750.6
 Col12a1
collagen, type XII, alpha 1
chr4_-_154636831 3.887 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr9_-_79718720 3.769 ENSMUST00000121227.1
 Col12a1
collagen, type XII, alpha 1
chr8_-_105637403 3.729 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr13_-_92131494 3.650 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr1_+_194938821 3.436 ENSMUST00000016638.2
ENSMUST00000110815.2
 Cd34

CD34 antigen

chr4_-_46991842 3.358 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr9_-_123260776 3.292 ENSMUST00000068140.4
 Tmem158
transmembrane protein 158

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.7 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 9.4 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.2 9.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.3 7.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.2 7.1 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.4 5.7 GO:1990403 embryonic brain development(GO:1990403)
0.6 5.3 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
1.0 5.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 4.8 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.5 4.4 GO:0042756 drinking behavior(GO:0042756)
0.1 4.2 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.5 3.9 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.7 3.7 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.9 3.6 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
1.1 3.4 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
1.1 3.3 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
0.1 3.2 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1 3.2 GO:0034629 cellular protein complex localization(GO:0034629)
0.4 3.0 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.2 3.0 GO:0006817 phosphate ion transport(GO:0006817)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 12.2 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 9.7 GO:0031012 extracellular matrix(GO:0031012)
0.1 7.2 GO:0031901 early endosome membrane(GO:0031901)
0.0 6.2 GO:0000139 Golgi membrane(GO:0000139)
0.0 5.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 5.3 GO:0001650 fibrillar center(GO:0001650)
0.0 4.5 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.9 GO:0016235 aggresome(GO:0016235)
0.5 3.7 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 3.7 GO:0005802 trans-Golgi network(GO:0005802)
0.1 3.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.7 3.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.3 3.4 GO:0046930 pore complex(GO:0046930)
0.2 3.4 GO:1902711 GABA-A receptor complex(GO:1902711)
1.0 3.1 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 3.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
1.0 2.9 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.2 2.9 GO:0042555 MCM complex(GO:0042555)
0.0 2.9 GO:0044297 cell body(GO:0044297)
0.1 2.7 GO:0005865 striated muscle thin filament(GO:0005865)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 16.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 8.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 6.4 GO:0005112 Notch binding(GO:0005112)
0.1 5.4 GO:0020037 heme binding(GO:0020037)
0.2 5.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 5.1 GO:0070412 R-SMAD binding(GO:0070412)
1.7 5.0 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.0 5.0 GO:0005096 GTPase activator activity(GO:0005096)
0.3 4.7 GO:0043495 protein anchor(GO:0043495)
0.1 4.6 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 4.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 4.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.6 3.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.5 3.4 GO:0043199 sulfate binding(GO:0043199)
0.2 3.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
1.0 3.1 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
0.1 2.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.7 2.7 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 2.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 2.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.2 NABA_COLLAGENS Genes encoding collagen proteins
0.1 9.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 6.9 PID_IL3_PATHWAY IL3-mediated signaling events
0.3 5.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 4.3 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 3.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 3.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.6 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 2.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.5 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 2.3 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.2 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 1.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.7 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.1 1.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.6 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 1.5 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.5 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 7.2 REACTOME_PI3K_AKT_ACTIVATION Genes involved in PI3K/AKT activation
0.0 5.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 5.0 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 4.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.3 4.1 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.3 3.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 3.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 3.4 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 3.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 3.0 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.2 2.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 2.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 2.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.2 2.1 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 1.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.5 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins