Motif ID: Tfap2e

Z-value: 0.788


Transcription factors associated with Tfap2e:

Gene SymbolEntrez IDGene Name
Tfap2e ENSMUSG00000042477.7 Tfap2e

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2emm10_v2_chr4_-_126736236_126736245-0.161.7e-01Click!


Activity profile for motif Tfap2e.

activity profile for motif Tfap2e


Sorted Z-values histogram for motif Tfap2e

Sorted Z-values for motif Tfap2e



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2e

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_91945703 21.555 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr11_-_102897123 14.158 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr11_-_102897146 9.118 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr6_+_108213086 5.130 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr15_-_102524615 4.988 ENSMUST00000023814.7
 Npff
neuropeptide FF-amide peptide precursor
chr13_-_101768154 3.953 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr8_+_94152607 3.706 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr8_+_41239718 3.341 ENSMUST00000045218.7
 Pcm1
pericentriolar material 1
chr2_+_102658640 3.231 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr3_-_113630068 3.229 ENSMUST00000092154.3
ENSMUST00000106536.1
ENSMUST00000106535.1
 Rnpc3


RNA-binding region (RNP1, RRM) containing 3


chr7_-_116443439 2.532 ENSMUST00000170430.1
 Pik3c2a
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
chr6_-_97617536 2.479 ENSMUST00000113355.2
 Frmd4b
FERM domain containing 4B
chr4_-_149774238 2.412 ENSMUST00000105686.2
 Slc25a33
solute carrier family 25, member 33
chr13_-_111490111 2.390 ENSMUST00000047627.7
 Gpbp1
GC-rich promoter binding protein 1
chr13_-_111490028 2.375 ENSMUST00000091236.4
 Gpbp1
GC-rich promoter binding protein 1
chr2_-_38287174 2.291 ENSMUST00000130472.1
 Dennd1a
DENN/MADD domain containing 1A
chrX_+_73716577 2.268 ENSMUST00000002084.7
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr17_-_79020816 2.212 ENSMUST00000168887.1
ENSMUST00000119284.1
 Prkd3

protein kinase D3

chr19_-_42752710 2.168 ENSMUST00000076505.3
 Pyroxd2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr9_-_97111117 2.127 ENSMUST00000085206.4
 Slc25a36
solute carrier family 25, member 36
chr6_-_39725448 2.080 ENSMUST00000002487.8
 Braf
Braf transforming gene
chr16_+_93832121 2.059 ENSMUST00000044068.6
 Morc3
microrchidia 3
chr7_-_19629355 2.021 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
 Relb


avian reticuloendotheliosis viral (v-rel) oncogene related B


chr8_+_107293463 1.951 ENSMUST00000169453.1
 Nfat5
nuclear factor of activated T cells 5
chrX_+_73716712 1.913 ENSMUST00000114461.2
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr15_-_58214882 1.899 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr13_+_37826225 1.870 ENSMUST00000128570.1
 Rreb1
ras responsive element binding protein 1
chr3_+_103914560 1.812 ENSMUST00000106806.1
 Rsbn1
rosbin, round spermatid basic protein 1
chr8_+_107293500 1.721 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
 Nfat5


nuclear factor of activated T cells 5


chrX_+_7722267 1.622 ENSMUST00000125991.1
ENSMUST00000148624.1
 Wdr45

WD repeat domain 45

chr6_-_39725193 1.508 ENSMUST00000101497.3
 Braf
Braf transforming gene
chr10_-_127211528 1.478 ENSMUST00000013970.7
 Pip4k2c
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr2_+_109890846 1.387 ENSMUST00000028583.7
 Lin7c
lin-7 homolog C (C. elegans)
chr5_-_34187670 1.341 ENSMUST00000042701.6
ENSMUST00000119171.1
 Mxd4

Max dimerization protein 4

chr9_+_100643605 1.303 ENSMUST00000041418.6
 Stag1
stromal antigen 1
chrX_+_7723278 1.225 ENSMUST00000144148.1
 Wdr45
WD repeat domain 45
chr9_+_100643448 1.169 ENSMUST00000146312.1
ENSMUST00000129269.1
 Stag1

stromal antigen 1

chr9_+_100643755 1.148 ENSMUST00000133388.1
 Stag1
stromal antigen 1
chr2_-_129297205 1.141 ENSMUST00000052708.6
 Ckap2l
cytoskeleton associated protein 2-like
chr1_+_136131382 1.056 ENSMUST00000075164.4
 Kif21b
kinesin family member 21B
chr11_-_51756378 1.044 ENSMUST00000109092.1
ENSMUST00000064297.4
ENSMUST00000109097.2
 Sec24a


Sec24 related gene family, member A (S. cerevisiae)


chr6_-_137649211 1.007 ENSMUST00000134630.1
ENSMUST00000058210.6
ENSMUST00000111878.1
 Eps8


epidermal growth factor receptor pathway substrate 8


chr9_-_121759788 0.976 ENSMUST00000181325.1
 E530011L22Rik
RIKEN cDNA E530011L22 gene
chrX_-_103981242 0.919 ENSMUST00000121153.1
ENSMUST00000070705.4
 Rlim

ring finger protein, LIM domain interacting

chr3_-_84040151 0.894 ENSMUST00000052342.7
 D930015E06Rik
RIKEN cDNA D930015E06 gene
chr16_-_46496955 0.859 ENSMUST00000023335.6
ENSMUST00000023334.8
 Pvrl3

poliovirus receptor-related 3

chr17_+_37046555 0.849 ENSMUST00000172789.1
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr19_+_42518759 0.756 ENSMUST00000026188.3
 R3hcc1l
R3H domain and coiled-coil containing 1 like
chr1_+_159737510 0.734 ENSMUST00000111669.3
 Tnr
tenascin R
chr4_+_151089570 0.733 ENSMUST00000105667.2
 Gm13090
predicted gene 13090
chr19_+_42518795 0.729 ENSMUST00000160107.1
ENSMUST00000160893.1
 R3hcc1l

R3H domain and coiled-coil containing 1 like

chr9_+_25252439 0.716 ENSMUST00000115272.2
ENSMUST00000165594.2
 Sept7

septin 7

chr5_+_64970069 0.557 ENSMUST00000031080.8
 Fam114a1
family with sequence similarity 114, member A1
chr17_-_85688252 0.550 ENSMUST00000024947.7
ENSMUST00000163568.2
 Six2

sine oculis-related homeobox 2

chr7_-_45333754 0.531 ENSMUST00000042194.8
 Trpm4
transient receptor potential cation channel, subfamily M, member 4
chr14_+_56887795 0.512 ENSMUST00000022511.8
 Zmym2
zinc finger, MYM-type 2
chr16_-_46496772 0.500 ENSMUST00000149901.1
ENSMUST00000096052.2
 Pvrl3

poliovirus receptor-related 3

chr4_+_42158092 0.382 ENSMUST00000098122.2
 Gm13306
predicted gene 13306
chr2_+_22895583 0.354 ENSMUST00000152170.1
 Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr15_-_97831460 0.335 ENSMUST00000079838.7
ENSMUST00000118294.1
 Hdac7

histone deacetylase 7

chr13_+_54949388 0.322 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr12_+_3572379 0.244 ENSMUST00000173199.1
ENSMUST00000164578.2
ENSMUST00000174479.1
ENSMUST00000173240.1
ENSMUST00000174663.1
ENSMUST00000173736.1
 Dtnb





dystrobrevin, beta





chr11_+_95414078 0.241 ENSMUST00000107724.2
ENSMUST00000150884.1
ENSMUST00000107722.1
ENSMUST00000127713.1
 Spop



speckle-type POZ protein



chr5_+_28165690 0.215 ENSMUST00000036177.7
 En2
engrailed 2
chr3_-_94786430 0.194 ENSMUST00000107272.1
 Cgn
cingulin
chr3_-_94786469 0.146 ENSMUST00000107273.1
 Cgn
cingulin
chr1_-_177796451 0.075 ENSMUST00000016105.8
 Adss
adenylosuccinate synthetase, non muscle
chr8_+_33386325 0.073 ENSMUST00000078058.3
ENSMUST00000070340.4
 Purg

purine-rich element binding protein G

chr2_-_150904620 0.056 ENSMUST00000056149.8
 Abhd12
abhydrolase domain containing 12
chr10_+_121365078 0.051 ENSMUST00000040344.6
 Gns
glucosamine (N-acetyl)-6-sulfatase
chr15_+_58872646 0.042 ENSMUST00000036937.7
 Trmt12
tRNA methyltranferase 12
chr5_-_137314175 0.027 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr10_-_7663245 0.014 ENSMUST00000163085.1
ENSMUST00000159917.1
 Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 23.3 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
1.4 4.2 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
1.2 3.7 GO:0097212 lysosomal membrane organization(GO:0097212)
1.1 4.5 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.9 8.9 GO:0010459 negative regulation of heart rate(GO:0010459)
0.9 5.1 GO:0042045 epithelial fluid transport(GO:0042045)
0.8 2.5 GO:0071579 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) regulation of zinc ion transport(GO:0071579)
0.6 1.9 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.5 3.3 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.5 3.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.4 3.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.4 2.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.3 2.2 GO:0089700 protein kinase D signaling(GO:0089700)
0.3 1.4 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.3 0.5 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.3 1.0 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.2 2.8 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.2 1.0 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.2 1.9 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601) regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.2 0.9 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.2 0.7 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.2 3.7 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1 1.5 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.1 0.5 GO:0097168 condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168)
0.1 2.0 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 0.8 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.1 2.1 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.1 2.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.7 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.1 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
0.0 0.2 GO:1990403 embryonic brain development(GO:1990403)
0.0 3.2 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 23.3 GO:0097450 astrocyte end-foot(GO:0097450)
1.7 5.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.3 2.0 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.3 6.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 0.7 GO:0072534 perineuronal net(GO:0072534)
0.2 0.7 GO:0005940 septin ring(GO:0005940)
0.2 2.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 1.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.2 0.8 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 4.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 3.3 GO:0000242 pericentriolar material(GO:0000242)
0.1 3.2 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 3.2 GO:0030673 axolemma(GO:0030673)
0.1 1.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 2.3 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 1.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 5.0 GO:0043204 perikaryon(GO:0043204)
0.0 0.5 GO:0034706 sodium channel complex(GO:0034706)
0.0 2.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.6 GO:0016605 PML body(GO:0016605)
0.0 1.5 GO:0005776 autophagosome(GO:0005776)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.0 3.7 GO:0008021 synaptic vesicle(GO:0008021)
0.0 2.1 GO:0001650 fibrillar center(GO:0001650)
0.0 2.5 GO:0001726 ruffle(GO:0001726)
0.0 0.3 GO:0032589 neuron projection membrane(GO:0032589)
0.0 4.5 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.0 4.0 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.8 4.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.5 3.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.5 1.5 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.3 3.2 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.3 23.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 2.5 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 5.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 1.4 GO:0097016 L27 domain binding(GO:0097016)
0.2 4.5 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 3.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.8 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 2.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 2.2 GO:0004697 protein kinase C activity(GO:0004697)
0.1 0.4 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.1 2.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.7 GO:0046625 sphingolipid binding(GO:0046625)
0.0 1.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.3 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.5 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 6.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.0 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 4.0 PID_IL5_PATHWAY IL5-mediated signaling events
0.2 3.6 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.4 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 2.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 2.5 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.0 1.9 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 23.3 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.4 4.0 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.2 4.2 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 3.6 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.2 2.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 0.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 5.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 3.6 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 3.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)