Motif ID: Tgif1_Meis3

Z-value: 1.756

Transcription factors associated with Tgif1_Meis3:

Gene SymbolEntrez IDGene Name
Meis3 ENSMUSG00000041420.12 Meis3
Tgif1 ENSMUSG00000047407.11 Tgif1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif1mm10_v2_chr17_-_70853482_70853546-0.805.8e-18Click!
Meis3mm10_v2_chr7_+_16175275_16175438-0.402.8e-04Click!


Activity profile for motif Tgif1_Meis3.

activity profile for motif Tgif1_Meis3


Sorted Z-values histogram for motif Tgif1_Meis3

Sorted Z-values for motif Tgif1_Meis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif1_Meis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 34.909 ENSMUST00000164163.1
 Sla
src-like adaptor
chr7_+_49246131 31.183 ENSMUST00000064395.6
 Nav2
neuron navigator 2
chr15_-_66801577 28.281 ENSMUST00000168589.1
 Sla
src-like adaptor
chr8_+_70501116 19.173 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr18_-_66291770 18.433 ENSMUST00000130300.1
 Ccbe1
collagen and calcium binding EGF domains 1
chr4_+_102254739 18.271 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_+_102254993 17.538 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr3_+_26331150 16.976 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr10_-_125328957 15.169 ENSMUST00000063318.2
 Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr7_+_49246812 14.787 ENSMUST00000184945.1
 Nav2
neuron navigator 2
chr7_+_112225856 14.010 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr13_+_83504032 13.487 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr1_+_159737510 12.684 ENSMUST00000111669.3
 Tnr
tenascin R
chr9_-_29963112 12.568 ENSMUST00000075069.4
 Ntm
neurotrimin
chr5_-_67847360 11.929 ENSMUST00000072971.6
 Atp8a1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
chr4_-_64046925 11.908 ENSMUST00000107377.3
 Tnc
tenascin C
chr15_+_21111452 11.902 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr19_-_57182293 11.523 ENSMUST00000133369.1
 Ablim1
actin-binding LIM protein 1
chr5_-_67847400 11.273 ENSMUST00000113652.1
ENSMUST00000113651.1
ENSMUST00000037380.8
 Atp8a1


ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1


chr10_+_90576872 11.100 ENSMUST00000182550.1
ENSMUST00000099364.5
 Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 605 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 51.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
3.8 49.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
11.5 46.0 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.7 31.4 GO:0034605 cellular response to heat(GO:0034605)
2.2 26.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.6 25.0 GO:0006376 mRNA splice site selection(GO:0006376)
3.5 24.7 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
4.7 23.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
4.6 22.8 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.2 21.5 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.3 21.0 GO:0030032 lamellipodium assembly(GO:0030032)
4.2 20.9 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
0.7 20.9 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
5.1 20.6 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
3.1 18.8 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.6 18.6 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
2.1 18.5 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
4.1 16.3 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.3 16.2 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
3.9 15.4 GO:1904457 positive regulation of neuronal action potential(GO:1904457)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 238 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 86.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 73.2 GO:0016021 integral component of membrane(GO:0016021)
0.5 63.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
3.6 57.6 GO:0005614 interstitial matrix(GO:0005614)
0.6 50.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
1.8 46.2 GO:0000930 gamma-tubulin complex(GO:0000930)
1.2 30.7 GO:0071565 nBAF complex(GO:0071565)
0.1 28.8 GO:0009986 cell surface(GO:0009986)
0.1 22.1 GO:0005802 trans-Golgi network(GO:0005802)
0.1 19.1 GO:0000139 Golgi membrane(GO:0000139)
0.3 19.0 GO:0005581 collagen trimer(GO:0005581)
0.2 18.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 18.1 GO:0016605 PML body(GO:0016605)
5.8 17.5 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
3.3 16.6 GO:0044316 cone cell pedicle(GO:0044316)
0.1 16.1 GO:0005769 early endosome(GO:0005769)
0.0 13.9 GO:0005768 endosome(GO:0005768)
0.8 13.6 GO:0032279 asymmetric synapse(GO:0032279)
0.1 13.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
4.2 12.7 GO:0072534 perineuronal net(GO:0072534)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 372 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 69.5 GO:0030552 cAMP binding(GO:0030552)
1.5 56.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.4 41.4 GO:0008201 heparin binding(GO:0008201)
0.1 34.6 GO:0005096 GTPase activator activity(GO:0005096)
0.8 27.9 GO:0043014 alpha-tubulin binding(GO:0043014)
1.0 25.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
1.2 25.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.4 25.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
3.1 21.4 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.4 21.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 20.5 GO:0005516 calmodulin binding(GO:0005516)
0.3 20.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
3.3 19.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 17.3 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.4 17.1 GO:0046875 ephrin receptor binding(GO:0046875)
4.1 16.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 16.2 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 15.1 GO:0044325 ion channel binding(GO:0044325)
1.6 13.0 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
1.1 12.9 GO:0032050 clathrin heavy chain binding(GO:0032050)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 49.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.3 41.8 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.4 24.1 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.3 22.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.3 20.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.7 19.6 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.4 17.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 15.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.5 15.0 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.3 14.7 PID_REELIN_PATHWAY Reelin signaling pathway
0.4 14.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.4 13.4 PID_SHP2_PATHWAY SHP2 signaling
0.3 10.6 PID_BMP_PATHWAY BMP receptor signaling
0.2 10.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 10.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 9.7 PID_ARF_3PATHWAY Arf1 pathway
0.2 7.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.2 7.3 PID_FGF_PATHWAY FGF signaling pathway
0.3 7.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.2 6.2 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 67.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.7 29.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.7 26.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
1.6 22.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.6 22.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.4 19.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.6 17.3 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
1.3 17.2 REACTOME_ACTIVATED_POINT_MUTANTS_OF_FGFR2 Genes involved in Activated point mutants of FGFR2
0.7 16.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.5 16.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.6 16.0 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.6 14.9 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.4 14.4 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 14.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.5 13.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
1.4 13.0 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.6 11.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.2 11.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 10.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.8 9.9 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors