Motif ID: Tfap4

Z-value: 0.684


Transcription factors associated with Tfap4:

Gene SymbolEntrez IDGene Name
Tfap4 ENSMUSG00000005718.7 Tfap4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap4mm10_v2_chr16_-_4559720_45597470.462.5e-05Click!


Activity profile for motif Tfap4.

activity profile for motif Tfap4


Sorted Z-values histogram for motif Tfap4

Sorted Z-values for motif Tfap4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap4

PNG image of the network

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Top targets:


Showing 1 to 20 of 199 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 8.590 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr3_+_90537242 6.451 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr16_+_43510267 6.128 ENSMUST00000114695.2
 Zbtb20
zinc finger and BTB domain containing 20
chr9_-_40346290 5.709 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr7_-_97417730 5.336 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr1_-_14310198 4.679 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr5_+_90772435 4.557 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr3_+_90537306 4.428 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chr5_-_28210022 4.411 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr8_+_66386292 3.759 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr3_+_5218546 3.446 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr1_-_97977233 3.426 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase
chrX_+_169685191 3.139 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr5_+_91517615 3.047 ENSMUST00000040576.9
 Parm1
prostate androgen-regulated mucin-like protein 1
chr7_-_120202104 2.994 ENSMUST00000033198.5
 Crym
crystallin, mu
chr3_+_5218516 2.954 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr2_+_170731807 2.841 ENSMUST00000029075.4
 Dok5
docking protein 5
chr5_+_111733924 2.750 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chr14_-_65425453 2.647 ENSMUST00000059339.5
 Pnoc
prepronociceptin
chr3_+_14863495 2.579 ENSMUST00000029076.4
 Car3
carbonic anhydrase 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.0 GO:0051592 response to calcium ion(GO:0051592)
0.1 7.9 GO:0048663 neuron fate commitment(GO:0048663)
0.2 6.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 5.3 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
1.2 4.7 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.8 4.7 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.9 4.6 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
0.5 4.3 GO:0035372 protein localization to microtubule(GO:0035372)
1.0 4.0 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.2 3.8 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.3 3.4 GO:0009404 toxin metabolic process(GO:0009404)
0.6 3.0 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 2.8 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 2.6 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.1 2.6 GO:0006730 one-carbon metabolic process(GO:0006730)
0.4 2.4 GO:0048597 post-embryonic camera-type eye morphogenesis(GO:0048597)
0.4 2.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 2.1 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.2 1.9 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 1.9 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.0 GO:0005615 extracellular space(GO:0005615)
0.0 6.7 GO:0005667 transcription factor complex(GO:0005667)
0.4 5.1 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 4.7 GO:0032993 protein-DNA complex(GO:0032993)
0.0 4.1 GO:0005802 trans-Golgi network(GO:0005802)
1.0 4.0 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 3.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 3.4 GO:0030667 secretory granule membrane(GO:0030667)
0.0 3.3 GO:0005769 early endosome(GO:0005769)
0.0 3.2 GO:0043679 axon terminus(GO:0043679)
0.2 2.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 2.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.5 2.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 1.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.3 GO:0097427 microtubule bundle(GO:0097427)
0.1 1.3 GO:0071564 npBAF complex(GO:0071564)
0.2 1.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.9 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 0.8 GO:0030314 junctional membrane complex(GO:0030314)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.1 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 8.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 7.1 GO:0046983 protein dimerization activity(GO:0046983)
0.5 4.7 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.9 4.6 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 4.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.5 4.0 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2 3.8 GO:0042287 MHC protein binding(GO:0042287)
0.0 3.5 GO:0051219 phosphoprotein binding(GO:0051219)
1.1 3.4 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.2 3.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.3 3.0 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 2.9 GO:0005158 insulin receptor binding(GO:0005158)
0.4 2.6 GO:0001515 opioid peptide activity(GO:0001515)
0.2 2.6 GO:0016151 nickel cation binding(GO:0016151)
0.2 2.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.3 2.4 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 2.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 2.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 2.2 GO:0017080 sodium channel regulator activity(GO:0017080)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 4.0 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 3.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 2.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 1.8 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.7 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.6 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.3 PID_CDC42_PATHWAY CDC42 signaling events
0.1 1.0 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.8 4.6 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.1 4.0 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 3.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 2.4 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.3 2.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 2.1 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 1.6 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 1.2 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 1.0 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.9 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.6 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.4 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.2 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.1 REACTOME_FRS2_MEDIATED_CASCADE Genes involved in FRS2-mediated cascade
0.0 0.1 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen