Motif ID: Tfcp2
Z-value: 1.807
Transcription factors associated with Tfcp2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tfcp2 | ENSMUSG00000009733.8 | Tfcp2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfcp2 | mm10_v2_chr15_-_100551959_100552010 | 0.61 | 2.9e-09 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 124 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 40.8 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 8.8 | 35.0 | GO:1902724 | positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728) |
| 0.2 | 34.2 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 1.8 | 30.1 | GO:0030953 | astral microtubule organization(GO:0030953) |
| 0.8 | 29.3 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 7.0 | 27.9 | GO:2001045 | closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 8.8 | 26.3 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.2 | 22.2 | GO:0010921 | regulation of phosphatase activity(GO:0010921) |
| 6.9 | 20.8 | GO:0043987 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) histone H3-S10 phosphorylation(GO:0043987) |
| 2.6 | 20.7 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
| 0.8 | 19.8 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.3 | 17.2 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
| 5.7 | 17.0 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 2.7 | 16.0 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) macropinocytosis(GO:0044351) |
| 0.5 | 15.7 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 1.1 | 14.8 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 4.3 | 12.9 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
| 1.0 | 12.6 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 2.5 | 12.3 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 2.4 | 12.0 | GO:0060266 | regulation of respiratory burst involved in inflammatory response(GO:0060264) negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 62 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 42.2 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.2 | 35.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 33.7 | GO:0030027 | lamellipodium(GO:0030027) |
| 5.3 | 26.3 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 5.2 | 20.8 | GO:0000942 | condensed nuclear chromosome outer kinetochore(GO:0000942) |
| 0.2 | 20.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 19.9 | GO:0005813 | centrosome(GO:0005813) |
| 0.1 | 17.8 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.8 | 17.4 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 2.3 | 15.8 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 3.0 | 14.8 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 3.7 | 11.1 | GO:0099573 | glutamatergic postsynaptic density(GO:0099573) |
| 0.4 | 10.8 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.7 | 9.7 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.0 | 9.1 | GO:0000785 | chromatin(GO:0000785) |
| 0.0 | 9.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 8.4 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.0 | 8.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.9 | 8.2 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.1 | 8.1 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 98 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 42.1 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 3.9 | 35.0 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 2.3 | 34.8 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.7 | 33.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 5.6 | 27.9 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 2.3 | 27.0 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 5.3 | 26.3 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 5.2 | 20.8 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.0 | 19.8 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.3 | 19.4 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.1 | 19.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 1.1 | 15.8 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 3.0 | 14.8 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.2 | 13.9 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.3 | 12.9 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 12.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.9 | 12.3 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.2 | 11.9 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 3.6 | 10.8 | GO:0098973 | structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
| 0.1 | 9.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 26 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 50.2 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 1.9 | 35.0 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.2 | 34.0 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 32.2 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.7 | 28.5 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.6 | 27.3 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
| 0.3 | 11.8 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.5 | 11.1 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.3 | 10.3 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 9.1 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 8.7 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.3 | 8.5 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 5.9 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 5.5 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 5.0 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 4.1 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 3.7 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
| 0.1 | 3.5 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 3.3 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.1 | 3.0 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 47 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 40.8 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 2.9 | 35.0 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 30.3 | REACTOME_HEMOSTASIS | Genes involved in Hemostasis |
| 2.7 | 27.0 | REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.4 | 26.3 | REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 1.0 | 18.7 | REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.2 | 15.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 13.6 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.8 | 12.2 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.4 | 11.4 | REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.4 | 11.1 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.9 | 10.5 | REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.3 | 9.5 | REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.1 | 8.5 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 8.1 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 7.9 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.3 | 7.8 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 7.3 | REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.0 | 6.9 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 6.7 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
