Motif ID: Zfhx3
Z-value: 0.902
Transcription factors associated with Zfhx3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Zfhx3 | ENSMUSG00000038872.8 | Zfhx3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zfhx3 | mm10_v2_chr8_+_108714644_108714644 | -0.20 | 8.4e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 6.3 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
| 1.4 | 4.1 | GO:1904884 | telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884) |
| 0.8 | 2.5 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
| 0.8 | 4.0 | GO:0033762 | response to glucagon(GO:0033762) |
| 0.5 | 2.7 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.5 | 1.5 | GO:1903244 | positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203) |
| 0.5 | 1.4 | GO:0003195 | tricuspid valve formation(GO:0003195) |
| 0.5 | 2.8 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.4 | 2.3 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.4 | 5.7 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.3 | 1.7 | GO:0097680 | double-strand break repair via classical nonhomologous end joining(GO:0097680) |
| 0.3 | 1.3 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 0.2 | 3.9 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.2 | 1.2 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.2 | 2.1 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.2 | 3.0 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.2 | 4.8 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.2 | 4.9 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.2 | 3.9 | GO:0033194 | response to hydroperoxide(GO:0033194) |
| 0.1 | 4.1 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
| 0.1 | 8.3 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.1 | 7.8 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.1 | 0.9 | GO:0051418 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.1 | 1.1 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.1 | 1.6 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.1 | 0.8 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.1 | 0.6 | GO:1903223 | positive regulation of oxidative stress-induced neuron death(GO:1903223) positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.1 | 2.8 | GO:0022401 | desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401) |
| 0.1 | 5.9 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.1 | 2.1 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.1 | 1.1 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.1 | 2.1 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.1 | 1.3 | GO:2000780 | negative regulation of double-strand break repair(GO:2000780) |
| 0.0 | 1.0 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.0 | 0.3 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 0.0 | 6.8 | GO:0051291 | protein heterooligomerization(GO:0051291) |
| 0.0 | 1.4 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
| 0.0 | 0.3 | GO:0030539 | male genitalia development(GO:0030539) |
| 0.0 | 3.3 | GO:0007224 | smoothened signaling pathway(GO:0007224) |
| 0.0 | 3.3 | GO:0017157 | regulation of exocytosis(GO:0017157) |
| 0.0 | 0.4 | GO:0030325 | adrenal gland development(GO:0030325) |
| 0.0 | 0.7 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 2.2 | GO:0045930 | negative regulation of mitotic cell cycle(GO:0045930) |
| 0.0 | 0.6 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.0 | 1.3 | GO:0007605 | sensory perception of sound(GO:0007605) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.1 | GO:0036396 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 0.4 | 4.0 | GO:0045275 | respiratory chain complex III(GO:0045275) |
| 0.3 | 4.5 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.3 | 1.7 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807) |
| 0.3 | 18.7 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.3 | 1.5 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.2 | 0.9 | GO:0000931 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 0.2 | 0.8 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.2 | 4.1 | GO:0001741 | XY body(GO:0001741) |
| 0.1 | 0.6 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.1 | 1.2 | GO:0002177 | manchette(GO:0002177) |
| 0.1 | 1.1 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.1 | 6.3 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 1.4 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 4.8 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 8.3 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 2.5 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 1.4 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 0.3 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.0 | 7.2 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 1.3 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 4.1 | GO:0042641 | actomyosin(GO:0042641) |
| 0.0 | 3.3 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.5 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.0 | 2.7 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 0.5 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 3.3 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 2.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 1.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.7 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 0.2 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) |
| 0.0 | 1.6 | GO:0001650 | fibrillar center(GO:0001650) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.8 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 0.7 | 4.1 | GO:0032405 | MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407) |
| 0.5 | 15.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.5 | 2.1 | GO:0016422 | mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422) |
| 0.5 | 4.0 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.5 | 1.4 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.4 | 6.3 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.4 | 2.5 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.3 | 6.8 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.3 | 2.3 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.3 | 1.7 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.3 | 1.5 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.2 | 2.7 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.2 | 4.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 3.3 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 1.1 | GO:0070739 | protein-glutamic acid ligase activity(GO:0070739) |
| 0.1 | 0.7 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.1 | 0.6 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.1 | 1.3 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.1 | 0.9 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.1 | 0.5 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 5.0 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.1 | 0.8 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 5.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 1.2 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 8.3 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.4 | GO:0045125 | bioactive lipid receptor activity(GO:0045125) |
| 0.0 | 0.6 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 5.7 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 5.9 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 2.1 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 0.5 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 0.3 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.2 | GO:0005537 | mannose binding(GO:0005537) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.1 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.1 | 4.9 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 3.9 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.1 | 1.7 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 3.0 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.5 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.7 | PID_TNF_PATHWAY | TNF receptor signaling pathway |
| 0.0 | 4.1 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.0 | 2.7 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 2.3 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.6 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 1.3 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.2 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.1 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.4 | 2.3 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 6.8 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 0.9 | REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 1.7 | REACTOME_INTEGRATION_OF_PROVIRUS | Genes involved in Integration of provirus |
| 0.1 | 2.5 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 6.4 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.5 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 2.0 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 1.5 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.5 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.3 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
