Motif ID: Zbtb6
Z-value: 0.941
Transcription factors associated with Zbtb6:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Zbtb6 | ENSMUSG00000066798.3 | Zbtb6 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zbtb6 | mm10_v2_chr2_-_37443096_37443178 | -0.19 | 9.9e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 11.3 | GO:0021837 | motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465) |
| 3.1 | 9.4 | GO:0006601 | creatine biosynthetic process(GO:0006601) |
| 2.8 | 19.5 | GO:0010624 | regulation of Schwann cell proliferation(GO:0010624) |
| 1.8 | 11.1 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 1.4 | 9.8 | GO:0036006 | response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006) |
| 1.0 | 4.1 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 1.0 | 3.0 | GO:2000564 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
| 0.9 | 3.6 | GO:0061743 | motor learning(GO:0061743) |
| 0.9 | 3.5 | GO:0010040 | response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468) |
| 0.9 | 2.6 | GO:0014063 | negative regulation of serotonin secretion(GO:0014063) |
| 0.8 | 2.5 | GO:0030321 | transepithelial chloride transport(GO:0030321) transepithelial ammonium transport(GO:0070634) |
| 0.8 | 2.4 | GO:1902630 | regulation of membrane hyperpolarization(GO:1902630) |
| 0.7 | 3.3 | GO:0060591 | chondroblast differentiation(GO:0060591) |
| 0.6 | 3.6 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.6 | 1.8 | GO:2000224 | regulation of testosterone biosynthetic process(GO:2000224) |
| 0.5 | 1.6 | GO:1903348 | positive regulation of bicellular tight junction assembly(GO:1903348) |
| 0.5 | 2.0 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.5 | 2.5 | GO:0032346 | positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) |
| 0.5 | 1.5 | GO:1902220 | positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902220) |
| 0.5 | 5.1 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.4 | 1.7 | GO:1904778 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.4 | 1.2 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.4 | 7.5 | GO:0014051 | gamma-aminobutyric acid secretion(GO:0014051) |
| 0.4 | 1.5 | GO:0042822 | pyridoxal phosphate metabolic process(GO:0042822) |
| 0.3 | 1.7 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.3 | 3.0 | GO:0038026 | reelin-mediated signaling pathway(GO:0038026) |
| 0.3 | 1.3 | GO:0009414 | response to water deprivation(GO:0009414) |
| 0.3 | 1.2 | GO:1901678 | iron coordination entity transport(GO:1901678) |
| 0.3 | 2.0 | GO:0050908 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.3 | 2.3 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.3 | 0.8 | GO:0021972 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
| 0.2 | 0.7 | GO:0030070 | insulin processing(GO:0030070) |
| 0.2 | 2.8 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.2 | 0.7 | GO:0048294 | negative regulation of isotype switching to IgE isotypes(GO:0048294) |
| 0.2 | 1.1 | GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) |
| 0.2 | 0.6 | GO:0032763 | regulation of mast cell cytokine production(GO:0032763) |
| 0.2 | 7.2 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.2 | 0.6 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 0.2 | 0.8 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 0.2 | 0.8 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.2 | 1.1 | GO:1903912 | negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912) |
| 0.2 | 1.5 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.2 | 0.5 | GO:0060455 | negative regulation of gastric acid secretion(GO:0060455) positive regulation of pancreatic juice secretion(GO:0090187) positive regulation of somatostatin secretion(GO:0090274) |
| 0.2 | 0.5 | GO:0009814 | defense response, incompatible interaction(GO:0009814) |
| 0.2 | 1.8 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.2 | 0.5 | GO:0097401 | synaptic vesicle lumen acidification(GO:0097401) |
| 0.1 | 0.4 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 0.1 | 1.0 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.1 | 2.4 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.1 | 1.4 | GO:0031118 | rRNA pseudouridine synthesis(GO:0031118) tRNA pseudouridine synthesis(GO:0031119) |
| 0.1 | 4.3 | GO:0030318 | melanocyte differentiation(GO:0030318) |
| 0.1 | 2.1 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.1 | 2.4 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.1 | 0.4 | GO:0046133 | pyrimidine ribonucleoside catabolic process(GO:0046133) |
| 0.1 | 1.0 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.1 | 0.7 | GO:0036515 | serotonergic neuron axon guidance(GO:0036515) |
| 0.1 | 1.8 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 0.8 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.1 | 8.2 | GO:0051453 | regulation of intracellular pH(GO:0051453) |
| 0.1 | 0.5 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 0.1 | 2.6 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 1.4 | GO:0055012 | ventricular cardiac muscle cell differentiation(GO:0055012) |
| 0.1 | 0.7 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.1 | 0.4 | GO:0051660 | establishment of centrosome localization(GO:0051660) |
| 0.1 | 0.2 | GO:0001692 | histamine metabolic process(GO:0001692) |
| 0.1 | 0.7 | GO:2000291 | regulation of myoblast proliferation(GO:2000291) |
| 0.0 | 0.1 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.0 | 2.3 | GO:0034198 | cellular response to amino acid starvation(GO:0034198) |
| 0.0 | 1.2 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.0 | 0.3 | GO:0061622 | glycolytic process through glucose-1-phosphate(GO:0061622) |
| 0.0 | 0.4 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 7.8 | GO:0006836 | neurotransmitter transport(GO:0006836) |
| 0.0 | 0.5 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.0 | 0.3 | GO:2000491 | positive regulation of hepatic stellate cell activation(GO:2000491) |
| 0.0 | 1.1 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.0 | 0.5 | GO:2000465 | regulation of glycogen (starch) synthase activity(GO:2000465) |
| 0.0 | 0.4 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 0.0 | 1.3 | GO:0045601 | regulation of endothelial cell differentiation(GO:0045601) |
| 0.0 | 0.9 | GO:0071158 | positive regulation of cell cycle arrest(GO:0071158) |
| 0.0 | 0.3 | GO:0034427 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427) |
| 0.0 | 0.1 | GO:0051105 | regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106) |
| 0.0 | 0.2 | GO:0048840 | otolith development(GO:0048840) |
| 0.0 | 0.1 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.0 | 0.3 | GO:0048742 | regulation of skeletal muscle fiber development(GO:0048742) |
| 0.0 | 0.4 | GO:0046500 | S-adenosylmethionine metabolic process(GO:0046500) |
| 0.0 | 0.7 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
| 0.0 | 1.0 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.0 | 0.7 | GO:0009268 | response to pH(GO:0009268) |
| 0.0 | 4.4 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.0 | 0.9 | GO:0006336 | DNA replication-independent nucleosome assembly(GO:0006336) |
| 0.0 | 0.8 | GO:0097178 | ruffle assembly(GO:0097178) |
| 0.0 | 0.3 | GO:0039703 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
| 0.0 | 1.6 | GO:0090090 | negative regulation of canonical Wnt signaling pathway(GO:0090090) |
| 0.0 | 0.2 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.0 | 0.0 | GO:0071550 | death-inducing signaling complex assembly(GO:0071550) |
| 0.0 | 0.5 | GO:0010762 | regulation of fibroblast migration(GO:0010762) |
| 0.0 | 0.7 | GO:0010718 | positive regulation of epithelial to mesenchymal transition(GO:0010718) |
| 0.0 | 0.2 | GO:0001505 | regulation of neurotransmitter levels(GO:0001505) |
| 0.0 | 0.9 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.0 | 0.9 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 0.1 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.0 | 0.4 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.0 | 0.3 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.7 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) |
| 0.0 | 0.2 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 0.3 | GO:0086010 | membrane depolarization during action potential(GO:0086010) |
| 0.0 | 0.4 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 19.5 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 2.2 | 11.1 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 1.1 | 4.3 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.9 | 3.5 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.9 | 10.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.7 | 3.6 | GO:0044301 | climbing fiber(GO:0044301) |
| 0.6 | 2.5 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.4 | 3.6 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.2 | 1.7 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.2 | 1.3 | GO:1990393 | 3M complex(GO:1990393) |
| 0.2 | 1.5 | GO:0060293 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
| 0.2 | 9.5 | GO:0034704 | calcium channel complex(GO:0034704) |
| 0.2 | 2.3 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 4.9 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
| 0.1 | 0.3 | GO:0055087 | Ski complex(GO:0055087) |
| 0.1 | 0.4 | GO:0032021 | NELF complex(GO:0032021) |
| 0.1 | 1.5 | GO:0070938 | contractile ring(GO:0070938) |
| 0.1 | 1.2 | GO:0043196 | varicosity(GO:0043196) |
| 0.1 | 0.3 | GO:0019034 | viral replication complex(GO:0019034) |
| 0.1 | 1.0 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 0.9 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 0.3 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.1 | 0.7 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.1 | 1.0 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.1 | 12.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 0.5 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.0 | 0.1 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.0 | 14.1 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 2.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.8 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 0.5 | GO:0042581 | specific granule(GO:0042581) |
| 0.0 | 1.5 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.4 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 7.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 2.8 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 1.8 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.2 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.0 | 3.8 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 1.5 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 2.9 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 0.6 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 12.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 0.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 3.5 | GO:0045177 | apical part of cell(GO:0045177) |
| 0.0 | 0.4 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 7.7 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 0.2 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 0.1 | GO:0070522 | ERCC4-ERCC1 complex(GO:0070522) |
| 0.0 | 0.5 | GO:0005768 | endosome(GO:0005768) |
| 0.0 | 0.0 | GO:0031143 | pseudopodium(GO:0031143) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 7.9 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 2.2 | 11.1 | GO:0097643 | amylin receptor activity(GO:0097643) |
| 1.4 | 9.8 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 1.3 | 11.3 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.8 | 10.4 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.7 | 3.0 | GO:0038025 | reelin receptor activity(GO:0038025) |
| 0.6 | 7.5 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.6 | 3.5 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.5 | 2.0 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.4 | 8.1 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.4 | 1.8 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.4 | 2.3 | GO:1904315 | GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.4 | 1.5 | GO:0033883 | pyridoxal phosphatase activity(GO:0033883) |
| 0.3 | 2.5 | GO:0015377 | cation:chloride symporter activity(GO:0015377) |
| 0.3 | 1.7 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.2 | 1.7 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.2 | 19.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 1.8 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.2 | 1.5 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.2 | 2.6 | GO:0008227 | G-protein coupled amine receptor activity(GO:0008227) |
| 0.2 | 2.5 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.2 | 0.8 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.2 | 2.4 | GO:0070513 | death domain binding(GO:0070513) |
| 0.2 | 0.5 | GO:0031752 | D5 dopamine receptor binding(GO:0031752) |
| 0.2 | 2.5 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.2 | 2.0 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.2 | 0.6 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 0.1 | 3.3 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.1 | 1.4 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.1 | 1.1 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.1 | 4.3 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.1 | 1.6 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 1.9 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.1 | 0.7 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.1 | 1.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 0.5 | GO:2001069 | glycogen binding(GO:2001069) |
| 0.1 | 0.5 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.1 | 4.9 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 0.8 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
| 0.1 | 0.8 | GO:0048495 | GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495) |
| 0.1 | 0.3 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
| 0.1 | 1.4 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.1 | 0.9 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.1 | 0.3 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.1 | 1.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 0.7 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.0 | 0.7 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
| 0.0 | 7.6 | GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity(GO:0008757) |
| 0.0 | 0.6 | GO:0048038 | quinone binding(GO:0048038) |
| 0.0 | 2.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 1.1 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 0.4 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 0.6 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 0.0 | 0.3 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 0.0 | 1.2 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 0.2 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 1.5 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.8 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.1 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 0.9 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 1.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.1 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.0 | 0.9 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 1.1 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.2 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.9 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 0.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.3 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 12.1 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.2 | 3.3 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 2.2 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.1 | 5.0 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.1 | 2.7 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 0.8 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 1.6 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.1 | 1.8 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 3.0 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.0 | 1.2 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 5.6 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.6 | PID_P73PATHWAY | p73 transcription factor network |
| 0.0 | 2.3 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.0 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.3 | PID_LYMPH_ANGIOGENESIS_PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.0 | 1.2 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.6 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 3.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.6 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.5 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 11.3 | REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.8 | 8.3 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.7 | 7.5 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.5 | 19.5 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.4 | 11.6 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.3 | 2.7 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 2.6 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.2 | 3.0 | REACTOME_PLATELET_SENSITIZATION_BY_LDL | Genes involved in Platelet sensitization by LDL |
| 0.2 | 2.6 | REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.1 | 2.3 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 2.1 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 13.3 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 2.5 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 1.1 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 3.6 | REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.1 | 10.7 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 1.6 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 0.7 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 3.5 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 1.5 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 9.6 | REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 1.6 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.8 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.0 | 0.4 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 2.0 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 1.2 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.4 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 0.5 | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.6 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.2 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 1.3 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.3 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 1.0 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.7 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.4 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
