Motif ID: Yy1_Yy2

Z-value: 3.402

Transcription factors associated with Yy1_Yy2:

Gene SymbolEntrez IDGene Name
Yy1 ENSMUSG00000021264.11 Yy1
Yy2 ENSMUSG00000091736.2 Yy2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Yy2mm10_v2_chrX_-_157598642_157598655-0.643.6e-10Click!
Yy1mm10_v2_chr12_+_108792946_108792988-0.181.3e-01Click!


Activity profile for motif Yy1_Yy2.

activity profile for motif Yy1_Yy2


Sorted Z-values histogram for motif Yy1_Yy2

Sorted Z-values for motif Yy1_Yy2



Network of associatons between targets according to the STRING database.



First level regulatory network of Yy1_Yy2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_50030735 19.729 ENSMUST00000071866.1
 Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr3_-_90213577 18.985 ENSMUST00000170122.2
 Rps27
ribosomal protein S27
chr17_-_23829095 17.679 ENSMUST00000069579.5
 Tceb2
transcription elongation factor B (SIII), polypeptide 2
chr14_-_54617993 13.256 ENSMUST00000022803.4
 Psmb5
proteasome (prosome, macropain) subunit, beta type 5
chr11_+_75732869 12.527 ENSMUST00000067664.3
 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr8_-_107263248 12.457 ENSMUST00000080443.6
 Rps18-ps3
ribosomal protein S18, pseudogene 3
chr19_+_25610533 11.772 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chrY_+_1010543 11.008 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr16_+_33056453 10.911 ENSMUST00000078804.5
ENSMUST00000115079.1
 Rpl35a

ribosomal protein L35A

chr16_-_22163299 10.897 ENSMUST00000100052.4
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr5_+_138161071 10.706 ENSMUST00000019638.8
ENSMUST00000110951.1
 Cops6

COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)

chr16_+_33056499 10.691 ENSMUST00000115078.1
 Rpl35a
ribosomal protein L35A
chr10_+_79669410 10.494 ENSMUST00000020552.5
 Tpgs1
tubulin polyglutamylase complex subunit 1
chr3_-_130730375 10.494 ENSMUST00000079085.6
 Rpl34
ribosomal protein L34
chr18_+_56707725 10.439 ENSMUST00000025486.8
 Lmnb1
lamin B1
chr19_-_59170978 10.258 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr7_-_99483645 10.229 ENSMUST00000107096.1
ENSMUST00000032998.6
 Rps3

ribosomal protein S3

chr18_+_74216118 10.215 ENSMUST00000025444.6
 Cxxc1
CXXC finger 1 (PHD domain)
chr7_-_29180454 9.900 ENSMUST00000182328.1
 Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr10_-_128549102 9.808 ENSMUST00000176906.1
 Rpl41
ribosomal protein L41

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 997 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 96.6 GO:0002181 cytoplasmic translation(GO:0002181)
1.8 75.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
2.3 72.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.1 69.6 GO:0032543 mitochondrial translation(GO:0032543)
3.0 69.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 43.6 GO:0042254 ribosome biogenesis(GO:0042254)
2.3 37.2 GO:0043248 proteasome assembly(GO:0043248)
0.7 30.7 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
1.0 28.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
1.7 28.4 GO:0000338 protein deneddylation(GO:0000338)
1.2 28.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.8 27.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
2.2 26.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
2.2 26.1 GO:0002227 innate immune response in mucosa(GO:0002227)
3.4 23.5 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
1.5 23.0 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785)
2.2 21.8 GO:0042989 sequestering of actin monomers(GO:0042989)
1.3 21.5 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
4.2 21.1 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
3.5 21.1 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 385 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 208.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 174.2 GO:0005739 mitochondrion(GO:0005739)
2.7 140.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.5 132.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
2.0 93.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
1.5 85.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
2.3 75.8 GO:0000788 nuclear nucleosome(GO:0000788)
1.6 50.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
2.1 47.5 GO:0005839 proteasome core complex(GO:0005839)
1.2 46.8 GO:0000786 nucleosome(GO:0000786)
0.0 35.9 GO:0005615 extracellular space(GO:0005615)
0.4 31.2 GO:0072562 blood microparticle(GO:0072562)
0.7 30.4 GO:0008180 COP9 signalosome(GO:0008180)
2.6 28.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
2.1 26.9 GO:0045277 respiratory chain complex IV(GO:0045277)
1.8 25.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
1.5 24.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
1.1 24.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.3 23.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
2.3 23.4 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 588 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 452.8 GO:0003735 structural constituent of ribosome(GO:0003735)
1.4 65.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
2.1 45.6 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.4 43.1 GO:0003954 NADH dehydrogenase activity(GO:0003954)
0.5 38.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.5 33.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 28.3 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.9 25.1 GO:0003785 actin monomer binding(GO:0003785)
1.2 23.9 GO:0001056 RNA polymerase III activity(GO:0001056)
0.4 23.7 GO:0003743 translation initiation factor activity(GO:0003743)
1.7 23.1 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
2.1 22.7 GO:0050815 phosphoserine binding(GO:0050815)
1.3 22.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.4 20.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
1.6 20.4 GO:0070513 death domain binding(GO:0070513)
1.1 19.9 GO:0055103 ligase regulator activity(GO:0055103)
2.0 19.7 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.7 19.6 GO:0019843 rRNA binding(GO:0019843)
6.4 19.3 GO:0015140 malate transmembrane transporter activity(GO:0015140)
1.1 17.4 GO:0008253 5'-nucleotidase activity(GO:0008253)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 53.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.9 42.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.4 39.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.5 38.3 PID_P73PATHWAY p73 transcription factor network
1.0 36.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.5 33.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.4 22.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.6 21.2 PID_IL3_PATHWAY IL3-mediated signaling events
0.5 20.8 PID_ATR_PATHWAY ATR signaling pathway
0.9 19.9 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.5 19.3 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.6 18.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 18.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.3 18.1 PID_E2F_PATHWAY E2F transcription factor network
0.4 17.8 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.3 16.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.6 14.7 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.6 14.2 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.4 14.1 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 14.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 196 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 356.7 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
2.0 138.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
2.3 120.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
2.1 113.9 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
1.0 47.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
2.2 38.9 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.5 36.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 34.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.6 32.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.8 32.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.2 32.0 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
1.2 25.8 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
1.2 24.2 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
1.3 22.4 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.6 21.5 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
1.0 21.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.8 20.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.6 19.0 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.5 17.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.7 17.1 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation