Motif ID: Zic2
Z-value: 0.735

Transcription factors associated with Zic2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Zic2 | ENSMUSG00000061524.8 | Zic2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Zic2 | mm10_v2_chr14_+_122475397_122475435 | 0.17 | 1.4e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 183 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.9 | 11.8 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
0.9 | 8.2 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
0.5 | 4.2 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
0.0 | 4.0 | GO:0051017 | actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572) |
0.3 | 3.8 | GO:0090232 | positive regulation of spindle checkpoint(GO:0090232) |
0.5 | 3.1 | GO:0019695 | choline metabolic process(GO:0019695) |
0.2 | 2.9 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
0.4 | 2.8 | GO:0061092 | regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
0.1 | 2.8 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
0.2 | 2.7 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
0.5 | 2.6 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
0.1 | 2.5 | GO:0005980 | polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247) |
0.5 | 2.4 | GO:0002339 | B cell selection(GO:0002339) |
0.2 | 2.4 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
0.5 | 2.3 | GO:1901731 | positive regulation of platelet aggregation(GO:1901731) |
0.3 | 2.3 | GO:0005513 | detection of calcium ion(GO:0005513) |
0.0 | 2.3 | GO:0046785 | microtubule polymerization(GO:0046785) |
0.1 | 2.1 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
0.1 | 2.1 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
0.2 | 2.0 | GO:2001046 | positive regulation of integrin-mediated signaling pathway(GO:2001046) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 82 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 12.8 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
3.9 | 11.8 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
0.1 | 5.8 | GO:0005581 | collagen trimer(GO:0005581) |
0.1 | 5.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.0 | 3.9 | GO:0030315 | T-tubule(GO:0030315) |
0.1 | 3.8 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.0 | 3.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
0.2 | 3.5 | GO:0098984 | asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984) |
0.2 | 3.1 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.1 | 3.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.0 | 3.0 | GO:0005901 | caveola(GO:0005901) |
0.7 | 2.9 | GO:0019815 | B cell receptor complex(GO:0019815) |
0.0 | 2.9 | GO:0005884 | actin filament(GO:0005884) |
0.9 | 2.8 | GO:0005940 | septin ring(GO:0005940) |
0.3 | 2.3 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
0.3 | 2.3 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.3 | 2.3 | GO:0097427 | microtubule bundle(GO:0097427) |
0.6 | 2.2 | GO:0032280 | symmetric synapse(GO:0032280) |
0.0 | 2.0 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 1.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 144 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.9 | 11.8 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
0.1 | 4.0 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.1 | 3.8 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.6 | 3.7 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
0.1 | 3.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.8 | 3.0 | GO:0004104 | cholinesterase activity(GO:0004104) choline binding(GO:0033265) |
0.2 | 2.7 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
0.1 | 2.7 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
0.5 | 2.6 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
0.2 | 2.4 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
0.1 | 2.4 | GO:0005507 | copper ion binding(GO:0005507) |
0.5 | 2.3 | GO:2001070 | starch binding(GO:2001070) |
0.2 | 2.3 | GO:0015250 | water channel activity(GO:0015250) |
0.1 | 2.3 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
0.1 | 2.3 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
0.1 | 2.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
0.1 | 2.1 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
0.1 | 2.1 | GO:0001968 | fibronectin binding(GO:0001968) |
0.0 | 1.9 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.6 | 1.8 | GO:0070905 | serine binding(GO:0070905) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 32 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 5.8 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.1 | 5.4 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
0.1 | 5.2 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
0.0 | 4.5 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.2 | 3.7 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
0.1 | 3.6 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.0 | 3.1 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
0.0 | 2.3 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
0.0 | 2.1 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
0.1 | 1.8 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
0.0 | 1.7 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
0.2 | 1.6 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
0.0 | 1.4 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.0 | 1.1 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
0.0 | 1.0 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
0.0 | 0.8 | PID_AVB3_OPN_PATHWAY | Osteopontin-mediated events |
0.0 | 0.8 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
0.0 | 0.8 | PID_ALK1_PATHWAY | ALK1 signaling events |
0.0 | 0.8 | PID_ERBB1_DOWNSTREAM_PATHWAY | ErbB1 downstream signaling |
0.0 | 0.7 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 57 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 11.8 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
0.1 | 5.6 | REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION | Genes involved in Extracellular matrix organization |
0.0 | 4.1 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
0.3 | 3.7 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
0.1 | 3.0 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
0.1 | 2.8 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
0.1 | 2.7 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
0.1 | 2.7 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
0.2 | 2.6 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
0.1 | 2.0 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
0.0 | 2.0 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
0.0 | 1.9 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.1 | 1.8 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
0.1 | 1.7 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
0.1 | 1.6 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
0.1 | 1.4 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
0.0 | 1.4 | REACTOME_TRIGLYCERIDE_BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
0.1 | 1.3 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
0.1 | 1.3 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.0 | 1.3 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |