Motif ID: Zbtb12

Z-value: 0.603


Transcription factors associated with Zbtb12:

Gene SymbolEntrez IDGene Name
Zbtb12 ENSMUSG00000049823.8 Zbtb12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb12mm10_v2_chr17_+_34894515_34894573-0.639.0e-10Click!


Activity profile for motif Zbtb12.

activity profile for motif Zbtb12


Sorted Z-values histogram for motif Zbtb12

Sorted Z-values for motif Zbtb12



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb12

PNG image of the network

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Top targets:


Showing 1 to 20 of 59 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12027958 11.460 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr17_-_15375969 7.382 ENSMUST00000014917.7
 Dll1
delta-like 1 (Drosophila)
chr3_+_88081997 7.270 ENSMUST00000071812.5
 Iqgap3
IQ motif containing GTPase activating protein 3
chr4_-_45489794 6.250 ENSMUST00000146236.1
 Shb
src homology 2 domain-containing transforming protein B
chr3_+_5218546 5.247 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr3_+_5218516 4.924 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr13_+_104229366 4.694 ENSMUST00000022227.6
 Cenpk
centromere protein K
chr11_-_88718078 4.422 ENSMUST00000092794.5
 Msi2
musashi RNA-binding protein 2
chr4_-_149909719 4.405 ENSMUST00000105685.1
 Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
chr3_+_5218589 3.965 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr6_-_124814288 3.425 ENSMUST00000172132.2
 Tpi1
triosephosphate isomerase 1
chr8_-_45382198 3.278 ENSMUST00000093526.6
 Fam149a
family with sequence similarity 149, member A
chr4_-_119173849 3.166 ENSMUST00000052715.4
ENSMUST00000179290.1
ENSMUST00000154226.1
 Zfp691


zinc finger protein 691


chr18_-_70472429 3.058 ENSMUST00000067556.3
 4930503L19Rik
RIKEN cDNA 4930503L19 gene
chr2_-_28916668 2.926 ENSMUST00000113847.1
 Barhl1
BarH-like 1 (Drosophila)
chr7_-_25477607 2.910 ENSMUST00000098669.1
ENSMUST00000098668.1
ENSMUST00000098666.2
 Ceacam1


carcinoembryonic antigen-related cell adhesion molecule 1


chr9_+_57827284 2.886 ENSMUST00000163186.1
 Gm17231
predicted gene 17231
chr4_-_151057933 2.759 ENSMUST00000030797.3
 Vamp3
vesicle-associated membrane protein 3
chr14_+_79481164 2.485 ENSMUST00000040131.5
 Elf1
E74-like factor 1
chr6_+_29398920 2.466 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 11.5 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
2.5 7.4 GO:0001757 somite specification(GO:0001757) arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101)
0.7 7.3 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.7 6.3 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
1.1 3.4 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
1.1 3.4 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
1.0 2.9 GO:2001187 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 2.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 2.9 GO:0030901 midbrain development(GO:0030901)
0.1 2.8 GO:0035493 SNARE complex assembly(GO:0035493)
0.2 2.5 GO:0001675 acrosome assembly(GO:0001675)
0.2 2.5 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 1.9 GO:0007032 endosome organization(GO:0007032)
0.1 1.7 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.5 1.6 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.5 1.6 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.1 1.6 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.1 1.3 GO:0036010 protein localization to endosome(GO:0036010)
0.1 1.2 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0 1.1 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.4 GO:0016324 apical plasma membrane(GO:0016324)
0.1 7.3 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 6.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 4.4 GO:0005844 polysome(GO:0005844)
0.0 3.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 2.9 GO:0042101 T cell receptor complex(GO:0042101)
0.1 2.8 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.1 2.5 GO:0002080 acrosomal membrane(GO:0002080)
0.0 1.9 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 1.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 1.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 1.2 GO:0045178 basal part of cell(GO:0045178)
0.4 1.1 GO:0055087 Ski complex(GO:0055087)
0.1 1.0 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.8 GO:0044447 axoneme part(GO:0044447)
0.0 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.5 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.4 GO:1990745 EARP complex(GO:1990745)
0.1 0.3 GO:0061702 inflammasome complex(GO:0061702)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 15.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 12.3 GO:0008270 zinc ion binding(GO:0008270)
0.5 7.4 GO:0030957 Tat protein binding(GO:0030957)
1.5 7.3 GO:0032027 myosin light chain binding(GO:0032027)
0.0 5.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 4.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 4.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.3 3.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.3 3.4 GO:0070097 delta-catenin binding(GO:0070097)
0.4 2.9 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.3 2.9 GO:0008430 selenium binding(GO:0008430)
0.1 2.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.7 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.6 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 1.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 1.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 1.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 1.0 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.8 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.5 PID_IGF1_PATHWAY IGF1 pathway
0.1 7.4 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 7.3 PID_RAC1_PATHWAY RAC1 signaling pathway
0.3 6.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 3.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.3 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 1.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 11.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.5 7.4 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 4.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 4.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 3.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.6 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.6 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.3 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 1.1 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.0 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.6 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.3 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.2 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport