Motif ID: Zfp219_Zfp740

Z-value: 1.123

Transcription factors associated with Zfp219_Zfp740:

Gene SymbolEntrez IDGene Name
Zfp219 ENSMUSG00000049295.10 Zfp219
Zfp740 ENSMUSG00000046897.10 Zfp740

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp219mm10_v2_chr14_-_52020698_520207370.161.8e-01Click!
Zfp740mm10_v2_chr15_+_102203639_1022037090.019.4e-01Click!


Activity profile for motif Zfp219_Zfp740.

activity profile for motif Zfp219_Zfp740


Sorted Z-values histogram for motif Zfp219_Zfp740

Sorted Z-values for motif Zfp219_Zfp740



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp219_Zfp740

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_44173271 8.679 ENSMUST00000088356.4
ENSMUST00000169582.1
 Gm608

predicted gene 608

chr5_-_134747241 8.446 ENSMUST00000015138.9
 Eln
elastin
chr7_-_78577771 8.402 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr7_-_78578308 8.109 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr15_+_57694651 8.008 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr1_-_56972437 7.348 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr16_+_44173239 7.077 ENSMUST00000119746.1
 Gm608
predicted gene 608
chr16_+_43503607 6.844 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
 Zbtb20


zinc finger and BTB domain containing 20


chr2_-_116065798 6.607 ENSMUST00000110907.1
ENSMUST00000110908.2
 Meis2

Meis homeobox 2

chr4_-_88033328 6.487 ENSMUST00000078090.5
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr12_-_27342696 6.386 ENSMUST00000079063.5
 Sox11
SRY-box containing gene 11
chr2_+_48949495 5.529 ENSMUST00000112745.1
 Mbd5
methyl-CpG binding domain protein 5
chr2_-_180225812 5.487 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr3_+_28263563 4.807 ENSMUST00000160307.2
ENSMUST00000159680.2
ENSMUST00000160518.1
ENSMUST00000162485.1
ENSMUST00000159308.1
ENSMUST00000162777.1
ENSMUST00000161964.1
 Tnik






TRAF2 and NCK interacting kinase






chr14_+_21500879 4.618 ENSMUST00000182964.1
 Kat6b
K(lysine) acetyltransferase 6B
chr6_+_4903350 4.603 ENSMUST00000175962.1
 Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr17_+_75005523 4.537 ENSMUST00000001927.5
 Ltbp1
latent transforming growth factor beta binding protein 1
chrX_-_94123087 4.425 ENSMUST00000113925.1
 Zfx
zinc finger protein X-linked
chr10_-_127341583 4.361 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr4_+_144892813 4.351 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 247 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.5 16.5 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.7 11.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.7 10.1 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 9.6 GO:0006402 mRNA catabolic process(GO:0006402)
0.3 8.5 GO:0030325 adrenal gland development(GO:0030325)
1.7 8.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.8 8.2 GO:0042118 endothelial cell activation(GO:0042118)
2.7 8.1 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.5 8.0 GO:1990403 embryonic brain development(GO:1990403)
0.6 7.8 GO:0070914 UV-damage excision repair(GO:0070914)
0.7 7.7 GO:0042572 retinol metabolic process(GO:0042572)
0.1 7.4 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
1.8 7.3 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.4 7.2 GO:0007379 segment specification(GO:0007379)
0.2 6.5 GO:0048599 oocyte development(GO:0048599)
2.1 6.4 GO:0060023 soft palate development(GO:0060023)
1.8 5.5 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.1 5.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.5 5.0 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.5 4.7 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.5 GO:0032993 protein-DNA complex(GO:0032993)
0.1 13.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 12.0 GO:0005730 nucleolus(GO:0005730)
0.1 11.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 10.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 9.8 GO:0055037 recycling endosome(GO:0055037)
2.8 8.4 GO:0071953 elastic fiber(GO:0071953)
0.2 8.3 GO:0008023 transcription elongation factor complex(GO:0008023)
1.6 8.1 GO:1990761 growth cone lamellipodium(GO:1990761)
0.2 8.0 GO:0035869 ciliary transition zone(GO:0035869)
0.0 7.6 GO:0016604 nuclear body(GO:0016604)
0.3 5.7 GO:0010369 chromocenter(GO:0010369)
1.4 5.5 GO:0043259 laminin-10 complex(GO:0043259)
0.0 5.5 GO:0016607 nuclear speck(GO:0016607)
0.1 4.9 GO:0009925 basal plasma membrane(GO:0009925)
1.5 4.5 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.4 4.5 GO:0044666 MLL3/4 complex(GO:0044666)
0.3 4.4 GO:0097542 ciliary tip(GO:0097542)
0.1 4.4 GO:0005844 polysome(GO:0005844)
0.6 4.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 25.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
3.3 16.5 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.3 10.0 GO:0070412 R-SMAD binding(GO:0070412)
0.1 9.9 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.2 8.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.6 8.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
2.1 8.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 7.9 GO:0008013 beta-catenin binding(GO:0008013)
1.1 7.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
2.4 7.3 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.3 7.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 7.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 6.6 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 6.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 5.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.3 5.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.5 4.9 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.3 4.9 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
1.1 4.5 GO:0050436 microfibril binding(GO:0050436)
0.7 4.5 GO:0045322 unmethylated CpG binding(GO:0045322)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.7 PID_SHP2_PATHWAY SHP2 signaling
0.2 15.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 10.9 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.2 10.5 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 8.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 6.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.7 6.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 5.8 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 5.0 PID_PLK1_PATHWAY PLK1 signaling events
0.1 4.9 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 4.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 4.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 4.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 3.6 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 3.5 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 3.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 2.7 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.1 2.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.6 PID_IL6_7_PATHWAY IL6-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.4 REACTOME_PI3K_AKT_ACTIVATION Genes involved in PI3K/AKT activation
0.2 7.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 6.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.2 5.2 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 5.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.4 4.8 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 4.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 3.6 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 3.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 3.2 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 3.2 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 3.1 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.8 3.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 3.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 2.9 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.1 2.8 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 2.7 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 2.7 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.1 2.4 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.5 2.3 REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING Genes involved in PI3K events in ERBB4 signaling