Motif ID: Zbtb7b

Z-value: 1.097


Transcription factors associated with Zbtb7b:

Gene SymbolEntrez IDGene Name
Zbtb7b ENSMUSG00000028042.9 Zbtb7b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb7bmm10_v2_chr3_-_89393294_893933780.454.6e-05Click!


Activity profile for motif Zbtb7b.

activity profile for motif Zbtb7b


Sorted Z-values histogram for motif Zbtb7b

Sorted Z-values for motif Zbtb7b



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb7b

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 198 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_32244632 16.541 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19
chr8_-_105471481 13.318 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr1_-_119053339 13.040 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr7_+_51879041 12.883 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr7_+_51878967 12.611 ENSMUST00000051912.6
 Gas2
growth arrest specific 2
chr9_-_91365778 12.195 ENSMUST00000065360.3
 Zic1
zinc finger protein of the cerebellum 1
chr2_-_117342709 9.424 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr2_-_117342949 9.309 ENSMUST00000102534.4
 Rasgrp1
RAS guanyl releasing protein 1
chr5_+_139543889 9.197 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_117342831 8.366 ENSMUST00000178884.1
 Rasgrp1
RAS guanyl releasing protein 1
chr3_+_90541146 8.216 ENSMUST00000107333.1
ENSMUST00000107331.1
ENSMUST00000098910.2
 S100a16


S100 calcium binding protein A16


chr14_-_62456286 7.857 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr19_+_55742242 7.415 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
 Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr7_-_101837776 7.355 ENSMUST00000165052.1
 Inppl1
inositol polyphosphate phosphatase-like 1
chr14_+_55854115 6.405 ENSMUST00000168479.1
 Nynrin
NYN domain and retroviral integrase containing
chr3_+_34649987 6.382 ENSMUST00000099151.2
 Sox2
SRY-box containing gene 2
chr7_-_4752972 6.327 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr2_+_146221921 6.299 ENSMUST00000089257.4
 Insm1
insulinoma-associated 1
chr2_+_102658640 6.108 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_+_70000578 5.763 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 27.1 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.2 21.8 GO:0007050 cell cycle arrest(GO:0007050)
0.2 13.3 GO:0046785 microtubule polymerization(GO:0046785)
3.3 13.0 GO:0060032 notochord regression(GO:0060032)
0.2 12.2 GO:0007628 adult walking behavior(GO:0007628)
0.8 10.5 GO:0055059 asymmetric neuroblast division(GO:0055059)
2.3 9.2 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
1.3 9.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 8.2 GO:0051592 response to calcium ion(GO:0051592)
0.0 8.1 GO:0007265 Ras protein signal transduction(GO:0007265)
0.2 7.6 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.5 7.5 GO:0051451 myoblast migration(GO:0051451)
1.1 7.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.9 7.4 GO:0048625 myoblast fate commitment(GO:0048625)
0.2 6.5 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.9 6.4 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.8 6.4 GO:0015074 DNA integration(GO:0015074)
0.4 6.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
1.6 6.3 GO:0003357 noradrenergic neuron differentiation(GO:0003357)
0.9 6.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 22.1 GO:0005794 Golgi apparatus(GO:0005794)
0.1 21.7 GO:0005667 transcription factor complex(GO:0005667)
1.5 13.3 GO:0097427 microtubule bundle(GO:0097427)
1.0 13.0 GO:0097542 ciliary tip(GO:0097542)
1.8 9.2 GO:0035189 Rb-E2F complex(GO:0035189)
0.4 7.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 7.6 GO:0005871 kinesin complex(GO:0005871)
1.1 7.5 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.8 7.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 6.7 GO:0030027 lamellipodium(GO:0030027)
0.4 6.3 GO:0030061 mitochondrial crista(GO:0030061)
0.3 6.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 6.1 GO:0030673 axolemma(GO:0030673)
0.1 5.4 GO:0016235 aggresome(GO:0016235)
0.3 4.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 4.3 GO:0051233 spindle midzone(GO:0051233)
0.5 4.1 GO:0042587 glycogen granule(GO:0042587)
0.2 3.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 3.7 GO:0005770 late endosome(GO:0005770)
0.0 3.6 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 31.4 GO:0008017 microtubule binding(GO:0008017)
2.5 27.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 19.1 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 13.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 13.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 10.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 9.7 GO:0015631 tubulin binding(GO:0015631)
0.1 9.4 GO:0001047 core promoter binding(GO:0001047)
0.0 7.9 GO:0003924 GTPase activity(GO:0003924)
0.4 7.6 GO:0004383 guanylate cyclase activity(GO:0004383)
0.7 7.4 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.4 7.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.7 6.5 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.3 6.4 GO:0035198 miRNA binding(GO:0035198)
0.1 6.3 GO:0030332 cyclin binding(GO:0030332)
1.0 6.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 5.9 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 5.8 GO:0005109 frizzled binding(GO:0005109)
0.3 5.5 GO:0070411 I-SMAD binding(GO:0070411)
0.8 4.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 27.1 PID_RAS_PATHWAY Regulation of Ras family activation
0.4 24.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.4 13.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.4 11.2 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.7 9.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 9.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 9.0 PID_E2F_PATHWAY E2F transcription factor network
0.2 8.1 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 7.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.2 7.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 7.4 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 7.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 4.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 4.2 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 2.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.8 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.4 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 1.2 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 1.1 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 25.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
1.1 25.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.1 13.5 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.3 10.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.5 8.1 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.3 7.6 REACTOME_KINESINS Genes involved in Kinesins
0.2 7.6 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.2 7.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 6.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 5.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 4.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 3.9 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.3 2.5 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.5 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.4 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.2 1.2 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 1.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors