Motif ID: Zbtb7c

Z-value: 0.663


Transcription factors associated with Zbtb7c:

Gene SymbolEntrez IDGene Name
Zbtb7c ENSMUSG00000044646.8 Zbtb7c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb7cmm10_v2_chr18_+_75820174_75820210-0.104.0e-01Click!


Activity profile for motif Zbtb7c.

activity profile for motif Zbtb7c


Sorted Z-values histogram for motif Zbtb7c

Sorted Z-values for motif Zbtb7c



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb7c

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 138 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_32938955 8.469 ENSMUST00000042868.4
Camk4
calcium/calmodulin-dependent protein kinase IV
chr6_+_51432678 7.420 ENSMUST00000160133.1
Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr16_+_11984581 6.745 ENSMUST00000170672.2
ENSMUST00000023138.7
Shisa9

shisa homolog 9 (Xenopus laevis)

chr6_+_51432663 5.679 ENSMUST00000005103.5
Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr1_-_21961581 5.402 ENSMUST00000029667.6
ENSMUST00000173058.1
ENSMUST00000173404.1
Kcnq5


potassium voltage-gated channel, subfamily Q, member 5


chr7_-_19310035 4.943 ENSMUST00000003640.2
Fosb
FBJ osteosarcoma oncogene B
chr11_+_104231465 4.421 ENSMUST00000145227.1
Mapt
microtubule-associated protein tau
chr11_+_104231573 4.209 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
Mapt


microtubule-associated protein tau


chr11_+_104231515 4.092 ENSMUST00000106993.3
Mapt
microtubule-associated protein tau
chr8_-_11312731 3.600 ENSMUST00000033898.9
Col4a1
collagen, type IV, alpha 1
chr7_+_5056706 3.494 ENSMUST00000144802.1
Ccdc106
coiled-coil domain containing 106
chr8_+_40862379 3.460 ENSMUST00000098816.3
ENSMUST00000057784.8
ENSMUST00000141505.1
Slc7a2


solute carrier family 7 (cationic amino acid transporter, y+ system), member 2


chr11_-_26210553 3.288 ENSMUST00000101447.3
5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr8_+_11312805 3.260 ENSMUST00000033899.7
Col4a2
collagen, type IV, alpha 2
chr2_-_118703963 3.135 ENSMUST00000104937.1
Ankrd63
ankyrin repeat domain 63
chr12_+_108334341 3.007 ENSMUST00000021684.4
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr2_-_29253001 2.923 ENSMUST00000071201.4
Ntng2
netrin G2
chr11_-_117873433 2.921 ENSMUST00000033230.7
Tha1
threonine aldolase 1
chr10_-_127263346 2.917 ENSMUST00000099172.3
Kif5a
kinesin family member 5A
chr12_+_81859964 2.909 ENSMUST00000021567.5
Pcnx
pecanex homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 12.7 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.0 10.3 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.5 8.5 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 7.4 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.3 6.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 4.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 4.7 GO:0015807 L-amino acid transport(GO:0015807)
0.5 3.6 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
1.2 3.5 GO:1902022 L-lysine transport(GO:1902022)
0.2 3.3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.3 3.0 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
1.0 2.9 GO:0006566 threonine metabolic process(GO:0006566)
0.4 2.9 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.2 2.9 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.0 2.9 GO:0007409 axonogenesis(GO:0007409)
0.2 2.8 GO:0035646 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.0 2.8 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 2.7 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.0 2.6 GO:0007411 axon guidance(GO:0007411)
0.2 2.4 GO:0000042 protein targeting to Golgi(GO:0000042)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 12.7 GO:0045298 tubulin complex(GO:0045298)
0.1 8.5 GO:0001650 fibrillar center(GO:0001650)
0.1 8.2 GO:0030118 clathrin coat(GO:0030118)
1.4 6.9 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.7 6.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 4.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 2.9 GO:0035253 ciliary rootlet(GO:0035253)
0.1 2.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 2.9 GO:0043034 costamere(GO:0043034)
0.4 2.7 GO:0008091 spectrin(GO:0008091)
0.3 2.6 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 2.4 GO:0030137 COPI-coated vesicle(GO:0030137)
0.4 2.1 GO:0001533 cornified envelope(GO:0001533)
0.4 1.7 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.1 1.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 1.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.3 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.4 1.2 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.0 1.1 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 12.7 GO:0099609 microtubule lateral binding(GO:0099609)
0.3 9.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 8.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7 8.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 6.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 5.5 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 4.7 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 4.3 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.0 3.9 GO:0030165 PDZ domain binding(GO:0030165)
0.9 3.5 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 3.3 GO:0030246 carbohydrate binding(GO:0030246)
0.1 3.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
1.0 2.9 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.3 2.9 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 2.7 GO:0030506 ankyrin binding(GO:0030506)
0.2 2.6 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 2.4 GO:0044325 ion channel binding(GO:0044325)
0.1 2.3 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 2.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 12.7 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 11.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 8.5 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 4.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 2.8 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 2.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 PID_RAC1_PATHWAY RAC1 signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 12.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 8.5 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.2 8.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 6.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 5.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 5.2 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 4.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.4 3.0 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 2.9 REACTOME_KINESINS Genes involved in Kinesins
0.1 2.7 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
0.0 2.5 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.9 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.3 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.0 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 0.9 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.9 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.4 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis