Motif ID: Zbtb7a

Z-value: 0.732


Transcription factors associated with Zbtb7a:

Gene SymbolEntrez IDGene Name
Zbtb7a ENSMUSG00000035011.9 Zbtb7a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb7amm10_v2_chr10_+_81136223_81136271-0.094.6e-01Click!


Activity profile for motif Zbtb7a.

activity profile for motif Zbtb7a


Sorted Z-values histogram for motif Zbtb7a

Sorted Z-values for motif Zbtb7a



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb7a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_51432663 6.926 ENSMUST00000005103.5
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr18_+_32938955 5.664 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr2_+_180499893 5.422 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr7_+_36698002 4.957 ENSMUST00000021641.6
 Tshz3
teashirt zinc finger family member 3
chr16_+_11984581 4.586 ENSMUST00000170672.2
ENSMUST00000023138.7
 Shisa9

shisa homolog 9 (Xenopus laevis)

chr7_+_131966446 4.572 ENSMUST00000045840.4
 Gpr26
G protein-coupled receptor 26
chr4_+_103619580 4.445 ENSMUST00000106827.1
 Dab1
disabled 1
chr11_+_24076529 3.999 ENSMUST00000148087.1
 Gm12063
predicted gene 12063
chr1_-_21961581 3.996 ENSMUST00000029667.6
ENSMUST00000173058.1
ENSMUST00000173404.1
 Kcnq5


potassium voltage-gated channel, subfamily Q, member 5


chr12_-_24680890 3.681 ENSMUST00000156453.2
 Cys1
cystin 1
chr6_-_126645784 3.614 ENSMUST00000055168.3
 Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
chr13_+_118714678 3.507 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr3_+_117575268 3.329 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr3_+_107036156 3.288 ENSMUST00000052718.3
 Kcna3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr1_-_154725920 3.287 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr1_-_30949756 3.177 ENSMUST00000076587.3
ENSMUST00000027232.7
 Ptp4a1

protein tyrosine phosphatase 4a1

chr2_-_57124003 3.115 ENSMUST00000112629.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr19_+_27217357 3.081 ENSMUST00000047645.6
ENSMUST00000167487.1
 Vldlr

very low density lipoprotein receptor

chr4_-_139075557 2.961 ENSMUST00000105802.1
 Htr6
5-hydroxytryptamine (serotonin) receptor 6
chr13_-_59556845 2.950 ENSMUST00000170378.1
ENSMUST00000169434.1
 Agtpbp1

ATP/GTP binding protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 213 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 8.6 GO:0050975 sensory perception of touch(GO:0050975)
1.4 8.4 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
1.2 6.0 GO:0034436 glycoprotein transport(GO:0034436)
0.1 6.0 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.3 5.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.4 5.7 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 4.7 GO:0006821 chloride transport(GO:0006821)
0.1 4.6 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
1.5 4.4 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
1.1 4.3 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 4.2 GO:0015807 L-amino acid transport(GO:0015807)
0.0 4.0 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 3.8 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.6 3.7 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.3 3.7 GO:0043252 prostaglandin transport(GO:0015732) sodium-independent organic anion transport(GO:0043252)
1.2 3.5 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.8 3.4 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.7 3.3 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.7 3.3 GO:0008355 olfactory learning(GO:0008355)
0.8 3.1 GO:0051866 general adaptation syndrome(GO:0051866)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.4 GO:0030139 endocytic vesicle(GO:0030139)
0.7 6.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 6.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 5.8 GO:0030425 dendrite(GO:0030425)
0.0 5.5 GO:0001650 fibrillar center(GO:0001650)
1.4 5.4 GO:0032280 symmetric synapse(GO:0032280)
0.0 4.6 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.4 4.4 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.3 4.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 4.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 4.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 4.1 GO:0014069 postsynaptic density(GO:0014069)
0.0 4.0 GO:0070382 exocytic vesicle(GO:0070382)
0.0 3.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 3.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.2 3.0 GO:1990635 proximal dendrite(GO:1990635)
0.5 2.9 GO:0097513 myosin II filament(GO:0097513)
0.0 2.9 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.6 GO:0019898 extrinsic component of membrane(GO:0019898)
0.1 2.4 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.5 GO:0070064 proline-rich region binding(GO:0070064)
0.4 6.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 6.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 6.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
2.0 6.0 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.5 5.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 5.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.3 5.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 5.1 GO:0042169 SH2 domain binding(GO:0042169)
0.0 4.9 GO:0008017 microtubule binding(GO:0008017)
0.3 4.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.2 4.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.2 3.7 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.5 3.7 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.9 3.5 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
1.1 3.4 GO:0005436 sodium:phosphate symporter activity(GO:0005436) sodium:inorganic phosphate symporter activity(GO:0015319)
0.5 3.4 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 3.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 3.2 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 3.1 GO:0050811 GABA receptor binding(GO:0050811)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.3 11.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 11.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 5.7 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 2.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.4 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 2.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 2.0 PID_ALK2_PATHWAY ALK2 signaling events
0.1 2.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.8 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.2 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.0 1.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.1 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.0 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.0 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.0 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 8.3 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 6.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 5.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 4.6 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 3.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 3.7 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 3.6 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.3 3.5 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.2 3.2 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 3.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.0 3.0 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 2.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.3 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 2.3 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 2.2 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.2 2.1 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 1.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation