ISMARA results: Trp73

Motif ID: Trp73

Z-value: 0.540

Transcription factors associated with Trp73:

Gene Symbol	Entrez ID	Gene Name
Trp73	ENSMUSG00000029026.10	Trp73

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Trp73	mm10_v2_chr4_-_154097105_154097173	0.46	2.4e-05	Click!

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Top targets:

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Showing 1 to 20 of 74 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr7_-_116038734	6.764	ENSMUST00000166877.1	Sox6	SRY-box containing gene 6
chr7_-_141443314	5.376	ENSMUST00000106005.2	Lrdd	leucine-rich and death domain containing
chr1_+_135729147	5.362	ENSMUST00000027677.7	Csrp1	cysteine and glycine-rich protein 1
chr1_+_153665274	5.293	ENSMUST00000152114.1 ENSMUST00000111812.1	Rgs8	regulator of G-protein signaling 8
chr17_+_29090969	5.012	ENSMUST00000119901.1	Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)
chr12_-_45074112	4.130	ENSMUST00000120531.1 ENSMUST00000143376.1	Stxbp6	syntaxin binding protein 6 (amisyn)
chrX_+_10717390	3.859	ENSMUST00000115524.1 ENSMUST00000008179.6	Mid1ip1	Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr13_+_48261427	3.700	ENSMUST00000021810.1	Id4	inhibitor of DNA binding 4
chr1_+_72824482	3.614	ENSMUST00000047328.4	Igfbp2	insulin-like growth factor binding protein 2
chrX_+_10717451	3.497	ENSMUST00000156321.1	Mid1ip1	Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr12_-_45074457	3.466	ENSMUST00000053768.6	Stxbp6	syntaxin binding protein 6 (amisyn)
chr16_-_17125106	3.449	ENSMUST00000093336.6	2610318N02Rik	RIKEN cDNA 2610318N02 gene
chr4_+_62583568	2.635	ENSMUST00000098031.3	Rgs3	regulator of G-protein signaling 3
chr9_-_67760208	2.585	ENSMUST00000068526.5	M5C1000I18Rik	RIKEN cDNA M5C1000I18 gene
chr11_-_69948145	2.489	ENSMUST00000179298.1 ENSMUST00000018710.6 ENSMUST00000135437.1 ENSMUST00000141837.2 ENSMUST00000142500.1	Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4
chr4_-_45489794	2.453	ENSMUST00000146236.1	Shb	src homology 2 domain-containing transforming protein B
chr11_-_102230091	2.338	ENSMUST00000008999.5	Hdac5	histone deacetylase 5
chr11_-_102230127	2.263	ENSMUST00000107150.1 ENSMUST00000156337.1 ENSMUST00000107151.2 ENSMUST00000107152.2	Hdac5	histone deacetylase 5
chr3_-_107931579	2.206	ENSMUST00000133947.2 ENSMUST00000124215.1 ENSMUST00000106688.1 ENSMUST00000106687.2	Gstm7	glutathione S-transferase, mu 7
chr15_+_84232030	2.040	ENSMUST00000023072.6	Parvb	parvin, beta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 38 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	7.6	GO:0035542	regulation of SNARE complex assembly(GO:0035542)
0.4	7.4	GO:0045723	positive regulation of fatty acid biosynthetic process(GO:0045723)
0.6	6.8	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.4	5.3	GO:0007213	G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159)
0.6	5.0	GO:0071493	cellular response to UV-B(GO:0071493)
0.1	5.0	GO:0070527	platelet aggregation(GO:0070527)
0.5	4.6	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.9	3.7	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.9	3.7	GO:0042360	vitamin E metabolic process(GO:0042360)
0.2	3.6	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.6	2.5	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.3	2.5	GO:1900194	negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.1	2.5	GO:0044381	glucose import in response to insulin stimulus(GO:0044381)
0.6	2.2	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.7	2.0	GO:0071963	establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.7	2.0	GO:0061357	Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.1	1.8	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.0	1.8	GO:0042462	eye photoreceptor cell development(GO:0042462)
0.0	1.7	GO:0006749	glutathione metabolic process(GO:0006749)
0.2	1.6	GO:0045900	negative regulation of translational elongation(GO:0045900)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 25 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.6	GO:0000145	exocyst(GO:0000145)
0.0	7.6	GO:0005667	transcription factor complex(GO:0005667)
0.0	7.4	GO:0005874	microtubule(GO:0005874)
0.0	6.9	GO:0005925	focal adhesion(GO:0005925)
1.7	5.0	GO:0070557	PCNA-p21 complex(GO:0070557)
0.1	5.0	GO:0032809	neuronal cell body membrane(GO:0032809)
0.6	4.6	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.0	3.3	GO:0016324	apical plasma membrane(GO:0016324)
0.1	2.5	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	2.5	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.1	2.4	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	2.2	GO:0016529	sarcoplasmic reticulum(GO:0016529)
0.2	1.8	GO:0061700	GATOR2 complex(GO:0061700)
0.0	1.8	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.3	1.7	GO:0035189	Rb-E2F complex(GO:0035189)
0.1	1.6	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.1	1.0	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.9	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	0.6	GO:0043034	costamere(GO:0043034)
0.0	0.5	GO:0008250	oligosaccharyltransferase complex(GO:0008250)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 35 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.6	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0	6.8	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	5.3	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
1.7	5.0	GO:0019912	cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.7	4.6	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.0	4.0	GO:0008022	protein C-terminus binding(GO:0008022)
0.0	3.7	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.5	3.6	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.6	2.5	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.1	2.5	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.1	2.2	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.2	2.0	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.3	1.8	GO:0070728	leucine binding(GO:0070728)
0.2	1.7	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	1.7	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.1	1.6	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1	1.5	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1	1.4	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.1	1.0	GO:0008242	omega peptidase activity(GO:0008242)
0.1	1.0	GO:0008483	transaminase activity(GO:0008483)

Gene overrepresentation in C2:CP category:

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Showing 1 to 14 of 14 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	5.0	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	4.6	PID_HDAC_CLASSII_PATHWAY	Signaling events mediated by HDAC Class II
0.1	3.0	PID_EPHRINB_REV_PATHWAY	Ephrin B reverse signaling
0.0	3.0	NABA_ECM_GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	2.5	PID_PDGFRA_PATHWAY	PDGFR-alpha signaling pathway
0.1	2.5	PID_INSULIN_GLUCOSE_PATHWAY	Insulin-mediated glucose transport
0.0	2.0	PID_ILK_PATHWAY	Integrin-linked kinase signaling
0.0	1.8	PID_P53_DOWNSTREAM_PATHWAY	Direct p53 effectors
0.0	1.7	PID_FOXM1_PATHWAY	FOXM1 transcription factor network
0.0	1.1	ST_G_ALPHA_I_PATHWAY	G alpha i Pathway
0.0	1.0	PID_PRL_SIGNALING_EVENTS_PATHWAY	Signaling events mediated by PRL
0.0	0.9	PID_E2F_PATHWAY	E2F transcription factor network
0.0	0.6	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	0.4	PID_TELOMERASE_PATHWAY	Regulation of Telomerase

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 14 of 14 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.4	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	Genes involved in G alpha (i) signalling events
0.2	5.0	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.1	4.6	REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3	3.7	REACTOME_HDL_MEDIATED_LIPID_TRANSPORT	Genes involved in HDL-mediated lipid transport
0.2	3.6	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2	2.5	REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.1	2.0	REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	1.7	REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1	1.0	REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	1.0	REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.9	REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.0	0.4	REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	0.3	REACTOME_CD28_DEPENDENT_VAV1_PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.2	REACTOME_UNWINDING_OF_DNA	Genes involved in Unwinding of DNA