Motif ID: Trp63

Z-value: 0.895


Transcription factors associated with Trp63:

Gene SymbolEntrez IDGene Name
Trp63 ENSMUSG00000022510.8 Trp63



Activity profile for motif Trp63.

activity profile for motif Trp63


Sorted Z-values histogram for motif Trp63

Sorted Z-values for motif Trp63



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp63

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_116038734 19.990 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr17_+_29090969 14.185 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr6_+_34709442 11.980 ENSMUST00000115021.1
 Cald1
caldesmon 1
chr6_+_34709610 11.556 ENSMUST00000031775.6
 Cald1
caldesmon 1
chr11_-_101466222 11.376 ENSMUST00000040430.7
 Vat1
vesicle amine transport protein 1 homolog (T californica)
chr1_-_9700209 10.350 ENSMUST00000088658.4
 Mybl1
myeloblastosis oncogene-like 1
chr7_-_141443314 8.320 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr12_-_108003594 7.887 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr12_-_108003414 7.745 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr19_-_5875210 7.283 ENSMUST00000155227.1
 Frmd8
FERM domain containing 8
chr11_-_69948145 6.936 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
 Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr7_-_37772868 6.868 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr19_-_5875268 6.739 ENSMUST00000025728.6
 Frmd8
FERM domain containing 8
chr8_-_87959560 6.059 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr11_-_106487796 5.285 ENSMUST00000001059.2
ENSMUST00000106799.1
ENSMUST00000106800.1
 Ern1


endoplasmic reticulum (ER) to nucleus signalling 1


chr8_-_31918203 4.915 ENSMUST00000073884.4
 Nrg1
neuregulin 1
chr11_-_106487833 4.706 ENSMUST00000106801.1
 Ern1
endoplasmic reticulum (ER) to nucleus signalling 1
chr2_-_170427828 4.270 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
 Bcas1


breast carcinoma amplified sequence 1


chr3_-_108402589 3.403 ENSMUST00000147565.1
 Celsr2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr10_-_80671976 3.292 ENSMUST00000003433.6
 Mknk2
MAP kinase-interacting serine/threonine kinase 2
chr2_+_59612034 2.728 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr4_-_96591555 2.713 ENSMUST00000055693.8
 Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr7_-_65370908 2.708 ENSMUST00000032729.6
 Tjp1
tight junction protein 1
chr4_-_134018829 2.362 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr16_+_37868383 1.889 ENSMUST00000078717.6
 Lrrc58
leucine rich repeat containing 58
chr8_-_47352348 1.859 ENSMUST00000110367.2
 Stox2
storkhead box 2
chrX_+_159255919 1.856 ENSMUST00000112492.1
 Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr15_+_76696725 1.766 ENSMUST00000023203.4
 Gpt
glutamic pyruvic transaminase, soluble
chr11_+_98863610 1.422 ENSMUST00000142414.1
ENSMUST00000037480.8
 Wipf2

WAS/WASL interacting protein family, member 2

chrX_+_159255782 1.353 ENSMUST00000126686.1
ENSMUST00000033671.6
 Rps6ka3

ribosomal protein S6 kinase polypeptide 3

chr7_-_65371210 1.152 ENSMUST00000102592.3
 Tjp1
tight junction protein 1
chr8_+_84686300 1.001 ENSMUST00000177531.1
 Trmt1
tRNA methyltransferase 1
chr7_-_126160992 1.001 ENSMUST00000164741.1
 Xpo6
exportin 6
chr5_-_5265224 0.828 ENSMUST00000115450.1
 Cdk14
cyclin-dependent kinase 14
chr18_-_15718046 0.589 ENSMUST00000053017.6
 Chst9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr10_-_61452658 0.571 ENSMUST00000167087.1
ENSMUST00000020288.7
 Eif4ebp2

eukaryotic translation initiation factor 4E binding protein 2

chr14_-_122451109 0.565 ENSMUST00000081580.2
 Gm5089
predicted gene 5089
chr19_-_6080311 0.459 ENSMUST00000159832.1
 Vps51
vacuolar protein sorting 51 homolog (S. cerevisiae)
chr2_+_25054396 0.239 ENSMUST00000102931.4
ENSMUST00000074422.7
ENSMUST00000132172.1
ENSMUST00000114388.1
ENSMUST00000114386.1
 Nsmf




NMDA receptor synaptonuclear signaling and neuronal migration factor




chr7_-_114254659 0.212 ENSMUST00000033012.7
 Copb1
coatomer protein complex, subunit beta 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 15.6 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
2.3 11.4 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
2.0 10.0 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
1.8 20.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
1.6 14.2 GO:0071493 cellular response to UV-B(GO:0071493)
0.9 3.4 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.7 4.9 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.4 6.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 23.5 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.3 1.0 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.3 3.9 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.3 6.9 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.3 2.4 GO:0010587 miRNA catabolic process(GO:0010587)
0.3 3.3 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.1 6.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 2.7 GO:0097062 dendritic spine maintenance(GO:0097062)
0.1 0.2 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.0 3.2 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.6 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 1.0 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.5 GO:0032456 endocytic recycling(GO:0032456)
0.0 9.2 GO:0000278 mitotic cell cycle(GO:0000278)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 14.2 GO:0070557 PCNA-p21 complex(GO:0070557)
2.6 23.5 GO:0030478 actin cap(GO:0030478)
2.0 10.0 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.5 3.9 GO:0046581 intercellular canaliculus(GO:0046581)
0.4 6.9 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 4.9 GO:0030673 axolemma(GO:0030673)
0.1 0.5 GO:1990745 EARP complex(GO:1990745)
0.1 11.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 20.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 2.7 GO:0043679 axon terminus(GO:0043679)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 14.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.7 6.9 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
1.3 10.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.5 10.0 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.5 6.9 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.4 3.9 GO:0071253 connexin binding(GO:0071253)
0.3 4.9 GO:0045499 chemorepellent activity(GO:0045499)
0.3 3.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 2.4 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.2 1.0 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.6 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.1 20.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.8 GO:0008483 transaminase activity(GO:0008483)
0.1 3.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 24.2 GO:0003779 actin binding(GO:0003779)
0.0 15.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 11.4 GO:0016491 oxidoreductase activity(GO:0016491)
0.0 10.3 GO:0042803 protein homodimerization activity(GO:0042803)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 14.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3 4.9 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.2 6.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.2 10.3 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 6.5 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 3.9 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 6.9 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.6 23.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.6 3.9 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.5 4.9 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.5 14.2 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 10.0 REACTOME_UNFOLDED_PROTEIN_RESPONSE Genes involved in Unfolded Protein Response
0.1 3.2 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 1.8 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.6 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.2 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport