Motif ID: Zbtb4

Z-value: 0.758


Transcription factors associated with Zbtb4:

Gene SymbolEntrez IDGene Name
Zbtb4 ENSMUSG00000018750.8 Zbtb4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb4mm10_v2_chr11_+_69765899_69765925-0.412.1e-04Click!


Activity profile for motif Zbtb4.

activity profile for motif Zbtb4


Sorted Z-values histogram for motif Zbtb4

Sorted Z-values for motif Zbtb4



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 10.231 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr6_+_47244359 9.188 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chrX_+_103422010 8.866 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr6_-_48841373 5.630 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B
chr4_+_125490688 5.070 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr6_-_48841098 4.505 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B
chr12_-_45074112 4.461 ENSMUST00000120531.1
ENSMUST00000143376.1
 Stxbp6

syntaxin binding protein 6 (amisyn)

chr14_-_30626196 4.303 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
 Prkcd


protein kinase C, delta


chr19_+_41482632 4.078 ENSMUST00000067795.5
 Lcor
ligand dependent nuclear receptor corepressor
chr6_+_48841476 3.635 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr12_-_45074457 3.628 ENSMUST00000053768.6
 Stxbp6
syntaxin binding protein 6 (amisyn)
chr6_+_48841633 3.598 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr7_+_123982799 3.451 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr18_-_13972617 3.324 ENSMUST00000025288.7
 Zfp521
zinc finger protein 521
chr9_+_75071386 3.237 ENSMUST00000155282.2
 Myo5a
myosin VA
chr9_+_75071579 2.915 ENSMUST00000136731.1
 Myo5a
myosin VA
chr9_+_75071148 2.843 ENSMUST00000123128.1
 Myo5a
myosin VA
chr8_-_122678653 2.810 ENSMUST00000134045.1
 Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chrX_+_164373363 2.654 ENSMUST00000033751.7
 Figf
c-fos induced growth factor
chr5_+_65764073 2.495 ENSMUST00000138239.1
ENSMUST00000087264.3
 N4bp2

NEDD4 binding protein 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 17.4 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.3 10.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.8 9.2 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
2.2 9.0 GO:0051643 endoplasmic reticulum localization(GO:0051643)
1.0 8.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.6 5.1 GO:0006004 fucose metabolic process(GO:0006004)
0.5 5.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.9 4.3 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.2 4.3 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.1 4.2 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.2 4.1 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 3.3 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 3.3 GO:0048663 neuron fate commitment(GO:0048663)
0.4 2.8 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.3 2.8 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 2.7 GO:0008209 androgen metabolic process(GO:0008209)
0.4 2.5 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 2.5 GO:1901998 toxin transport(GO:1901998)
0.6 2.4 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 2.4 GO:0015693 magnesium ion transport(GO:0015693)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
3.0 9.0 GO:0042642 actomyosin, myosin complex part(GO:0042642)
0.4 8.1 GO:0000145 exocyst(GO:0000145)
0.2 5.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 4.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 4.0 GO:0005829 cytosol(GO:0005829)
0.1 2.9 GO:0044447 axoneme part(GO:0044447)
0.0 2.9 GO:0016605 PML body(GO:0016605)
0.0 2.4 GO:0045171 intercellular bridge(GO:0045171)
0.2 2.1 GO:0042587 glycogen granule(GO:0042587)
0.2 2.1 GO:0005938 cell cortex(GO:0005938)
0.1 2.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.8 GO:0005876 spindle microtubule(GO:0005876)
0.0 1.8 GO:0030175 filopodium(GO:0030175)
0.2 1.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 1.4 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 1.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 1.3 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 1.1 GO:0035748 myelin sheath abaxonal region(GO:0035748)
0.1 1.0 GO:0072546 ER membrane protein complex(GO:0072546)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.0 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.1 7.2 GO:0002020 protease binding(GO:0002020)
0.4 6.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 5.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
1.3 5.1 GO:0042806 fucose binding(GO:0042806)
1.0 5.1 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
1.1 4.3 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.7 4.3 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.2 4.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 4.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 3.3 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 3.2 GO:0097602 cullin family protein binding(GO:0097602)
0.3 2.8 GO:0046790 virion binding(GO:0046790)
0.1 2.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 2.7 GO:0008017 microtubule binding(GO:0008017)
0.3 2.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 2.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.6 2.4 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 2.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.4 2.2 GO:0005173 stem cell factor receptor binding(GO:0005173)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 4.7 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 4.2 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 2.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 2.7 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 2.7 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 2.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.2 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.8 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.7 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.6 PID_ATM_PATHWAY ATM pathway
0.0 1.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 0.9 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.3 5.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 4.3 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 4.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 3.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.2 2.7 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 2.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 2.4 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 2.1 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 2.1 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 1.8 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 1.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.4 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 1.3 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.1 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 1.1 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 1.1 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins