Motif ID: Xbp1_Creb3l1

Z-value: 0.973

Transcription factors associated with Xbp1_Creb3l1:

Gene SymbolEntrez IDGene Name
Creb3l1 ENSMUSG00000027230.9 Creb3l1
Xbp1 ENSMUSG00000020484.12 Xbp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb3l1mm10_v2_chr2_-_92024502_920245290.561.0e-07Click!
Xbp1mm10_v2_chr11_+_5520652_5520659-0.252.7e-02Click!


Activity profile for motif Xbp1_Creb3l1.

activity profile for motif Xbp1_Creb3l1


Sorted Z-values histogram for motif Xbp1_Creb3l1

Sorted Z-values for motif Xbp1_Creb3l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Xbp1_Creb3l1

PNG image of the network

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Top targets:


Showing 1 to 20 of 188 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_45092130 21.622 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45092198 18.831 ENSMUST00000140449.1
ENSMUST00000117546.1
ENSMUST00000019683.3
 Rcn3


reticulocalbin 3, EF-hand calcium binding domain


chr7_-_45091713 12.318 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr6_-_54593139 9.658 ENSMUST00000046520.6
 Fkbp14
FK506 binding protein 14
chr15_-_32244632 8.801 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19
chr4_+_88094599 6.659 ENSMUST00000097992.3
 Focad
focadhesin
chr1_-_55226768 6.322 ENSMUST00000027121.8
ENSMUST00000114428.2
 Rftn2

raftlin family member 2

chr5_-_135251209 5.864 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr15_+_79516396 5.723 ENSMUST00000010974.7
 Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr10_+_128908907 5.030 ENSMUST00000105229.1
 Cd63
CD63 antigen
chr8_+_125995102 4.724 ENSMUST00000046765.8
 Kcnk1
potassium channel, subfamily K, member 1
chr3_+_96697076 4.456 ENSMUST00000162778.2
ENSMUST00000064900.9
 Pias3

protein inhibitor of activated STAT 3

chr3_+_96697100 4.349 ENSMUST00000107077.3
 Pias3
protein inhibitor of activated STAT 3
chr1_-_163313661 3.849 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr6_-_101377342 3.782 ENSMUST00000151175.1
 Pdzrn3
PDZ domain containing RING finger 3
chr10_+_41519493 3.549 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr5_-_71095765 3.529 ENSMUST00000000572.5
 Gabra2
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
chrX_+_136741821 3.410 ENSMUST00000089350.4
 BC065397
cDNA sequence BC065397
chr3_+_88206786 3.364 ENSMUST00000181134.1
ENSMUST00000181550.1
 Gm3764

predicted gene 3764

chr3_+_88207308 3.109 ENSMUST00000180582.1
 Gm3764
predicted gene 3764

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.8 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 8.5 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.9 6.3 GO:0032596 protein transport into membrane raft(GO:0032596) dsRNA transport(GO:0033227)
2.0 5.9 GO:1990523 bone regeneration(GO:1990523)
0.8 5.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.6 5.2 GO:0090166 Golgi disassembly(GO:0090166)
0.3 5.1 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
1.0 5.0 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.8 4.7 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.3 3.8 GO:0048664 neuron fate determination(GO:0048664)
0.1 3.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.4 3.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 3.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 3.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 3.2 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 3.1 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.3 2.9 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.3 2.8 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.0 2.7 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.3 2.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 64.0 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 7.9 GO:0005925 focal adhesion(GO:0005925)
0.2 5.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 5.4 GO:0031527 filopodium membrane(GO:0031527)
0.0 5.3 GO:0030425 dendrite(GO:0030425)
1.3 5.0 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
1.2 4.7 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 4.6 GO:0031201 SNARE complex(GO:0031201)
0.0 4.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 3.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 3.8 GO:0005844 polysome(GO:0005844)
0.0 3.8 GO:0031594 neuromuscular junction(GO:0031594)
0.2 3.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 3.5 GO:0005581 collagen trimer(GO:0005581)
0.4 3.4 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.2 2.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 2.7 GO:0001917 photoreceptor inner segment(GO:0001917)
0.2 2.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 2.2 GO:0005801 cis-Golgi network(GO:0005801)
0.3 2.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 44.9 GO:0005509 calcium ion binding(GO:0005509)
0.3 8.8 GO:0019789 SUMO transferase activity(GO:0019789)
0.4 8.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 5.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
1.3 5.4 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 5.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 5.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.4 4.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 3.8 GO:0071837 HMG box domain binding(GO:0071837)
0.9 3.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.6 3.5 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 3.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 3.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.3 2.9 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.9 2.7 GO:0001729 ceramide kinase activity(GO:0001729)
0.6 2.6 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 2.6 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 2.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 2.4 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 2.2 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.8 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.2 5.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 5.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.4 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 3.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.6 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.0 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.3 PID_ATF2_PATHWAY ATF-2 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 20.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 5.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.7 4.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 4.3 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 3.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 2.6 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 2.6 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 2.6 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 2.3 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 2.2 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.2 1.9 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.5 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 1.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 0.9 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 0.7 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.7 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.6 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein