Motif ID: Zbtb18
Z-value: 1.232
Transcription factors associated with Zbtb18:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Zbtb18 | ENSMUSG00000063659.6 | Zbtb18 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zbtb18 | mm10_v2_chr1_+_177445660_177445821 | -0.31 | 6.9e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.2 | GO:0099548 | trans-synaptic signaling by nitric oxide(GO:0099548) |
| 2.2 | 6.7 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
| 2.2 | 11.1 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 2.1 | 6.2 | GO:1901421 | positive regulation of response to alcohol(GO:1901421) |
| 2.0 | 6.0 | GO:0035934 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
| 2.0 | 5.9 | GO:0001803 | antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805) |
| 1.8 | 5.5 | GO:2000642 | negative regulation of early endosome to late endosome transport(GO:2000642) |
| 1.1 | 3.3 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) |
| 1.0 | 3.0 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 1.0 | 4.9 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
| 0.9 | 26.7 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.9 | 4.3 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.8 | 3.3 | GO:0071034 | CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051) |
| 0.8 | 2.5 | GO:0015882 | L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904) |
| 0.8 | 4.0 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.7 | 2.2 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.7 | 2.8 | GO:0042822 | pyridoxal phosphate metabolic process(GO:0042822) |
| 0.7 | 10.4 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.7 | 5.5 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.7 | 14.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.7 | 3.3 | GO:0097527 | necroptotic signaling pathway(GO:0097527) |
| 0.7 | 11.1 | GO:1902993 | positive regulation of amyloid precursor protein catabolic process(GO:1902993) |
| 0.6 | 1.9 | GO:1902162 | regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) |
| 0.6 | 1.9 | GO:2000097 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.6 | 0.6 | GO:0098917 | retrograde trans-synaptic signaling(GO:0098917) |
| 0.6 | 3.0 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.6 | 2.4 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.6 | 2.3 | GO:0099550 | trans-synaptic signalling, modulating synaptic transmission(GO:0099550) |
| 0.5 | 2.2 | GO:0015786 | UDP-glucose transport(GO:0015786) |
| 0.5 | 2.7 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.5 | 6.2 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.5 | 2.5 | GO:0072014 | proximal tubule development(GO:0072014) |
| 0.5 | 1.5 | GO:0061056 | positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) sclerotome development(GO:0061056) kidney smooth muscle tissue development(GO:0072194) negative regulation of dopaminergic neuron differentiation(GO:1904339) |
| 0.5 | 2.5 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
| 0.5 | 1.5 | GO:0003274 | tolerance induction to self antigen(GO:0002513) endocardial cushion fusion(GO:0003274) |
| 0.5 | 3.4 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.4 | 9.9 | GO:0045063 | T-helper 1 cell differentiation(GO:0045063) |
| 0.4 | 2.5 | GO:0060754 | positive regulation of mast cell chemotaxis(GO:0060754) |
| 0.4 | 1.6 | GO:0018343 | protein farnesylation(GO:0018343) |
| 0.4 | 1.1 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 0.4 | 2.3 | GO:0070166 | enamel mineralization(GO:0070166) |
| 0.4 | 1.5 | GO:0032532 | regulation of microvillus length(GO:0032532) |
| 0.4 | 3.9 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.4 | 1.8 | GO:0019659 | fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
| 0.3 | 3.1 | GO:0043117 | positive regulation of vascular permeability(GO:0043117) |
| 0.3 | 4.1 | GO:0070995 | toxin metabolic process(GO:0009404) NADPH oxidation(GO:0070995) |
| 0.3 | 2.0 | GO:1901727 | positive regulation of histone deacetylase activity(GO:1901727) |
| 0.3 | 3.0 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.3 | 6.2 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.3 | 1.8 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.3 | 1.8 | GO:0071494 | cellular response to UV-C(GO:0071494) |
| 0.3 | 5.6 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.3 | 2.9 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.3 | 1.4 | GO:0015960 | diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966) |
| 0.3 | 1.7 | GO:0032796 | uropod organization(GO:0032796) |
| 0.3 | 0.8 | GO:0071918 | urea transmembrane transport(GO:0071918) |
| 0.3 | 1.7 | GO:0002317 | plasma cell differentiation(GO:0002317) positive regulation of viral entry into host cell(GO:0046598) |
| 0.3 | 1.7 | GO:1901837 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) |
| 0.3 | 3.0 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.3 | 2.1 | GO:0051151 | negative regulation of smooth muscle cell differentiation(GO:0051151) |
| 0.3 | 1.0 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration(GO:0051562) |
| 0.2 | 1.5 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
| 0.2 | 1.0 | GO:0043328 | protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) |
| 0.2 | 2.6 | GO:1990173 | protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173) |
| 0.2 | 1.0 | GO:1903764 | regulation of potassium ion export across plasma membrane(GO:1903764) |
| 0.2 | 0.5 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
| 0.2 | 0.5 | GO:0046416 | D-amino acid metabolic process(GO:0046416) |
| 0.2 | 0.7 | GO:0002940 | tRNA N2-guanine methylation(GO:0002940) |
| 0.2 | 2.5 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.2 | 1.8 | GO:0070813 | hydrogen sulfide metabolic process(GO:0070813) |
| 0.2 | 6.5 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
| 0.2 | 0.2 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) |
| 0.2 | 4.9 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
| 0.2 | 3.8 | GO:0014051 | gamma-aminobutyric acid secretion(GO:0014051) |
| 0.2 | 8.2 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.2 | 10.2 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.2 | 1.2 | GO:0032488 | Cdc42 protein signal transduction(GO:0032488) |
| 0.2 | 1.1 | GO:0007128 | meiotic prophase I(GO:0007128) prophase(GO:0051324) |
| 0.2 | 1.1 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
| 0.2 | 1.8 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.2 | 0.5 | GO:0042097 | interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) |
| 0.2 | 3.5 | GO:0001553 | luteinization(GO:0001553) |
| 0.2 | 0.7 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.2 | 0.7 | GO:1905098 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.2 | 1.3 | GO:2000491 | positive regulation of hepatic stellate cell activation(GO:2000491) |
| 0.2 | 0.5 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.2 | 7.5 | GO:0014003 | oligodendrocyte development(GO:0014003) |
| 0.2 | 0.5 | GO:0006059 | hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401) |
| 0.2 | 0.9 | GO:0010993 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 0.2 | 0.7 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.2 | 3.2 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.2 | 1.0 | GO:0007320 | insemination(GO:0007320) |
| 0.2 | 0.7 | GO:1904451 | regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453) |
| 0.1 | 3.0 | GO:0045760 | positive regulation of action potential(GO:0045760) |
| 0.1 | 0.7 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.1 | 1.0 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.1 | 0.4 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.1 | 0.4 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 0.1 | 1.1 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.1 | 2.2 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.1 | 0.8 | GO:0044336 | canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336) |
| 0.1 | 0.4 | GO:0019046 | release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382) |
| 0.1 | 0.6 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.1 | 2.1 | GO:0051968 | positive regulation of synaptic transmission, glutamatergic(GO:0051968) |
| 0.1 | 1.5 | GO:0035814 | negative regulation of renal sodium excretion(GO:0035814) |
| 0.1 | 1.6 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.1 | 0.8 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.1 | 1.6 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.1 | 0.7 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.1 | 1.7 | GO:0006047 | UDP-N-acetylglucosamine metabolic process(GO:0006047) |
| 0.1 | 0.6 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 0.1 | 4.3 | GO:0010718 | positive regulation of epithelial to mesenchymal transition(GO:0010718) |
| 0.1 | 0.3 | GO:0036216 | response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) |
| 0.1 | 0.3 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
| 0.1 | 0.9 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.1 | 1.9 | GO:0048266 | behavioral response to pain(GO:0048266) |
| 0.1 | 0.7 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.1 | 0.9 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.1 | 2.0 | GO:0009303 | rRNA transcription(GO:0009303) |
| 0.1 | 0.5 | GO:0010807 | regulation of synaptic vesicle priming(GO:0010807) |
| 0.1 | 1.4 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.1 | 0.6 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.1 | 1.1 | GO:0048148 | behavioral response to cocaine(GO:0048148) |
| 0.1 | 2.6 | GO:0046825 | regulation of protein export from nucleus(GO:0046825) |
| 0.1 | 8.2 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.1 | 2.1 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.1 | 0.7 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
| 0.1 | 3.6 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 0.1 | 1.4 | GO:0035987 | endodermal cell differentiation(GO:0035987) |
| 0.1 | 1.7 | GO:2000401 | regulation of lymphocyte migration(GO:2000401) |
| 0.1 | 0.7 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 0.1 | 2.1 | GO:0032469 | endoplasmic reticulum calcium ion homeostasis(GO:0032469) |
| 0.1 | 4.7 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.1 | 0.2 | GO:0006550 | isoleucine catabolic process(GO:0006550) |
| 0.1 | 0.1 | GO:0019062 | virion attachment to host cell(GO:0019062) adhesion of symbiont to host cell(GO:0044650) |
| 0.1 | 0.5 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.1 | 0.7 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
| 0.1 | 0.7 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.1 | 0.1 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.1 | 2.3 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.1 | 0.2 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.1 | 2.6 | GO:0034620 | cellular response to unfolded protein(GO:0034620) |
| 0.1 | 0.6 | GO:0002227 | innate immune response in mucosa(GO:0002227) organ or tissue specific immune response(GO:0002251) mucosal immune response(GO:0002385) |
| 0.1 | 0.4 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.1 | 2.3 | GO:0048678 | response to axon injury(GO:0048678) |
| 0.1 | 8.1 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
| 0.0 | 2.0 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 1.4 | GO:0009409 | response to cold(GO:0009409) |
| 0.0 | 0.2 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
| 0.0 | 0.1 | GO:0010726 | positive regulation of hydrogen peroxide metabolic process(GO:0010726) |
| 0.0 | 3.6 | GO:0022900 | electron transport chain(GO:0022900) |
| 0.0 | 0.6 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.0 | 0.9 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 0.0 | 0.3 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 1.8 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
| 0.0 | 0.8 | GO:0002076 | osteoblast development(GO:0002076) |
| 0.0 | 1.1 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 1.1 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 0.0 | 0.6 | GO:0000956 | nuclear-transcribed mRNA catabolic process(GO:0000956) |
| 0.0 | 1.7 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
| 0.0 | 0.8 | GO:0042219 | cellular modified amino acid catabolic process(GO:0042219) |
| 0.0 | 1.1 | GO:0032008 | positive regulation of TOR signaling(GO:0032008) |
| 0.0 | 0.3 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.0 | 0.2 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.0 | 4.2 | GO:0030041 | actin filament polymerization(GO:0030041) |
| 0.0 | 0.8 | GO:0006801 | superoxide metabolic process(GO:0006801) |
| 0.0 | 3.0 | GO:0050821 | protein stabilization(GO:0050821) |
| 0.0 | 2.1 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 0.4 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.0 | 0.1 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 0.0 | 0.2 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.0 | 0.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.0 | 3.0 | GO:0008654 | phospholipid biosynthetic process(GO:0008654) |
| 0.0 | 0.5 | GO:0071346 | cellular response to interferon-gamma(GO:0071346) |
| 0.0 | 0.9 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.6 | GO:0045471 | response to ethanol(GO:0045471) |
| 0.0 | 0.5 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
| 0.0 | 0.5 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.0 | 0.2 | GO:0046855 | inositol phosphate dephosphorylation(GO:0046855) |
| 0.0 | 0.2 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 1.1 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 0.2 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.0 | 1.7 | GO:0000086 | G2/M transition of mitotic cell cycle(GO:0000086) |
| 0.0 | 3.1 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 3.4 | GO:0006869 | lipid transport(GO:0006869) |
| 0.0 | 0.6 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
| 0.0 | 0.4 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 0.5 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.0 | 2.4 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 0.0 | 0.3 | GO:0006040 | amino sugar metabolic process(GO:0006040) |
| 0.0 | 1.6 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.0 | 0.3 | GO:0035518 | histone H2A monoubiquitination(GO:0035518) |
| 0.0 | 1.1 | GO:0021549 | cerebellum development(GO:0021549) |
| 0.0 | 1.0 | GO:0060041 | retina development in camera-type eye(GO:0060041) |
| 0.0 | 0.3 | GO:0043297 | apical junction assembly(GO:0043297) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.7 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.9 | 11.1 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.8 | 35.6 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.6 | 3.0 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.6 | 2.9 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.6 | 3.3 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.5 | 5.5 | GO:0032009 | early phagosome(GO:0032009) |
| 0.5 | 1.6 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
| 0.5 | 2.4 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.4 | 4.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.4 | 3.2 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.4 | 7.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.4 | 1.5 | GO:0031983 | vesicle lumen(GO:0031983) |
| 0.4 | 1.9 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.3 | 4.5 | GO:0001726 | ruffle(GO:0001726) |
| 0.3 | 1.0 | GO:0000814 | ESCRT II complex(GO:0000814) |
| 0.3 | 3.3 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.3 | 0.5 | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
| 0.2 | 14.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.2 | 4.1 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.2 | 2.1 | GO:0005883 | neurofilament(GO:0005883) |
| 0.2 | 2.6 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.2 | 1.0 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
| 0.2 | 1.0 | GO:1990246 | uniplex complex(GO:1990246) |
| 0.2 | 2.8 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.2 | 0.6 | GO:0098842 | postsynaptic early endosome(GO:0098842) |
| 0.2 | 1.7 | GO:0002177 | manchette(GO:0002177) |
| 0.2 | 1.5 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.2 | 1.5 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.2 | 2.8 | GO:0070938 | contractile ring(GO:0070938) |
| 0.2 | 1.1 | GO:0071986 | Ragulator complex(GO:0071986) |
| 0.2 | 0.7 | GO:0097574 | lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795) |
| 0.2 | 1.7 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.2 | 3.0 | GO:0005605 | basal lamina(GO:0005605) |
| 0.1 | 2.0 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 0.8 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 2.1 | GO:0043218 | compact myelin(GO:0043218) |
| 0.1 | 6.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 1.8 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 7.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 12.9 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 6.0 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 1.1 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.1 | 9.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 0.3 | GO:0031533 | mRNA cap methyltransferase complex(GO:0031533) |
| 0.1 | 0.6 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 10.1 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.1 | 0.3 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 0.7 | GO:0005655 | nucleolar ribonuclease P complex(GO:0005655) |
| 0.1 | 1.4 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.1 | 0.6 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.1 | 0.7 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 3.1 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 1.4 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.1 | 2.5 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 1.6 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.1 | 0.4 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 0.9 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 1.0 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.1 | 6.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 2.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 15.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 0.9 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.1 | 2.3 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 0.5 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 0.2 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
| 0.1 | 0.4 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.1 | 1.5 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 1.7 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.5 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 1.1 | GO:0030904 | retromer complex(GO:0030904) |
| 0.0 | 8.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 1.9 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 8.9 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 2.6 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 1.8 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 9.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.4 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.0 | 1.1 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 2.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 0.6 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 2.9 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 1.0 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.1 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.0 | 1.3 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.7 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 1.6 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 2.0 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 1.0 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 2.0 | GO:0097708 | cytoplasmic vesicle(GO:0031410) intracellular vesicle(GO:0097708) |
| 0.0 | 0.4 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.0 | 0.8 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 4.6 | GO:0005768 | endosome(GO:0005768) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.7 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 1.5 | 5.9 | GO:0001847 | opsonin receptor activity(GO:0001847) |
| 1.4 | 4.3 | GO:0022865 | transmembrane electron transfer carrier(GO:0022865) |
| 1.2 | 5.9 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 1.1 | 3.3 | GO:0043120 | tumor necrosis factor binding(GO:0043120) |
| 1.1 | 3.3 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 1.0 | 6.2 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.9 | 11.7 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.8 | 2.5 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.8 | 2.5 | GO:0070890 | L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
| 0.8 | 6.5 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.8 | 4.1 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.8 | 4.0 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.7 | 10.4 | GO:0031005 | filamin binding(GO:0031005) |
| 0.7 | 11.1 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.7 | 2.8 | GO:0033883 | pyridoxal phosphatase activity(GO:0033883) |
| 0.7 | 4.9 | GO:0032453 | histone demethylase activity (H3-K4 specific)(GO:0032453) |
| 0.7 | 8.5 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.6 | 26.5 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.6 | 7.5 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
| 0.6 | 3.7 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.6 | 3.0 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.6 | 2.2 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.5 | 4.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.5 | 1.6 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
| 0.5 | 4.5 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.5 | 4.3 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.5 | 2.3 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.4 | 1.8 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.4 | 2.7 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.4 | 3.0 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.4 | 1.5 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.3 | 7.0 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.3 | 1.7 | GO:0008761 | UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) |
| 0.3 | 1.7 | GO:0005534 | galactose binding(GO:0005534) |
| 0.3 | 3.8 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.3 | 4.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.3 | 0.8 | GO:0015204 | urea transmembrane transporter activity(GO:0015204) |
| 0.3 | 1.4 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
| 0.3 | 1.6 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.3 | 1.6 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.3 | 6.1 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.3 | 4.5 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.2 | 2.5 | GO:0015250 | water channel activity(GO:0015250) |
| 0.2 | 1.1 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.2 | 0.7 | GO:0005119 | smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) |
| 0.2 | 4.5 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.2 | 2.6 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.2 | 1.8 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 1.8 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.2 | 0.8 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.2 | 0.7 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.2 | 0.7 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.2 | 0.5 | GO:0070492 | chitinase activity(GO:0004568) oligosaccharide binding(GO:0070492) |
| 0.2 | 2.5 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.2 | 1.7 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.2 | 2.5 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.2 | 2.5 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.2 | 0.9 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.2 | 0.5 | GO:0036361 | racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661) |
| 0.2 | 1.7 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.1 | 1.8 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.1 | 1.6 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 0.1 | 0.7 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.1 | 0.5 | GO:0005483 | soluble NSF attachment protein activity(GO:0005483) |
| 0.1 | 0.8 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.1 | 2.7 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 2.9 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 0.7 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.1 | 0.6 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 0.1 | 1.0 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.1 | 0.3 | GO:0004482 | mRNA (guanine-N7-)-methyltransferase activity(GO:0004482) |
| 0.1 | 0.5 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.1 | 0.8 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 0.6 | GO:0033142 | progesterone receptor binding(GO:0033142) |
| 0.1 | 2.6 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 8.7 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 2.0 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 2.4 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 3.2 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 2.3 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.1 | 1.4 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.1 | 3.4 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.1 | 0.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 3.0 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 0.2 | GO:0042895 | antibiotic transporter activity(GO:0042895) |
| 0.1 | 3.0 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.1 | 1.8 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 0.3 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.1 | 6.8 | GO:0005525 | GTP binding(GO:0005525) |
| 0.1 | 0.7 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.1 | 1.3 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.1 | 1.4 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 0.1 | 3.1 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 0.6 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 0.1 | 0.9 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.1 | 0.7 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.1 | 1.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 3.3 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 5.5 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.1 | 1.4 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.1 | 0.8 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 3.4 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.1 | 0.8 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.1 | 1.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 4.3 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.1 | 4.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 0.8 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 0.7 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 0.9 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.6 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 0.4 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.0 | 1.2 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 0.2 | GO:0000832 | inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) |
| 0.0 | 0.5 | GO:0046977 | TAP binding(GO:0046977) |
| 0.0 | 0.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 3.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 4.3 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492) |
| 0.0 | 1.1 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.9 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 1.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 1.1 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.2 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.0 | 1.0 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 0.9 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 9.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 3.5 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.5 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.0 | 0.2 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.0 | 14.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.8 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 1.7 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 3.1 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.2 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.0 | 0.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.5 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 1.0 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.1 | GO:0002135 | CTP binding(GO:0002135) |
| 0.0 | 3.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 0.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 1.1 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.0 | 1.3 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 1.1 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 2.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.1 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 0.2 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 0.5 | GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.3 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.4 | 6.4 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.3 | 3.2 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.2 | 11.1 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 4.2 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 22.5 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.0 | PID_S1P_META_PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.1 | 3.5 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.1 | 3.1 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.1 | 7.3 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 6.7 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 1.3 | PID_LYMPH_ANGIOGENESIS_PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.1 | 2.3 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.1 | 4.3 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 6.1 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 2.2 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 1.5 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.1 | 1.4 | PID_IL23_PATHWAY | IL23-mediated signaling events |
| 0.1 | 1.9 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 2.1 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 2.8 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.5 | PID_IGF1_PATHWAY | IGF1 pathway |
| 0.0 | 1.3 | PID_IFNG_PATHWAY | IFN-gamma pathway |
| 0.0 | 1.7 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 0.7 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 0.6 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 0.8 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 4.8 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.0 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.0 | 2.6 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 2.9 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 4.8 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.4 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.0 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.8 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.3 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.8 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.4 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
| 0.0 | 0.7 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
| 0.0 | 0.3 | PID_RAS_PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 9.4 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.6 | 27.3 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.5 | 6.7 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.5 | 3.7 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
| 0.5 | 5.0 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.4 | 3.8 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PS | Genes involved in Acyl chain remodelling of PS |
| 0.4 | 10.4 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.4 | 9.9 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.4 | 6.4 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.3 | 3.3 | REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.3 | 2.7 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.3 | 9.2 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.3 | 5.8 | REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.3 | 3.3 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.2 | 10.9 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 3.0 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.2 | 6.3 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.2 | 2.4 | REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.1 | 2.6 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 4.0 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 5.2 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 1.1 | REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.1 | 6.5 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 3.0 | REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.1 | 1.9 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 1.8 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
| 0.1 | 0.7 | REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.1 | 2.5 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 0.7 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 1.4 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 0.8 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 2.4 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 1.5 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 1.9 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 2.1 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.8 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 0.3 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.4 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.7 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.6 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 2.5 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 1.0 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.7 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.0 | 0.7 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.7 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 0.6 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.9 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.5 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 2.9 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 0.4 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.7 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 2.6 | REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.0 | 0.1 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.4 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 0.5 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 2.8 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 0.6 | REACTOME_TRANSLATION | Genes involved in Translation |
