Motif ID: Zbtb18

Z-value: 1.232


Transcription factors associated with Zbtb18:

Gene SymbolEntrez IDGene Name
Zbtb18 ENSMUSG00000063659.6 Zbtb18

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb18mm10_v2_chr1_+_177445660_177445821-0.316.9e-03Click!


Activity profile for motif Zbtb18.

activity profile for motif Zbtb18


Sorted Z-values histogram for motif Zbtb18

Sorted Z-values for motif Zbtb18



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb18

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45311538 11.093 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr4_-_141598206 10.384 ENSMUST00000131317.1
ENSMUST00000006381.4
ENSMUST00000129602.1
 Fblim1


filamin binding LIM protein 1


chr11_-_107794557 9.381 ENSMUST00000021066.3
 Cacng4
calcium channel, voltage-dependent, gamma subunit 4
chr4_-_136898803 9.362 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr3_-_82074639 9.187 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr11_-_95514570 9.086 ENSMUST00000058866.7
 Nxph3
neurexophilin 3
chr7_+_122671378 8.728 ENSMUST00000182563.1
 Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr11_-_67922136 8.651 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr7_+_122671401 8.638 ENSMUST00000182095.1
 Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr5_-_30945393 7.517 ENSMUST00000031051.6
 Cgref1
cell growth regulator with EF hand domain 1
chr16_+_91269759 7.201 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr10_-_86732409 6.926 ENSMUST00000070435.4
 Fabp3-ps1
fatty acid binding protein 3, muscle and heart, pseudogene 1
chr4_+_130915949 6.803 ENSMUST00000030316.6
 Laptm5
lysosomal-associated protein transmembrane 5
chr7_-_19699008 6.657 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chrX_-_162643629 6.505 ENSMUST00000112334.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chrX_-_162643575 6.415 ENSMUST00000101102.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr13_+_13784278 6.272 ENSMUST00000021734.7
 Gng4
guanine nucleotide binding protein (G protein), gamma 4
chr6_+_7555053 6.020 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr15_-_79804717 5.935 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr1_-_171059390 5.852 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 195 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 26.7 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.7 14.1 GO:0006958 complement activation, classical pathway(GO:0006958)
2.2 11.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.7 11.1 GO:1902993 positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.7 10.4 GO:0033623 regulation of integrin activation(GO:0033623)
0.2 10.2 GO:0034605 cellular response to heat(GO:0034605)
0.4 9.9 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
3.1 9.2 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.2 8.2 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 8.2 GO:0016579 protein deubiquitination(GO:0016579)
0.1 8.1 GO:0030308 negative regulation of cell growth(GO:0030308)
0.2 7.5 GO:0014003 oligodendrocyte development(GO:0014003)
2.2 6.7 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.2 6.5 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
2.1 6.2 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.5 6.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.3 6.2 GO:0032060 bleb assembly(GO:0032060)
2.0 6.0 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
2.0 5.9 GO:0001803 antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.3 5.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 35.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 15.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 14.8 GO:0005581 collagen trimer(GO:0005581)
0.1 12.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.9 11.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 10.1 GO:0030863 cortical cytoskeleton(GO:0030863)
0.1 9.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 9.2 GO:0000139 Golgi membrane(GO:0000139)
0.0 8.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 8.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 7.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 7.3 GO:0009925 basal plasma membrane(GO:0009925)
2.2 6.7 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 6.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 6.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 6.0 GO:0005604 basement membrane(GO:0005604)
0.5 5.5 GO:0032009 early phagosome(GO:0032009)
0.4 4.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 4.6 GO:0005768 endosome(GO:0005768)
0.3 4.5 GO:0001726 ruffle(GO:0001726)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 26.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 14.5 GO:0005509 calcium ion binding(GO:0005509)
0.9 11.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.7 11.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.7 10.4 GO:0031005 filamin binding(GO:0031005)
0.0 9.7 GO:0005096 GTPase activator activity(GO:0005096)
0.1 8.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.7 8.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.6 7.5 GO:0004016 adenylate cyclase activity(GO:0004016)
0.3 7.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 6.8 GO:0005525 GTP binding(GO:0005525)
2.2 6.7 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.8 6.5 GO:0097322 7SK snRNA binding(GO:0097322)
1.0 6.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.3 6.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
1.5 5.9 GO:0001847 opsonin receptor activity(GO:0001847)
1.2 5.9 GO:0019770 IgG receptor activity(GO:0019770)
0.1 5.5 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.7 4.9 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.5 4.8 GO:0005212 structural constituent of eye lens(GO:0005212)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 11.1 NABA_COLLAGENS Genes encoding collagen proteins
0.1 7.3 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 6.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.4 6.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 6.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 4.8 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 4.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 4.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 3.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.4 3.3 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.3 3.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 3.1 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 3.0 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 2.9 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 2.8 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 2.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 27.3 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.2 10.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.4 10.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.4 9.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
1.6 9.4 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 9.2 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.5 6.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 6.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.4 6.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.2 6.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.3 5.8 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 5.2 REACTOME_AMYLOIDS Genes involved in Amyloids
0.5 5.0 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 4.0 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.4 3.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.5 3.7 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.3 3.3 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.3 3.3 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 3.0 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 3.0 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)