Motif ID: Zbtb49

Z-value: 0.266


Transcription factors associated with Zbtb49:

Gene SymbolEntrez IDGene Name
Zbtb49 ENSMUSG00000029127.9 Zbtb49

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb49mm10_v2_chr5_-_38220400_38220459-0.308.6e-03Click!


Activity profile for motif Zbtb49.

activity profile for motif Zbtb49


Sorted Z-values histogram for motif Zbtb49

Sorted Z-values for motif Zbtb49



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb49

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_140154712 3.404 ENSMUST00000059241.7
 Sprn
shadow of prion protein
chr18_-_61911783 2.194 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr1_+_32172711 1.786 ENSMUST00000027226.5
 Khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr9_+_40269430 1.477 ENSMUST00000171835.2
 Scn3b
sodium channel, voltage-gated, type III, beta
chr9_+_40269273 1.342 ENSMUST00000176185.1
 Scn3b
sodium channel, voltage-gated, type III, beta
chr9_+_40269202 1.259 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta

chr15_-_102257449 0.999 ENSMUST00000043172.8
 Rarg
retinoic acid receptor, gamma
chr15_-_102257306 0.803 ENSMUST00000135466.1
 Rarg
retinoic acid receptor, gamma
chr18_+_23753708 0.768 ENSMUST00000115830.1
 Mapre2
microtubule-associated protein, RP/EB family, member 2
chr9_+_50856924 0.731 ENSMUST00000174628.1
ENSMUST00000034560.7
ENSMUST00000114437.2
ENSMUST00000175645.1
ENSMUST00000176349.1
ENSMUST00000176798.1
ENSMUST00000175640.1
 Ppp2r1b






protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform






chr15_-_100422991 0.477 ENSMUST00000138843.1
ENSMUST00000023774.5
 Slc11a2

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

chr6_+_117906755 0.447 ENSMUST00000170346.1
ENSMUST00000179224.1
ENSMUST00000035493.7
 Hnrnpf


heterogeneous nuclear ribonucleoprotein F


chr17_+_24736639 0.432 ENSMUST00000115262.1
 Msrb1
methionine sulfoxide reductase B1
chr6_+_117906809 0.376 ENSMUST00000177918.1
ENSMUST00000163168.2
 Hnrnpf

heterogeneous nuclear ribonucleoprotein F

chr5_+_108629990 0.300 ENSMUST00000078323.6
ENSMUST00000120327.1
 Tmem175

transmembrane protein 175

chr8_+_4493443 0.275 ENSMUST00000175781.2
 Cers4
ceramide synthase 4
chr17_+_24736673 0.263 ENSMUST00000101800.5
 Msrb1
methionine sulfoxide reductase B1
chr5_+_108629791 0.176 ENSMUST00000063272.6
 Tmem175
transmembrane protein 175
chr5_-_108629712 0.168 ENSMUST00000046603.8
 Gak
cyclin G associated kinase
chr17_+_32993123 0.134 ENSMUST00000087666.4
ENSMUST00000157017.1
 Zfp952

zinc finger protein 952

chr3_+_36552600 0.124 ENSMUST00000029269.5
ENSMUST00000136890.1
 Exosc9

exosome component 9

chr14_-_68655804 0.091 ENSMUST00000111072.1
ENSMUST00000022642.5
 Adam28

a disintegrin and metallopeptidase domain 28

chr6_+_59208870 0.061 ENSMUST00000062626.3
 Tigd2
tigger transposable element derived 2
chr2_-_167240588 0.043 ENSMUST00000088041.4
ENSMUST00000018113.7
 Ptgis

prostaglandin I2 (prostacyclin) synthase

chr3_-_154597045 0.041 ENSMUST00000052774.1
ENSMUST00000170461.1
ENSMUST00000122976.1
 Tyw3


tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.5 1.8 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.2 0.7 GO:0030091 protein repair(GO:0030091)
0.1 0.5 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.1 0.2 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.5 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.7 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0 0.1 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 2.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 1.8 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 0.8 GO:0043484 regulation of RNA splicing(GO:0043484)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.5 GO:0070826 paraferritin complex(GO:0070826)
0.0 3.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.8 GO:0035371 microtubule plus-end(GO:0035371)
0.0 2.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.7 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 0.5 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 1.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 1.8 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.8 GO:0017025 TBP-class protein binding(GO:0017025)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 4.1 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 0.5 PID_HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.2 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 0.7 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 1.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease