Motif ID: Zbtb16
Z-value: 1.531
Transcription factors associated with Zbtb16:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Zbtb16 | ENSMUSG00000066687.4 | Zbtb16 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zbtb16 | mm10_v2_chr9_-_48835932_48835962 | -0.35 | 1.5e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 21.1 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 6.1 | 18.4 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 6.0 | 29.9 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 3.7 | 14.7 | GO:0046121 | deoxyribonucleoside catabolic process(GO:0046121) |
| 3.5 | 17.7 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 3.4 | 13.7 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 2.5 | 7.5 | GO:0019343 | cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344) |
| 1.9 | 5.7 | GO:0045004 | DNA replication proofreading(GO:0045004) |
| 1.7 | 19.1 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 1.5 | 4.4 | GO:0042737 | drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) |
| 1.4 | 4.1 | GO:0086053 | AV node cell to bundle of His cell communication by electrical coupling(GO:0086053) |
| 1.3 | 3.9 | GO:0090285 | negative regulation of protein glycosylation in Golgi(GO:0090285) |
| 1.2 | 11.9 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 1.0 | 4.1 | GO:0045409 | negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
| 1.0 | 2.9 | GO:1902527 | positive regulation of protein K48-linked ubiquitination(GO:1902524) positive regulation of protein monoubiquitination(GO:1902527) |
| 1.0 | 3.9 | GO:0006545 | glycine biosynthetic process(GO:0006545) |
| 0.9 | 3.7 | GO:0032382 | positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373) |
| 0.9 | 2.7 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
| 0.8 | 5.0 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
| 0.8 | 5.4 | GO:0006561 | proline biosynthetic process(GO:0006561) |
| 0.6 | 2.6 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.6 | 3.8 | GO:0036337 | Fas signaling pathway(GO:0036337) |
| 0.6 | 1.8 | GO:0098902 | regulation of membrane depolarization during action potential(GO:0098902) regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825) |
| 0.5 | 30.6 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) |
| 0.5 | 2.5 | GO:0071267 | amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267) |
| 0.5 | 2.9 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.5 | 1.4 | GO:2000564 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
| 0.5 | 2.3 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
| 0.5 | 13.3 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.4 | 2.5 | GO:0051461 | regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.4 | 3.3 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.4 | 2.4 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.4 | 11.2 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.4 | 5.4 | GO:0006309 | apoptotic DNA fragmentation(GO:0006309) |
| 0.4 | 23.4 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 0.3 | 5.9 | GO:0044872 | lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872) |
| 0.3 | 0.9 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) |
| 0.3 | 2.0 | GO:0045002 | double-strand break repair via single-strand annealing(GO:0045002) |
| 0.2 | 1.7 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) |
| 0.2 | 1.9 | GO:0045835 | negative regulation of meiotic nuclear division(GO:0045835) |
| 0.2 | 2.8 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.2 | 3.0 | GO:2000773 | negative regulation of cellular senescence(GO:2000773) |
| 0.2 | 1.4 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.2 | 2.2 | GO:0015838 | amino-acid betaine transport(GO:0015838) |
| 0.2 | 9.9 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.2 | 1.5 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.2 | 0.6 | GO:0044837 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 0.2 | 5.0 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.2 | 1.2 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.2 | 0.6 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
| 0.2 | 1.0 | GO:0006777 | Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) |
| 0.2 | 2.7 | GO:0000479 | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479) |
| 0.2 | 1.3 | GO:0090400 | stress-induced premature senescence(GO:0090400) |
| 0.2 | 7.6 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.2 | 3.6 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.2 | 0.5 | GO:0036233 | glycine import(GO:0036233) |
| 0.2 | 7.9 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.2 | 2.6 | GO:0006999 | nuclear pore organization(GO:0006999) |
| 0.1 | 9.5 | GO:0007569 | cell aging(GO:0007569) |
| 0.1 | 24.3 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.1 | 9.7 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
| 0.1 | 2.6 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.1 | 0.8 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.1 | 1.2 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.1 | 1.4 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 0.1 | 11.2 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.1 | 1.0 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.1 | 1.1 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.1 | 3.5 | GO:0009214 | cyclic nucleotide catabolic process(GO:0009214) |
| 0.1 | 3.0 | GO:0045103 | intermediate filament-based process(GO:0045103) |
| 0.1 | 1.4 | GO:0032460 | negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 1.5 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.1 | 2.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.3 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.1 | 3.2 | GO:0003341 | cilium movement(GO:0003341) |
| 0.1 | 5.2 | GO:0030148 | sphingolipid biosynthetic process(GO:0030148) |
| 0.0 | 0.8 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.0 | 3.3 | GO:0048477 | oogenesis(GO:0048477) |
| 0.0 | 1.8 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
| 0.0 | 0.1 | GO:0006419 | alanyl-tRNA aminoacylation(GO:0006419) |
| 0.0 | 1.3 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.0 | 0.9 | GO:0045070 | positive regulation of viral genome replication(GO:0045070) |
| 0.0 | 0.8 | GO:0001913 | T cell mediated cytotoxicity(GO:0001913) |
| 0.0 | 0.8 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
| 0.0 | 2.4 | GO:0042472 | inner ear morphogenesis(GO:0042472) |
| 0.0 | 0.9 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.0 | 1.3 | GO:0045843 | negative regulation of striated muscle tissue development(GO:0045843) |
| 0.0 | 0.8 | GO:0016925 | protein sumoylation(GO:0016925) |
| 0.0 | 0.3 | GO:0043536 | positive regulation of blood vessel endothelial cell migration(GO:0043536) |
| 0.0 | 1.9 | GO:0030534 | adult behavior(GO:0030534) |
| 0.0 | 0.1 | GO:0030539 | male genitalia development(GO:0030539) |
| 0.0 | 4.9 | GO:0008380 | RNA splicing(GO:0008380) |
| 0.0 | 2.0 | GO:0008360 | regulation of cell shape(GO:0008360) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 21.1 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 2.8 | 11.2 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 1.4 | 17.7 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 1.1 | 5.7 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 1.0 | 3.9 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.8 | 29.9 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.6 | 2.5 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.6 | 8.4 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.5 | 3.7 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 0.5 | 1.5 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.5 | 3.7 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.4 | 1.3 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.4 | 3.5 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.4 | 2.3 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.3 | 1.7 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.3 | 2.4 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.3 | 2.0 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.3 | 0.9 | GO:0071001 | U4/U6 snRNP(GO:0071001) |
| 0.3 | 4.1 | GO:0005922 | connexon complex(GO:0005922) |
| 0.3 | 2.9 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.3 | 0.8 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 0.3 | 1.3 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.2 | 0.8 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.2 | 2.9 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.2 | 16.3 | GO:1990204 | oxidoreductase complex(GO:1990204) |
| 0.1 | 23.4 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 5.2 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.1 | 1.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 34.6 | GO:0005938 | cell cortex(GO:0005938) |
| 0.1 | 0.8 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.1 | 3.6 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.1 | 9.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 1.8 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 0.6 | GO:0090543 | Flemming body(GO:0090543) |
| 0.1 | 7.6 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 2.0 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.1 | 1.3 | GO:0071004 | U1 snRNP(GO:0005685) U2-type prespliceosome(GO:0071004) |
| 0.1 | 17.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 9.7 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.1 | 0.8 | GO:0005684 | U2-type spliceosomal complex(GO:0005684) |
| 0.1 | 1.2 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 1.4 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 3.0 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 3.8 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.3 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.0 | 2.2 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 0.3 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.0 | 0.6 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 3.2 | GO:0005930 | axoneme(GO:0005930) |
| 0.0 | 8.6 | GO:0045177 | apical part of cell(GO:0045177) |
| 0.0 | 1.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 2.2 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 2.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 26.0 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 22.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 0.7 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.8 | GO:0042641 | actomyosin(GO:0042641) |
| 0.0 | 0.3 | GO:0016592 | mediator complex(GO:0016592) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 21.1 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 2.9 | 17.7 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 1.9 | 5.7 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 1.8 | 5.4 | GO:0004531 | deoxyribonuclease II activity(GO:0004531) |
| 1.8 | 29.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 1.7 | 5.2 | GO:0001729 | ceramide kinase activity(GO:0001729) |
| 1.7 | 13.3 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 1.4 | 18.6 | GO:0016832 | aldehyde-lyase activity(GO:0016832) |
| 1.4 | 4.1 | GO:0086077 | gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077) |
| 1.3 | 5.4 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 1.3 | 3.9 | GO:0071633 | dihydroceramidase activity(GO:0071633) |
| 1.1 | 18.4 | GO:0016594 | glycine binding(GO:0016594) |
| 1.1 | 4.4 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 1.0 | 2.9 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.9 | 7.5 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.9 | 4.7 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.9 | 3.7 | GO:0050632 | propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121) |
| 0.9 | 2.7 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
| 0.9 | 7.9 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.7 | 11.9 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.7 | 2.7 | GO:0034511 | U3 snoRNA binding(GO:0034511) |
| 0.7 | 2.0 | GO:0008534 | oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534) |
| 0.6 | 9.2 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.5 | 3.8 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.5 | 24.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.5 | 4.1 | GO:0097642 | calcitonin family receptor activity(GO:0097642) |
| 0.5 | 26.2 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.5 | 2.5 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.5 | 2.5 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.5 | 5.0 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.4 | 1.7 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.4 | 1.6 | GO:0051377 | mannose-ethanolamine phosphotransferase activity(GO:0051377) |
| 0.4 | 1.2 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
| 0.4 | 2.6 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.4 | 1.5 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
| 0.3 | 10.3 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.3 | 2.4 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.3 | 6.1 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.3 | 24.8 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
| 0.3 | 2.3 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.2 | 4.1 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.2 | 4.9 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.2 | 1.5 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.2 | 0.6 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.2 | 2.0 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.2 | 34.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 1.9 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.1 | 1.3 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.1 | 3.6 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.1 | 1.3 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.1 | 0.8 | GO:0001226 | RNA polymerase II transcription corepressor binding(GO:0001226) |
| 0.1 | 1.7 | GO:0016799 | hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799) |
| 0.1 | 1.7 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 0.8 | GO:0044388 | small protein activating enzyme binding(GO:0044388) |
| 0.1 | 0.9 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 2.9 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 1.4 | GO:0034237 | AMP binding(GO:0016208) protein kinase A regulatory subunit binding(GO:0034237) |
| 0.1 | 3.5 | GO:0030551 | cyclic nucleotide binding(GO:0030551) |
| 0.1 | 0.3 | GO:0043532 | angiostatin binding(GO:0043532) |
| 0.1 | 3.3 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.1 | 2.3 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 0.8 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.0 | 0.5 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.0 | 1.3 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 0.3 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 0.0 | 2.5 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.1 | GO:0004813 | alanine-tRNA ligase activity(GO:0004813) |
| 0.0 | 4.8 | GO:0016853 | isomerase activity(GO:0016853) |
| 0.0 | 1.4 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.0 | 1.1 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 12.6 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 1.0 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 2.2 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 2.0 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.0 | 2.2 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.0 | 2.3 | GO:0008514 | organic anion transmembrane transporter activity(GO:0008514) |
| 0.0 | 0.3 | GO:0001104 | RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.0 | 0.7 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 0.3 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 0.9 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 4.0 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 0.3 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 51.0 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.5 | 14.6 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.4 | 11.2 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.2 | 3.8 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.2 | 24.3 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 12.6 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.1 | 4.1 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 2.2 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 2.7 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 5.0 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.1 | 2.3 | PID_BARD1_PATHWAY | BARD1 signaling events |
| 0.1 | 2.4 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 2.0 | PID_FAS_PATHWAY | FAS (CD95) signaling pathway |
| 0.0 | 2.0 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.4 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 3.3 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.7 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.3 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
| 0.0 | 2.1 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 0.8 | PID_CDC42_PATHWAY | CDC42 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 11.2 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 1.1 | 29.9 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.6 | 3.5 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.4 | 5.7 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.3 | 4.1 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.3 | 3.7 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.3 | 7.5 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.3 | 19.9 | REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.2 | 3.3 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.2 | 2.0 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.2 | 2.7 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.2 | 6.1 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 2.3 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 2.1 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 2.6 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 8.6 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 2.4 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 3.9 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 1.2 | REACTOME_MRNA_CAPPING | Genes involved in mRNA Capping |
| 0.1 | 2.2 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 1.3 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 2.8 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.1 | 2.2 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 5.0 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.6 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 1.8 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 21.1 | REACTOME_HEMOSTASIS | Genes involved in Hemostasis |
| 0.0 | 0.8 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 2.0 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 1.1 | REACTOME_CELL_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell-cell junction organization |
| 0.0 | 0.3 | REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 0.3 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 3.0 | REACTOME_GENERIC_TRANSCRIPTION_PATHWAY | Genes involved in Generic Transcription Pathway |
