Motif ID: Tlx1
Z-value: 0.702
Transcription factors associated with Tlx1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tlx1 | ENSMUSG00000025215.9 | Tlx1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.3 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
| 0.9 | 4.7 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) |
| 0.9 | 2.6 | GO:1904207 | chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.8 | 2.5 | GO:0031335 | regulation of sulfur amino acid metabolic process(GO:0031335) |
| 0.7 | 4.5 | GO:0032713 | negative regulation of interleukin-4 production(GO:0032713) |
| 0.7 | 4.4 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.7 | 1.3 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
| 0.7 | 2.0 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 0.6 | 1.9 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 0.6 | 14.0 | GO:0097091 | synaptic vesicle clustering(GO:0097091) |
| 0.6 | 3.7 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.6 | 3.1 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.6 | 4.3 | GO:0061092 | regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
| 0.5 | 1.6 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.5 | 2.5 | GO:0046950 | cellular ketone body metabolic process(GO:0046950) |
| 0.5 | 1.4 | GO:0019401 | alditol biosynthetic process(GO:0019401) |
| 0.5 | 1.4 | GO:1901608 | regulation of vesicle transport along microtubule(GO:1901608) |
| 0.5 | 1.8 | GO:0016128 | phytosteroid metabolic process(GO:0016128) phytosteroid biosynthetic process(GO:0016129) |
| 0.4 | 2.2 | GO:1903598 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) positive regulation of gap junction assembly(GO:1903598) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 0.4 | 2.4 | GO:0071630 | nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630) |
| 0.4 | 1.2 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.4 | 2.6 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.4 | 1.8 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.4 | 1.5 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 0.4 | 1.8 | GO:1905049 | negative regulation of metallopeptidase activity(GO:1905049) |
| 0.4 | 1.8 | GO:0046654 | 'de novo' IMP biosynthetic process(GO:0006189) tetrahydrofolate biosynthetic process(GO:0046654) |
| 0.4 | 3.2 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.3 | 2.4 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 0.3 | 1.2 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.3 | 1.4 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.3 | 1.3 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 0.2 | 1.5 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.2 | 0.6 | GO:0032240 | negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
| 0.2 | 0.6 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.2 | 1.1 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.2 | 0.5 | GO:0071918 | urea transmembrane transport(GO:0071918) |
| 0.2 | 2.1 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.2 | 0.5 | GO:2000564 | CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) |
| 0.2 | 2.5 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159) |
| 0.2 | 0.7 | GO:0060709 | glycogen cell differentiation involved in embryonic placenta development(GO:0060709) |
| 0.2 | 0.5 | GO:1904049 | negative regulation of spontaneous neurotransmitter secretion(GO:1904049) |
| 0.1 | 1.5 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.1 | 1.0 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 2.0 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.1 | 2.2 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.1 | 1.3 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.1 | 0.9 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 0.4 | GO:0035963 | response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963) |
| 0.1 | 0.9 | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 0.1 | 2.3 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 0.7 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.1 | 2.0 | GO:0014051 | gamma-aminobutyric acid secretion(GO:0014051) |
| 0.1 | 0.7 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 0.1 | 3.0 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 0.6 | GO:0044351 | macropinocytosis(GO:0044351) |
| 0.1 | 3.1 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.1 | 0.3 | GO:0070488 | neutrophil aggregation(GO:0070488) |
| 0.1 | 0.4 | GO:0019372 | lipoxygenase pathway(GO:0019372) |
| 0.1 | 1.1 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.1 | 0.6 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.1 | 0.2 | GO:0032765 | positive regulation of mast cell cytokine production(GO:0032765) |
| 0.1 | 0.6 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.1 | 0.4 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 0.1 | 1.1 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.1 | 0.5 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.1 | 0.5 | GO:2000767 | positive regulation of cytoplasmic translation(GO:2000767) |
| 0.1 | 1.1 | GO:0042407 | cristae formation(GO:0042407) |
| 0.1 | 1.9 | GO:0002437 | inflammatory response to antigenic stimulus(GO:0002437) |
| 0.1 | 0.3 | GO:1901970 | positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101) |
| 0.1 | 0.2 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
| 0.1 | 0.2 | GO:0071707 | immunoglobulin heavy chain V-D-J recombination(GO:0071707) |
| 0.1 | 0.4 | GO:1903351 | response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351) |
| 0.1 | 1.0 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.1 | 0.7 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) negative regulation of ubiquitin protein ligase activity(GO:1904667) |
| 0.1 | 0.6 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
| 0.0 | 1.5 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.0 | 0.5 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 1.5 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.0 | 1.1 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 0.3 | GO:0060290 | transdifferentiation(GO:0060290) |
| 0.0 | 0.5 | GO:2000465 | regulation of glycogen (starch) synthase activity(GO:2000465) |
| 0.0 | 2.9 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 0.0 | 1.1 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) |
| 0.0 | 9.2 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.0 | 0.6 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
| 0.0 | 0.5 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.0 | 0.7 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
| 0.0 | 0.3 | GO:0001539 | cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285) |
| 0.0 | 0.3 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.0 | 2.8 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 2.8 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 0.1 | GO:0019355 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
| 0.0 | 1.1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.1 | GO:0035701 | hematopoietic stem cell migration(GO:0035701) |
| 0.0 | 0.1 | GO:1902947 | regulation of tau-protein kinase activity(GO:1902947) |
| 0.0 | 0.1 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
| 0.0 | 0.3 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.0 | 2.9 | GO:0007613 | memory(GO:0007613) |
| 0.0 | 0.1 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.0 | 2.7 | GO:0031214 | biomineral tissue development(GO:0031214) |
| 0.0 | 0.1 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.0 | 0.1 | GO:0030070 | insulin processing(GO:0030070) |
| 0.0 | 0.2 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.0 | 0.9 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.0 | 2.7 | GO:0030178 | negative regulation of Wnt signaling pathway(GO:0030178) |
| 0.0 | 0.0 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.0 | 0.2 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.0 | 1.6 | GO:0006413 | translational initiation(GO:0006413) |
| 0.0 | 0.7 | GO:1904031 | positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
| 0.0 | 0.4 | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) |
| 0.0 | 0.4 | GO:0048678 | response to axon injury(GO:0048678) |
| 0.0 | 0.6 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.0 | 1.7 | GO:0050821 | protein stabilization(GO:0050821) |
| 0.0 | 0.4 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.0 | 0.0 | GO:0002309 | T cell proliferation involved in immune response(GO:0002309) |
| 0.0 | 0.2 | GO:0060395 | SMAD protein signal transduction(GO:0060395) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.7 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.7 | 3.3 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.6 | 4.4 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.4 | 2.1 | GO:0042025 | host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094) |
| 0.3 | 2.8 | GO:0000836 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.3 | 2.6 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.3 | 1.5 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.3 | 1.1 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.2 | 14.0 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.2 | 5.2 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.2 | 1.9 | GO:0000243 | commitment complex(GO:0000243) |
| 0.2 | 2.2 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.1 | 1.3 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.1 | 2.0 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 0.9 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 0.4 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.1 | 1.1 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.1 | 4.4 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 2.0 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 0.6 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.1 | 0.3 | GO:0098835 | presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) |
| 0.1 | 0.5 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.1 | 0.9 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 4.7 | GO:0034704 | calcium channel complex(GO:0034704) |
| 0.1 | 0.5 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.1 | 0.4 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.1 | 2.6 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.1 | 6.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 0.3 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.1 | 0.7 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 0.6 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.1 | 1.1 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 1.0 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 0.5 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.0 | 3.6 | GO:0005930 | axoneme(GO:0005930) |
| 0.0 | 0.5 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 2.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.5 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 0.1 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 0.1 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.0 | 4.5 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.9 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 0.3 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 0.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.9 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 4.2 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.1 | GO:0071986 | Ragulator complex(GO:0071986) |
| 0.0 | 1.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.7 | GO:0000791 | euchromatin(GO:0000791) |
| 0.0 | 4.4 | GO:0098793 | presynapse(GO:0098793) |
| 0.0 | 0.3 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 2.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.4 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 4.7 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.6 | 2.8 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.5 | 1.4 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.4 | 2.2 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 0.4 | 1.7 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 0.4 | 2.0 | GO:0008865 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.4 | 1.2 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.4 | 1.8 | GO:0019238 | cyclohydrolase activity(GO:0019238) |
| 0.4 | 1.4 | GO:0008967 | phosphoglycolate phosphatase activity(GO:0008967) |
| 0.3 | 2.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.3 | 2.2 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.3 | 1.8 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.3 | 1.5 | GO:0097643 | amylin receptor activity(GO:0097643) |
| 0.2 | 1.2 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
| 0.2 | 0.7 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.2 | 1.1 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
| 0.2 | 1.3 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.2 | 5.1 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.2 | 3.2 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.2 | 2.0 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.2 | 1.2 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.2 | 4.4 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.2 | 2.8 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.2 | 2.0 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.2 | 1.4 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.2 | 1.6 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.2 | 0.8 | GO:0015265 | urea channel activity(GO:0015265) |
| 0.1 | 3.0 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 0.7 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.1 | 4.3 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.1 | 13.8 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.1 | 0.7 | GO:0016453 | acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453) |
| 0.1 | 0.7 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.1 | 0.5 | GO:2001069 | glycogen binding(GO:2001069) |
| 0.1 | 1.7 | GO:0099602 | acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602) |
| 0.1 | 2.1 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 0.4 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.1 | 1.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.3 | GO:0003692 | left-handed Z-DNA binding(GO:0003692) |
| 0.1 | 1.5 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 1.1 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 0.1 | 1.3 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.1 | 0.7 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.1 | 3.7 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 0.6 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.1 | 2.5 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 1.4 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 0.3 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.1 | 0.2 | GO:0032896 | palmitoyl-CoA 9-desaturase activity(GO:0032896) |
| 0.1 | 2.3 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.1 | 0.6 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.1 | 0.7 | GO:0030235 | nitric-oxide synthase regulator activity(GO:0030235) |
| 0.1 | 1.6 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 1.3 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 0.5 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.6 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 0.2 | GO:0001733 | galactosylceramide sulfotransferase activity(GO:0001733) |
| 0.0 | 1.9 | GO:0017069 | snRNA binding(GO:0017069) |
| 0.0 | 0.6 | GO:0043495 | protein anchor(GO:0043495) |
| 0.0 | 0.5 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.0 | 1.8 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.5 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.0 | 1.2 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 0.2 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.0 | 0.3 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.0 | 2.2 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 0.1 | GO:0004515 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515) |
| 0.0 | 3.4 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 8.3 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 0.1 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.0 | 0.2 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
| 0.0 | 0.2 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.0 | 0.3 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 0.9 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 1.0 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 0.1 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.0 | 1.6 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.4 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.0 | 0.5 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.2 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.0 | 0.8 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 0.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 2.0 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.0 | 1.4 | GO:0016247 | channel regulator activity(GO:0016247) |
| 0.0 | 1.0 | GO:0002020 | protease binding(GO:0002020) |
| 0.0 | 1.1 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 0.8 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 0.7 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 1.6 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 0.4 | GO:0045309 | protein phosphorylated amino acid binding(GO:0045309) |
| 0.0 | 0.3 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.9 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.1 | 4.5 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.1 | 4.8 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 0.4 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.1 | 4.3 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 3.4 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 1.4 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.1 | 5.6 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 4.6 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 2.3 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.6 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.0 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.4 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.3 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 0.6 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.4 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.6 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.9 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.3 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.7 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.2 | 3.9 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.2 | 2.0 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.2 | 1.9 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.2 | 3.7 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.8 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 5.4 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 5.1 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 1.8 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.1 | 2.0 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 1.7 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.1 | 1.1 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 1.8 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 1.1 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 2.4 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 2.6 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
| 0.1 | 4.5 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 0.5 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 1.2 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 1.2 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.4 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 0.6 | REACTOME_P38MAPK_EVENTS | Genes involved in p38MAPK events |
| 0.0 | 1.4 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.3 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.7 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 2.5 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 4.1 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 0.6 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.5 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 1.3 | REACTOME_REGULATION_OF_INSULIN_SECRETION | Genes involved in Regulation of Insulin Secretion |
| 0.0 | 0.2 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.3 | REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
