Motif ID: Thra
Z-value: 0.746
Transcription factors associated with Thra:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Thra | ENSMUSG00000058756.7 | Thra |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Thra | mm10_v2_chr11_+_98741805_98741816 | -0.62 | 1.9e-09 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 5.9 | GO:1902915 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
| 1.2 | 8.6 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 1.2 | 3.5 | GO:0021849 | neuroblast division in subventricular zone(GO:0021849) |
| 1.1 | 5.3 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.9 | 2.8 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
| 0.9 | 3.5 | GO:0043973 | histone H3-K4 acetylation(GO:0043973) |
| 0.9 | 2.6 | GO:0072554 | arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) |
| 0.9 | 2.6 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) |
| 0.8 | 3.2 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) |
| 0.8 | 3.1 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) regulation of potassium ion export across plasma membrane(GO:1903764) regulation of membrane repolarization during ventricular cardiac muscle cell action potential(GO:1905024) |
| 0.8 | 3.1 | GO:0051295 | establishment of meiotic spindle localization(GO:0051295) |
| 0.7 | 2.2 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.7 | 2.9 | GO:1903463 | regulation of mitotic cell cycle DNA replication(GO:1903463) |
| 0.7 | 5.1 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 0.7 | 4.9 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.7 | 4.1 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.7 | 8.6 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.6 | 3.9 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.6 | 2.3 | GO:0071105 | response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105) |
| 0.6 | 1.7 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
| 0.6 | 2.2 | GO:0021847 | ventricular zone neuroblast division(GO:0021847) |
| 0.6 | 1.7 | GO:0001827 | inner cell mass cell fate commitment(GO:0001827) |
| 0.5 | 3.3 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.5 | 4.6 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.5 | 6.5 | GO:0021979 | hypothalamus cell differentiation(GO:0021979) |
| 0.5 | 4.1 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.4 | 2.2 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.4 | 1.3 | GO:0036118 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 0.4 | 1.2 | GO:0097402 | neuroblast migration(GO:0097402) |
| 0.4 | 2.4 | GO:0043654 | skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654) |
| 0.4 | 2.7 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.4 | 1.8 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.4 | 1.4 | GO:1901491 | negative regulation of lymphangiogenesis(GO:1901491) |
| 0.3 | 1.0 | GO:0090202 | regulation of primitive erythrocyte differentiation(GO:0010725) transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 0.3 | 3.8 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
| 0.3 | 2.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.3 | 1.6 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 0.3 | 2.3 | GO:0010571 | positive regulation of nuclear cell cycle DNA replication(GO:0010571) |
| 0.3 | 5.1 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.3 | 2.2 | GO:0035902 | response to immobilization stress(GO:0035902) |
| 0.3 | 3.6 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.3 | 1.2 | GO:0019372 | lipoxygenase pathway(GO:0019372) |
| 0.3 | 2.0 | GO:0035826 | rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476) |
| 0.3 | 0.8 | GO:0019046 | release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382) |
| 0.3 | 1.3 | GO:0051890 | cardiac ventricle formation(GO:0003211) regulation of cardioblast differentiation(GO:0051890) |
| 0.2 | 3.2 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.2 | 2.0 | GO:0006855 | drug transmembrane transport(GO:0006855) |
| 0.2 | 3.7 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.2 | 1.7 | GO:0019240 | citrulline biosynthetic process(GO:0019240) |
| 0.2 | 2.6 | GO:0002385 | mucosal immune response(GO:0002385) |
| 0.2 | 1.7 | GO:0070072 | vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.2 | 0.7 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 0.2 | 0.9 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.2 | 1.1 | GO:0051004 | plasma membrane to endosome transport(GO:0048227) regulation of lipoprotein lipase activity(GO:0051004) |
| 0.2 | 8.2 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) |
| 0.1 | 0.6 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.1 | 0.6 | GO:0045829 | negative regulation of isotype switching(GO:0045829) |
| 0.1 | 0.7 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
| 0.1 | 0.4 | GO:0014819 | regulation of skeletal muscle contraction(GO:0014819) |
| 0.1 | 1.0 | GO:0061368 | maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.1 | 0.5 | GO:0033762 | response to glucagon(GO:0033762) |
| 0.1 | 1.5 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 1.6 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.1 | 1.4 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.1 | 1.1 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.1 | 0.6 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.1 | 0.5 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.1 | 0.5 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 0.1 | 1.2 | GO:0090136 | epithelial cell-cell adhesion(GO:0090136) |
| 0.1 | 1.4 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.1 | 0.4 | GO:0032055 | negative regulation of translation in response to stress(GO:0032055) |
| 0.1 | 1.1 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 0.4 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.1 | 0.4 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.1 | 0.4 | GO:0002002 | regulation of angiotensin levels in blood(GO:0002002) |
| 0.1 | 0.8 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.1 | 1.0 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.1 | 1.0 | GO:0021702 | cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.1 | 0.2 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.1 | 0.6 | GO:1900121 | negative regulation of receptor binding(GO:1900121) |
| 0.1 | 1.4 | GO:1900027 | regulation of ruffle assembly(GO:1900027) |
| 0.0 | 4.0 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.6 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.0 | 1.1 | GO:0031116 | positive regulation of microtubule polymerization(GO:0031116) |
| 0.0 | 0.9 | GO:0015813 | L-glutamate transport(GO:0015813) |
| 0.0 | 0.7 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 1.0 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 0.0 | 0.5 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.0 | 2.3 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity(GO:0032088) |
| 0.0 | 0.7 | GO:0032933 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 0.0 | 0.9 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.0 | 0.4 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.0 | 0.5 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
| 0.0 | 2.2 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 2.3 | GO:0002028 | regulation of sodium ion transport(GO:0002028) |
| 0.0 | 0.6 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.0 | 0.4 | GO:0002931 | response to ischemia(GO:0002931) |
| 0.0 | 0.2 | GO:0039703 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
| 0.0 | 0.8 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.0 | 0.7 | GO:0014003 | oligodendrocyte development(GO:0014003) |
| 0.0 | 0.1 | GO:0097494 | regulation of vesicle size(GO:0097494) |
| 0.0 | 0.6 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 2.7 | GO:0030217 | T cell differentiation(GO:0030217) |
| 0.0 | 1.2 | GO:0000045 | autophagosome assembly(GO:0000045) |
| 0.0 | 0.2 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.0 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.6 | 3.1 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.5 | 2.6 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.4 | 3.1 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.3 | 8.6 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.3 | 1.7 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.3 | 5.1 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.2 | 2.2 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.2 | 2.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 2.0 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.2 | 4.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 3.6 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.2 | 2.0 | GO:0046930 | pore complex(GO:0046930) |
| 0.2 | 1.8 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 2.2 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 1.1 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 1.3 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 2.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 3.9 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 4.2 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 1.6 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.1 | 2.4 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 0.4 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 0.1 | 5.1 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.1 | 2.2 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 0.4 | GO:0036396 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 0.1 | 3.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 0.8 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.1 | 0.9 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.1 | 1.1 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 0.6 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.1 | 1.7 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.0 | 0.1 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.0 | 4.5 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 3.8 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 0.4 | GO:0070578 | RISC-loading complex(GO:0070578) |
| 0.0 | 1.1 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 2.2 | GO:0044815 | nucleosome(GO:0000786) DNA packaging complex(GO:0044815) |
| 0.0 | 1.1 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 12.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 5.1 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.0 | 1.2 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 2.9 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 3.3 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.4 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.0 | 1.8 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.9 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 2.4 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 0.9 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 1.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.0 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.5 | GO:0030904 | retromer complex(GO:0030904) |
| 0.0 | 0.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.4 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
| 0.0 | 3.5 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 1.5 | GO:0000785 | chromatin(GO:0000785) |
| 0.0 | 1.7 | GO:0005938 | cell cortex(GO:0005938) |
| 0.0 | 1.6 | GO:0042383 | sarcolemma(GO:0042383) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 8.6 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.8 | 3.3 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.8 | 3.9 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.6 | 3.2 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.6 | 5.3 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.5 | 3.1 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.4 | 2.2 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.4 | 1.7 | GO:0034618 | arginine binding(GO:0034618) |
| 0.4 | 1.3 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.4 | 3.5 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.3 | 2.4 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.3 | 1.7 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.3 | 2.0 | GO:0019841 | retinol binding(GO:0019841) |
| 0.3 | 2.0 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.3 | 5.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.3 | 1.8 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.3 | 2.0 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.3 | 5.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.3 | 1.0 | GO:0050347 | trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347) |
| 0.2 | 3.1 | GO:0043495 | protein anchor(GO:0043495) |
| 0.2 | 1.1 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.2 | 0.6 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
| 0.2 | 8.6 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.2 | 2.3 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.2 | 5.1 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.2 | 3.2 | GO:0030553 | cGMP binding(GO:0030553) 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.2 | 6.1 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.2 | 2.2 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.2 | 2.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 0.6 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.1 | 2.8 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.9 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.1 | 1.0 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.1 | 5.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 1.2 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.1 | 3.8 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 4.3 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 0.8 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.1 | 0.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 1.0 | GO:0070742 | DNA binding, bending(GO:0008301) C2H2 zinc finger domain binding(GO:0070742) |
| 0.1 | 2.2 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
| 0.1 | 1.5 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.9 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.1 | 2.6 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.1 | 0.9 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.1 | 0.4 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 0.1 | 0.4 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.1 | 1.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 2.3 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.1 | 1.2 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.1 | 4.8 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.6 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.0 | 3.2 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 1.6 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.0 | 0.4 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 0.7 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 0.2 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 1.7 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.0 | 2.2 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.9 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 1.0 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.9 | GO:0001104 | RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.0 | 0.2 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.0 | 0.4 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 1.1 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 4.6 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.0 | 0.5 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 0.2 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
| 0.0 | 1.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 2.3 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 1.6 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 1.1 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 0.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 0.8 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 10.6 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 2.7 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.9 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.2 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 8.0 | PID_ATM_PATHWAY | ATM pathway |
| 0.1 | 2.2 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 5.3 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 2.7 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 3.6 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 3.8 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 4.4 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.5 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 3.1 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.0 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 1.7 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.3 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 5.7 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.5 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 0.5 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.5 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
| 0.0 | 1.1 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.9 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.4 | PID_CERAMIDE_PATHWAY | Ceramide signaling pathway |
| 0.0 | 0.7 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 6.3 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.5 | 5.0 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.4 | 7.2 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.3 | 2.0 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.2 | 3.1 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.2 | 2.2 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.2 | 1.9 | REACTOME_COMPLEMENT_CASCADE | Genes involved in Complement cascade |
| 0.2 | 8.6 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 4.4 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 4.3 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 3.2 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 3.9 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 2.2 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
| 0.1 | 1.7 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 1.1 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 0.6 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 2.4 | REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.1 | 0.4 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 1.7 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 1.3 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 2.4 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 3.8 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 9.6 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.6 | REACTOME_MRNA_CAPPING | Genes involved in mRNA Capping |
| 0.0 | 2.2 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.9 | REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.0 | 0.9 | REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 0.0 | 1.9 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.7 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.8 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.4 | REACTOME_PERK_REGULATED_GENE_EXPRESSION | Genes involved in PERK regulated gene expression |
| 0.0 | 0.9 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.8 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.4 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
