Motif ID: Vsx1_Uncx_Prrx2_Shox2_Noto

Z-value: 1.535

Transcription factors associated with Vsx1_Uncx_Prrx2_Shox2_Noto:

Gene SymbolEntrez IDGene Name
Noto ENSMUSG00000068302.7 Noto
Prrx2 ENSMUSG00000039476.7 Prrx2
Shox2 ENSMUSG00000027833.10 Shox2
Uncx ENSMUSG00000029546.11 Uncx
Vsx1 ENSMUSG00000033080.8 Vsx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Uncxmm10_v2_chr5_+_139543889_1395439040.757.8e-15Click!
Shox2mm10_v2_chr3_-_66981279_669813180.324.0e-03Click!
Prrx2mm10_v2_chr2_+_30845059_30845059-0.075.6e-01Click!


Activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto.

activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto


Sorted Z-values histogram for motif Vsx1_Uncx_Prrx2_Shox2_Noto

Sorted Z-values for motif Vsx1_Uncx_Prrx2_Shox2_Noto



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx1_Uncx_Prrx2_Shox2_Noto

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_118478182 87.508 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 83.374 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr5_+_139543889 80.743 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr8_-_61902669 50.563 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr3_+_55782500 42.406 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr4_-_97778042 37.837 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr14_-_48665098 31.978 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr7_-_49636847 28.873 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr5_-_62766153 28.206 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_25372315 28.115 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr13_+_44121167 26.670 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr12_+_38780284 26.654 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr2_+_20737306 26.001 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr3_-_86548268 25.981 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr8_+_45658666 25.362 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr17_+_34592248 25.019 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr14_-_118052235 24.750 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr8_+_45658731 24.530 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr15_+_25773985 24.474 ENSMUST00000125667.1
 Myo10
myosin X
chr7_-_37773555 24.024 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
57.0 170.9 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
9.1 100.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
10.1 80.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.4 63.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
3.4 54.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
2.7 50.6 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
2.0 35.6 GO:0001833 inner cell mass cell proliferation(GO:0001833)
8.8 35.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
2.4 31.8 GO:0021796 cerebral cortex regionalization(GO:0021796)
10.2 30.7 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
2.2 28.9 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 25.0 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
4.1 24.8 GO:0006570 tyrosine metabolic process(GO:0006570)
8.2 24.6 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
1.0 24.6 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 24.5 GO:0022409 positive regulation of cell-cell adhesion(GO:0022409)
1.1 21.6 GO:0007530 sex determination(GO:0007530)
1.4 19.5 GO:0060013 righting reflex(GO:0060013)
3.9 19.4 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
6.4 19.1 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 629.9 GO:0005634 nucleus(GO:0005634)
0.2 70.9 GO:0005667 transcription factor complex(GO:0005667)
1.1 50.6 GO:0002102 podosome(GO:0002102)
0.3 35.6 GO:0000792 heterochromatin(GO:0000792)
0.9 24.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
6.2 24.6 GO:0060187 cell pole(GO:0060187)
0.4 24.5 GO:0016459 myosin complex(GO:0016459)
3.1 18.6 GO:0000444 MIS12/MIND type complex(GO:0000444)
1.2 18.5 GO:0042788 polysomal ribosome(GO:0042788)
0.2 16.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 15.4 GO:0005769 early endosome(GO:0005769)
0.3 14.8 GO:0070382 exocytic vesicle(GO:0070382)
0.1 14.7 GO:0005925 focal adhesion(GO:0005925)
0.4 12.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 11.8 GO:0097440 apical dendrite(GO:0097440)
0.1 11.7 GO:0005938 cell cortex(GO:0005938)
0.3 10.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 9.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 9.4 GO:0005615 extracellular space(GO:0005615)
1.5 9.0 GO:0000172 ribonuclease MRP complex(GO:0000172)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 273.0 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.6 194.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
2.7 177.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
4.5 67.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 42.4 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.1 36.6 GO:0019904 protein domain specific binding(GO:0019904)
4.6 32.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
3.8 30.7 GO:0050693 LBD domain binding(GO:0050693)
1.9 24.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.5 23.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.7 21.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.6 20.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.9 19.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.8 19.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
1.6 18.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.5 18.5 GO:0017091 AU-rich element binding(GO:0017091)
2.0 18.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 17.9 GO:0003779 actin binding(GO:0003779)
0.3 17.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.3 16.8 GO:0030507 spectrin binding(GO:0030507)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 170.9 PID_IL12_2PATHWAY IL12-mediated signaling events
3.1 104.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.7 32.0 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.3 30.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.6 24.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.6 23.3 PID_ARF6_PATHWAY Arf6 signaling events
0.7 21.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.7 19.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.7 15.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.3 14.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 12.6 NABA_COLLAGENS Genes encoding collagen proteins
0.1 10.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 9.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 9.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 6.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 4.0 ST_ADRENERGIC Adrenergic Pathway
0.3 3.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 3.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 3.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 37.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.8 32.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 31.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.4 24.2 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 20.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 12.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 12.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 8.3 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.3 7.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 6.7 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.4 6.4 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.7 6.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.2 6.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.5 5.1 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 4.8 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.4 4.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.2 4.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 4.1 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.4 3.7 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 3.7 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction