Motif ID: Tfcp2l1

Z-value: 0.744


Transcription factors associated with Tfcp2l1:

Gene SymbolEntrez IDGene Name
Tfcp2l1 ENSMUSG00000026380.9 Tfcp2l1



Activity profile for motif Tfcp2l1.

activity profile for motif Tfcp2l1


Sorted Z-values histogram for motif Tfcp2l1

Sorted Z-values for motif Tfcp2l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfcp2l1

PNG image of the network

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Top targets:


Showing 1 to 20 of 101 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_172549581 16.252 ENSMUST00000030391.2
 Tfap2c
transcription factor AP-2, gamma
chr16_-_22161450 11.371 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr15_-_98004695 9.759 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr15_-_98004634 9.619 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr5_+_114568016 5.726 ENSMUST00000043650.7
 Fam222a
family with sequence similarity 222, member A
chr3_-_101836223 4.450 ENSMUST00000061831.4
 Mab21l3
mab-21-like 3 (C. elegans)
chr5_+_30105161 4.222 ENSMUST00000058045.4
 Gareml
GRB2 associated, regulator of MAPK1-like
chr8_+_57511833 3.787 ENSMUST00000067925.6
 Hmgb2
high mobility group box 2
chr14_+_11553523 3.750 ENSMUST00000022264.6
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr1_+_184034381 3.486 ENSMUST00000048655.7
 Dusp10
dual specificity phosphatase 10
chr6_-_90810118 3.150 ENSMUST00000101151.3
 Iqsec1
IQ motif and Sec7 domain 1
chr19_+_48206025 2.856 ENSMUST00000078880.5
 Sorcs3
sortilin-related VPS10 domain containing receptor 3
chr9_+_45138437 2.641 ENSMUST00000060125.5
 Scn4b
sodium channel, type IV, beta
chrX_-_7319291 2.337 ENSMUST00000128319.1
 Clcn5
chloride channel 5
chr17_+_35059035 2.300 ENSMUST00000007255.6
ENSMUST00000174493.1
 Ddah2

dimethylarginine dimethylaminohydrolase 2

chr16_-_76403673 2.288 ENSMUST00000052867.7
 Gm9843
predicted gene 9843
chrX_-_7319186 2.270 ENSMUST00000115746.1
 Clcn5
chloride channel 5
chr7_-_38107490 2.229 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr2_+_157424255 2.145 ENSMUST00000029175.7
ENSMUST00000092576.4
 Src

Rous sarcoma oncogene

chr2_-_91931696 2.092 ENSMUST00000090602.5
 Mdk
midkine

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 19.4 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
5.4 16.3 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 11.4 GO:0051028 mRNA transport(GO:0051028)
0.1 4.6 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 4.1 GO:0040034 regulation of development, heterochronic(GO:0040034)
1.3 3.8 GO:0030421 defecation(GO:0030421)
0.5 3.8 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 3.8 GO:1901998 toxin transport(GO:1901998)
0.7 3.5 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 3.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 2.9 GO:1900452 regulation of long term synaptic depression(GO:1900452)
0.9 2.7 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.2 2.6 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307)
0.2 2.4 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.2 2.3 GO:0006527 arginine catabolic process(GO:0006527)
0.1 2.2 GO:0007129 synapsis(GO:0007129)
0.5 2.1 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0 1.9 GO:0015807 L-amino acid transport(GO:0015807)
0.1 1.8 GO:0061436 establishment of skin barrier(GO:0061436)
0.3 1.7 GO:0070459 prolactin secretion(GO:0070459)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 19.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 4.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 2.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 2.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 2.4 GO:0005801 cis-Golgi network(GO:0005801)
0.0 2.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.1 GO:0002102 podosome(GO:0002102)
0.0 1.6 GO:0031519 PcG protein complex(GO:0031519)
0.1 1.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.0 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 0.9 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.9 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 0.8 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.7 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.6 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.6 GO:0042587 glycogen granule(GO:0042587)
0.1 0.6 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.5 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 19.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 14.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.4 11.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.3 4.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 3.9 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.6 3.8 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 3.8 GO:0008083 growth factor activity(GO:0008083)
0.0 3.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 3.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 3.3 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 3.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 3.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.7 GO:0001786 phosphatidylserine binding(GO:0001786) calcium-dependent phospholipid binding(GO:0005544)
0.4 2.6 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 2.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.4 2.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 2.1 GO:0071253 connexin binding(GO:0071253)
0.0 1.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.6 1.7 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.0 1.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 19.4 NABA_COLLAGENS Genes encoding collagen proteins
0.3 16.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.0 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.5 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 3.1 PID_ARF6_PATHWAY Arf6 signaling events
0.2 2.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 0.9 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 0.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.6 PID_RAC1_PATHWAY RAC1 signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 19.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 9.9 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.1 3.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 3.8 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 3.4 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 2.2 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 2.1 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 1.6 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 1.4 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.0 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.7 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis