Motif ID: Zfp524

Z-value: 0.866


Transcription factors associated with Zfp524:

Gene SymbolEntrez IDGene Name
Zfp524 ENSMUSG00000051184.6 Zfp524

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp524mm10_v2_chr7_+_5015466_5015509-0.552.3e-07Click!


Activity profile for motif Zfp524.

activity profile for motif Zfp524


Sorted Z-values histogram for motif Zfp524

Sorted Z-values for motif Zfp524



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp524

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_136898803 11.637 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr13_-_92131494 8.847 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr7_+_3303643 8.239 ENSMUST00000172109.1
 Prkcg
protein kinase C, gamma
chr7_-_112159034 8.216 ENSMUST00000033036.5
 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chr19_-_57118981 5.883 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr13_+_8885937 5.862 ENSMUST00000177397.1
ENSMUST00000177400.1
ENSMUST00000177447.1
 Idi1


isopentenyl-diphosphate delta isomerase


chr19_+_54045182 5.857 ENSMUST00000036700.5
 Adra2a
adrenergic receptor, alpha 2a
chr18_-_61911783 5.800 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr13_+_43785107 5.151 ENSMUST00000015540.2
 Cd83
CD83 antigen
chr11_-_6065737 5.005 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr13_+_8885501 4.841 ENSMUST00000169314.2
 Idi1
isopentenyl-diphosphate delta isomerase
chr16_-_76373827 4.700 ENSMUST00000121927.1
 Nrip1
nuclear receptor interacting protein 1
chr19_+_26623419 4.635 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr9_+_95559817 4.556 ENSMUST00000079597.5
 Paqr9
progestin and adipoQ receptor family member IX
chr7_+_73375494 4.397 ENSMUST00000094312.5
ENSMUST00000119206.1
 Rgma

RGM domain family, member A

chr15_-_79505241 4.268 ENSMUST00000057801.6
 Kcnj4
potassium inwardly-rectifying channel, subfamily J, member 4
chr2_-_5676046 4.061 ENSMUST00000114987.3
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr3_+_63295815 4.037 ENSMUST00000029400.1
 Mme
membrane metallo endopeptidase
chr5_+_81021583 3.995 ENSMUST00000121707.1
 Lphn3
latrophilin 3
chr7_-_45103747 3.881 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 213 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.6 13.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.5 13.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
1.8 11.0 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.5 10.2 GO:0097091 synaptic vesicle clustering(GO:0097091)
1.9 9.3 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.4 8.9 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
1.6 8.2 GO:0032423 regulation of mismatch repair(GO:0032423)
2.2 6.6 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
0.5 6.5 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
1.5 5.9 GO:0035624 receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) thermoception(GO:0050955)
0.2 5.4 GO:0010107 potassium ion import(GO:0010107)
0.9 5.2 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.2 5.0 GO:0033344 cholesterol efflux(GO:0033344)
1.2 4.9 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.6 4.8 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
1.6 4.7 GO:0001543 ovarian follicle rupture(GO:0001543)
0.5 4.6 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.4 4.4 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.6 4.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 17.1 GO:0097060 synaptic membrane(GO:0097060)
0.1 14.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 12.6 GO:0005581 collagen trimer(GO:0005581)
0.2 10.3 GO:0031901 early endosome membrane(GO:0031901)
0.3 7.6 GO:0071565 nBAF complex(GO:0071565)
0.0 6.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 6.2 GO:0051233 spindle midzone(GO:0051233)
0.0 5.1 GO:0008021 synaptic vesicle(GO:0008021)
0.0 4.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 4.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 3.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 3.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 3.8 GO:0005882 intermediate filament(GO:0005882)
0.4 3.7 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 3.7 GO:0043235 receptor complex(GO:0043235)
0.1 3.5 GO:0032420 stereocilium(GO:0032420)
0.5 3.4 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 3.1 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 3.1 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.1 GO:0003779 actin binding(GO:0003779)
0.4 13.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 12.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 11.2 GO:0005525 GTP binding(GO:0005525)
2.7 8.2 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.6 7.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 7.6 GO:0035254 glutamate receptor binding(GO:0035254)
0.3 6.9 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 6.4 GO:0005096 GTPase activator activity(GO:0005096)
0.7 6.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 6.0 GO:0015485 cholesterol binding(GO:0015485)
2.0 5.9 GO:0004936 alpha-adrenergic receptor activity(GO:0004936) epinephrine binding(GO:0051379)
0.7 5.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
1.3 5.0 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.2 4.8 GO:0046965 retinoid X receptor binding(GO:0046965)
0.1 4.6 GO:0005496 steroid binding(GO:0005496)
0.1 4.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.3 4.5 GO:0070402 NADPH binding(GO:0070402)
0.2 4.4 GO:0015026 coreceptor activity(GO:0015026)
1.4 4.3 GO:0022865 transmembrane electron transfer carrier(GO:0022865)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 11.1 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.3 9.5 PID_ARF6_PATHWAY Arf6 signaling events
0.2 9.2 PID_BMP_PATHWAY BMP receptor signaling
0.4 8.8 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.2 7.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.2 7.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.3 6.2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 5.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.7 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.3 4.6 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 4.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 3.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.6 PID_ATM_PATHWAY ATM pathway
0.0 2.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.1 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.2 2.0 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 2.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.8 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.0 1.7 PID_RAC1_PATHWAY RAC1 signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 18.9 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.6 15.6 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
1.9 11.6 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.4 11.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.3 8.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3 7.1 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 6.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.3 6.0 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.5 5.9 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 5.4 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.3 5.0 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.3 4.5 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 3.7 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 3.7 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 2.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.6 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 2.6 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.1 2.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 2.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits