Motif ID: Tlx2

Z-value: 1.145


Transcription factors associated with Tlx2:

Gene SymbolEntrez IDGene Name
Tlx2 ENSMUSG00000068327.3 Tlx2



Activity profile for motif Tlx2.

activity profile for motif Tlx2


Sorted Z-values histogram for motif Tlx2

Sorted Z-values for motif Tlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_82074639 11.282 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr15_+_21111452 9.529 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr9_-_21037775 9.499 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr16_+_91225550 9.401 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr8_+_94772009 8.661 ENSMUST00000034230.5
 Cx3cl1
chemokine (C-X3-C motif) ligand 1
chr15_+_54745702 8.148 ENSMUST00000050027.8
 Nov
nephroblastoma overexpressed gene
chr14_-_66280949 7.590 ENSMUST00000111121.1
ENSMUST00000022622.7
ENSMUST00000089250.2
 Ptk2b


PTK2 protein tyrosine kinase 2 beta


chr9_+_111311674 7.440 ENSMUST00000078626.3
 Trank1
tetratricopeptide repeat and ankyrin repeat containing 1
chrX_-_162565514 7.409 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr17_+_68837062 7.235 ENSMUST00000178545.1
 Tmem200c
transmembrane protein 200C
chr19_+_6401675 6.802 ENSMUST00000113471.1
ENSMUST00000113469.2
 Rasgrp2

RAS, guanyl releasing protein 2

chr6_+_108660772 6.799 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40
chr13_-_49309217 6.420 ENSMUST00000110087.2
 Fgd3
FYVE, RhoGEF and PH domain containing 3
chr3_+_134236483 6.227 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr6_+_108660616 6.186 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr11_-_51650813 5.996 ENSMUST00000142721.1
ENSMUST00000156835.1
ENSMUST00000001080.9
 N4bp3


NEDD4 binding protein 3


chr7_+_87803815 5.946 ENSMUST00000125009.1
ENSMUST00000155358.1
 Grm5

glutamate receptor, metabotropic 5

chr19_-_24031006 5.833 ENSMUST00000096164.4
 Fam189a2
family with sequence similarity 189, member A2
chr14_+_66344369 5.790 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
 Stmn4



stathmin-like 4



chr14_+_74640840 5.767 ENSMUST00000036653.3
 Htr2a
5-hydroxytryptamine (serotonin) receptor 2A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 237 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 13.1 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.4 13.0 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
3.8 11.3 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
3.1 9.4 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 8.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.2 8.7 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
2.8 8.5 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.8 7.8 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
2.5 7.6 GO:0010752 signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752)
0.1 7.6 GO:0034605 cellular response to heat(GO:0034605)
1.8 7.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.0 7.0 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.1 6.8 GO:0071277 cellular response to calcium ion(GO:0071277)
2.1 6.4 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
2.0 5.9 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.5 5.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.4 5.8 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.8 5.6 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.2 5.6 GO:0018345 protein palmitoylation(GO:0018345)
0.1 5.6 GO:0032543 mitochondrial translation(GO:0032543)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 16.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 13.5 GO:0005802 trans-Golgi network(GO:0005802)
0.1 11.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 10.9 GO:0005794 Golgi apparatus(GO:0005794)
0.1 8.3 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.6 7.6 GO:0070852 cell body fiber(GO:0070852)
0.4 7.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.6 7.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 7.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.6 6.8 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.3 6.5 GO:0000242 pericentriolar material(GO:0000242)
0.1 6.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 6.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 6.1 GO:0043195 terminal bouton(GO:0043195)
0.4 5.9 GO:0097449 astrocyte projection(GO:0097449)
0.6 5.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 5.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 5.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 4.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 4.6 GO:0032279 asymmetric synapse(GO:0032279)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 19.4 GO:0005509 calcium ion binding(GO:0005509)
1.4 16.3 GO:0004016 adenylate cyclase activity(GO:0004016)
0.6 14.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
2.2 13.0 GO:0043426 MRF binding(GO:0043426)
0.6 12.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 10.7 GO:0030165 PDZ domain binding(GO:0030165)
0.1 10.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 10.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 9.4 GO:0071837 HMG box domain binding(GO:0071837)
0.3 8.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.2 7.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.9 7.6 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
1.2 7.0 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.9 7.0 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 6.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
1.1 6.4 GO:0016936 galactoside binding(GO:0016936)
0.5 6.0 GO:0032050 clathrin heavy chain binding(GO:0032050)
1.5 5.9 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) A2A adenosine receptor binding(GO:0031687) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.5 5.9 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.9 5.8 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 16.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 15.6 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.7 13.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 10.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.3 10.3 PID_ARF_3PATHWAY Arf1 pathway
0.4 7.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.5 7.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.2 5.9 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.3 5.7 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.2 5.6 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.1 5.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 5.1 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 4.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 3.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 3.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.3 PID_MTOR_4PATHWAY mTOR signaling pathway
0.2 3.2 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 3.1 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.2 2.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 15.3 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.3 13.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 13.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.4 12.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.5 12.5 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.4 11.3 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.5 7.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.3 7.0 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.3 6.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
1.9 5.8 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.9 5.6 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 5.4 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 5.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 4.9 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.5 4.7 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.2 4.7 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.2 4.6 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 4.5 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.2 4.3 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 4.3 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport