Motif ID: Zfp423
Z-value: 0.809
Transcription factors associated with Zfp423:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Zfp423 | ENSMUSG00000045333.9 | Zfp423 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zfp423 | mm10_v2_chr8_-_87804411_87804463 | -0.36 | 1.5e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 17.0 | GO:0090238 | positive regulation of arachidonic acid secretion(GO:0090238) |
| 2.2 | 13.4 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 1.6 | 7.8 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 1.5 | 4.5 | GO:2000501 | natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501) |
| 1.4 | 5.7 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) negative regulation of low-density lipoprotein particle clearance(GO:0010989) positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805) |
| 0.5 | 2.0 | GO:0097477 | lateral motor column neuron migration(GO:0097477) |
| 0.4 | 2.3 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.3 | 6.1 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.3 | 5.7 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.3 | 0.8 | GO:0016561 | protein import into peroxisome matrix, translocation(GO:0016561) |
| 0.2 | 0.8 | GO:1905167 | positive regulation of lysosomal protein catabolic process(GO:1905167) |
| 0.2 | 1.0 | GO:0046654 | tetrahydrofolate biosynthetic process(GO:0046654) |
| 0.2 | 6.3 | GO:1900273 | positive regulation of long-term synaptic potentiation(GO:1900273) |
| 0.2 | 2.3 | GO:0002087 | regulation of respiratory gaseous exchange by neurological system process(GO:0002087) |
| 0.2 | 0.9 | GO:0009405 | pathogenesis(GO:0009405) |
| 0.1 | 0.8 | GO:0072103 | glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104) |
| 0.1 | 0.5 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.1 | 5.5 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.1 | 0.6 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.1 | 1.0 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.1 | 7.3 | GO:0006633 | fatty acid biosynthetic process(GO:0006633) |
| 0.0 | 2.7 | GO:0031641 | regulation of myelination(GO:0031641) |
| 0.0 | 3.5 | GO:0032526 | response to retinoic acid(GO:0032526) |
| 0.0 | 0.2 | GO:0097343 | ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026) |
| 0.0 | 3.3 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 5.1 | GO:0006413 | translational initiation(GO:0006413) |
| 0.0 | 2.3 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.0 | 0.8 | GO:0000731 | DNA synthesis involved in DNA repair(GO:0000731) |
| 0.0 | 1.4 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.0 | 0.8 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.0 | 0.1 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) |
| 0.0 | 1.7 | GO:0034620 | cellular response to unfolded protein(GO:0034620) |
| 0.0 | 3.2 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 1.7 | GO:0051453 | regulation of intracellular pH(GO:0051453) |
| 0.0 | 3.1 | GO:0048167 | regulation of synaptic plasticity(GO:0048167) |
| 0.0 | 1.1 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919) |
| 0.0 | 2.0 | GO:0009615 | response to virus(GO:0009615) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 17.0 | GO:0032280 | symmetric synapse(GO:0032280) |
| 1.9 | 5.7 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.7 | 7.8 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.5 | 6.3 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.3 | 0.8 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.2 | 5.4 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.1 | 2.3 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 6.6 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 1.5 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.1 | 6.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.7 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.0 | 3.2 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 0.9 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.8 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 1.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 2.0 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 4.0 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 1.0 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 2.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 13.4 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 2.6 | 7.8 | GO:0070905 | serine binding(GO:0070905) |
| 1.9 | 5.7 | GO:0034190 | very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190) |
| 1.1 | 4.5 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 0.9 | 2.7 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.9 | 17.0 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.8 | 4.0 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.5 | 5.7 | GO:0008430 | selenium binding(GO:0008430) |
| 0.4 | 2.0 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 0.4 | 6.1 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.3 | 6.3 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.3 | 1.4 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) |
| 0.3 | 0.8 | GO:0016964 | alpha-2 macroglobulin receptor activity(GO:0016964) |
| 0.3 | 1.0 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488) |
| 0.2 | 0.9 | GO:0005093 | Rab GDP-dissociation inhibitor activity(GO:0005093) |
| 0.2 | 2.3 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.2 | 0.8 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.1 | 6.6 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 0.7 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.1 | 0.5 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.1 | 3.1 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.1 | 1.7 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 0.8 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.1 | 5.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 3.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 1.5 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.9 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.6 | GO:0004559 | alpha-mannosidase activity(GO:0004559) |
| 0.0 | 0.1 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.0 | 0.4 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 0.9 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 0.8 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 6.4 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 0.4 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 1.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 3.3 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.1 | 5.8 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 2.0 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.8 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 3.3 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.3 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.9 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.9 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.2 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.9 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.1 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.8 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.3 | 13.4 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.2 | 17.0 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 6.4 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 2.3 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 1.2 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 0.8 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.1 | 3.2 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 1.4 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 0.8 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 3.1 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.0 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.0 | 2.7 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.2 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.0 | 1.7 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 2.0 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 0.5 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
