Motif ID: Thra

Z-value: 0.746


Transcription factors associated with Thra:

Gene SymbolEntrez IDGene Name
Thra ENSMUSG00000058756.7 Thra

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Thramm10_v2_chr11_+_98741805_98741816-0.621.9e-09Click!


Activity profile for motif Thra.

activity profile for motif Thra


Sorted Z-values histogram for motif Thra

Sorted Z-values for motif Thra



Network of associatons between targets according to the STRING database.



First level regulatory network of Thra

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_44300876 8.697 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr7_-_141214080 8.389 ENSMUST00000026573.5
ENSMUST00000170841.1
 1600016N20Rik

RIKEN cDNA 1600016N20 gene

chr13_+_94875600 6.512 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr1_-_84839304 5.868 ENSMUST00000027421.6
 Trip12
thyroid hormone receptor interactor 12
chr13_+_44729794 5.580 ENSMUST00000172830.1
 Jarid2
jumonji, AT rich interactive domain 2
chr10_+_93641041 5.268 ENSMUST00000020204.4
 Ntn4
netrin 4
chrX_-_143827391 5.056 ENSMUST00000087316.5
 Capn6
calpain 6
chr6_+_113531675 5.055 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr11_-_40733373 5.021 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr2_+_102706356 4.832 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
 Slc1a2


solute carrier family 1 (glial high affinity glutamate transporter), member 2


chr3_-_52104891 4.619 ENSMUST00000121440.1
 Maml3
mastermind like 3 (Drosophila)
chr10_-_92162753 4.360 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr4_-_20778527 4.356 ENSMUST00000119374.1
 Nkain3
Na+/K+ transporting ATPase interacting 3
chr11_-_106272927 4.272 ENSMUST00000021052.9
 Smarcd2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chr10_+_80148263 4.141 ENSMUST00000099492.3
ENSMUST00000042057.5
 Midn

midnolin

chr4_-_135272798 4.139 ENSMUST00000037099.8
 Clic4
chloride intracellular channel 4 (mitochondrial)
chr12_+_44328882 3.869 ENSMUST00000020939.8
ENSMUST00000110748.2
 Nrcam

neuron-glia-CAM-related cell adhesion molecule

chr8_+_120537423 3.809 ENSMUST00000118136.1
 Gse1
genetic suppressor element 1
chr2_+_102658640 3.765 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr1_+_74791516 3.763 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.6 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.7 8.6 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 8.2 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.5 6.5 GO:0021979 hypothalamus cell differentiation(GO:0021979)
2.0 5.9 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
1.1 5.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.7 5.1 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.3 5.1 GO:0006337 nucleosome disassembly(GO:0006337)
0.7 4.9 GO:0007296 vitellogenesis(GO:0007296)
0.5 4.6 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.7 4.1 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.5 4.1 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 4.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.6 3.9 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.3 3.8 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.2 3.7 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.3 3.6 GO:0001675 acrosome assembly(GO:0001675)
1.2 3.5 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.9 3.5 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.5 3.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.9 GO:0016607 nuclear speck(GO:0016607)
0.3 8.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 5.1 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 5.1 GO:0005876 spindle microtubule(GO:0005876)
0.0 5.1 GO:0000793 condensed chromosome(GO:0000793)
0.0 4.5 GO:0000776 kinetochore(GO:0000776)
0.2 4.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 4.2 GO:0030673 axolemma(GO:0030673)
0.1 3.9 GO:0043194 axon initial segment(GO:0043194)
0.0 3.8 GO:0000922 spindle pole(GO:0000922)
0.2 3.6 GO:0002080 acrosomal membrane(GO:0002080)
0.0 3.5 GO:0000790 nuclear chromatin(GO:0000790)
0.0 3.3 GO:0005604 basement membrane(GO:0005604)
0.1 3.2 GO:0034707 chloride channel complex(GO:0034707)
0.6 3.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.4 3.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 2.9 GO:0016605 PML body(GO:0016605)
0.5 2.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 2.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 2.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.6 GO:0043565 sequence-specific DNA binding(GO:0043565)
1.4 8.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 8.6 GO:0032452 histone demethylase activity(GO:0032452)
0.2 6.1 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.6 5.3 GO:0043237 laminin-1 binding(GO:0043237)
0.1 5.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 5.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 5.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.3 5.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 4.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 4.6 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 4.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.8 3.9 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 3.8 GO:0005109 frizzled binding(GO:0005109)
0.4 3.5 GO:0030274 LIM domain binding(GO:0030274)
0.8 3.3 GO:0004111 creatine kinase activity(GO:0004111)
0.6 3.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.2 3.2 GO:0030553 cGMP binding(GO:0030553) 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 3.2 GO:0005254 chloride channel activity(GO:0005254)
0.5 3.1 GO:0097016 L27 domain binding(GO:0097016)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.0 PID_ATM_PATHWAY ATM pathway
0.0 5.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 4.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 3.8 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 3.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 3.1 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 2.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 2.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.7 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.5 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.1 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 8.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.4 7.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.6 6.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.5 5.0 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 4.4 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 4.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 3.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 3.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.2 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 3.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.4 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1 2.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 2.2 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.2 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 2.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 2.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 1.9 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.0 1.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.7 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism