Motif ID: Trp53

Z-value: 1.454


Transcription factors associated with Trp53:

Gene SymbolEntrez IDGene Name
Trp53 ENSMUSG00000059552.7 Trp53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp53mm10_v2_chr11_+_69580392_695804190.325.2e-03Click!


Activity profile for motif Trp53.

activity profile for motif Trp53


Sorted Z-values histogram for motif Trp53

Sorted Z-values for motif Trp53



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp53

PNG image of the network

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Top targets:


Showing 1 to 20 of 149 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_69206146 34.280 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr1_+_6487231 28.844 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr17_-_33890584 27.412 ENSMUST00000114361.2
ENSMUST00000173492.1
 Kifc1

kinesin family member C1

chr2_-_69206133 27.404 ENSMUST00000112320.1
 Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr8_+_94977101 25.848 ENSMUST00000179619.1
 Gpr56
G protein-coupled receptor 56
chr17_-_33890539 24.767 ENSMUST00000173386.1
 Kifc1
kinesin family member C1
chr17_+_29090969 24.553 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr14_+_13454010 22.686 ENSMUST00000112656.2
 Synpr
synaptoporin
chr3_-_75956888 17.234 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
 Golim4


golgi integral membrane protein 4


chr15_+_85859689 16.878 ENSMUST00000170629.1
 Gtse1
G two S phase expressed protein 1
chr8_-_22185758 16.323 ENSMUST00000046916.7
 Ckap2
cytoskeleton associated protein 2
chr11_-_102925086 16.162 ENSMUST00000021311.9
 Kif18b
kinesin family member 18B
chr14_+_13453937 16.035 ENSMUST00000153954.1
 Synpr
synaptoporin
chr14_+_73237891 15.958 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr14_-_34374617 12.906 ENSMUST00000023826.4
 Sncg
synuclein, gamma
chr14_-_54926784 12.671 ENSMUST00000022813.6
 Efs
embryonal Fyn-associated substrate
chr9_+_45138437 10.703 ENSMUST00000060125.5
 Scn4b
sodium channel, type IV, beta
chr9_-_106158109 10.609 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
 Glyctk



glycerate kinase



chr10_+_93641041 10.605 ENSMUST00000020204.4
 Ntn4
netrin 4
chr1_+_82339049 10.526 ENSMUST00000140020.1
 Rhbdd1
rhomboid domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 61.7 GO:0007052 mitotic spindle organization(GO:0007052)
17.4 52.2 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.5 32.5 GO:0007019 microtubule depolymerization(GO:0007019)
3.4 30.4 GO:0071493 cellular response to UV-B(GO:0071493)
2.4 28.8 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.6 23.8 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
1.7 18.4 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.7 16.0 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
1.0 15.7 GO:0070986 left/right axis specification(GO:0070986)
0.4 12.9 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
2.1 10.6 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
3.5 10.5 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.6 9.3 GO:0099623 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) regulation of cardiac muscle cell membrane repolarization(GO:0099623)
0.0 8.8 GO:0042113 B cell activation(GO:0042113)
2.1 8.6 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
2.1 8.3 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
1.2 8.2 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
2.6 7.8 GO:0002865 immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.1 7.6 GO:1902017 regulation of cilium assembly(GO:1902017)
1.2 7.3 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.3 61.7 GO:0031262 Ndc80 complex(GO:0031262)
2.7 54.5 GO:0031616 spindle pole centrosome(GO:0031616)
1.6 38.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.5 33.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 33.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 27.2 GO:0005794 Golgi apparatus(GO:0005794)
8.2 24.6 GO:0070557 PCNA-p21 complex(GO:0070557)
6.0 23.8 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
1.5 18.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 17.8 GO:0043679 axon terminus(GO:0043679)
3.2 16.2 GO:0000235 astral microtubule(GO:0000235)
0.2 10.8 GO:0005882 intermediate filament(GO:0005882)
0.7 10.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.8 10.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 10.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 8.7 GO:0005871 kinesin complex(GO:0005871)
0.8 8.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 8.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 6.6 GO:0097440 apical dendrite(GO:0097440)
0.1 6.6 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 52.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 34.4 GO:0001047 core promoter binding(GO:0001047)
0.0 30.8 GO:0005215 transporter activity(GO:0005215)
0.4 24.8 GO:0003777 microtubule motor activity(GO:0003777)
8.2 24.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.0 23.8 GO:0000400 four-way junction DNA binding(GO:0000400)
3.7 18.4 GO:0042289 MHC class II protein binding(GO:0042289)
2.3 16.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.4 12.9 GO:0043014 alpha-tubulin binding(GO:0043014)
1.5 10.7 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 9.2 GO:0019905 syntaxin binding(GO:0019905)
0.2 8.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.9 8.4 GO:0043237 laminin-1 binding(GO:0043237)
0.6 8.3 GO:1990825 sequence-specific mRNA binding(GO:1990825)
1.0 8.2 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 7.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.7 7.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 7.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 6.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
1.0 6.0 GO:0008494 translation activator activity(GO:0008494)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 24.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 18.4 NABA_COLLAGENS Genes encoding collagen proteins
0.1 9.9 PID_E2F_PATHWAY E2F transcription factor network
0.4 8.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 7.6 PID_PLK1_PATHWAY PLK1 signaling events
0.3 7.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 7.3 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.3 6.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 6.0 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.0 PID_IL1_PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 62.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.9 52.2 REACTOME_KINESINS Genes involved in Kinesins
0.9 24.6 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 23.8 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.4 18.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
1.8 16.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.2 10.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.4 8.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 7.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 6.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.6 5.8 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 4.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 4.5 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.3 4.1 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.7 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.3 3.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 3.2 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.2 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery