Motif ID: Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 1.171

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2:

Gene SymbolEntrez IDGene Name
Bhlhe41 ENSMUSG00000030256.5 Bhlhe41
Srebf1 ENSMUSG00000020538.9 Srebf1
Srebf2 ENSMUSG00000022463.7 Srebf2
Tfeb ENSMUSG00000023990.12 Tfeb
Usf1 ENSMUSG00000026641.7 Usf1
Usf2 ENSMUSG00000058239.7 Usf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srebf1mm10_v2_chr11_-_60220550_602206320.496.6e-06Click!
Srebf2mm10_v2_chr15_+_82147238_82147275-0.421.6e-04Click!
Tfebmm10_v2_chr17_+_47785720_477857390.342.6e-03Click!
Usf2mm10_v2_chr7_-_30956742_30956803-0.325.1e-03Click!
Usf1mm10_v2_chr1_+_171411305_171411337-0.113.6e-01Click!


Activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2.

activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2


Sorted Z-values histogram for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Sorted Z-values for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_41519493 36.380 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr11_+_70000578 20.941 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr15_-_10714612 20.556 ENSMUST00000169385.1
 Rai14
retinoic acid induced 14
chr18_-_6135888 19.672 ENSMUST00000182383.1
ENSMUST00000062584.7
ENSMUST00000077128.6
ENSMUST00000182038.1
ENSMUST00000182213.1
 Arhgap12




Rho GTPase activating protein 12




chr4_+_148039035 18.736 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr9_-_87255536 17.788 ENSMUST00000093802.4
 4922501C03Rik
RIKEN cDNA 4922501C03 gene
chr4_-_34882919 17.248 ENSMUST00000098163.2
ENSMUST00000047950.5
 Zfp292

zinc finger protein 292

chr9_-_22389113 16.912 ENSMUST00000040912.7
 Anln
anillin, actin binding protein
chr4_+_148039097 16.547 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr18_-_6136057 16.288 ENSMUST00000182559.1
 Arhgap12
Rho GTPase activating protein 12
chr2_-_79456750 16.114 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr6_+_128362919 15.539 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr3_+_159495408 14.759 ENSMUST00000120272.1
ENSMUST00000029825.7
ENSMUST00000106041.2
 Depdc1a


DEP domain containing 1a


chr15_-_3995708 14.607 ENSMUST00000046633.8
 AW549877
expressed sequence AW549877
chr1_-_82291370 13.987 ENSMUST00000069799.2
 Irs1
insulin receptor substrate 1
chr10_+_127063599 13.935 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr14_-_72602945 13.915 ENSMUST00000162825.1
 Fndc3a
fibronectin type III domain containing 3A
chr7_-_46795881 13.852 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
 Hps5



Hermansky-Pudlak syndrome 5 homolog (human)



chr7_-_46795661 12.738 ENSMUST00000123725.1
 Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr10_+_127063527 12.360 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 390 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 36.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.4 35.9 GO:0021510 spinal cord development(GO:0021510)
8.8 35.3 GO:0070829 heterochromatin maintenance(GO:0070829)
0.5 28.5 GO:0002011 morphogenesis of an epithelial sheet(GO:0002011)
6.6 26.3 GO:0010288 response to lead ion(GO:0010288)
0.4 24.8 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
5.6 22.3 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
4.2 20.9 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.8 19.1 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
5.6 16.9 GO:1904170 regulation of bleb assembly(GO:1904170)
1.7 16.5 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
5.5 16.4 GO:1904959 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003) regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.2 16.4 GO:0043473 pigmentation(GO:0043473)
4.0 16.1 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
5.1 15.2 GO:0030421 defecation(GO:0030421)
0.7 15.1 GO:0060009 Sertoli cell development(GO:0060009)
2.8 14.0 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.2 13.3 GO:0007492 endoderm development(GO:0007492)
4.4 13.1 GO:0099547 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
2.2 12.9 GO:1903564 regulation of protein localization to cilium(GO:1903564)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 172 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.7 26.7 GO:0031084 BLOC-2 complex(GO:0031084)
6.6 26.3 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 25.6 GO:0005887 integral component of plasma membrane(GO:0005887)
1.4 22.3 GO:0043196 varicosity(GO:0043196)
0.4 22.2 GO:0016235 aggresome(GO:0016235)
4.8 19.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
1.5 18.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.6 18.1 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
3.4 16.9 GO:0005826 actomyosin contractile ring(GO:0005826)
0.8 15.0 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 14.1 GO:0017053 transcriptional repressor complex(GO:0017053)
4.7 14.0 GO:0005899 insulin receptor complex(GO:0005899)
0.9 13.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
3.3 13.1 GO:1902737 dendritic filopodium(GO:1902737)
1.8 12.4 GO:0033503 HULC complex(GO:0033503)
0.6 12.0 GO:0010369 chromocenter(GO:0010369)
0.6 11.7 GO:0097431 mitotic spindle pole(GO:0097431)
1.1 11.5 GO:0071141 SMAD protein complex(GO:0071141)
0.1 10.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 10.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 264 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 79.4 GO:0005096 GTPase activator activity(GO:0005096)
0.2 73.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
11.8 35.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.6 29.0 GO:0030332 cyclin binding(GO:0030332)
0.5 21.8 GO:0005109 frizzled binding(GO:0005109)
2.8 19.7 GO:0033592 RNA strand annealing activity(GO:0033592)
0.3 19.1 GO:0017022 myosin binding(GO:0017022)
0.3 16.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
5.5 16.4 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
2.3 16.1 GO:0031419 cobalamin binding(GO:0031419)
0.1 14.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
1.6 14.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 13.7 GO:0008565 protein transporter activity(GO:0008565)
0.1 13.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 12.9 GO:0008083 growth factor activity(GO:0008083)
0.4 12.1 GO:0070064 proline-rich region binding(GO:0070064)
0.6 11.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.8 11.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.3 11.4 GO:0017134 fibroblast growth factor binding(GO:0017134)
3.8 11.3 GO:0035500 MH2 domain binding(GO:0035500)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 28.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.8 22.7 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.5 19.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.5 12.4 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.4 11.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.2 11.8 PID_PLK1_PATHWAY PLK1 signaling events
0.1 10.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 9.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 9.0 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.2 8.8 PID_IL2_1PATHWAY IL2-mediated signaling events
0.2 8.7 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.9 8.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 8.1 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.2 7.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 6.1 PID_ATM_PATHWAY ATM pathway
0.3 6.0 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 6.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.6 4.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.2 4.6 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 4.2 PID_ILK_PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 32.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.5 31.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.6 29.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 29.6 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.3 28.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.4 26.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.8 25.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.2 23.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.6 16.1 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.4 15.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.7 11.7 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.1 11.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.7 10.9 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.8 8.1 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.7 8.1 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3 7.8 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.4 7.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 7.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 7.0 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.5 6.9 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression