Motif ID: Wrnip1_Mta3_Rcor1

Z-value: 3.978

Transcription factors associated with Wrnip1_Mta3_Rcor1:

Gene SymbolEntrez IDGene Name
Mta3 ENSMUSG00000055817.11 Mta3
Rcor1 ENSMUSG00000037896.11 Rcor1
Wrnip1 ENSMUSG00000021400.6 Wrnip1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rcor1mm10_v2_chr12_+_111039334_111039400-0.783.1e-17Click!
Wrnip1mm10_v2_chr13_+_32802007_328021520.504.3e-06Click!
Mta3mm10_v2_chr17_+_83706170_837062000.281.3e-02Click!


Activity profile for motif Wrnip1_Mta3_Rcor1.

activity profile for motif Wrnip1_Mta3_Rcor1


Sorted Z-values histogram for motif Wrnip1_Mta3_Rcor1

Sorted Z-values for motif Wrnip1_Mta3_Rcor1



Network of associatons between targets according to the STRING database.



First level regulatory network of Wrnip1_Mta3_Rcor1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_180499893 37.636 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr11_+_101246405 31.051 ENSMUST00000122006.1
ENSMUST00000151830.1
 Ramp2

receptor (calcitonin) activity modifying protein 2

chrX_+_73483602 29.053 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr7_-_120202104 27.452 ENSMUST00000033198.5
 Crym
crystallin, mu
chr15_-_66948419 26.677 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr5_+_90772435 24.055 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr17_-_29237759 23.893 ENSMUST00000137727.1
ENSMUST00000024805.7
 Cpne5

copine V

chr7_-_31042078 23.689 ENSMUST00000162116.1
ENSMUST00000159924.1
ENSMUST00000159753.1
ENSMUST00000160689.1
ENSMUST00000162733.1
ENSMUST00000162087.1
ENSMUST00000009831.7
 Fxyd5






FXYD domain-containing ion transport regulator 5






chr7_+_43797567 23.606 ENSMUST00000085461.2
 Klk8
kallikrein related-peptidase 8
chr7_-_19699008 23.504 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr8_+_70501116 23.160 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr5_+_130448801 22.837 ENSMUST00000111288.2
 Caln1
calneuron 1
chr9_-_110742577 22.620 ENSMUST00000006005.7
 Pth1r
parathyroid hormone 1 receptor
chr2_+_90885860 22.449 ENSMUST00000111466.2
 C1qtnf4
C1q and tumor necrosis factor related protein 4
chr10_+_79716588 21.874 ENSMUST00000099513.1
ENSMUST00000020581.2
 Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr4_-_139092958 21.545 ENSMUST00000042844.6
 Nbl1
neuroblastoma, suppression of tumorigenicity 1
chr4_-_138396438 21.230 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr11_+_104132841 21.014 ENSMUST00000093925.4
 Crhr1
corticotropin releasing hormone receptor 1
chr8_+_11312805 20.806 ENSMUST00000033899.7
 Col4a2
collagen, type IV, alpha 2
chr18_-_66291770 20.773 ENSMUST00000130300.1
 Ccbe1
collagen and calcium binding EGF domains 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,519 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 96.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
2.2 86.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
13.9 83.5 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
2.8 78.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
3.8 76.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
2.2 75.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
3.6 68.0 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
1.4 66.5 GO:0032543 mitochondrial translation(GO:0032543)
1.6 64.9 GO:0006414 translational elongation(GO:0006414)
7.0 63.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
2.4 61.2 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
6.7 60.5 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
1.5 60.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
2.3 54.9 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
3.1 53.3 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
3.5 52.7 GO:0048681 negative regulation of axon regeneration(GO:0048681)
2.9 52.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
4.8 48.3 GO:0034116 positive regulation of heterotypic cell-cell adhesion(GO:0034116)
1.9 48.3 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
6.8 47.7 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 451 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 875.5 GO:0016021 integral component of membrane(GO:0016021)
0.7 447.2 GO:0005615 extracellular space(GO:0005615)
0.4 439.8 GO:0005576 extracellular region(GO:0005576)
0.5 240.7 GO:0005887 integral component of plasma membrane(GO:0005887)
1.3 227.3 GO:0070382 exocytic vesicle(GO:0070382)
1.0 226.9 GO:0097060 synaptic membrane(GO:0097060)
0.7 226.0 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
2.8 210.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.0 208.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
3.1 201.8 GO:0005581 collagen trimer(GO:0005581)
3.3 166.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.0 149.7 GO:0043209 myelin sheath(GO:0043209)
2.8 133.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.4 125.9 GO:0031225 anchored component of membrane(GO:0031225)
0.5 122.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
1.0 118.6 GO:0031012 extracellular matrix(GO:0031012)
0.7 114.2 GO:0000139 Golgi membrane(GO:0000139)
2.4 112.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
1.0 100.8 GO:0016323 basolateral plasma membrane(GO:0016323)
1.8 99.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 777 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 513.9 GO:0003735 structural constituent of ribosome(GO:0003735)
1.3 299.6 GO:0003924 GTPase activity(GO:0003924)
1.8 165.1 GO:0008201 heparin binding(GO:0008201)
7.8 116.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.6 108.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.6 107.6 GO:0008083 growth factor activity(GO:0008083)
2.1 97.1 GO:0050840 extracellular matrix binding(GO:0050840)
1.5 94.6 GO:0035254 glutamate receptor binding(GO:0035254)
1.6 88.9 GO:0005125 cytokine activity(GO:0005125)
16.4 81.9 GO:0097643 amylin receptor activity(GO:0097643)
1.1 81.6 GO:0005178 integrin binding(GO:0005178)
2.8 81.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.3 80.8 GO:0005509 calcium ion binding(GO:0005509)
3.3 79.2 GO:0003746 translation elongation factor activity(GO:0003746)
5.7 67.8 GO:0004016 adenylate cyclase activity(GO:0004016)
2.2 66.7 GO:0004364 glutathione transferase activity(GO:0004364)
1.5 66.6 GO:0030276 clathrin binding(GO:0030276)
4.9 59.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
1.9 57.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
1.9 57.5 GO:0003954 NADH dehydrogenase activity(GO:0003954)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 390.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
1.6 188.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.5 176.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
2.2 149.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
3.5 131.3 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
2.3 126.8 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
3.4 122.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
2.5 98.9 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
2.7 89.4 PID_ALK1_PATHWAY ALK1 signaling events
2.9 84.7 PID_ARF_3PATHWAY Arf1 pathway
2.1 75.9 PID_ENDOTHELIN_PATHWAY Endothelins
1.5 63.4 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
1.9 61.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.9 59.3 PID_P73PATHWAY p73 transcription factor network
3.5 58.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
1.6 56.9 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.9 56.6 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
1.9 54.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
3.0 50.6 PID_S1P_S1P4_PATHWAY S1P4 pathway
2.2 46.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 227 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 380.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
2.5 173.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
2.2 170.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
2.2 166.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
2.5 122.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
2.7 120.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
2.5 106.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.9 99.5 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
2.4 94.9 REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION Genes involved in Glucagon signaling in metabolic regulation
1.9 83.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
2.7 80.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
2.9 80.0 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
5.9 77.0 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.4 74.5 REACTOME_AMYLOIDS Genes involved in Amyloids
3.2 74.3 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
5.6 73.1 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.4 72.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
4.5 71.9 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
2.1 69.7 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
2.8 66.4 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis