Motif ID: Tgif2_Tgif2lx1_Tgif2lx2

Z-value: 1.026

Transcription factors associated with Tgif2_Tgif2lx1_Tgif2lx2:

Gene SymbolEntrez IDGene Name
Tgif2 ENSMUSG00000062175.7 Tgif2
Tgif2lx1 ENSMUSG00000061283.4 Tgif2lx1
Tgif2lx2 ENSMUSG00000063242.6 Tgif2lx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif2mm10_v2_chr2_+_156840966_1568410170.832.4e-20Click!


Activity profile for motif Tgif2_Tgif2lx1_Tgif2lx2.

activity profile for motif Tgif2_Tgif2lx1_Tgif2lx2


Sorted Z-values histogram for motif Tgif2_Tgif2lx1_Tgif2lx2

Sorted Z-values for motif Tgif2_Tgif2lx1_Tgif2lx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif2_Tgif2lx1_Tgif2lx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 168 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_105675478 18.563 ENSMUST00000167211.2
ENSMUST00000111083.3
 Pax6

paired box gene 6

chr2_+_105675429 17.738 ENSMUST00000111085.1
 Pax6
paired box gene 6
chr5_-_115119277 14.677 ENSMUST00000031524.7
 Acads
acyl-Coenzyme A dehydrogenase, short chain
chr3_+_102010138 14.444 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr7_+_51621830 13.050 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr1_+_19103022 12.713 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr13_+_108316332 9.675 ENSMUST00000051594.5
 Depdc1b
DEP domain containing 1B
chr6_+_112273758 9.442 ENSMUST00000032376.5
 Lmcd1
LIM and cysteine-rich domains 1
chr11_-_87108656 8.783 ENSMUST00000051395.8
 Prr11
proline rich 11
chr13_+_108316395 8.433 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr4_-_133967235 7.593 ENSMUST00000123234.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr2_-_129297205 7.383 ENSMUST00000052708.6
 Ckap2l
cytoskeleton associated protein 2-like
chr15_+_85510812 6.818 ENSMUST00000079690.2
 Gm4825
predicted pseudogene 4825
chr10_-_92165159 6.707 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr11_+_115154139 6.183 ENSMUST00000021076.5
 Rab37
RAB37, member of RAS oncogene family
chr10_-_81430966 6.174 ENSMUST00000117966.1
 Nfic
nuclear factor I/C
chr10_-_88146867 6.002 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein



chr7_-_44670820 5.726 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr10_-_92164666 5.462 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr5_-_124095749 5.123 ENSMUST00000031354.4
 Abcb9
ATP-binding cassette, sub-family B (MDR/TAP), member 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.3 36.3 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.2 20.4 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
1.6 14.7 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
1.4 13.0 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.2 12.7 GO:0030901 midbrain development(GO:0030901)
0.9 9.4 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 8.8 GO:0007050 cell cycle arrest(GO:0007050)
0.3 7.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.2 6.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 6.2 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.2 6.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.4 6.0 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.3 5.8 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.2 5.7 GO:0071625 vocalization behavior(GO:0071625)
1.2 4.6 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
0.9 4.4 GO:0034421 post-translational protein acetylation(GO:0034421)
0.4 4.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.2 3.8 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 3.8 GO:0035329 hippo signaling(GO:0035329)
0.3 3.6 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 56.7 GO:0005667 transcription factor complex(GO:0005667)
0.1 18.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.6 13.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 7.4 GO:0072686 mitotic spindle(GO:0072686)
0.0 7.3 GO:0000785 chromatin(GO:0000785)
0.0 6.6 GO:0031012 extracellular matrix(GO:0031012)
0.1 6.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 6.2 GO:0001650 fibrillar center(GO:0001650)
1.0 6.1 GO:0031262 Ndc80 complex(GO:0031262)
1.0 5.7 GO:0097513 myosin II filament(GO:0097513)
0.5 4.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 4.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 3.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 3.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 2.8 GO:0042101 T cell receptor complex(GO:0042101)
0.1 2.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 2.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 2.3 GO:0036064 ciliary basal body(GO:0036064)
0.3 2.2 GO:0031298 replication fork protection complex(GO:0031298)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 36.3 GO:0003680 AT DNA binding(GO:0003680)
0.1 17.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 15.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.8 14.7 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.7 14.4 GO:0015172 acidic amino acid transmembrane transporter activity(GO:0015172)
0.2 14.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 10.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.4 5.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
1.0 5.1 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.2 4.6 GO:0046965 retinoid X receptor binding(GO:0046965)
0.5 4.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.4 4.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 4.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.6 3.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 3.6 GO:0042605 peptide antigen binding(GO:0042605)
1.1 3.4 GO:0046997 sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.0 3.1 GO:0008276 protein methyltransferase activity(GO:0008276)
0.4 2.8 GO:0050897 cobalt ion binding(GO:0050897)
0.4 2.8 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.2 2.5 GO:0016151 nickel cation binding(GO:0016151)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 37.1 PID_CDC42_PATHWAY CDC42 signaling events
0.1 6.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 3.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 2.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.2 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 1.3 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.5 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.3 PID_IL3_PATHWAY IL3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 36.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 15.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.9 14.7 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 12.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 7.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 5.7 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 3.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 3.6 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 2.8 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 2.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 2.3 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 2.2 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.3 2.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 2.0 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 1.8 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 1.6 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 1.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.8 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 0.5 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)