Motif ID: Zbtb33_Chd2

Z-value: 2.827

Transcription factors associated with Zbtb33_Chd2:

Gene SymbolEntrez IDGene Name
Chd2 ENSMUSG00000078671.4 Chd2
Zbtb33 ENSMUSG00000048047.3 Zbtb33

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Chd2mm10_v2_chr7_-_73541738_735417580.845.0e-22Click!
Zbtb33mm10_v2_chrX_+_38189780_381898260.801.4e-18Click!


Activity profile for motif Zbtb33_Chd2.

activity profile for motif Zbtb33_Chd2


Sorted Z-values histogram for motif Zbtb33_Chd2

Sorted Z-values for motif Zbtb33_Chd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb33_Chd2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_34833631 36.803 ENSMUST00000093191.2
 Spdl1
spindle apparatus coiled-coil protein 1
chr5_+_45669907 33.247 ENSMUST00000117396.1
 Ncapg
non-SMC condensin I complex, subunit G
chr11_-_90638062 33.081 ENSMUST00000020858.7
ENSMUST00000107875.1
ENSMUST00000107872.1
ENSMUST00000143203.1
 Stxbp4



syntaxin binding protein 4



chr9_+_121719172 25.839 ENSMUST00000035112.6
ENSMUST00000182311.1
 Nktr

natural killer tumor recognition sequence

chr3_+_69004969 24.588 ENSMUST00000136502.1
ENSMUST00000107803.1
 Smc4

structural maintenance of chromosomes 4

chr2_-_156180135 24.448 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
 Rbm39




RNA binding motif protein 39




chr16_+_48994185 24.243 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chr9_+_54863742 24.090 ENSMUST00000034843.7
 Ireb2
iron responsive element binding protein 2
chr9_+_121719403 23.889 ENSMUST00000182225.1
 Nktr
natural killer tumor recognition sequence
chr3_+_69004711 23.660 ENSMUST00000042901.8
 Smc4
structural maintenance of chromosomes 4
chr11_+_29172890 23.519 ENSMUST00000102856.2
ENSMUST00000020755.5
 Smek2

SMEK homolog 2, suppressor of mek1 (Dictyostelium)

chr19_+_38931008 22.299 ENSMUST00000145051.1
 Hells
helicase, lymphoid specific
chr9_-_72491939 21.423 ENSMUST00000185151.1
ENSMUST00000085358.5
ENSMUST00000184125.1
ENSMUST00000183574.1
ENSMUST00000184831.1
 Tex9




testis expressed gene 9




chr19_+_38930909 19.259 ENSMUST00000025965.5
 Hells
helicase, lymphoid specific
chr1_+_130717320 18.992 ENSMUST00000049813.4
 Yod1
YOD1 OTU deubiquitinating enzyme 1 homologue (S. cerevisiae)
chr14_-_105176860 18.814 ENSMUST00000163545.1
 Rbm26
RNA binding motif protein 26
chr4_-_118437331 18.044 ENSMUST00000006565.6
 Cdc20
cell division cycle 20
chrX_-_166440671 17.944 ENSMUST00000049501.8
 Ofd1
oral-facial-digital syndrome 1 gene homolog (human)
chr17_+_45433823 17.892 ENSMUST00000181149.1
 B230354K17Rik
RIKEN cDNA B230354K17 gene
chr3_+_152396664 17.617 ENSMUST00000089982.4
ENSMUST00000106101.1
 Zzz3

zinc finger, ZZ domain containing 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 200 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 49.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
6.0 48.2 GO:0010032 meiotic chromosome condensation(GO:0010032)
2.6 44.9 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.6 42.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
5.9 41.6 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
3.2 35.2 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
8.3 33.1 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
2.5 27.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
2.8 25.5 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.6 25.2 GO:0035329 hippo signaling(GO:0035329)
1.3 24.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
8.0 24.1 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.3 23.4 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
1.3 21.8 GO:0030953 astral microtubule organization(GO:0030953)
4.2 21.1 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.8 19.8 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.5 19.3 GO:0006284 base-excision repair(GO:0006284)
0.1 19.2 GO:0006470 protein dephosphorylation(GO:0006470)
6.3 19.0 GO:0035523 protein K29-linked deubiquitination(GO:0035523)
6.0 18.1 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.6 95.9 GO:0000796 condensin complex(GO:0000796)
0.1 57.5 GO:0005815 microtubule organizing center(GO:0005815)
4.1 52.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.5 44.6 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 24.5 GO:0030424 axon(GO:0030424)
0.9 22.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.7 21.7 GO:0034451 centriolar satellite(GO:0034451)
0.7 19.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.3 19.1 GO:0044815 DNA packaging complex(GO:0044815)
0.1 18.6 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
3.6 18.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
5.9 17.6 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
5.9 17.6 GO:0035101 FACT complex(GO:0035101)
1.1 17.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
1.7 17.3 GO:0016589 NURF complex(GO:0016589)
0.1 17.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
2.0 16.0 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 14.7 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.1 14.2 GO:0030426 growth cone(GO:0030426)
0.6 13.8 GO:0005685 U1 snRNP(GO:0005685)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 91.3 GO:0004386 helicase activity(GO:0004386)
1.2 49.7 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.5 49.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 39.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
7.4 36.8 GO:0043515 kinetochore binding(GO:0043515)
0.3 35.2 GO:0019905 syntaxin binding(GO:0019905)
0.1 31.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
3.8 26.5 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
1.4 25.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.8 24.9 GO:0043014 alpha-tubulin binding(GO:0043014)
8.0 24.1 GO:0030350 iron-responsive element binding(GO:0030350)
2.4 19.0 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
1.1 18.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.5 18.1 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 18.1 GO:0045296 cadherin binding(GO:0045296)
3.0 18.0 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.8 17.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.2 16.5 GO:0008565 protein transporter activity(GO:0008565)
0.7 16.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.7 15.3 GO:0070410 co-SMAD binding(GO:0070410)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 101.9 PID_AURORA_B_PATHWAY Aurora B signaling
1.8 80.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 42.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.5 26.4 PID_PLK1_PATHWAY PLK1 signaling events
0.4 22.6 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.6 19.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.6 18.9 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.2 17.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.3 11.5 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.3 9.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 9.1 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 7.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 5.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.3 5.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 5.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 3.4 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 3.0 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.3 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.0 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 46.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 39.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.8 25.2 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
1.2 22.2 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.3 19.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.6 18.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
1.1 18.1 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.4 12.9 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.3 11.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 11.0 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 11.0 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
1.0 9.5 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 8.7 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.3 8.6 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.5 8.1 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.3 7.4 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.8 7.1 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 7.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 6.7 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.3 6.6 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer