Motif ID: Zbtb3

Z-value: 0.504


Transcription factors associated with Zbtb3:

Gene SymbolEntrez IDGene Name
Zbtb3 ENSMUSG00000071661.6 Zbtb3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb3mm10_v2_chr19_+_8802486_88025300.271.7e-02Click!


Activity profile for motif Zbtb3.

activity profile for motif Zbtb3


Sorted Z-values histogram for motif Zbtb3

Sorted Z-values for motif Zbtb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb3

PNG image of the network

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Top targets:


Showing 1 to 20 of 133 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_172043466 3.297 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr8_+_10272572 2.868 ENSMUST00000042103.8
 Myo16
myosin XVI
chr7_-_103843154 2.622 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr9_-_97018823 2.615 ENSMUST00000055433.4
 Spsb4
splA/ryanodine receptor domain and SOCS box containing 4
chr15_+_98167806 2.600 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr15_-_66969616 2.018 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr19_-_58455903 2.015 ENSMUST00000131877.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr2_-_25627960 1.925 ENSMUST00000028307.8
 Fcna
ficolin A
chr17_+_46254017 1.408 ENSMUST00000095262.4
 Lrrc73
leucine rich repeat containing 73
chr5_-_138996087 1.351 ENSMUST00000110897.1
 Pdgfa
platelet derived growth factor, alpha
chr10_+_60346851 1.342 ENSMUST00000020301.7
ENSMUST00000105460.1
ENSMUST00000170507.1
 4632428N05Rik


RIKEN cDNA 4632428N05 gene


chrX_+_53607918 1.284 ENSMUST00000114827.1
 Cxx1c
CAAX box 1C
chr8_+_83715504 1.265 ENSMUST00000109810.1
 Ddx39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
chrX_+_53607987 1.241 ENSMUST00000063384.3
ENSMUST00000169626.1
 Cxx1c

CAAX box 1C

chr14_-_26067355 1.206 ENSMUST00000100819.5
 Tmem254c
transmembrane protein 254c
chr7_+_24507122 1.202 ENSMUST00000177205.1
 Zfp428
zinc finger protein 428
chr8_+_83715177 1.200 ENSMUST00000019576.8
 Ddx39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
chr14_-_104467984 1.168 ENSMUST00000053016.8
 Pou4f1
POU domain, class 4, transcription factor 1
chr7_+_19024387 1.098 ENSMUST00000153976.1
 Sympk
symplekin
chr5_+_37242025 1.056 ENSMUST00000114158.2
 Crmp1
collapsin response mediator protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.5 2.6 GO:0015671 oxygen transport(GO:0015671)
0.0 2.6 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.2 2.0 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.0 2.0 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 2.0 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.3 1.9 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 1.6 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.5 1.4 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.1 1.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.4 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 1.3 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 1.2 GO:0019230 proprioception(GO:0019230)
0.4 1.1 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.3 1.1 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.3 0.9 GO:0006106 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533)
0.0 0.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 0.8 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.1 0.8 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.8 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0016459 myosin complex(GO:0016459)
0.3 2.6 GO:0005833 hemoglobin complex(GO:0005833)
0.1 2.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.4 GO:0005581 collagen trimer(GO:0005581)
0.0 2.1 GO:0005902 microvillus(GO:0005902)
0.2 2.0 GO:0097165 nuclear stress granule(GO:0097165)
0.1 2.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)
0.0 1.6 GO:0030286 dynein complex(GO:0030286)
0.0 1.1 GO:0031941 filamentous actin(GO:0031941)
0.0 0.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.8 GO:0097440 apical dendrite(GO:0097440)
0.1 0.7 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.7 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.6 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.6 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.6 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 2.7 GO:0003774 motor activity(GO:0003774)
0.7 2.6 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.0 2.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 2.0 GO:0005178 integrin binding(GO:0005178)
0.1 1.6 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 1.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.4 1.1 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.1 1.1 GO:0031005 filamin binding(GO:0031005)
0.0 1.1 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.3 0.9 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 0.9 GO:0008494 translation activator activity(GO:0008494)
0.1 0.9 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.8 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.8 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.8 GO:0015485 cholesterol binding(GO:0015485)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 2.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.6 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.4 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 1.2 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.1 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 0.8 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.7 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.4 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.4 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.5 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 2.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 1.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.2 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 1.1 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.9 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 0.7 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.6 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.6 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.6 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.6 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.6 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 0.5 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation