Motif ID: Zic2

Z-value: 0.735


Transcription factors associated with Zic2:

Gene SymbolEntrez IDGene Name
Zic2 ENSMUSG00000061524.8 Zic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic2mm10_v2_chr14_+_122475397_1224754350.171.4e-01Click!


Activity profile for motif Zic2.

activity profile for motif Zic2


Sorted Z-values histogram for motif Zic2

Sorted Z-values for motif Zic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_19699008 5.712 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
Apoe





apolipoprotein E





chr8_+_104170513 5.651 ENSMUST00000171018.1
ENSMUST00000167633.1
ENSMUST00000093245.5
ENSMUST00000164076.1
Bean1



brain expressed, associated with Nedd4, 1



chr6_+_65671590 4.416 ENSMUST00000054351.4
Ndnf
neuron-derived neurotrophic factor
chr4_+_47208005 3.587 ENSMUST00000082303.6
ENSMUST00000102917.4
Col15a1

collagen, type XV, alpha 1

chr7_-_19698206 3.466 ENSMUST00000172808.1
ENSMUST00000174191.1
Apoe

apolipoprotein E

chr5_+_137288273 3.034 ENSMUST00000024099.4
ENSMUST00000085934.3
Ache

acetylcholinesterase

chr11_+_67586675 2.796 ENSMUST00000108680.1
Gas7
growth arrest specific 7
chr9_-_111690313 2.786 ENSMUST00000035083.7
Stac
src homology three (SH3) and cysteine rich domain
chrX_-_36991724 2.760 ENSMUST00000152291.1
Sept6
septin 6
chr14_-_78725089 2.713 ENSMUST00000074729.5
Dgkh
diacylglycerol kinase, eta
chr7_-_19698383 2.576 ENSMUST00000173739.1
Apoe
apolipoprotein E
chr4_+_42240639 2.564 ENSMUST00000117202.2
Gm10600
predicted gene 10600
chr4_+_42091207 2.476 ENSMUST00000178882.1
Gm3893
predicted gene 3893
chr5_-_139130159 2.419 ENSMUST00000129851.1
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr15_-_66969616 2.417 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
Ndrg1



N-myc downstream regulated gene 1



chr11_+_84525669 2.293 ENSMUST00000126072.1
ENSMUST00000128121.1
1500016L03Rik

RIKEN cDNA 1500016L03 gene

chr2_-_93452679 2.256 ENSMUST00000111257.1
ENSMUST00000145553.1
Cd82

CD82 antigen

chr11_+_84525647 2.223 ENSMUST00000134800.1
1500016L03Rik
RIKEN cDNA 1500016L03 gene
chr4_+_141368116 2.190 ENSMUST00000006380.4
Fam131c
family with sequence similarity 131, member C
chr12_-_113422730 2.096 ENSMUST00000177715.1
ENSMUST00000103426.1
Ighm

immunoglobulin heavy constant mu


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 183 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 11.8 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.9 8.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.5 4.2 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 4.0 GO:0051017 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.3 3.8 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.5 3.1 GO:0019695 choline metabolic process(GO:0019695)
0.2 2.9 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.4 2.8 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1 2.8 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.2 2.7 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.5 2.6 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 2.5 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.5 2.4 GO:0002339 B cell selection(GO:0002339)
0.2 2.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.5 2.3 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
0.3 2.3 GO:0005513 detection of calcium ion(GO:0005513)
0.0 2.3 GO:0046785 microtubule polymerization(GO:0046785)
0.1 2.1 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 2.1 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.2 2.0 GO:2001046 positive regulation of integrin-mediated signaling pathway(GO:2001046)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.8 GO:0005887 integral component of plasma membrane(GO:0005887)
3.9 11.8 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 5.8 GO:0005581 collagen trimer(GO:0005581)
0.1 5.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 3.9 GO:0030315 T-tubule(GO:0030315)
0.1 3.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 3.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 3.5 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.2 3.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 3.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.0 GO:0005901 caveola(GO:0005901)
0.7 2.9 GO:0019815 B cell receptor complex(GO:0019815)
0.0 2.9 GO:0005884 actin filament(GO:0005884)
0.9 2.8 GO:0005940 septin ring(GO:0005940)
0.3 2.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.3 2.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 2.3 GO:0097427 microtubule bundle(GO:0097427)
0.6 2.2 GO:0032280 symmetric synapse(GO:0032280)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.9 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 11.8 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 4.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 3.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.6 3.7 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 3.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.8 3.0 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.2 2.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 2.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.5 2.6 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.2 2.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 2.4 GO:0005507 copper ion binding(GO:0005507)
0.5 2.3 GO:2001070 starch binding(GO:2001070)
0.2 2.3 GO:0015250 water channel activity(GO:0015250)
0.1 2.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 2.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 2.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 2.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 2.1 GO:0001968 fibronectin binding(GO:0001968)
0.0 1.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.6 1.8 GO:0070905 serine binding(GO:0070905)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.8 NABA_COLLAGENS Genes encoding collagen proteins
0.1 5.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 5.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 4.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 3.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 3.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 3.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.3 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 2.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 1.8 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.7 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.2 1.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.0 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.8 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 0.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.8 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.0 0.7 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 11.8 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 5.6 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION Genes involved in Extracellular matrix organization
0.0 4.1 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 3.7 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 3.0 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 2.8 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 2.7 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 2.6 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 2.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 2.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.7 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.6 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 1.4 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.4 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 1.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.3 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation