Motif ID: Tgif2_Tgif2lx1_Tgif2lx2

Z-value: 1.026

Transcription factors associated with Tgif2_Tgif2lx1_Tgif2lx2:

Gene SymbolEntrez IDGene Name
Tgif2 ENSMUSG00000062175.7 Tgif2
Tgif2lx1 ENSMUSG00000061283.4 Tgif2lx1
Tgif2lx2 ENSMUSG00000063242.6 Tgif2lx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif2mm10_v2_chr2_+_156840966_1568410170.832.4e-20Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif2_Tgif2lx1_Tgif2lx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_105675478 18.563 ENSMUST00000167211.2
ENSMUST00000111083.3
Pax6

paired box gene 6

chr2_+_105675429 17.738 ENSMUST00000111085.1
Pax6
paired box gene 6
chr5_-_115119277 14.677 ENSMUST00000031524.7
Acads
acyl-Coenzyme A dehydrogenase, short chain
chr3_+_102010138 14.444 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr7_+_51621830 13.050 ENSMUST00000032710.5
Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr1_+_19103022 12.713 ENSMUST00000037294.7
Tfap2d
transcription factor AP-2, delta
chr13_+_108316332 9.675 ENSMUST00000051594.5
Depdc1b
DEP domain containing 1B
chr6_+_112273758 9.442 ENSMUST00000032376.5
Lmcd1
LIM and cysteine-rich domains 1
chr11_-_87108656 8.783 ENSMUST00000051395.8
Prr11
proline rich 11
chr13_+_108316395 8.433 ENSMUST00000171178.1
Depdc1b
DEP domain containing 1B
chr4_-_133967235 7.593 ENSMUST00000123234.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr2_-_129297205 7.383 ENSMUST00000052708.6
Ckap2l
cytoskeleton associated protein 2-like
chr15_+_85510812 6.818 ENSMUST00000079690.2
Gm4825
predicted pseudogene 4825
chr10_-_92165159 6.707 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr11_+_115154139 6.183 ENSMUST00000021076.5
Rab37
RAB37, member of RAS oncogene family
chr10_-_81430966 6.174 ENSMUST00000117966.1
Nfic
nuclear factor I/C
chr10_-_88146867 6.002 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
Parpbp



PARP1 binding protein



chr7_-_44670820 5.726 ENSMUST00000048102.7
Myh14
myosin, heavy polypeptide 14
chr10_-_92164666 5.462 ENSMUST00000183123.1
ENSMUST00000182033.1
Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr5_-_124095749 5.123 ENSMUST00000031354.4
Abcb9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr3_-_45378206 5.099 ENSMUST00000181047.1
2610316D01Rik
RIKEN cDNA 2610316D01 gene
chr1_+_36307745 4.601 ENSMUST00000142319.1
ENSMUST00000097778.2
ENSMUST00000115031.1
ENSMUST00000115032.1
ENSMUST00000137906.1
ENSMUST00000115029.1
Arid5a





AT rich interactive domain 5A (MRF1-like)





chr15_-_55090422 4.438 ENSMUST00000110231.1
ENSMUST00000023059.6
Dscc1

defective in sister chromatid cohesion 1 homolog (S. cerevisiae)

chr17_-_35697971 4.383 ENSMUST00000146472.1
Ddr1
discoidin domain receptor family, member 1
chr2_+_110597298 3.879 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr17_-_36989504 3.607 ENSMUST00000169189.1
H2-M5
histocompatibility 2, M region locus 5
chr4_-_82859571 3.578 ENSMUST00000156055.1
ENSMUST00000030110.8
Zdhhc21

zinc finger, DHHC domain containing 21

chr7_-_61982290 3.409 ENSMUST00000180481.1
A330076H08Rik
RIKEN cDNA A330076H08 gene
chr2_-_27246814 3.387 ENSMUST00000149733.1
Sardh
sarcosine dehydrogenase
chrX_-_23365044 3.237 ENSMUST00000115313.1
Klhl13
kelch-like 13
chr6_-_88874597 3.183 ENSMUST00000061262.4
ENSMUST00000140455.1
ENSMUST00000145780.1
Podxl2


podocalyxin-like 2


chr1_-_163725123 3.132 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr1_-_169531343 3.100 ENSMUST00000028000.7
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr14_-_70653081 3.094 ENSMUST00000062629.4
Npm2
nucleophosmin/nucleoplasmin 2
chr1_-_169531447 2.977 ENSMUST00000111368.1
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr7_-_61982348 2.959 ENSMUST00000181804.1
ENSMUST00000181187.1
A330076H08Rik

RIKEN cDNA A330076H08 gene

chr17_+_86753900 2.791 ENSMUST00000024954.9
Epas1
endothelial PAS domain protein 1
chr7_-_25477607 2.772 ENSMUST00000098669.1
ENSMUST00000098668.1
ENSMUST00000098666.2
Ceacam1


carcinoembryonic antigen-related cell adhesion molecule 1


chr1_+_49244616 2.744 ENSMUST00000056879.8
C230029F24Rik
RIKEN cDNA C230029F24 gene
chr9_-_44134481 2.724 ENSMUST00000180670.1
Gm10687
predicted gene 10687
chr10_+_82699007 2.642 ENSMUST00000020478.7
Hcfc2
host cell factor C2
chr6_-_88875035 2.585 ENSMUST00000145944.1
Podxl2
podocalyxin-like 2
chr8_+_13705884 2.515 ENSMUST00000166277.1
4932443I19Rik
RIKEN cDNA 4932443I19 gene
chr3_+_14863495 2.486 ENSMUST00000029076.4
Car3
carbonic anhydrase 3
chr7_-_80401707 2.272 ENSMUST00000120753.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr9_+_64281575 2.237 ENSMUST00000034964.6
Tipin
timeless interacting protein
chr6_-_99666762 2.205 ENSMUST00000032151.2
Eif4e3
eukaryotic translation initiation factor 4E member 3
chr1_-_52727457 2.141 ENSMUST00000156876.1
ENSMUST00000087701.3
Mfsd6

major facilitator superfamily domain containing 6

chr9_+_48362034 2.139 ENSMUST00000093853.4
Nxpe4
neurexophilin and PC-esterase domain family, member 4
chr4_+_133176336 2.057 ENSMUST00000105912.1
Wasf2
WAS protein family, member 2
chr6_-_108185552 2.051 ENSMUST00000167338.1
ENSMUST00000172188.1
ENSMUST00000032191.9
Sumf1


sulfatase modifying factor 1


chr9_+_53384017 2.049 ENSMUST00000037853.3
Kdelc2
KDEL (Lys-Asp-Glu-Leu) containing 2
chr2_-_127788854 2.024 ENSMUST00000028857.7
ENSMUST00000110357.1
Nphp1

nephronophthisis 1 (juvenile) homolog (human)

chr9_+_85842852 2.018 ENSMUST00000098500.3
Tpbg
trophoblast glycoprotein
chr9_-_62510498 2.005 ENSMUST00000164246.2
Coro2b
coronin, actin binding protein, 2B
chrX_+_36795642 1.964 ENSMUST00000016463.3
Slc25a5
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
chr6_+_83326016 1.939 ENSMUST00000055261.4
Mob1a
MOB kinase activator 1A
chr6_-_38046994 1.854 ENSMUST00000096040.4
Svopl
SV2 related protein homolog (rat)-like
chr6_+_83326071 1.832 ENSMUST00000038658.8
ENSMUST00000101245.2
Mob1a

MOB kinase activator 1A

chr1_-_153408429 1.817 ENSMUST00000097535.4
E330020D12Rik
Riken cDNA E330020D12 gene
chr11_+_117986292 1.765 ENSMUST00000132676.1
Pgs1
phosphatidylglycerophosphate synthase 1
chr8_-_41133697 1.652 ENSMUST00000155055.1
ENSMUST00000059115.6
ENSMUST00000145860.1
Mtus1


mitochondrial tumor suppressor 1


chr1_-_5070281 1.605 ENSMUST00000147158.1
ENSMUST00000118000.1
Rgs20

regulator of G-protein signaling 20

chr7_-_42578588 1.570 ENSMUST00000179470.1
Gm21028
predicted gene, 21028
chr18_+_6332587 1.548 ENSMUST00000097682.2
Rpl27-ps3
ribosomal protein L27, pseudogene 3
chr14_-_69707546 1.530 ENSMUST00000118374.1
R3hcc1
R3H domain and coiled-coil containing 1
chr8_+_125054195 1.525 ENSMUST00000118942.1
ENSMUST00000117658.1
ENSMUST00000074562.4
ENSMUST00000098311.4
ENSMUST00000115885.2
ENSMUST00000075730.4
ENSMUST00000122389.1
ENSMUST00000121953.1
Disc1







disrupted in schizophrenia 1







chr4_-_87806276 1.510 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_-_87806296 1.491 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr14_-_69707493 1.490 ENSMUST00000121142.1
R3hcc1
R3H domain and coiled-coil containing 1
chr19_-_33761949 1.433 ENSMUST00000025694.6
ENSMUST00000147153.1
Lipo1
Lipo2
lipase, member O1
lipase, member O2
chr17_-_6477102 1.424 ENSMUST00000167717.2
Tmem181b-ps
transmembrane protein 181B, pseudogene
chr7_+_126862431 1.420 ENSMUST00000132808.1
Hirip3
HIRA interacting protein 3
chr8_+_3655762 1.374 ENSMUST00000012849.8
ENSMUST00000169234.2
Retn

resistin

chr9_-_85749308 1.349 ENSMUST00000039213.8
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr11_+_23306884 1.346 ENSMUST00000180046.1
Usp34
ubiquitin specific peptidase 34
chr2_-_165473187 1.313 ENSMUST00000029208.8
ENSMUST00000109279.2
Slc13a3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

chr7_+_27927592 1.258 ENSMUST00000181644.1
Gm26891
predicted gene, 26891
chr17_-_55712571 1.175 ENSMUST00000086876.5
Pot1b
protection of telomeres 1B
chr11_+_58917889 1.168 ENSMUST00000069941.6
Btnl10
butyrophilin-like 10
chr9_-_51963533 1.161 ENSMUST00000034552.6
Fdx1
ferredoxin 1
chr3_+_107877227 1.141 ENSMUST00000037375.8
Eps8l3
EPS8-like 3
chrY_+_90755657 1.104 ENSMUST00000167967.2
Gm21857
predicted gene, 21857
chr7_+_25221417 1.091 ENSMUST00000055604.4
Zfp526
zinc finger protein 526
chr5_-_114773488 1.076 ENSMUST00000178440.1
ENSMUST00000043283.7
ENSMUST00000112185.2
Git2


G protein-coupled receptor kinase-interactor 2


chr15_+_40655020 1.052 ENSMUST00000053467.4
Zfpm2
zinc finger protein, multitype 2
chr5_-_114773372 1.036 ENSMUST00000112183.1
ENSMUST00000086564.4
Git2

G protein-coupled receptor kinase-interactor 2

chr2_+_49451486 1.004 ENSMUST00000092123.4
Epc2
enhancer of polycomb homolog 2 (Drosophila)
chr4_+_11123950 0.972 ENSMUST00000142297.1
Gm11827
predicted gene 11827
chr4_+_134930898 0.961 ENSMUST00000030622.2
Syf2
SYF2 homolog, RNA splicing factor (S. cerevisiae)
chr7_+_4137475 0.959 ENSMUST00000154571.1
Leng8
leukocyte receptor cluster (LRC) member 8
chrX_+_94367147 0.942 ENSMUST00000113897.2
ENSMUST00000113896.1
ENSMUST00000113895.1
Apoo


apolipoprotein O


chr11_+_87109221 0.930 ENSMUST00000020794.5
Ska2
spindle and kinetochore associated complex subunit 2
chr8_+_104250869 0.905 ENSMUST00000034342.5
Cklf
chemokine-like factor
chr14_+_55561060 0.897 ENSMUST00000117701.1
Dcaf11
DDB1 and CUL4 associated factor 11
chrX_+_94367112 0.877 ENSMUST00000113898.1
Apoo
apolipoprotein O
chr19_+_55894508 0.872 ENSMUST00000142291.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr3_-_106014630 0.862 ENSMUST00000010280.4
Pifo
primary cilia formation
chr9_-_108079279 0.862 ENSMUST00000162355.1
ENSMUST00000047746.6
ENSMUST00000174504.1
ENSMUST00000178267.1
ENSMUST00000160649.1
Rnf123




ring finger protein 123




chr8_-_3467617 0.849 ENSMUST00000111081.3
ENSMUST00000118194.1
ENSMUST00000004686.6
Pex11g


peroxisomal biogenesis factor 11 gamma


chr11_+_23306910 0.836 ENSMUST00000137823.1
Usp34
ubiquitin specific peptidase 34
chr2_+_157456917 0.832 ENSMUST00000109529.1
Src
Rous sarcoma oncogene
chr3_-_57301919 0.779 ENSMUST00000029376.8
Tm4sf1
transmembrane 4 superfamily member 1
chr13_-_8870967 0.752 ENSMUST00000164183.2
Wdr37
WD repeat domain 37
chrX_+_169036610 0.749 ENSMUST00000087016.4
ENSMUST00000112129.1
ENSMUST00000112131.2
Arhgap6


Rho GTPase activating protein 6


chr3_+_116594959 0.695 ENSMUST00000029571.8
Sass6
spindle assembly 6 homolog (C. elegans)
chr1_-_16093286 0.690 ENSMUST00000145070.1
ENSMUST00000151004.1
4930444P10Rik

RIKEN cDNA 4930444P10 gene

chr14_+_55560904 0.682 ENSMUST00000072530.4
ENSMUST00000128490.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr19_+_23675839 0.679 ENSMUST00000056396.5
Gm6563
predicted pseudogene 6563
chr11_-_101424519 0.670 ENSMUST00000107257.1
ENSMUST00000107259.3
ENSMUST00000107252.2
ENSMUST00000093933.4
Gm27029

Ptges3l

predicted gene, 27029

prostaglandin E synthase 3 (cytosolic)-like

chr8_+_70724064 0.629 ENSMUST00000034307.7
ENSMUST00000110095.2
Pde4c

phosphodiesterase 4C, cAMP specific

chr9_-_108079255 0.613 ENSMUST00000162516.1
Rnf123
ring finger protein 123
chr7_+_27862557 0.601 ENSMUST00000053722.8
Zfp607
zinc finger proten 607
chr7_+_131371138 0.596 ENSMUST00000075610.6
Pstk
phosphoseryl-tRNA kinase
chr13_-_25020289 0.590 ENSMUST00000021772.2
Mrs2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr9_+_50768228 0.578 ENSMUST00000042391.6
Fdxacb1
ferredoxin-fold anticodon binding domain containing 1
chr6_+_82402475 0.554 ENSMUST00000032122.8
Tacr1
tachykinin receptor 1
chr7_+_48789003 0.552 ENSMUST00000118927.1
ENSMUST00000125280.1
Zdhhc13

zinc finger, DHHC domain containing 13

chr8_+_4226827 0.540 ENSMUST00000053035.6
Lrrc8e
leucine rich repeat containing 8 family, member E
chr8_-_72213636 0.536 ENSMUST00000109987.1
Gm11034
predicted gene 11034
chr10_+_80826656 0.491 ENSMUST00000060987.8
ENSMUST00000177850.1
ENSMUST00000180036.1
ENSMUST00000179172.1
Oaz1



ornithine decarboxylase antizyme 1



chr4_+_74251928 0.479 ENSMUST00000030102.5
Kdm4c
lysine (K)-specific demethylase 4C
chr15_-_102004305 0.476 ENSMUST00000023952.8
Krt8
keratin 8
chr11_+_30954389 0.472 ENSMUST00000020551.6
ENSMUST00000117883.1
Asb3

ankyrin repeat and SOCS box-containing 3

chr7_-_16286744 0.457 ENSMUST00000150528.2
ENSMUST00000118976.2
ENSMUST00000146609.2
Ccdc9


coiled-coil domain containing 9


chr17_-_26886175 0.442 ENSMUST00000108741.2
Gm17382
predicted gene, 17382
chr10_+_88147061 0.441 ENSMUST00000169309.1
Nup37
nucleoporin 37
chr17_+_6270475 0.427 ENSMUST00000088940.4
Tmem181a
transmembrane protein 181A
chr11_+_6292120 0.426 ENSMUST00000135124.1
Ogdh
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr10_+_88146992 0.402 ENSMUST00000052355.7
Nup37
nucleoporin 37
chr12_+_32953874 0.392 ENSMUST00000076698.5
Sypl
synaptophysin-like protein
chr15_+_82147238 0.384 ENSMUST00000023100.6
Srebf2
sterol regulatory element binding factor 2
chr3_-_78892451 0.379 ENSMUST00000164923.1
Gm5277
predicted gene 5277
chr19_+_46623387 0.371 ENSMUST00000111855.4
Wbp1l
WW domain binding protein 1 like
chr8_+_85026833 0.349 ENSMUST00000047281.8
2310036O22Rik
RIKEN cDNA 2310036O22 gene
chr9_-_114982739 0.348 ENSMUST00000053150.5
Gm9846
predicted gene 9846
chr9_-_71592265 0.339 ENSMUST00000169573.1
ENSMUST00000166843.1
ENSMUST00000163998.1
Myzap
Gcom1

myocardial zonula adherens protein
GRINL1A complex locus

chr5_+_148959263 0.332 ENSMUST00000135240.1
Gm15409
predicted gene 15409
chr1_-_93343482 0.328 ENSMUST00000128253.1
Pask
PAS domain containing serine/threonine kinase
chr1_-_133753681 0.309 ENSMUST00000125659.1
ENSMUST00000165602.2
ENSMUST00000048953.7
Atp2b4


ATPase, Ca++ transporting, plasma membrane 4


chr1_+_185204165 0.305 ENSMUST00000069652.6
Rab3gap2
RAB3 GTPase activating protein subunit 2
chr14_+_14346400 0.298 ENSMUST00000090591.2
Il3ra
interleukin 3 receptor, alpha chain
chr16_+_19028232 0.289 ENSMUST00000074116.4
Gm10088
predicted gene 10088
chr7_+_83584910 0.273 ENSMUST00000039317.7
ENSMUST00000164944.1
Tmc3

transmembrane channel-like gene family 3

chr13_-_8870999 0.269 ENSMUST00000177404.1
ENSMUST00000176922.1
ENSMUST00000021572.4
Wdr37


WD repeat domain 37


chr6_+_4755327 0.262 ENSMUST00000176551.1
Peg10
paternally expressed 10
chr17_+_26113286 0.248 ENSMUST00000025010.7
Tmem8
transmembrane protein 8 (five membrane-spanning domains)
chr10_+_120201586 0.216 ENSMUST00000156877.1
Tmbim4
transmembrane BAX inhibitor motif containing 4
chr2_-_120731503 0.215 ENSMUST00000110701.1
ENSMUST00000110700.1
Cdan1

congenital dyserythropoietic anemia, type I (human)

chr17_-_46202576 0.189 ENSMUST00000024749.7
Polh
polymerase (DNA directed), eta (RAD 30 related)
chr4_+_115088708 0.185 ENSMUST00000171877.1
ENSMUST00000177647.1
ENSMUST00000106548.2
ENSMUST00000030488.2
Pdzk1ip1



PDZK1 interacting protein 1



chr5_+_150673739 0.167 ENSMUST00000016569.4
ENSMUST00000038900.8
Pds5b

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)

chr12_+_112999964 0.154 ENSMUST00000180971.1
9230104M06Rik
RIKEN cDNA 9230104M06 gene
chr11_+_69981127 0.150 ENSMUST00000108593.1
Ctdnep1
CTD nuclear envelope phosphatase 1
chr11_-_20741447 0.149 ENSMUST00000177543.1
Aftph
aftiphilin
chr10_-_30618337 0.145 ENSMUST00000019925.5
Hint3
histidine triad nucleotide binding protein 3
chr2_+_30364227 0.136 ENSMUST00000077977.7
ENSMUST00000140075.2
Fam73b

family with sequence similarity 73, member B

chr8_+_104250925 0.126 ENSMUST00000098464.4
Cklf
chemokine-like factor
chr13_-_12464925 0.124 ENSMUST00000124888.1
Lgals8
lectin, galactose binding, soluble 8
chr3_-_92429403 0.107 ENSMUST00000047300.7
Gm9774
predicted pseudogene 9774
chr15_+_85832301 0.106 ENSMUST00000146088.1
Ttc38
tetratricopeptide repeat domain 38
chr14_-_50930803 0.071 ENSMUST00000160538.1
ENSMUST00000162957.1
ENSMUST00000161166.1
ENSMUST00000160835.1
ENSMUST00000049312.7
Tmem55b




transmembrane protein 55b




chr3_+_105973711 0.066 ENSMUST00000000573.2
Ovgp1
oviductal glycoprotein 1
chr17_+_46202740 0.037 ENSMUST00000087031.5
Xpo5
exportin 5
chr18_-_77047243 0.034 ENSMUST00000137354.1
ENSMUST00000137498.1
Katnal2

katanin p60 subunit A-like 2

chr5_+_145283343 0.031 ENSMUST00000094116.3
Zscan25
zinc finger and SCAN domain containing 25
chr1_-_172632931 0.010 ENSMUST00000027826.5
Dusp23
dual specificity phosphatase 23
chr14_-_88123824 0.004 ENSMUST00000074245.3
Rps3a2
ribosomal protein S3A2

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.3 36.3 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
1.6 14.7 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
1.4 13.0 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
1.2 4.6 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
1.1 3.4 GO:1901052 sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053)
0.9 2.8 GO:2001187 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.9 4.4 GO:0034421 post-translational protein acetylation(GO:0034421)
0.9 9.4 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.7 2.0 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.6 2.3 GO:0090472 dibasic protein processing(GO:0090472)
0.6 2.8 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.5 1.5 GO:0021852 pyramidal neuron migration(GO:0021852)
0.4 2.2 GO:0048478 replication fork protection(GO:0048478)
0.4 6.0 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.4 1.2 GO:0048239 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.4 4.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.4 1.1 GO:0003195 tricuspid valve formation(GO:0003195) right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.3 5.8 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.3 7.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.3 1.3 GO:0015744 succinate transport(GO:0015744)
0.3 3.6 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.3 2.0 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.3 0.8 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.3 1.4 GO:0042701 progesterone secretion(GO:0042701)
0.2 3.1 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836)
0.2 1.8 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.2 12.7 GO:0030901 midbrain development(GO:0030901)
0.2 0.8 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.2 3.0 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 5.7 GO:0071625 vocalization behavior(GO:0071625)
0.2 0.6 GO:0042713 operant conditioning(GO:0035106) sperm ejaculation(GO:0042713)
0.2 20.4 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.2 6.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 3.8 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.2 6.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.2 0.3 GO:0097051 establishment of protein localization to endoplasmic reticulum membrane(GO:0097051)
0.1 0.6 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.8 GO:0044375 regulation of peroxisome size(GO:0044375)
0.1 0.9 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.5 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 2.1 GO:0035855 megakaryocyte development(GO:0035855)
0.1 3.1 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 1.5 GO:0042407 cristae formation(GO:0042407)
0.1 1.2 GO:0070995 NADPH oxidation(GO:0070995)
0.1 6.2 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.1 0.4 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 3.6 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 3.8 GO:0035329 hippo signaling(GO:0035329)
0.1 2.1 GO:0048266 behavioral response to pain(GO:0048266)
0.1 0.4 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.1 0.6 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 2.7 GO:0048246 macrophage chemotaxis(GO:0048246)
0.1 0.4 GO:0009405 pathogenesis(GO:0009405)
0.1 2.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 8.8 GO:0007050 cell cycle arrest(GO:0007050)
0.1 1.0 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.7 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.0 0.3 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.5 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.6 GO:0015693 magnesium ion transport(GO:0015693)
0.0 1.0 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.2 GO:0071494 pyrimidine dimer repair(GO:0006290) cellular response to UV-C(GO:0071494)
0.0 0.1 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.7 GO:0007099 centriole replication(GO:0007099)
0.0 2.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 3.2 GO:0000910 cytokinesis(GO:0000910)
0.0 2.0 GO:0006664 glycolipid metabolic process(GO:0006664) liposaccharide metabolic process(GO:1903509)
0.0 0.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 2.2 GO:0006413 translational initiation(GO:0006413)
0.0 2.7 GO:0006814 sodium ion transport(GO:0006814)
0.0 3.6 GO:0015833 peptide transport(GO:0015833)
0.0 1.3 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209) negative regulation of sequestering of calcium ion(GO:0051283)
0.0 0.3 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.0 GO:1900368 regulation of RNA interference(GO:1900368)
0.0 0.9 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.1 GO:0031262 Ndc80 complex(GO:0031262)
1.0 5.7 GO:0097513 myosin II filament(GO:0097513)
0.6 13.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.5 4.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.3 2.0 GO:0071817 MMXD complex(GO:0071817)
0.3 2.2 GO:0031298 replication fork protection complex(GO:0031298)
0.3 1.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.2 0.6 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.2 2.8 GO:0042101 T cell receptor complex(GO:0042101)
0.2 1.5 GO:0061617 MICOS complex(GO:0061617)
0.2 2.1 GO:0031209 SCAR complex(GO:0031209)
0.2 2.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 56.7 GO:0005667 transcription factor complex(GO:0005667)
0.1 1.0 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 1.2 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 0.7 GO:0098536 deuterosome(GO:0098536)
0.1 1.0 GO:0070545 PeBoW complex(GO:0070545)
0.1 3.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 6.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 0.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 7.4 GO:0072686 mitotic spindle(GO:0072686)
0.1 1.2 GO:0030061 mitochondrial crista(GO:0030061)
0.1 18.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 2.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 2.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.2 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 2.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.4 GO:0045252 dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.0 3.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 6.2 GO:0001650 fibrillar center(GO:0001650)
0.0 0.5 GO:0045095 keratin filament(GO:0045095)
0.0 0.8 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.6 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 2.3 GO:0036064 ciliary basal body(GO:0036064)
0.0 2.1 GO:0005925 focal adhesion(GO:0005925)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.0 0.0 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.3 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 3.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 4.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 7.3 GO:0000785 chromatin(GO:0000785)
0.0 6.6 GO:0031012 extracellular matrix(GO:0031012)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 36.3 GO:0003680 AT DNA binding(GO:0003680)
1.1 3.4 GO:0046997 sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
1.0 5.1 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.8 14.7 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.7 14.4 GO:0015172 acidic amino acid transmembrane transporter activity(GO:0015172)
0.6 3.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.5 4.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.4 4.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.4 2.8 GO:0050897 cobalt ion binding(GO:0050897)
0.4 2.8 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.4 5.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.3 1.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.2 2.5 GO:0016151 nickel cation binding(GO:0016151)
0.2 1.8 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.2 14.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 2.3 GO:0048406 nerve growth factor binding(GO:0048406)
0.2 4.6 GO:0046965 retinoid X receptor binding(GO:0046965)
0.2 2.0 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.2 1.2 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.2 3.6 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.2 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 4.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 2.0 GO:0046527 glucosyltransferase activity(GO:0046527)
0.1 0.5 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 0.6 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 0.8 GO:0071253 connexin binding(GO:0071253)
0.1 0.4 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.1 0.7 GO:0016004 phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.1 17.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 10.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 3.1 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.4 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 2.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 2.4 GO:0019894 kinesin binding(GO:0019894)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 2.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 15.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 0.3 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 2.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.0 GO:0051015 actin filament binding(GO:0051015)
0.0 0.6 GO:0000049 tRNA binding(GO:0000049)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 37.1 PID_CDC42_PATHWAY CDC42 signaling events
0.1 6.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 2.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 2.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 3.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 2.2 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 2.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.3 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.3 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.5 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 36.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.9 14.7 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 2.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.3 2.3 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 12.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 5.7 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.8 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 3.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 3.6 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 15.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 7.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 0.5 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 0.8 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 2.0 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 2.2 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.6 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.8 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.3 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 2.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation