Motif ID: Zfhx3

Z-value: 0.902


Transcription factors associated with Zfhx3:

Gene SymbolEntrez IDGene Name
Zfhx3 ENSMUSG00000038872.8 Zfhx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfhx3mm10_v2_chr8_+_108714644_108714644-0.208.4e-02Click!


Activity profile for motif Zfhx3.

activity profile for motif Zfhx3


Sorted Z-values histogram for motif Zfhx3

Sorted Z-values for motif Zfhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfhx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 97 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_101377897 8.315 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chrM_-_14060 6.857 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr1_-_24612700 5.149 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chrM_+_9870 4.799 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chrM_+_7759 4.542 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr2_-_63184253 4.187 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr2_+_82053222 4.116 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr9_+_95857597 4.066 ENSMUST00000034980.7
 Atr
ataxia telangiectasia and Rad3 related
chrM_+_14138 3.982 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chrM_+_2743 3.901 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr5_-_107875035 3.889 ENSMUST00000138111.1
ENSMUST00000112642.1
 Evi5

ecotropic viral integration site 5

chr9_+_86485407 3.460 ENSMUST00000034987.8
 Dopey1
dopey family member 1
chr13_-_110280103 3.327 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr12_+_71170589 3.271 ENSMUST00000129376.1
 2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr8_-_67818284 3.224 ENSMUST00000120071.1
 Psd3
pleckstrin and Sec7 domain containing 3
chr10_-_110000219 3.183 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chr5_+_107497718 3.131 ENSMUST00000112671.2
 A830010M20Rik
RIKEN cDNA A830010M20 gene
chr4_-_32923455 3.016 ENSMUST00000035719.4
ENSMUST00000084749.1
 Ankrd6

ankyrin repeat domain 6

chrM_+_7005 2.954 ENSMUST00000082405.1
 mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr17_+_35076902 2.764 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.3 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 7.8 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 6.8 GO:0051291 protein heterooligomerization(GO:0051291)
2.1 6.3 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.1 5.9 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.4 5.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 4.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 4.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
1.4 4.1 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 4.1 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.8 4.0 GO:0033762 response to glucagon(GO:0033762)
0.2 3.9 GO:0006895 Golgi to endosome transport(GO:0006895)
0.2 3.9 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 3.3 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 3.3 GO:0017157 regulation of exocytosis(GO:0017157)
0.2 3.0 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.5 2.8 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 2.8 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.5 2.7 GO:0007256 activation of JNKK activity(GO:0007256)
0.8 2.5 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.7 GO:0070469 respiratory chain(GO:0070469)
0.1 8.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 7.2 GO:0030426 growth cone(GO:0030426)
0.1 6.3 GO:0044295 axonal growth cone(GO:0044295)
0.1 4.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.3 4.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 4.1 GO:0001741 XY body(GO:0001741)
0.0 4.1 GO:0042641 actomyosin(GO:0042641)
0.4 4.0 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 3.3 GO:0005814 centriole(GO:0005814)
0.0 3.3 GO:0008021 synaptic vesicle(GO:0008021)
0.0 2.8 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.7 GO:0055037 recycling endosome(GO:0055037)
0.1 2.5 GO:0030673 axolemma(GO:0030673)
0.4 2.1 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.3 1.7 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.0 1.6 GO:0001650 fibrillar center(GO:0001650)
0.3 1.5 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 1.4 GO:0016580 Sin3 complex(GO:0016580)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 15.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 8.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 6.8 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.4 6.3 GO:0045499 chemorepellent activity(GO:0045499)
0.0 5.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 5.9 GO:0008017 microtubule binding(GO:0008017)
0.0 5.7 GO:0000287 magnesium ion binding(GO:0000287)
0.1 5.0 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.2 4.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.7 4.1 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.5 4.0 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 3.3 GO:0031489 myosin V binding(GO:0031489)
0.9 2.8 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.2 2.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.4 2.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.3 2.3 GO:0001849 complement component C1q binding(GO:0001849)
0.5 2.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 2.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.3 1.7 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.3 1.5 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 4.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 4.1 PID_CDC42_PATHWAY CDC42 signaling events
0.1 3.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 3.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 2.7 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 2.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 2.3 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 1.7 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 0.6 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 6.4 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.4 4.1 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 2.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.4 2.3 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 2.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.7 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 1.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.5 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.9 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.3 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling