Motif ID: Trp53

Z-value: 1.454


Transcription factors associated with Trp53:

Gene SymbolEntrez IDGene Name
Trp53 ENSMUSG00000059552.7 Trp53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp53mm10_v2_chr11_+_69580392_695804190.325.2e-03Click!


Activity profile for motif Trp53.

activity profile for motif Trp53


Sorted Z-values histogram for motif Trp53

Sorted Z-values for motif Trp53



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp53

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_69206146 34.280 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr1_+_6487231 28.844 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr17_-_33890584 27.412 ENSMUST00000114361.2
ENSMUST00000173492.1
Kifc1

kinesin family member C1

chr2_-_69206133 27.404 ENSMUST00000112320.1
Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr8_+_94977101 25.848 ENSMUST00000179619.1
Gpr56
G protein-coupled receptor 56
chr17_-_33890539 24.767 ENSMUST00000173386.1
Kifc1
kinesin family member C1
chr17_+_29090969 24.553 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr14_+_13454010 22.686 ENSMUST00000112656.2
Synpr
synaptoporin
chr3_-_75956888 17.234 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
Golim4


golgi integral membrane protein 4


chr15_+_85859689 16.878 ENSMUST00000170629.1
Gtse1
G two S phase expressed protein 1
chr8_-_22185758 16.323 ENSMUST00000046916.7
Ckap2
cytoskeleton associated protein 2
chr11_-_102925086 16.162 ENSMUST00000021311.9
Kif18b
kinesin family member 18B
chr14_+_13453937 16.035 ENSMUST00000153954.1
Synpr
synaptoporin
chr14_+_73237891 15.958 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr14_-_34374617 12.906 ENSMUST00000023826.4
Sncg
synuclein, gamma
chr14_-_54926784 12.671 ENSMUST00000022813.6
Efs
embryonal Fyn-associated substrate
chr9_+_45138437 10.703 ENSMUST00000060125.5
Scn4b
sodium channel, type IV, beta
chr9_-_106158109 10.609 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
Glyctk



glycerate kinase



chr10_+_93641041 10.605 ENSMUST00000020204.4
Ntn4
netrin 4
chr1_+_82339049 10.526 ENSMUST00000140020.1
Rhbdd1
rhomboid domain containing 1
chr11_-_3527916 10.393 ENSMUST00000020718.4
Smtn
smoothelin
chr15_-_98004695 9.510 ENSMUST00000023123.8
Col2a1
collagen, type II, alpha 1
chr15_-_98004634 8.856 ENSMUST00000131560.1
ENSMUST00000088355.5
Col2a1

collagen, type II, alpha 1

chr17_+_26917091 8.684 ENSMUST00000078961.4
Kifc5b
kinesin family member C5B
chr1_-_79858627 8.575 ENSMUST00000027467.4
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr10_-_81350389 8.414 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
Hmg20b



high mobility group 20B



chr2_+_72285637 8.362 ENSMUST00000090824.5
ENSMUST00000135469.1
Zak

sterile alpha motif and leucine zipper containing kinase AZK

chr5_-_30073554 8.339 ENSMUST00000026846.6
Tyms
thymidylate synthase
chrX_-_142306170 8.161 ENSMUST00000134825.2
Kcne1l
potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene
chr10_-_81350191 8.055 ENSMUST00000122993.1
Hmg20b
high mobility group 20B
chr9_+_72438534 8.019 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr9_-_100486788 7.797 ENSMUST00000098458.3
Il20rb
interleukin 20 receptor beta
chr9_+_72438519 7.678 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr10_-_81350305 7.371 ENSMUST00000167481.1
Hmg20b
high mobility group 20B
chr7_+_75455534 7.295 ENSMUST00000147005.1
ENSMUST00000166315.1
Akap13

A kinase (PRKA) anchor protein 13

chr4_-_83285141 7.000 ENSMUST00000150522.1
Ttc39b
tetratricopeptide repeat domain 39B
chr5_+_114707760 6.018 ENSMUST00000094441.4
Tchp
trichoplein, keratin filament binding
chr6_-_38837224 5.980 ENSMUST00000160962.1
Hipk2
homeodomain interacting protein kinase 2
chr9_+_66946057 5.980 ENSMUST00000040917.7
ENSMUST00000127896.1
Rps27l

ribosomal protein S27-like

chr9_+_107576915 5.826 ENSMUST00000112387.2
ENSMUST00000123005.1
ENSMUST00000010195.7
ENSMUST00000144392.1
Hyal1



hyaluronoglucosaminidase 1



chr13_+_113317084 5.709 ENSMUST00000136755.2
BC067074
cDNA sequence BC067074
chr11_+_17211912 5.252 ENSMUST00000046955.6
Wdr92
WD repeat domain 92
chr17_+_35821675 5.238 ENSMUST00000003635.6
Ier3
immediate early response 3
chr4_+_116596672 5.202 ENSMUST00000051869.7
Ccdc17
coiled-coil domain containing 17
chr12_+_59129757 5.171 ENSMUST00000069430.8
ENSMUST00000177370.1
Ctage5

CTAGE family, member 5

chr7_-_114927726 4.934 ENSMUST00000059737.2
Gm6816
predicted gene 6816
chr12_+_59129720 4.794 ENSMUST00000175912.1
ENSMUST00000176892.1
Ctage5

CTAGE family, member 5

chr4_-_129641060 4.763 ENSMUST00000046425.9
ENSMUST00000133803.1
Txlna

taxilin alpha

chr2_-_155592567 4.644 ENSMUST00000155347.1
ENSMUST00000130881.1
ENSMUST00000079691.6
Gss


glutathione synthetase


chr14_-_70653081 4.638 ENSMUST00000062629.4
Npm2
nucleophosmin/nucleoplasmin 2
chr4_-_155056784 4.544 ENSMUST00000131173.2
Plch2
phospholipase C, eta 2
chr4_-_129640959 4.470 ENSMUST00000132217.1
ENSMUST00000130017.1
ENSMUST00000154105.1
Txlna


taxilin alpha


chr18_+_61639542 4.401 ENSMUST00000183083.1
ENSMUST00000183087.1
Gm20748

predicted gene, 20748

chr13_+_21754067 4.227 ENSMUST00000091709.2
Hist1h2bn
histone cluster 1, H2bn
chr8_-_84893887 4.210 ENSMUST00000003907.7
ENSMUST00000182458.1
ENSMUST00000109745.1
ENSMUST00000142748.1
Gcdh



glutaryl-Coenzyme A dehydrogenase



chr14_-_55944536 4.148 ENSMUST00000022834.6
Cma1
chymase 1, mast cell
chr3_+_90669063 4.003 ENSMUST00000069927.8
S100a8
S100 calcium binding protein A8 (calgranulin A)
chr2_+_59612034 3.945 ENSMUST00000112568.1
ENSMUST00000037526.4
Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr2_+_29889217 3.882 ENSMUST00000123335.1
Odf2
outer dense fiber of sperm tails 2
chr3_-_19264959 3.783 ENSMUST00000121951.1
Pde7a
phosphodiesterase 7A
chr16_+_20651652 3.735 ENSMUST00000007212.8
Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr2_+_29890063 3.694 ENSMUST00000028128.6
Odf2
outer dense fiber of sperm tails 2
chr5_+_34989473 3.614 ENSMUST00000114284.1
ENSMUST00000114285.1
Rgs12

regulator of G-protein signaling 12

chr8_-_22694061 3.482 ENSMUST00000131767.1
Ikbkb
inhibitor of kappaB kinase beta
chr4_-_135573623 3.453 ENSMUST00000105855.1
Grhl3
grainyhead-like 3 (Drosophila)
chr7_+_97332311 3.407 ENSMUST00000054107.5
Kctd21
potassium channel tetramerisation domain containing 21
chr9_-_114982739 3.228 ENSMUST00000053150.5
Gm9846
predicted gene 9846
chr9_-_72985344 3.184 ENSMUST00000124565.2
Gm5918
predicted gene 5918
chr14_-_20496780 2.922 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr3_-_19265007 2.905 ENSMUST00000091314.4
Pde7a
phosphodiesterase 7A
chr6_+_128438757 2.813 ENSMUST00000144745.1
Gm10069
predicted gene 10069
chr3_-_28765364 2.749 ENSMUST00000094335.3
Gm6505
predicted pseudogene 6505
chr15_+_100154379 2.744 ENSMUST00000023768.6
ENSMUST00000108971.2
Dip2b

DIP2 disco-interacting protein 2 homolog B (Drosophila)

chr4_-_43030440 2.652 ENSMUST00000135660.1
Stoml2
stomatin (Epb7.2)-like 2
chr17_+_52602700 2.583 ENSMUST00000039366.10
Kcnh8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr6_-_118562226 2.582 ENSMUST00000112830.1
Ankrd26
ankyrin repeat domain 26
chr16_-_11909398 2.577 ENSMUST00000127972.1
ENSMUST00000121750.1
ENSMUST00000096272.4
ENSMUST00000073371.6
Cpped1



calcineurin-like phosphoesterase domain containing 1



chr14_+_74735641 2.478 ENSMUST00000177283.1
Esd
esterase D/formylglutathione hydrolase
chr5_-_115194283 2.424 ENSMUST00000112113.1
Cabp1
calcium binding protein 1
chrX_+_74254782 2.328 ENSMUST00000119197.1
ENSMUST00000088313.4
Emd

emerin

chr1_+_161969179 2.281 ENSMUST00000111594.2
ENSMUST00000028021.6
Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr17_+_32506446 2.277 ENSMUST00000165999.1
Cyp4f17
cytochrome P450, family 4, subfamily f, polypeptide 17
chr1_+_161969284 2.241 ENSMUST00000160881.1
ENSMUST00000159648.1
Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr15_-_102350692 2.160 ENSMUST00000041208.7
Aaas
achalasia, adrenocortical insufficiency, alacrimia
chr6_+_134981998 2.152 ENSMUST00000167323.1
Apold1
apolipoprotein L domain containing 1
chr19_-_4793851 2.113 ENSMUST00000178615.1
ENSMUST00000179189.1
ENSMUST00000164376.2
ENSMUST00000164209.2
ENSMUST00000180248.1
Rbm4




RNA binding motif protein 4




chr7_-_98309471 1.980 ENSMUST00000033020.7
Acer3
alkaline ceramidase 3
chr7_+_64392645 1.967 ENSMUST00000037205.8
Mcee
methylmalonyl CoA epimerase
chr14_+_47001336 1.955 ENSMUST00000125113.1
Samd4
sterile alpha motif domain containing 4
chr7_-_97332017 1.939 ENSMUST00000139582.2
Usp35
ubiquitin specific peptidase 35
chr2_-_127521358 1.914 ENSMUST00000028850.8
ENSMUST00000103215.4
Kcnip3

Kv channel interacting protein 3, calsenilin

chr4_-_96591555 1.757 ENSMUST00000055693.8
Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr11_+_88204396 1.750 ENSMUST00000118784.1
ENSMUST00000139170.1
ENSMUST00000107915.3
ENSMUST00000144070.1
Mrps23



mitochondrial ribosomal protein S23



chr17_+_87282880 1.624 ENSMUST00000041110.5
ENSMUST00000125875.1
Ttc7

tetratricopeptide repeat domain 7

chr10_+_110745433 1.602 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
E2f7



E2F transcription factor 7



chr14_-_59365410 1.584 ENSMUST00000161031.1
ENSMUST00000160425.1
Phf11d

PHD finger protein 11D

chr4_+_115057410 1.565 ENSMUST00000136946.1
Tal1
T cell acute lymphocytic leukemia 1
chr17_-_34862473 1.426 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
Cfb


complement factor B


chr16_-_59632520 1.398 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr5_-_116422858 1.371 ENSMUST00000036991.4
Hspb8
heat shock protein 8
chrX_-_38635066 1.327 ENSMUST00000058265.7
C1galt1c1
C1GALT1-specific chaperone 1
chr10_+_94550852 1.317 ENSMUST00000148910.1
ENSMUST00000117460.1
Tmcc3

transmembrane and coiled coil domains 3

chr1_-_191907527 1.266 ENSMUST00000069573.5
1700034H15Rik
RIKEN cDNA 1700034H15 gene
chr5_+_34999046 1.257 ENSMUST00000114281.1
Rgs12
regulator of G-protein signaling 12
chr7_-_103741322 1.207 ENSMUST00000051346.2
Olfr629
olfactory receptor 629
chr11_+_87582201 1.180 ENSMUST00000133202.1
Sept4
septin 4
chr10_+_80622677 1.173 ENSMUST00000079773.6
Csnk1g2
casein kinase 1, gamma 2
chr19_-_43524462 1.146 ENSMUST00000026196.7
Got1
glutamate oxaloacetate transaminase 1, soluble
chr9_-_59486323 1.128 ENSMUST00000165322.1
Arih1
ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)
chr19_+_44203265 1.106 ENSMUST00000026220.5
Scd3
stearoyl-coenzyme A desaturase 3
chr4_+_132351768 1.085 ENSMUST00000172202.1
Gm17300
predicted gene, 17300
chr5_+_34999070 1.080 ENSMUST00000114280.1
Rgs12
regulator of G-protein signaling 12
chr8_-_105851981 1.052 ENSMUST00000040776.4
Cenpt
centromere protein T
chr13_-_27582168 1.032 ENSMUST00000006664.1
ENSMUST00000095926.1
Prl8a1

prolactin family 8, subfamily a, member 1

chr13_+_22035821 1.025 ENSMUST00000110455.2
Hist1h2bk
histone cluster 1, H2bk
chr7_-_141902361 1.019 ENSMUST00000055819.6
ENSMUST00000130439.1
ENSMUST00000001950.5
Tollip


toll interacting protein


chr19_-_10604258 0.948 ENSMUST00000037678.6
Dak
dihydroxyacetone kinase 2 homolog (yeast)
chr15_-_77927728 0.916 ENSMUST00000174468.1
ENSMUST00000174529.1
ENSMUST00000173631.1
Txn2


thioredoxin 2


chr2_+_10372426 0.914 ENSMUST00000114864.2
ENSMUST00000116594.2
ENSMUST00000041105.6
Sfmbt2


Scm-like with four mbt domains 2


chr16_+_20717665 0.893 ENSMUST00000021405.7
Polr2h
polymerase (RNA) II (DNA directed) polypeptide H
chr9_+_38719024 0.872 ENSMUST00000129598.1
Vwa5a
von Willebrand factor A domain containing 5A
chr2_-_17731035 0.861 ENSMUST00000028080.5
Nebl
nebulette
chr6_+_127446819 0.799 ENSMUST00000112191.1
Parp11
poly (ADP-ribose) polymerase family, member 11
chr5_+_34999111 0.613 ENSMUST00000114283.1
Rgs12
regulator of G-protein signaling 12
chr1_-_161131428 0.578 ENSMUST00000111611.1
Klhl20
kelch-like 20
chr2_+_152962485 0.537 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9

tubulin tyrosine ligase-like family, member 9

chr17_-_24696147 0.531 ENSMUST00000046839.8
Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr19_+_4097392 0.508 ENSMUST00000174514.1
ENSMUST00000174149.1
Cdk2ap2

CDK2-associated protein 2

chr12_-_81532840 0.487 ENSMUST00000166664.1
ENSMUST00000164386.1
ENSMUST00000169158.1
ENSMUST00000164431.1
ENSMUST00000163402.1
Gm20498

Synj2bp


predicted gene 20498

synaptojanin 2 binding protein


chr5_+_24100578 0.484 ENSMUST00000030841.5
ENSMUST00000163409.1
Klhl7

kelch-like 7

chr7_-_64872993 0.480 ENSMUST00000094331.2
Ndnl2
necdin-like 2
chr19_+_46328179 0.470 ENSMUST00000026256.2
ENSMUST00000177667.1
Fbxl15

F-box and leucine-rich repeat protein 15

chr2_-_164857542 0.466 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
Pltp



phospholipid transfer protein



chr4_+_115057683 0.453 ENSMUST00000161601.1
Tal1
T cell acute lymphocytic leukemia 1
chr8_+_35587780 0.451 ENSMUST00000037666.5
Mfhas1
malignant fibrous histiocytoma amplified sequence 1
chr7_+_24884809 0.439 ENSMUST00000156372.1
ENSMUST00000124035.1
Rps19

ribosomal protein S19

chr15_+_83100281 0.436 ENSMUST00000167389.1
ENSMUST00000166427.1
Serhl

serine hydrolase-like

chr3_-_84305385 0.381 ENSMUST00000122849.1
ENSMUST00000132283.1
Trim2

tripartite motif-containing 2

chr19_-_47138280 0.364 ENSMUST00000140512.1
ENSMUST00000035822.1
Calhm2

calcium homeostasis modulator 2

chr11_-_98438941 0.361 ENSMUST00000002655.7
Mien1
migration and invasion enhancer 1
chr3_+_96172327 0.356 ENSMUST00000076372.4
Sf3b4
splicing factor 3b, subunit 4
chr1_-_38664947 0.323 ENSMUST00000039827.7
ENSMUST00000027250.7
Aff3

AF4/FMR2 family, member 3

chrX_-_37191160 0.311 ENSMUST00000016571.7
Ndufa1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1
chr5_-_138272733 0.275 ENSMUST00000161665.1
ENSMUST00000100530.1
Gal3st4

galactose-3-O-sulfotransferase 4

chr3_-_146495115 0.195 ENSMUST00000093951.2
Spata1
spermatogenesis associated 1
chr4_+_108459389 0.109 ENSMUST00000106673.1
ENSMUST00000043368.5
Zcchc11

zinc finger, CCHC domain containing 11

chr2_+_180078623 0.103 ENSMUST00000087563.6
Mtg2
mitochondrial ribosome associated GTPase 2
chr7_-_19458494 0.056 ENSMUST00000085715.5
Mark4
MAP/microtubule affinity-regulating kinase 4
chr4_+_141213948 0.055 ENSMUST00000097813.2
Rsg1
REM2 and RAB-like small GTPase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
17.4 52.2 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
3.5 10.5 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
3.4 30.4 GO:0071493 cellular response to UV-B(GO:0071493)
2.6 7.8 GO:0002865 immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
2.4 28.8 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
2.1 8.6 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
2.1 10.6 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
2.1 8.3 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
1.7 18.4 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
1.6 23.8 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
1.3 4.0 GO:0070488 neutrophil aggregation(GO:0070488)
1.3 6.6 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
1.2 7.3 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
1.2 8.2 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
1.0 15.7 GO:0070986 left/right axis specification(GO:0070986)
0.9 2.7 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.9 6.0 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.7 5.2 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.7 16.0 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.7 3.5 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.7 2.0 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.7 6.0 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.6 2.6 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.6 2.5 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.6 9.3 GO:0099623 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) regulation of cardiac muscle cell membrane repolarization(GO:0099623)
0.6 61.7 GO:0007052 mitotic spindle organization(GO:0007052)
0.5 1.6 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.5 32.5 GO:0007019 microtubule depolymerization(GO:0007019)
0.4 12.9 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.4 2.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.4 4.6 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.4 1.1 GO:0006106 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.4 6.2 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.3 1.4 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.3 6.0 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.3 4.1 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.3 1.1 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.3 3.5 GO:0061436 establishment of skin barrier(GO:0061436)
0.2 1.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 1.3 GO:0016266 O-glycan processing(GO:0016266)
0.2 2.0 GO:0046512 sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.2 1.2 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.2 3.9 GO:0097062 dendritic spine maintenance(GO:0097062)
0.1 0.5 GO:0042360 vitamin E metabolic process(GO:0042360)
0.1 2.3 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 7.6 GO:1902017 regulation of cilium assembly(GO:1902017)
0.1 2.6 GO:0060259 regulation of feeding behavior(GO:0060259)
0.1 4.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 1.9 GO:0048266 behavioral response to pain(GO:0048266)
0.1 1.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.3 GO:0035137 embryonic hindlimb morphogenesis(GO:0035116) hindlimb morphogenesis(GO:0035137)
0.1 4.1 GO:0032611 interleukin-1 beta production(GO:0032611)
0.1 2.0 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 0.9 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 3.4 GO:0051260 protein homooligomerization(GO:0051260)
0.1 0.5 GO:0097421 liver regeneration(GO:0097421)
0.0 1.0 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 4.5 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.0 0.5 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 8.8 GO:0042113 B cell activation(GO:0042113)
0.0 1.2 GO:0007608 sensory perception of smell(GO:0007608)
0.0 1.6 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.6 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.5 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 3.0 GO:0051028 mRNA transport(GO:0051028)
0.0 2.7 GO:0006334 nucleosome assembly(GO:0006334)
0.0 4.0 GO:0007018 microtubule-based movement(GO:0007018)
0.0 1.9 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.5 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.4 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 4.2 GO:0042176 regulation of protein catabolic process(GO:0042176)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
10.3 61.7 GO:0031262 Ndc80 complex(GO:0031262)
8.2 24.6 GO:0070557 PCNA-p21 complex(GO:0070557)
6.0 23.8 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
3.2 16.2 GO:0000235 astral microtubule(GO:0000235)
2.7 54.5 GO:0031616 spindle pole centrosome(GO:0031616)
1.6 38.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
1.5 18.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.0 6.0 GO:0045179 apical cortex(GO:0045179)
0.8 10.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.8 8.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.7 10.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.7 2.0 GO:0033193 Lsd1/2 complex(GO:0033193)
0.5 33.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 6.1 GO:0097539 ciliary transition fiber(GO:0097539)
0.3 4.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.3 3.7 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.3 3.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 33.0 GO:0032993 protein-DNA complex(GO:0032993)
0.2 2.7 GO:0042101 T cell receptor complex(GO:0042101)
0.2 10.8 GO:0005882 intermediate filament(GO:0005882)
0.2 6.6 GO:0097440 apical dendrite(GO:0097440)
0.2 8.7 GO:0005871 kinesin complex(GO:0005871)
0.1 1.1 GO:0097413 Lewy body(GO:0097413)
0.1 1.2 GO:0097227 sperm annulus(GO:0097227)
0.1 5.8 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 8.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 17.8 GO:0043679 axon terminus(GO:0043679)
0.1 6.6 GO:0016605 PML body(GO:0016605)
0.1 3.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 6.2 GO:0005884 actin filament(GO:0005884)
0.0 3.0 GO:0005643 nuclear pore(GO:0005643)
0.0 0.9 GO:0016235 aggresome(GO:0016235)
0.0 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 2.2 GO:0005604 basement membrane(GO:0005604)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 10.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 2.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 27.2 GO:0005794 Golgi apparatus(GO:0005794)
0.0 1.1 GO:0072562 blood microparticle(GO:0072562)
0.0 5.6 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 0.6 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
8.2 24.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
3.7 52.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
3.7 18.4 GO:0042289 MHC class II protein binding(GO:0042289)
2.3 16.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
1.9 5.8 GO:0050501 hyaluronan synthase activity(GO:0050501)
1.5 10.7 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
1.2 3.5 GO:0008384 IkappaB kinase activity(GO:0008384)
1.0 23.8 GO:0000400 four-way junction DNA binding(GO:0000400)
1.0 8.2 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
1.0 6.0 GO:0008494 translation activator activity(GO:0008494)
0.9 8.4 GO:0043237 laminin-1 binding(GO:0043237)
0.8 2.5 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.7 6.0 GO:0046790 virion binding(GO:0046790)
0.7 7.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.7 4.0 GO:0050786 arachidonic acid binding(GO:0050544) RAGE receptor binding(GO:0050786)
0.6 2.6 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.6 8.3 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.5 3.2 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.4 4.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.4 12.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.4 1.1 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.4 2.7 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.4 24.8 GO:0003777 microtubule motor activity(GO:0003777)
0.3 2.0 GO:0017040 ceramidase activity(GO:0017040)
0.3 0.9 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.3 4.6 GO:0016594 glycine binding(GO:0016594)
0.3 1.1 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.2 4.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 4.2 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.2 1.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 6.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 0.6 GO:0019961 interferon binding(GO:0019961)
0.2 2.1 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.2 8.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 34.4 GO:0001047 core promoter binding(GO:0001047)
0.1 0.5 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 1.3 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 0.9 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 2.0 GO:0016854 racemase and epimerase activity(GO:0016854)
0.1 1.0 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 7.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 7.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 9.2 GO:0019905 syntaxin binding(GO:0019905)
0.1 0.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 2.0 GO:0030371 translation repressor activity(GO:0030371)
0.0 5.3 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.3 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.0 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 2.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 30.8 GO:0005215 transporter activity(GO:0005215)
0.0 1.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 2.6 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 2.0 GO:0042393 histone binding(GO:0042393)
0.0 1.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 4.6 GO:0003682 chromatin binding(GO:0003682)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 24.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 8.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.4 18.4 NABA_COLLAGENS Genes encoding collagen proteins
0.3 6.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.3 7.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 7.6 PID_PLK1_PATHWAY PLK1 signaling events
0.1 7.3 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 9.9 PID_E2F_PATHWAY E2F transcription factor network
0.1 6.0 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 1.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.0 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 1.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 52.2 REACTOME_KINESINS Genes involved in Kinesins
1.8 16.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.9 24.6 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.6 62.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.6 5.8 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.4 8.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.4 18.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 3.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.3 1.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.3 4.1 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 23.8 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 10.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 4.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 4.5 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 2.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 7.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.2 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 3.2 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 3.7 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 1.1 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.9 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 6.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.5 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.3 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.0 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.4 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway