Motif ID: Tfap2e

Z-value: 0.788


Transcription factors associated with Tfap2e:

Gene SymbolEntrez IDGene Name
Tfap2e ENSMUSG00000042477.7 Tfap2e

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2emm10_v2_chr4_-_126736236_126736245-0.161.7e-01Click!


Activity profile for motif Tfap2e.

activity profile for motif Tfap2e


Sorted Z-values histogram for motif Tfap2e

Sorted Z-values for motif Tfap2e



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2e

PNG image of the network

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Top targets:


Showing 1 to 20 of 73 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_91945703 21.555 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr11_-_102897123 14.158 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr11_-_102897146 9.118 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr6_+_108213086 5.130 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr15_-_102524615 4.988 ENSMUST00000023814.7
 Npff
neuropeptide FF-amide peptide precursor
chr13_-_101768154 3.953 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr8_+_94152607 3.706 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr8_+_41239718 3.341 ENSMUST00000045218.7
 Pcm1
pericentriolar material 1
chr2_+_102658640 3.231 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr3_-_113630068 3.229 ENSMUST00000092154.3
ENSMUST00000106536.1
ENSMUST00000106535.1
 Rnpc3


RNA-binding region (RNP1, RRM) containing 3


chr7_-_116443439 2.532 ENSMUST00000170430.1
 Pik3c2a
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
chr6_-_97617536 2.479 ENSMUST00000113355.2
 Frmd4b
FERM domain containing 4B
chr4_-_149774238 2.412 ENSMUST00000105686.2
 Slc25a33
solute carrier family 25, member 33
chr13_-_111490111 2.390 ENSMUST00000047627.7
 Gpbp1
GC-rich promoter binding protein 1
chr13_-_111490028 2.375 ENSMUST00000091236.4
 Gpbp1
GC-rich promoter binding protein 1
chr2_-_38287174 2.291 ENSMUST00000130472.1
 Dennd1a
DENN/MADD domain containing 1A
chrX_+_73716577 2.268 ENSMUST00000002084.7
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr17_-_79020816 2.212 ENSMUST00000168887.1
ENSMUST00000119284.1
 Prkd3

protein kinase D3

chr19_-_42752710 2.168 ENSMUST00000076505.3
 Pyroxd2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr9_-_97111117 2.127 ENSMUST00000085206.4
 Slc25a36
solute carrier family 25, member 36

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 23.3 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.9 8.9 GO:0010459 negative regulation of heart rate(GO:0010459)
0.9 5.1 GO:0042045 epithelial fluid transport(GO:0042045)
1.1 4.5 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
1.4 4.2 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
1.2 3.7 GO:0097212 lysosomal membrane organization(GO:0097212)
0.2 3.7 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.4 3.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.5 3.3 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.5 3.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 3.2 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.2 2.8 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.8 2.5 GO:0071579 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) regulation of zinc ion transport(GO:0071579)
0.1 2.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.4 2.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.3 2.2 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 2.1 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.1 2.0 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.6 1.9 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 1.9 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601) regulation of wound healing, spreading of epidermal cells(GO:1903689)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.8 23.3 GO:0097450 astrocyte end-foot(GO:0097450)
0.3 6.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
1.7 5.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 5.0 GO:0043204 perikaryon(GO:0043204)
0.0 4.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 4.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 3.7 GO:0008021 synaptic vesicle(GO:0008021)
0.1 3.3 GO:0000242 pericentriolar material(GO:0000242)
0.1 3.2 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 3.2 GO:0030673 axolemma(GO:0030673)
0.2 2.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 2.6 GO:0016605 PML body(GO:0016605)
0.0 2.5 GO:0001726 ruffle(GO:0001726)
0.1 2.3 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 2.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.1 GO:0001650 fibrillar center(GO:0001650)
0.3 2.0 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 1.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.5 GO:0005776 autophagosome(GO:0005776)
0.2 1.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 23.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 6.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.7 5.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2 5.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 4.5 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.8 4.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
1.0 4.0 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 3.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.5 3.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 3.2 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 2.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.3 2.5 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 2.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 2.2 GO:0004697 protein kinase C activity(GO:0004697)
0.0 1.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.5 1.5 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.2 1.4 GO:0097016 L27 domain binding(GO:0097016)
0.0 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.0 GO:0035591 signaling adaptor activity(GO:0035591)
0.1 0.8 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 4.0 PID_IL5_PATHWAY IL5-mediated signaling events
0.2 3.6 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 2.5 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.0 2.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.9 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.4 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 23.3 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 5.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 4.2 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.4 4.0 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.2 3.6 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 3.6 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 3.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 3.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 2.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.3 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)