Motif ID: Thrb

Z-value: 0.478


Transcription factors associated with Thrb:

Gene SymbolEntrez IDGene Name
Thrb ENSMUSG00000021779.10 Thrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Thrbmm10_v2_chr14_+_17660956_176609630.084.7e-01Click!


Activity profile for motif Thrb.

activity profile for motif Thrb


Sorted Z-values histogram for motif Thrb

Sorted Z-values for motif Thrb



Network of associatons between targets according to the STRING database.



First level regulatory network of Thrb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_25470031 7.654 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr2_-_25469742 6.867 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr12_+_112620030 4.895 ENSMUST00000180015.1
ENSMUST00000021726.6
 Adssl1

adenylosuccinate synthetase like 1

chr5_-_111761697 4.060 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr9_-_107668967 3.322 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr3_+_14863495 3.092 ENSMUST00000029076.4
 Car3
carbonic anhydrase 3
chr16_+_36934976 2.103 ENSMUST00000023531.8
 Hcls1
hematopoietic cell specific Lyn substrate 1
chr11_+_109485606 1.511 ENSMUST00000106697.1
 Arsg
arylsulfatase G
chr11_-_103344651 1.347 ENSMUST00000041385.7
 Arhgap27
Rho GTPase activating protein 27
chr12_+_108334341 1.283 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr16_+_37916440 1.167 ENSMUST00000061274.7
 Gpr156
G protein-coupled receptor 156
chr4_+_20042046 1.099 ENSMUST00000098242.3
 Ggh
gamma-glutamyl hydrolase
chr11_-_115612491 1.065 ENSMUST00000106507.2
 Mif4gd
MIF4G domain containing
chr5_-_92278155 1.062 ENSMUST00000159345.1
ENSMUST00000113102.3
 Naaa

N-acylethanolamine acid amidase

chr3_-_36475688 1.048 ENSMUST00000029266.8
 Anxa5
annexin A5
chr14_+_54476100 0.977 ENSMUST00000164766.1
ENSMUST00000164697.1
 Rem2

rad and gem related GTP binding protein 2

chr4_-_148444744 0.921 ENSMUST00000051633.2
 Ubiad1
UbiA prenyltransferase domain containing 1
chr14_-_61360395 0.735 ENSMUST00000022494.8
 Ebpl
emopamil binding protein-like
chr3_-_116712198 0.726 ENSMUST00000120120.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr2_+_92382911 0.584 ENSMUST00000054316.2
ENSMUST00000111280.2
 1700029I15Rik

RIKEN cDNA 1700029I15 gene

chr1_-_83408190 0.459 ENSMUST00000160953.1
 Sphkap
SPHK1 interactor, AKAP domain containing
chr3_+_67374116 0.452 ENSMUST00000061322.8
 Mlf1
myeloid leukemia factor 1
chr11_-_58938851 0.389 ENSMUST00000094151.5
 Rnf187
ring finger protein 187
chr3_+_67374091 0.350 ENSMUST00000077916.5
 Mlf1
myeloid leukemia factor 1
chr2_-_24049389 0.344 ENSMUST00000051416.5
 Hnmt
histamine N-methyltransferase
chr1_-_137969213 0.329 ENSMUST00000182680.1
ENSMUST00000182424.1
 Gm26936

predicted gene, 26936

chr9_+_102626278 0.321 ENSMUST00000038673.7
 Anapc13
anaphase promoting complex subunit 13
chr5_-_30461902 0.297 ENSMUST00000133509.1
ENSMUST00000074171.6
ENSMUST00000114747.2
ENSMUST00000144125.1
 Otof



otoferlin



chr9_-_102626095 0.277 ENSMUST00000093791.3
 Cep63
centrosomal protein 63
chr16_+_32419696 0.217 ENSMUST00000014220.8
ENSMUST00000080316.7
 Tctex1d2

Tctex1 domain containing 2

chr2_-_105399286 0.162 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr5_+_130219706 0.113 ENSMUST00000065329.6
 Tmem248
transmembrane protein 248
chr9_-_102626509 0.103 ENSMUST00000161645.1
ENSMUST00000162297.1
ENSMUST00000162655.1
 Cep63


centrosomal protein 63



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 14.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.6 4.9 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.7 3.3 GO:0015817 glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365)
0.4 1.1 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.3 2.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.3 1.0 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.2 0.9 GO:0042373 vitamin K metabolic process(GO:0042373)
0.1 0.7 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 1.3 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 1.0 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.1 0.8 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.1 0.3 GO:0001692 histamine metabolic process(GO:0001692) imidazole-containing compound catabolic process(GO:0052805)
0.1 3.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 0.4 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.3 GO:0016082 synaptic vesicle priming(GO:0016082)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 14.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.2 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.0 0.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.8 GO:0097546 ciliary base(GO:0097546)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 3.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.0 GO:0014704 intercalated disc(GO:0014704)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 14.5 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
1.1 3.3 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.3 3.1 GO:0016151 nickel cation binding(GO:0016151)
0.2 1.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 1.1 GO:0008242 omega peptidase activity(GO:0008242)
0.1 1.5 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 4.9 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.1 1.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.9 GO:0004659 prenyltransferase activity(GO:0004659)
0.1 0.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.7 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 3.5 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.9 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2 1.5 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 1.3 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 3.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.7 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules